Research Topics
Species | Nansheng ChenSummaryAffiliation: Cold Spring Harbor Laboratory Country: USA Publications
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Detail Information
Publications
WormBase as an integrated platform for the C. elegans ORFeomeNansheng Chen
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 14:2155-61. 2004....
WormBase: a comprehensive data resource for Caenorhabditis biology and genomicsNansheng Chen
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 33:D383-9. 2005..Internally, we have restructured the database models to rationalize the representation of genes and to prepare the system to accept the genome sequences of three additional Caenorhabditis species over the coming year...- Identification of a nematode chemosensory gene familyNansheng Chen
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 102:146-51. 2005..The expansion of both the srab and sra gene families in C. elegans relative to C. briggsae is due to multiple rounds of tandem duplication and translocation of individual genes... - WormBase: a multi-species resource for nematode biology and genomicsTodd W Harris
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nucleic Acids Res 32:D411-7. 2004..These advances continue to increase the utility of WormBase for C.elegans researchers, as well as for those researchers exploring problems in functional and comparative genomics in the context of a powerful genetic system... - Conservation and functional significance of gene topology in the genome of Caenorhabditis elegansNansheng Chen
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Res 16:606-17. 2006.... - The genome sequence of Caenorhabditis briggsae: a platform for comparative genomicsLincoln D Stein
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Biol 1:E45. 2003..elegans genome. Based on similarity to C. briggsae, we found strong evidence for 1,300 new C. elegans genes. In addition, comparisons of the two genomes will help to understand the evolutionary forces that mold nematode genomes... - Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomicsNansheng Chen
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Genome Biol 7:R126. 2006..Taking this approach, we have identified numerous novel ciliary genes in C. elegans, some of which may be orthologs of unidentified human ciliopathy genes... 
Using RepeatMasker to identify repetitive elements in genomic sequencesNansheng Chen
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
Curr Protoc Bioinformatics . 2004..The protocols in this chapter detail how to use RepeatMasker both remotely and locally to extract repetitive elements data and mask these repetitive elements in nucleotide sequences...- Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6Allan K Mah
Department Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
J Biol Chem 282:28074-86. 2007..These parallels in transcriptional control between Brn1 and CEH-6 suggest that C. elegans may well be an appropriate model for determining gene-regulatory networks in the developing vertebrate kidney... - Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis speciesZhongying Zhao
British Columbia Cancer Research Center, Vancouver, British Columbia V5Z 1L6, Canada
Genetics 175:1407-18. 2007..Sites undergoing positive selection within subfamily D, which are implicated in very-long-chain fatty acid transport, were identified. The evolution of these sites might be driven by the changes in food source with time... - Gene structure evolution of the Na+-Ca2+ exchanger (NCX) familyCaly On
Cardiac Membrane Research Laboratory Kinesiology, Simon Fraser University, Burnaby, BC, Canada
BMC Evol Biol 8:127. 2008.... - WormBase: new content and better accessTamberlyn Bieri
Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA
Nucleic Acids Res 35:D506-10. 2007..Access to and searching WormBase has become more dependable and flexible via multiple mirror sites and indexing through Google... - The genome of the sea urchin Strongylocentrotus purpuratusErica Sodergren
Science 314:941-52. 2006..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes... - Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolutionJulia Tischler
The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Genome Biol 7:R69. 2006..Developing tools for the systematic mapping of genetic interactions is thus a key step in exploring the relationship between genotype and phenotype... - WormBase: better software, richer contentErich M Schwarz
Division of Biology, 156 29 California Institute of Technology, Pasadena, CA, 91125, USA
Nucleic Acids Res 34:D475-8. 2006.... - Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegansZhongying Zhao
Department of Genome Science, University of Washington, Seattle, Washington 98195 7730, USA
J Biol Chem 280:38787-94. 2005..The results indicate that distinct regulatory elements are able to mediate the similar expression patterns... - Identification and characterization of novel human tissue-specific RFX transcription factorsSyed Aftab
Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada
BMC Evol Biol 8:226. 2008....