Andrei Chabes

Summary

Affiliation: Cold Spring Harbor Laboratory
Country: USA

Publications

  1. pmc Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae
    Andrei Chabes
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:1183-8. 2007
  2. ncbi request reprint Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
    Andrei Chabes
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Cell 112:391-401. 2003
  3. ncbi request reprint DNA building blocks at the foundation of better survival
    Andrei Chabes
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell Cycle 2:171-3. 2003
  4. pmc Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools
    Olga Tsaponina
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS Genet 7:e1002061. 2011
  5. pmc Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
    Dinesh Kumar
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 39:1360-71. 2011
  6. pmc Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
    Dinesh Kumar
    Department of Medical Biochemistry and Biophysics, Umea University, SE 90187 Umea, Sweden
    Nucleic Acids Res 38:3975-83. 2010
  7. pmc A common telomeric gene silencing assay is affected by nucleotide metabolism
    Marlies P Rossmann
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell 42:127-36. 2011
  8. pmc Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
    Nasim Sabouri
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 36:5660-7. 2008
  9. ncbi request reprint Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex
    Vladimir Domkin
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    J Biol Chem 277:18574-8. 2002
  10. pmc A top-down view on DNA replication and recombination from 9,000 feet above sea level
    Erik Johansson
    Department of Medical Biochemistry and Biophysics, Umea University, SE 90187 Umea, Sweden
    Genome Biol 12:304. 2011

Collaborators

  • BRUCE W STILLMAN
  • Shigeaki Saitoh
  • Dinesh Kumar
  • Olga Tsaponina
  • Erik Johansson
  • Jörgen Viberg
  • Marlies P Rossmann
  • Anna Karin Nilsson
  • Nasim Sabouri
  • Vladimir Domkin
  • Christian Speck
  • Weijun Luo
  • Thomas A Kunkel
  • Amy L Abdulovic
  • Emad Barsoum
  • Stefan U Aström
  • Dinesh Kumar Goyal
  • Lars Thelander

Detail Information

Publications11

  1. pmc Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae
    Andrei Chabes
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:1183-8. 2007
    ..We propose that fluctuation of dNTP concentration controls cell cycle progression and the initiation of DNA replication...
  2. ncbi request reprint Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
    Andrei Chabes
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Cell 112:391-401. 2003
    ..We propose that increased survival and mutation rates result from more efficient translesion DNA synthesis at elevated dNTP concentrations...
  3. ncbi request reprint DNA building blocks at the foundation of better survival
    Andrei Chabes
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell Cycle 2:171-3. 2003
  4. pmc Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools
    Olga Tsaponina
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS Genet 7:e1002061. 2011
    ..A reduction of the histone gene dosage in the rad53 mutant restores Ixr1 levels. Our results demonstrate that Ixr1, but not Dun1, is required for the proper RNR1 expression both during an unperturbed cell cycle and after DNA damage...
  5. pmc Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
    Dinesh Kumar
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 39:1360-71. 2011
    ..An interesting mutational strand bias is observed in one rnr1 strain, suggesting that the S-phase checkpoint selectively prevents replication errors during leading strand replication...
  6. pmc Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
    Dinesh Kumar
    Department of Medical Biochemistry and Biophysics, Umea University, SE 90187 Umea, Sweden
    Nucleic Acids Res 38:3975-83. 2010
    ..In contrast, when none of the dNTPs was limiting for DNA replication, even extreme and mutagenic dNTP pool imbalances did not activate the S-phase checkpoint and did not interfere with the cell cycle progression...
  7. pmc A common telomeric gene silencing assay is affected by nucleotide metabolism
    Marlies P Rossmann
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell 42:127-36. 2011
    ..We conclude that metabolic changes caused by the drug employed and certain mutants being studied are incompatible with the use of certain prototrophic markers for TPEV...
  8. pmc Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
    Nasim Sabouri
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 36:5660-7. 2008
    ..The nucleotide inserted opposite 8-oxoG is dATP. We propose that during DNA damage in S. cerevisiae increased dNTP concentration allows replicative DNA polymerases to bypass certain DNA lesions...
  9. ncbi request reprint Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex
    Vladimir Domkin
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    J Biol Chem 277:18574-8. 2002
    ..In complex with inactive Rnr1-C428A, the activity of Rnr3 is controlled by effector binding to Rnr1-C428A. This result indicates cross-talk between the Rnr1 and Rnr3 polypeptides of the large subunit...
  10. pmc A top-down view on DNA replication and recombination from 9,000 feet above sea level
    Erik Johansson
    Department of Medical Biochemistry and Biophysics, Umea University, SE 90187 Umea, Sweden
    Genome Biol 12:304. 2011
    ..A report of the Keystone Symposium 'DNA Replication and Recombination' held in Keystone, USA, 27 February to 4 March 2011...
  11. ncbi request reprint Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA
    Shigeaki Saitoh
    Department of Molecular Biology, The Scripts Research Institute, La Jolla, CA 92037, USA
    Cell 109:563-73. 2002
    ..cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance...