Research Topics
Species | Eric P CohenSummaryCountry: USA Publications
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Publications
Mitigation of late renal and pulmonary injury after hematopoietic stem cell transplantationEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Int J Radiat Oncol Biol Phys 83:292-6. 2012....- Effect of high-dose total body irradiation on ACTH, corticosterone, and catecholamines in the ratEric P Cohen
Medical College of Wisconsin, Milwaukee, USA
Transl Res 157:38-47. 2011..This activation was attributable at least partially to enhanced pituitary ACTH production... - Chronic kidney disease after hematopoietic stem cell transplantationEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Semin Nephrol 30:627-34. 2010..Investigation of the causes of chronic kidney disease is needed, as are ways to prevent, mitigate, and treat it... 
Mitigation of radiation injuries via suppression of the renin-angiotensin system: emphasis on radiation nephropathyE P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Curr Drug Targets 11:1423-9. 2010..These drugs are likely to act in a similar way to mitigate radiation nephropathy...
C-reactive protein and dialysis accessEric P Cohen
Nephrology Division, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA
Kidney Int 76:1025-6. 2009..Inflammation associated with dialysis catheter use could have an independent adverse effect on patient outcomes. Awareness and further study of the role of inflammation are needed...- Successful treatment of BK viremia using reduction in immunosuppression without antiviral therapyEhab R Saad
Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Transplantation 85:850-4. 2008..Treatment of BK virus (BKV) infection in renal transplant recipients remains controversial. This retrospective analysis evaluated efficacy and safety of reducing immunosuppression without antiviral therapy... - Role of the angiotensin II type-2 receptor in radiation nephropathyEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Transl Res 150:106-15. 2007..The effect of AT(2) blockade in radiation nephropathy cannot be explained by binding to the AT(1) receptor, and the efficacy of the AT(1) blockade in the same model cannot be explained by unopposed overstimulation of the AT(2) receptor... - Chronic oxidative stress as a mechanism for radiation nephropathyMarek Lenarczyk
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Radiat Res 171:164-72. 2009..If chronic oxidative stress is part of the pathogenesis of radiation nephropathy, it does not leave widespread or easily detectable evidence behind... - Radiation nephropathy is not mitigated by antagonists of oxidative stressEric P Cohen
Departments of Medicine and, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA
Radiat Res 172:260-4. 2009..Thus three different types of antioxidants, when used at doses consistent with an antioxidant effect, had no mitigation efficacy against radiation nephropathy... - Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trialEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Int J Radiat Oncol Biol Phys 70:1546-51. 2008..To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT)... - BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritisSundaram Hariharan
The Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA
Am J Transplant 5:2719-24. 2005..Recovery from BKVN and elimination of BKV is associated with the development of BKV-specific IgG antibodies and this provides insight into the role of humoral immunity to BKV in the pathogenesis of BKVN... - The renin-angiotensin system in experimental radiation nephropathyEric P Cohen
Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
J Lab Clin Med 139:251-7. 2002..We hypothesize that even the normal activity of the RAS contributes to injury after kidney irradiation, possibly by supporting the proliferation of cells that carry potentially lethal radiation injuries... - Recovery of BK virus large T-antigen-specific cellular immune response correlates with resolution of bk virus nephritisSimon E Prosser
1 Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Transplantation 85:185-92. 2008..BKV infection progresses to BKV nephritis (BKVN) in approximately 8% of transplants and in half of these cases the graft is lost... - Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathyJohn E Moulder
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Radiat Res 161:312-7. 2004..We speculate that the beneficial effect of the angiotensin II type 2 receptor blocker is due to a reduction in radiation-induced renal cell proliferation or fibrosis... - BK virus nephritis: risk factors, timing, and outcome in renal transplant recipientsBrahm Vasudev
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Kidney Int 68:1834-9. 2005..There was a steep decline in renal function in months preceding the diagnosis of BKVN, and reduction in calcineurin inhibitor dose, but not overall immunosuppression, correlated with stabilization of renal function... - Captopril and losartan for mitigation of renal injury caused by single-dose total-body irradiationJohn E Moulder
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Radiat Res 175:29-36. 2011..This lays the necessary groundwork for pivotal rodent studies under the FDA Animal Efficacy Rule and provides an outline of how the FDA-required large-animal studies could be designed... - Radiation nephropathyEric P Cohen
Medical College of Wisconsin, Milwaukee, WI, USA
Semin Nephrol 23:486-99. 2003..Recent findings suggest a similar benefit in clinical radiation nephropathy... - Effect of animal facility construction on basal hypothalamic-pituitary-adrenal and renin-aldosterone activity in the ratHershel Raff
Endocrine Research Laboratory, Aurora St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
Endocrinology 152:1218-21. 2011..We conclude that nearby construction can cause a stress response without long-term effects on hypothalamic-pituitary-adrenal axis gene expression and body weight... - Dietary selenium for the mitigation of radiation injury: effects of selenium dose escalation and timing of supplementationFritz Sieber
Department of Pediatrics and Children s Research Institute, Milwaukee, Wisconsin 53226, USA
Radiat Res 176:366-74. 2011..The high dose requirements, the pronounced threshold effect, and the superior performance of selenite suggest that the mitigation of radiation nephropathy involves mechanisms that go beyond the induction of selenoproteins... - Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathyJohn E Moulder
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Radiat Res 157:393-401. 2002.... - The urine proteome for radiation biodosimetry: effect of total body vs. local kidney irradiationMukut Sharma
Nephrology Division, Department of Medicine, Research Building Room F2 100, Stop 151, KCVA Medical Center, 4801 Lindwood Blvd, Kansas City, MO 64128, USA
Health Phys 98:186-95. 2010..These novel findings demonstrate intriguing differences between TBI and LKI, and suggest that urine proteome may be useful in determining organ-specific changes caused by partial body irradiation... - High-dose selenium for the mitigation of radiation injury: a pilot study in a rat modelFritz Sieber
Department of Pediatrics and Children s Research Institute, Wisconsin, USA
Radiat Res 171:368-73. 2009..Our results suggest that dietary supplementation with high-dose selenium may provide a safe, effective and practical way to mitigate radiation injury to kidneys... - Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injuryJohn E Moulder
Radiation Oncology and Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Semin Radiat Oncol 17:141-8. 2007.... - Arachidonic acid metabolites mediate the radiation-induced increase in glomerular albumin permeabilityMukut Sharma
Division of Nephrology and the Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Exp Biol Med (Maywood) 231:99-106. 2006..Understanding of the early epigenetic effects of irradiation may lead to new intervention strategies against radiation-induced injury of normal tissues... - Successful treatment of radiation nephropathy with angiotensin II blockadeEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Int J Radiat Oncol Biol Phys 55:190-3. 2003..The aim of this report is to document the successful treatment of radiation nephropathy... - Benefit of child-to-parent kidney donationEric P Cohen
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Am J Transplant 3:865-72. 2003..We conclude that CTP kidney donation should not be discouraged, and represents a useful source of transplantable kidneys... - Evolution of endpoints for renal transplant outcomeSundaram Hariharan
Division of Nephrology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Am J Transplant 3:933-41. 2003..A practical approach for assessing newer therapies in future studies is to use composite endpoints, which combine conventional endpoints (graft loss, death, acute rejection) with newer endpoints (renal function, histological indices)... - Stenosis of the glomerulotubular neckEric P Cohen
Nephrology Division, Medical College of Wisconsin, Froedtert Hospital, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Nephron 92:259-62. 2002 - Decreased risk of radiation pneumonitis with incidental concurrent use of angiotensin-converting enzyme inhibitors and thoracic radiation therapyJordan Kharofa
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
Int J Radiat Oncol Biol Phys 84:238-43. 2012..The aim of this study was to evaluate whether ACE inhibitors decrease the risk of radiation pneumonitis in lung cancer patients receiving thoracic irradiation... - Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorderVasundhara Ganne
Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Clin Transplant 17:417-22. 2003..5 yr. CONCLUSION: Rituximab is an effective agent in the treatment of PTLD without the morbidity characteristic of chemotherapy. Chemotherapy should be reserved only for those refractory to Rituximab therapy... - Percussion hemoglobinuria - a novel term for hand trauma-induced mechanical hemolysis: a case reportMonica Vasudev
Division of Nephrology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee WI 53226, USA
J Med Case Reports 5:508. 2011..abstract:.. - Retinoic acid exacerbates experimental radiation nephropathyJohn E Moulder
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Radiat Res 157:199-203. 2002.... - Subdural hematomas in chronic dialysis patients: significant and increasingPuneet Sood
Department of Medicine, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Clin J Am Soc Nephrol 2:956-9. 2007..Subdural hematoma is a known complication of long-term hemodialysis... - Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agentsSyed Hussain
Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
Clin Transplant 16:43-7. 2002..005. The use of ALA was associated with a rapid fall in GFR and graft failure in patients with PVi nephritis. Careful diagnosis of PVi is warranted in renal allograft recipients prior to initiating ALA therapy...