Research Topics
| Alex SpyropoulosSummaryAffiliation: Clinical Thrombosis Center Country: USA Publications
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Detail Information
Publications
Prevention of venous thromboembolism: clinical and economic implications. IntroductionAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, Albuquerque, NM 87108, USA
Am J Health Syst Pharm 63:S3-4. 2006- Prevention of venous thromboembolism in the cancer surgery patientAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, Albuquerque, NM 87108, USA
Cleve Clin J Med 75:S17-26. 2008..The risk-benefit profile of low-dose anticoagulant prophylaxis appears to be favorable even in many cancer patients undergoing neurosurgery, for whom pharmacologic VTE prophylaxis has been controversial because of bleeding risks... - Direct medical costs of venous thromboembolism and subsequent hospital readmission rates: an administrative claims analysis from 30 managed care organizationsAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, 5400 Gibson Blvd, SE, Albuquerque, NM 87108, USA
J Manag Care Pharm 13:475-86. 2007..Venous thromboembolism (VTE) is a common medical condition manifested as deep vein thrombosis (DVT) or pulmonary embolism (PE). Few data exist on the total economic burden of DVT and PE... - Investigational treatments of venous thromboembolismAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, 5400 Gibson Boulevard SE, Albuquerque, NM 87108, USA
Expert Opin Investig Drugs 16:431-40. 2007.... - Management of venous thromboembolism in the elderlyAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Sandia Health Systems, Albuquerque, New Mexico 87108, USA
Drugs Aging 23:651-71. 2006..New anticoagulants that may be of potential benefit in this patient population include fondaparinux sodium, but clinical experience of this drug in the elderly remains limited... - Pharmacologic therapy for the management of thrombosis: unfractionated heparin or low-molecular-weight heparin?Alex C Spyropoulos
Clinical Thrombosis Center, Lovelace Sandia Health Systems, Albuquerque, New Mexico 87108, USA
Clin Cornerstone 7:39-48. 2005..The aim of this article is to summarize efficacy, safety, and pharmacoeconomic considerations when selecting LMWH versus UFH for thrombosis management in VTE and NSTE ACS... - Emerging strategies in the prevention of venous thromboembolism in hospitalized medical patientsAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Sandia Health Systems, 5400 Gibson Blvd SE, Albuquerque, NM 87108, USA
Chest 128:958-69. 2005..Despite the availability of effective thromboprophylactic therapies, VTE prophylaxis continues to be underutilized in hospitalized medical patients... 
Update in the treatment of venous thromboembolismDavid A Garcia
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Semin Respir Crit Care Med 29:40-6. 2008..In addition to presenting evidence relevant to the optimal duration of warfarin therapy, we highlight circumstances under which extended therapy with a parenteral agent such as a low molecular weight heparin might be preferable...- Management of acute proximal deep vein thrombosis: pharmacoeconomic evaluation of outpatient treatment with enoxaparin vs inpatient treatment with unfractionated heparinAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Health Systems, Albuquerque, NM 87108, USA
Chest 122:108-14. 2002..Results demonstrated equivalent safety and efficacy for home care with enoxaparin with a reduction in cost. Our objective was to validate these findings in the routine practice setting of a US health maintenance organization... - Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulationAlex C Spyropoulos
Clinical Thrombosis Center Lovelace Medical Center Albuquerque, New Mexico 87108, USA
Curr Opin Pulm Med 11:373-9. 2005.... - Venous thromboembolism prophylaxis with unfractionated heparin in the hospitalized medical patient: the case for thrice daily over twice daily dosingCharles E Mahan
Cardinal Health Pharmacy Solutions, Lovelace Medical Center, Lovelace Rehabilitation Hospital, Lovelace Health Systems, 601 Dr Martin Luther King Jr Ave NE, Albuquerque, NM, 87102, USA
Intern Emerg Med 5:299-306. 2010..Newly published risk-assessment models may be beneficial in determining which patients would best benefit from BID UFH or TID UFH... - Anticoagulation with anisindione in a patient with a warfarin-induced skin eruptionAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Health Systems, 5400 Gibson Boulevard SE, Albuquerque, NM 87108, USA
Pharmacotherapy 23:533-6. 2003..Health care providers managing patients who are receiving oral anticoagulant therapy should be aware of the maculopapular allergic reactions associated with warfarin and consider alternative treatment options such as anisindione... - Bridging of oral anticoagulation therapy for invasive proceduresAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Sandia Health Systems, 5400 Gibson Blvd SE, Albuquerque, NM 87108, USA
Curr Hematol Rep 4:405-13. 2005..This paper reviews these clinical data on bridging therapy and provides an evidence-based perioperative management strategy for the at-risk patient on chronic OAC... - Managing oral anticoagulation requires expert experience and clinical evidenceAlex C Spyropoulos
Lovelace Sandia Health Systems, Clinical Thrombosis Center, 5400 Gibson Blvd SE, Albuquerque, NM 87108, USA
J Thromb Thrombolysis 21:91-4. 2006.... - A disease management protocol for outpatient perioperative bridge therapy with enoxaparin in patients requiring temporary interruption of long-term oral anticoagulationAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Sandia Health Systems, Albuquerque, New Mexico 87108, USA
Pharmacotherapy 24:649-58. 2004..We sought to determine whether an alternate strategy of outpatient-based perioperative disease management with low-molecular-weight heparin (LMWH) as bridge therapy provides the potential for cost savings... - Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry)Alex C Spyropoulos
Lovelace Medical Center, Albuquerque, New Mexico, USA
Am J Cardiol 102:883-9. 2008.... - The clinical thrombosis center and clinical thrombologist: a new US health systems paradigm for the management of venous thromboembolic diseaseAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Health Systems, 5400 Gibson Boulevard SE, Albuquerque, NM 87108, USA
J Thromb Thrombolysis 15:227-32. 2003.... - Costs and clinical outcomes associated with low-molecular-weight heparin vs unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapyAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Health Systems, Albuquerque, NM 87108, USA
Chest 125:1642-50. 2004..v. UH, administered in a hospital setting, or LMWH, administered primarily in the outpatient setting using disease management guidelines... - Periprocedural bridging therapy in patients receiving chronic oral anticoagulation therapyAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, Albuquerque, NM 87108, USA
Curr Med Res Opin 22:1109-22. 2006..This, however, creates a clinical dilemma, since discontinuing VKAs may place the patient at risk of thromboembolism... - Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndromeDavid B Talmadge
University of New Mexico School of Medicine, Albuquerque, USA
Pharmacotherapy 23:674-7. 2003..No further complications occurred with long-term therapy. Although a rare complication of therapy, clinicians should monitor for the development of purple toes syndrome in patients taking warfarin... - Rates of symptomatic venous thromboembolism in US surgical patients: a retrospective administrative database studyAlex C Spyropoulos
University of New Mexico Health Sciences Center, Albuquerque, NM, USA
J Thromb Thrombolysis 28:458-64. 2009..2-11.4), and orthopedic versus abdominal surgery (OR 1.4; 95% CI: 1.4-1.6). Patients undergoing orthopedic or abdominal surgery remain at-risk for VTE. Implementation of national performance measures may help reduce the burden of VTE... - Brave new world: the current and future use of novel anticoagulantsAlex C Spyropoulos
Clinical Thrombosis Center, ABQ Health Partners, University of New Mexico Health Center College of Pharmacy, Albuquerque, NM 87102, USA
Thromb Res 123:S29-35. 2008.... - Outpatient-based primary and secondary thromboprophylaxis with low-molecular-weight heparinAlex C Spyropoulos
Clinical Thrombosis Center, Lovelace Medical Center, Albuquerque, New Mexico 87108, USA
Clin Appl Thromb Hemost 14:63-74. 2008.... - Management patterns and outcomes of patients with venous thromboembolism in the usual community practice settingVincent J Willey
HealthCore, Inc, Wilmington, DE 19081, USA
Clin Ther 26:1149-59. 2004.... - Prevention of venous thromboembolism in the orthopedic surgery patientSteven B Deitelzweig
Department of Hospital Medicine, Ochsner Health System, New Orleans, LA 70121, USA
Cleve Clin J Med 75:S27-36. 2008..Extended-duration prophylaxis (for 4 to 5 weeks) is now recommended for patients undergoing hip arthroplasty or hip fracture repair. Patients undergoing knee arthroscopy do not require routine pharmacologic VTE prophylaxis... - Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patientsAlexander T Cohen
Vascular Medicine, Department of Surgery, Guy s, King s and St Thomas School of Medicine, London, UK
Thromb Haemost 94:750-9. 2005..These medical conditions and risk factors are included in a risk-assessment model which is hoped will provide a simple means of assisting clinicians in deciding whether thromboprophylaxis should be used in an individual patient... - Longitudinal evaluation of health plan cost per venous thromboembolism or bleed event in patients with a prior venous thromboembolism event during hospitalizationMichael F Bullano
HealthCore, Inc, 800 Delaware Ave, Wilmington, DE 19801, USA
J Manag Care Pharm 11:663-73. 2005.... - Prevention of venous thromboembolism in the hospitalized medical patientAmir K Jaffer
Department of Medicine, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Cleve Clin J Med 75:S7-16. 2008.... - Perioperative bridging therapy for the at-risk patient on chronic anticoagulationAlex C Spyropoulos
Dis Mon 51:183-93. 2005 - Oral anticoagulation: preparing for changeEdith A Nutescu
University of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA
J Am Med Dir Assoc 5:2-11. 2004..Further, the results of clinical trials suggest that ximelagatran may be as effective as warfarin in preventing stroke and VTE... 
Management of venous thromboembolism: why not treat it at home?Alex C Spyropoulos
Can Fam Physician 51:181-2, 184-5. 2005- Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous ThromboembolismVictor F Tapson
Division of Pulmonary and Critical Care, Box 31175, Room 351 Bell Building, Duke University Medical Center, Durham, NC 27710, USA
Chest 132:936-45. 2007..Our aim was to characterize the clinical practices for VTE prophylaxis in acutely ill hospitalized medical patients enrolled in the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE)... - Community-based treatment of venous thromboembolism with a low-molecular-weight heparin and warfarinThomas M Hyers
Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO, USA
J Thromb Thrombolysis 24:225-32. 2007..Home therapy in the usual practice setting should achieve substantial overall cost savings in the treatment of DVT... - Prevention of venous thromboembolismMario Pini
Medicina Interna II, Ospedale di Fidenza, Fidenza, Parma, Italy
Semin Thromb Hemost 32:755-66. 2006.... - The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)James D Douketis
McMaster University, Hamilton, Ontario, Canada
Chest 133:299S-339S. 2008.... - Primary prevention of venous thromboembolism in long-term care: identifying and managing the riskSylvia Haas
Institut für Experimentelle Onkologie und Therapieforschung, Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
Clin Appl Thromb Hemost 14:149-58. 2008..This review addresses the role of risk assessment in the decision of when to provide prophylaxis to an individual in long-term care and highlights key management issues for those prescribed prophylaxis...