Ming Zhou

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Clear cell tubulopapillary renal cell carcinoma: a study of 36 distinctive low-grade epithelial tumors of the kidney
    Hakan Aydin
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 34:1608-21. 2010
  2. ncbi Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification
    Ming Zhou
    Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 33:1840-9. 2009
  3. ncbi Prostate basal cell lesions can be negative for basal cell keratins: a diagnostic pitfall
    Ming Zhou
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anal Quant Cytol Histol 28:125-9. 2006
  4. ncbi Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence
    Ming Zhou
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 33:72-80. 2009
  5. ncbi Differential expression in clear cell renal cell carcinoma identified by gene expression profiling
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 181:849-60. 2009
  6. ncbi Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    Ali Reza Golshayan
    Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    J Clin Oncol 27:235-41. 2009
  7. ncbi Surgical resection of renal cell carcinoma after targeted therapy
    Anil A Thomas
    Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    J Urol 182:881-6. 2009
  8. ncbi Single focus prostate cancer: pathological features and ERG fusion status
    Sara M Falzarano
    Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 185:489-94. 2011
  9. ncbi The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies
    Oksana Yaskiv
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA
    Am J Surg Pathol 35:1062-8. 2011
  10. ncbi The diagnostic utility of novel immunohistochemical marker ERG in the workup of prostate biopsies with "atypical glands suspicious for cancer"
    Huiying He
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 35:608-14. 2011

Detail Information

Publications98

  1. ncbi Clear cell tubulopapillary renal cell carcinoma: a study of 36 distinctive low-grade epithelial tumors of the kidney
    Hakan Aydin
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 34:1608-21. 2010
    ....
  2. ncbi Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification
    Ming Zhou
    Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 33:1840-9. 2009
    ..quot; However, before it is accepted as a distinct renal cell carcinoma subtype, further studies are needed to document a characteristic molecular signature associated with this tumor...
  3. ncbi Prostate basal cell lesions can be negative for basal cell keratins: a diagnostic pitfall
    Ming Zhou
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anal Quant Cytol Histol 28:125-9. 2006
    ..We reported two cases of prostate basal cell lesions with negative basal cell keratin expression by immunohistochemistry...
  4. ncbi Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence
    Ming Zhou
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 33:72-80. 2009
    ..By immunohistochemistry, expression of both receptors was similar between CN and MEST. This study provides the most convincing molecular evidence that CN and MEST represent different parts of the morphologic spectrum of the same disease...
  5. ncbi Differential expression in clear cell renal cell carcinoma identified by gene expression profiling
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 181:849-60. 2009
    ..We present data using a custom kidney cancer cDNA array that can predict the outcome in patients with unilateral and bilateral renal cell carcinoma...
  6. ncbi Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    Ali Reza Golshayan
    Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    J Clin Oncol 27:235-41. 2009
    ..The utility of vascular endothelial growth factor (VEGF)-targeted therapy in patients with this disease is unknown...
  7. ncbi Surgical resection of renal cell carcinoma after targeted therapy
    Anil A Thomas
    Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    J Urol 182:881-6. 2009
    ..The integration of targeted therapy and surgery requires careful consideration due to the potential for increased perioperative morbidity...
  8. ncbi Single focus prostate cancer: pathological features and ERG fusion status
    Sara M Falzarano
    Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 185:489-94. 2011
    ..We evaluated the clinicopathological characteristics of single focus prostate cancer in radical prostatectomies, its clinical relevance and the occurrence of TMPRSS2-ERG rearrangement...
  9. ncbi The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies
    Oksana Yaskiv
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA
    Am J Surg Pathol 35:1062-8. 2011
    ..The high specificity of ERG for the presence of cancer may have important implications for prostate biopsy interpretation and needs to be further validated in larger prospective studies...
  10. ncbi The diagnostic utility of novel immunohistochemical marker ERG in the workup of prostate biopsies with "atypical glands suspicious for cancer"
    Huiying He
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 35:608-14. 2011
    ..Furthermore, positive ERG staining is not entirely specific for PCa and can occasionally be found in high-grade prostatic intraepithelial neoplasia and benign glands that are not associated with PCa in prostate biopsies...
  11. ncbi Clinical correlates of renal angiomyolipoma subtypes in 209 patients: classic, fat poor, tuberous sclerosis associated and epithelioid
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 180:836-43. 2008
    ..We investigated the clinical, radiographic and histological characteristics of each angiomyolipoma subtype...
  12. ncbi Discrepancy in prostate cancer localization between biopsy and prostatectomy specimens in patients with unilateral positive biopsy: implications for focal therapy
    Michael Sinnott
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Prostate 72:1179-86. 2012
    ..Unilateral ablative strategy success depends on reliable prediction of prostate cancer (PCA) location. We evaluated the discrepancy in PCA localization between unilateral positive biopsy (PBx) and radical prostatectomy (RP)...
  13. ncbi TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients
    Cristina Magi-Galluzzi
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Prostate 71:489-97. 2011
    ..We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients...
  14. ncbi Neoadjuvant docetaxel treatment for locally advanced prostate cancer: a clinicopathologic study
    Cristina Magi-Galluzzi
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer 110:1248-54. 2007
    ..The objective of the current study was to determine the histologic and molecular changes that occurred in patients with high-risk, localized prostate cancer (PCa) after neoadjuvant docetaxel chemotherapy...
  15. ncbi Renal angiomyolipoma: clinicopathologic study of 194 cases with emphasis on the epithelioid histology and tuberous sclerosis association
    Hakan Aydin
    Department of Anatomic Pathology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 33:289-97. 2009
    ..Epithelioid component, epithelial cysts, and microscopic AML foci are strongly associated with TSC and the presence of all 3 features should raise strong suspicion for TSC...
  16. ncbi Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor
    Ming Zhou
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Mod Pathol 22:385-92. 2009
    ..In view of the previous and current data, the staging system for bladder neck involvement should be revised and patients may be best categorized as having pT3a disease...
  17. ncbi Differential expression of caveolin-1 in renal neoplasms
    Ila Tamaskar
    Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Cancer 110:776-82. 2007
    ..In the current study, the authors used immunohistochemistry to investigate the membranous and cytoplasmic expression of caveolin-1 and its correlation with other pathologic parameters in different subtypes of renal neoplasms...
  18. ncbi Angiomyolipoma with minimal fat on MDCT: can counts of negative-attenuation pixels aid diagnosis?
    Claus Simpfendorfer
    Section of Abdominal Imaging, Imaging Institute, Desk Hb6, Cleveland Clinic, Cleveland, OH 44195, USA
    AJR Am J Roentgenol 192:438-43. 2009
    ..The purpose of this study was to determine whether counts of pixels with subzero attenuation on CT scans can aid in the diagnosis of renal angiomyolipoma with minimal fat...
  19. ncbi Renal cell carcinomas with intratumoral fat and concomitant angiomyolipoma: potential pitfalls in staging and diagnosis
    Manju Aron
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, L25, Cleveland, OH 44195, USA
    Am J Clin Pathol 134:807-12. 2010
    ..Our study highlights the potential pitfalls in staging and diagnosis when intratumoral fat or AML is found within RCC...
  20. ncbi Pathologic stage migration has slowed in the late PSA era
    Fei Dong
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Urology 70:839-42. 2007
    ..We examined patients treated by radical prostatectomy between 1987 and 2005 to establish temporal trends in pathologic stage migration as assessed by the proportion of patients with nonorgan-confined disease (NOCD)...
  21. ncbi Clinicopathological features of prostate cancers detected after an initial diagnosis of 'atypical glands suspicious for cancer'
    Ming Zhou
    Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Pathology 42:334-8. 2010
    ..Pathological characteristics of prostate cancer following an initial diagnosis of ATYP are rarely studied...
  22. ncbi Clinical and immunomodulatory effects of celecoxib plus interferon-alpha in metastatic renal cell carcinoma patients with COX-2 tumor immunostaining
    Anita Schwandt
    Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    J Clin Immunol 31:690-8. 2011
    ..A phase II trial of celecoxib and IFN-α in a targeted population of metastatic renal cell carcinoma patients with maximal COX-2 expression was conducted...
  23. ncbi The prognostic significance of epidermal growth factor receptor expression in clear-cell renal cell carcinoma: a call for standardized methods for immunohistochemical evaluation
    David Cohen
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Clin Genitourin Cancer 5:264-70. 2007
    ..The prognostic significance of EGFR overexpression after nephrectomy, however, is controversial because of different methods used in the immunohistochemical (IHC) evaluation of EGFR expression...
  24. ncbi The incidence of high-grade prostatic intraepithelial neoplasia and atypical glands suspicious for carcinoma on first-time saturation needle biopsy, and the subsequent risk of cancer
    Lynn Schoenfield
    Department of Pathology, Cleveland Clinic, Cleveland, OH, USA
    BJU Int 99:770-4. 2007
    ....
  25. ncbi Can saturation biopsy predict prostate cancer localization in radical prostatectomy specimens: a correlative study and implications for focal therapy
    Sara M Falzarano
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 76:682-7. 2010
    ..The success of focal therapy for PCA relies on accurate mapping of cancer before the procedure...
  26. ncbi ERG gene rearrangement status in prostate cancer detected by immunohistochemistry
    Sara Moscovita Falzarano
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Virchows Arch 459:441-7. 2011
    ..Given the high yield and the easier task of performing immunohistochemistry vs. FISH, ERG assessment by immunohistochemistry may be useful for characterizing ERG status in prostate cancer...
  27. ncbi Ductal adenocarcinoma of the prostate diagnosed on transurethral biopsy or resection is not always indicative of aggressive disease: implications for clinical management
    Hakan Aydin
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    BJU Int 105:476-80. 2010
    ..To report the clinicopathological characteristics of 23 cases of ductal adenocarcinoma of the prostate (DCP) and discuss the implications for clinical management, as DCP is considered an aggressive subtype of prostate adenocarcinoma (PA)...
  28. ncbi ERG rearrangement is present in a subset of transition zone prostatic tumors
    Sara M Falzarano
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 23:1499-506. 2010
    ..Further studies are necessary to confirm this hypothesis...
  29. ncbi Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 71:1142-8. 2008
    ..Clinical and radiographic data regarding these lesions are sparse, especially with respect to factors providing clinical suspicion for CN or MEST...
  30. ncbi Perineural invasion on prostate needle biopsy does not predict biochemical failure following brachytherapy for prostate cancer
    Christopher J Weight
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 65:347-50. 2006
    ..45). PNI did not correlate with biochemical relapse free survival (p = 0.40). CONCLUSION: Perineural invasion is not a significant predictor of biochemical recurrence in patients undergoing brachytherapy for prostate cancer...
  31. ncbi The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms
    Ming Zhou
    Division of Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Lab Med 25:247-57. 2005
    ..Useful markers in the differential diagnosis between ChRCC and CCRCCare CK7, RCC Ma, CD10, VIM, CD117, parvalbumin, and E-cadherin. We propose CK7/CK20/CD15 as a useful primary immunopanel to differentiate ChRCC from ONC reliably...
  32. ncbi Renal mass biopsy--a renaissance?
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 179:20-7. 2008
    ....
  33. ncbi Renal neuroendocrine tumours: a clinicopathological study
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio, USA
    BJU Int 100:1030-5. 2007
    ....
  34. ncbi A preoperative prognostic nomogram for solid enhancing renal tumors 7 cm or less amenable to partial nephrectomy
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 178:429-34. 2007
    ..We present novel nomograms that predict the likelihood of benign, likely indolent or potentially aggressive pathological findings based only on readily identifiable preoperative factors...
  35. ncbi The distinction of clear cell carcinoma of the female genital tract, clear cell renal cell carcinoma, and translocation-associated renal cell carcinoma: an immunohistochemical study using tissue microarray
    Huiying He
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA
    Int J Gynecol Pathol 30:425-30. 2011
    ..CCCa is mostly CK7/CD10/CA IX/TFE3, TA-RCC is usually CK7/CD10/CA IX/TFE3, whereas CCRCC is mostly CK7/CD10/CA IX/TFE3. To the best of our knowledge, this was the first study to directly compare the immunophenotypes of these 3 lesions...
  36. ncbi Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials
    Grace X Zhou
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 75:257-61. 2010
    ..Recent studies found protein levels of CAIX, quantified using immunohistochemistry, correlated with clinical outcomes and therapeutic response to immunotherapy in advanced stage clear cell renal cell carcinoma (CCRCC)...
  37. ncbi Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas
    Andres A Roma
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 131:122-5. 2007
    ..Characteristically, tumor cells express melanocytic markers such as HMB-45 and Melan-A. Recently, several other markers have been described as having excellent diagnostic sensitivity in cutaneous melanocytic lesions...
  38. ncbi Phase II trial of capecitabine and rHu-interferon-alpha-2a in patients with metastatic renal cell carcinoma, limited efficacy, and moderate toxicity
    Ena Segota
    Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 41950, USA
    Urol Oncol 25:46-52. 2007
    ....
  39. ncbi Renal mass sampling: an enlightened perspective
    Mary K Samplaski
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Int J Urol 18:5-19. 2011
    ..Incorporation of novel biomarkers and molecular fingerprinting into RMS protocols will likely allow for more rational management of patients with renal masses in the near future...
  40. ncbi Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 19:392-8. 2006
    ....
  41. ncbi Differing von hippel lindau genotype in paired primary and metastatic tumors in patients with clear cell renal cell carcinoma
    Susan A J Vaziri
    Taussig Cancer Institute, Cleveland Clinic Foundation Cleveland, OH, USA
    Front Oncol 2:51. 2012
    ..These results demonstrate for the first time that the VHL gene status can be different between paired primary and metastatic tissue in patients with CCRCC...
  42. ncbi Mucinous adenocarcinoma of the prostate does not confer poor prognosis
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 68:825-30. 2006
    ..4 years. MC appears to behave clinically in a similar fashion to AC, with no statistically significant difference in biochemical failure or survival...
  43. ncbi Distinguishing clear cell renal cell carcinoma, retroperitoneal paraganglioma, and adrenal cortical lesions on limited biopsy material: utility of immunohistochemical markers
    James E Lapinski
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 18:414-21. 2010
    ..Therefore, a panel of, rather than single, epithelial, "CCRCC-specific," adrenocortical and neuroendocrine markers should be applied in the differential diagnosis of CCRCC, adrenocortical lesions, and paragangliomas...
  44. ncbi Clinical implications of caveolins in malignancy and their potential as therapeutic targets
    Ila Tamaskar
    Department of Experimental Therapeutics, Cleveland Clinic Taussig Cancer Center, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA
    Curr Oncol Rep 10:101-6. 2008
    ..In addition, it also discusses the use of caveolin-1 as a potential diagnostic and prognostic marker and therapeutic target...
  45. ncbi Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma
    Kristi L Bennett
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Chromosomes Cancer 50:654-61. 2011
    ....
  46. ncbi The changing face of renal cell carcinoma pathology
    Hakan Aydin
    Department of Pathology, Cleveland Clinic Taussig Cancer Center, 9500 Euclid Avenue L25, Cleveland, OH, USA
    Curr Oncol Rep 10:235-44. 2008
    ....
  47. ncbi Second prize: preliminary experience with the Niris optical coherence tomography system during laparoscopic and robotic prostatectomy
    Monish Aron
    Section of Laparoscopic and Robotic Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44115, USA
    J Endourol 21:814-8. 2007
    ..To evaluate the feasibility of high-resolution optical coherence tomography (OCT) in the identification of neurovascular bundles (NVBs) during laparoscopic and robotic radical prostatectomy (LRP)...
  48. ncbi Pathologic characteristics of solitary small renal masses: can they be predicted by preoperative clinical parameters?
    Tom DeRoche
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Am J Clin Pathol 130:560-4. 2008
    ..Multivariate analyses using sex, age, tumor size, and symptomatology failed to produce a model useful to predict the pathology of individual tumors. This inability may argue for an increased role for needle biopsy in their evaluation...
  49. ncbi Giant cell fibroblastoma of the penis
    Lynn L Woo
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 68:427.e5-6. 2006
    ..Pathologic examination confirmed recurrent GCF. GCF is a benign, but locally recurrent tumor, as demonstrated by our case. To our knowledge, no cases of penile involvement have been previously reported...
  50. ncbi Pathology of genitourinary malignancies: implications for clinical management
    Laura S Wood
    Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave R 33, Cleveland, OH 44195, USA
    Semin Oncol Nurs 28:143-53. 2012
    ..To describe the pathologic and molecular characteristics of genitourinary malignancies relevant to the implications for the practice of oncology nurses...
  51. ncbi Papillary renal cell carcinoma is associated with PTEN hamartoma tumor syndrome
    Jessica L Mester
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 79:1187.e1-7. 2012
    ..To formally study the prevalence and histologic classification of renal cell carcinoma (RCC) in a series of patients with PTEN hamartoma tumor syndrome (PHTS)...
  52. ncbi Molecular genetics of familial renal cell carcinoma syndromes
    David Cohen
    The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Lab Med 25:259-77. 2005
    ..Understanding of the molecular pathways of these genes will have a significant impact on the diagnosis and treatment of familial and sporadic RCC...
  53. ncbi Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms
    Angelo Baccala
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 70:385-90. 2007
    ..Recently, PSMA has been found in the neovasculature in association with other solid malignant tumors, including clear cell renal carcinoma (RCC). We studied the expression of PSMA in different primary renal tumors...
  54. ncbi Phase II trial of neoadjuvant docetaxel before radical prostatectomy for locally advanced prostate cancer
    Robert Dreicer
    Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 63:1138-42. 2004
    ..Additional study of this paradigm with other agents alone and in combination with docetaxel seems warranted...
  55. ncbi The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study
    Andres Roma
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Clin Pathol 130:265-73. 2008
    ..Coexpression of CDX-2 and TTF-1 was found in 11 teratomas (32%) but none of the BCs. BCs can be reliably distinguished from teratomas based on the gross, histologic, and immunohistochemical features...
  56. ncbi Renal neuroendocrine tumors
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Indian J Urol 25:155-60. 2009
    ..Primary NETs of the kidney, including carcinoid tumor, small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare...
  57. ncbi Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages
    Keke Fan
    Department of Cancer Biology, The Cleveland Clinic Foundation, OH 44195, USA
    J Immunol 175:7003-8. 2005
    ..Our findings suggest that SSG might improve anti-RCC efficacy of IL-2 therapy by enhancing antitumor immunity...
  58. ncbi The reporting of prostate cancer on needle biopsy: prognostic and therapeutic implications and the utility of diagnostic markers
    Ming Zhou
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Pathology 35:472-9. 2003
    ..While several are extremely promising as diagnostic immunohistochemical markers, other prognostic markers are not yet ready to be used in routine practice until they are validated by large prospective studies...
  59. ncbi Virilizing adrenal ganglioneuroma in a woman with subclinical Cushing syndrome
    Dima L Diab
    Department of Endocrinology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Endocr Pract 14:584-7. 2008
    ..To describe a patient with a virilizing adrenal ganglioneuroma and subclinical Cushing syndrome...
  60. ncbi Merkel cell carcinoma of the genitourinary tract
    Manju Aron
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Ohio 44195, USA
    Arch Pathol Lab Med 135:1067-71. 2011
    ..The discovery of the Merkel cell polyomavirus as a possible causative agent adds a new dimension in the understanding of the pathogenesis and diagnosis, and possible targeted therapies for this tumor...
  61. ncbi Usefulness of basal cell cocktail (34betaE12 + p63) in the diagnosis of atypical prostate glandular proliferations
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Am J Clin Pathol 122:517-23. 2004
    ..The cocktail provides a simple, cost-effective improvement in basal cell immunohistochemical analysis of difficult prostate lesions...
  62. ncbi How often does alpha-methylacyl-CoA-racemase contribute to resolving an atypical diagnosis on prostate needle biopsy beyond that provided by basal cell markers?
    Ming Zhou
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 28:239-43. 2004
    ..However, it is not known how often a positive AMACR staining is used merely to support a malignant diagnosis that could otherwise be established based on routine H&E histology and negative basal cell staining...
  63. ncbi Expression and diagnostic utility of alpha-methylacyl-CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer
    Ming Zhou
    Department of Pathology, John Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Am J Surg Pathol 27:772-8. 2003
    ..The major caveat in the interpretation of positive staining is that high-grade prostatic intraepithelial neoplasia cannot be in the differential diagnosis...
  64. ncbi Basal cell cocktail (34betaE12 + p63) improves the detection of prostate basal cells
    Ming Zhou
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Am J Surg Pathol 27:365-71. 2003
    ..We recommend this basal cell cocktail for routine Pca diagnostic work-up...
  65. ncbi The polycomb group protein EZH2 is involved in progression of prostate cancer
    Sooryanarayana Varambally
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 419:624-9. 2002
    ..Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression...
  66. ncbi alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation
    Rainer Kuefer
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602, USA
    Am J Pathol 161:841-8. 2002
    ..Taken together, these data suggest that AMACR expression is not hormone-dependent but may in fact be a marker of tumor differentiation...
  67. ncbi Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions
    Ming Zhou
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, USA
    Am J Surg Pathol 26:926-31. 2002
    ..In conclusion, our study suggests that AMACR is potentially an important tumor marker for several cancers and their precursor lesions, especially those linked to high-fat diets...
  68. ncbi Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer
    Rajal B Shah
    Deparment of Pathology and Urology, University of Michigan School of Medicine and Comprenhensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Am J Surg Pathol 26:1161-8. 2002
    ..p63 may be used as an alternative to 34betaE12 stain for difficult prostate lesions...
  69. ncbi Number and location of nucleoli and presence of apoptotic bodies in diagnostically challenging cases of prostate adenocarcinoma on needle biopsy
    Hakan Aydin
    Department of Pathology, Baskent University Hospital, Ankara, Turkey
    Hum Pathol 36:1172-7. 2005
    ..Our findings indicate that the presence of apoptotic bodies should be added to the list of histological features that are helpful in the diagnosis of challenging cases of prostate cancer on needle biopsy...
  70. ncbi Tumor volume does not predict for biochemical recurrence after radical prostatectomy in patients with surgical Gleason score 6 or less prostate cancer
    Megan M Merrill
    Christiana Care Health Systems, Newark, Delaware, USA
    Urology 70:294-8. 2007
    ..We assessed this relationship in a large cohort of patients treated at one institution with standardized pathologic assessment from 1998 to 2005...
  71. ncbi Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization
    Ximing J Yang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 32:177-87. 2008
    ....
  72. ncbi Preoperative PSA is still predictive of cancer volume and grade in late PSA era
    Bradley D Figler
    Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA
    Urology 70:711-6. 2007
    ....
  73. ncbi von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    Toni K Choueiri
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Urol 180:860-5; discussion 865-6. 2008
    ..The von Hippel-Lindau (VHL) gene is often inactivated (by mutation or promoter hypermethylation) in renal cell carcinoma but the relation to therapeutic outcome is unclear...
  74. ncbi BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating beta-catenin and ERK pathways
    Cong Peng
    Cancer Research Institute, Central South University, Changsha, Hunan, China
    Mol Cell Biochem 303:141-9. 2007
    ..Taken together, our present results provide new insights for BRD7 function to inhibit NPC cells growth through negative regulating beta-catenin and ERK1/2 pathways...
  75. ncbi Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis
    Song-qing Fan
    Cancer Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha, Hunan, China; Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China
    Hum Pathol 37:593-605. 2006
    ..179-29.111, P < .001). In conclusion, EBV infection, together with overexpressions of p53, and loss expressions of p16 and p27 proteins are involved in the multistep process of human nasopharyngeal epithelial carcinogenesis...
  76. ncbi Profiling genes differentially expressed in NGX6 overexpressed nasopharyngeal carcinoma cells by cDNA array
    Jian Ma
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, 88 Xiang ya Road, Changsha, Hunan, 410078, PR China
    J Cancer Res Clin Oncol 128:683-90. 2002
    ..To investigate the role of the NGX6 gene in carcinoma proliferation and profile the downstream genes regulated by NGX6 in a nasopharyngeal carcinoma (NPC) cell line...
  77. ncbi Port site, retroperitoneal and intra-abdominal recurrence after laparoscopic acrenalectomy for apparently isolated metastasis
    Bert Chen
    Department of Urology, University of Michigan, Ann Arbor, USA
    J Urol 168:2528-9. 2002
  78. ncbi [Effect of growth inhibition of the secretory protein SPLUNC1 on Pseudomonas aeruginosa]
    Hou-De Zhou
    Cancer Research Institute, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:464-9. 2006
    ..CONCLUSION: SPLUNC1 can inhibit the growth of Pseudomonas aeruginosa and bind LPS, and play an important defensive role in innate immunity of the upper airway...
  79. ncbi The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells
    Shu Ping Peng
    Cancer Research Institute, Central South University, Changsha, Hunan, China
    Oncology 71:273-81. 2006
    ..To demonstrate the subcellular localization of nasopharyngeal carcinoma (NPC)-associated gene 6 (NGX6) and its basic structure and function...
  80. ncbi The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor
    Shuping Peng
    Cancer Research Institute, Xiang Ya Shool of Medicine, Central South University, Hunan, 410078, China
    Cancer Sci 98:341-9. 2007
    ..These results demonstrated that nasopharyngeal carcinoma-associated gene 6 was probably involved in the modulation of invasive and adhesive ability of nasopharyngeal carcinoma cells by down-regulating the expression level of ezrin...
  81. ncbi A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis
    Anthony J Scarzello
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Mol Biol Cell 18:2455-62. 2007
    ....
  82. ncbi Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells
    Shengli Xu
    Department of Neurobiology and the Sino Japan Joint Laboratory of Neurodegenerative diseases, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, China
    Biochem Biophys Res Commun 342:330-5. 2006
    ..Our present results indicated that 200microM H(2)O(2) treatment induces the intranuclear accumulation of the C-terminal fragment of alpha-synuclein in dopaminergic neurons, whose role remains to be investigated...
  83. ncbi [Metabolomics and its application in malignant tumors]
    Jue Ou Yang
    Cancer Research Institute, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:221-5. 2007
    ..In this paper, the definition and objective of metabolomics are provided, and the current application of metabolomic research in malignant tumors (diagnosis and therapy) are summarized...
  84. ncbi Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma
    Christopher J Herrem
    Department of Immunology and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Clin Cancer Res 11:226-31. 2005
    ....
  85. ncbi NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells
    Lili Wang
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, 410078, China
    J Cell Biochem 95:64-73. 2005
    ..We propose that NGX6, as an EGF-like domain gene, could delay cell cycle G0-G1 progression and thus inhibit cell proliferation by negatively regulating EGFR pathway in NPC cells and down-regulating the expression of cyclin D1 and E...
  86. ncbi Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
    ..An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease...
  87. ncbi Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells
    Jian Ma
    Cancer Research Institute, Xiang Ya School of Medicine, 110 Xiang Ya Road, Changsha, Hunan 410078, China
    Carcinogenesis 26:281-91. 2005
    ..The data revealed that NGX6 plays a role in cell adhesion modulation in NPC cells...
  88. ncbi alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer
    Mark A Rubin
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    JAMA 287:1662-70. 2002
    ..Molecular profiling of prostate cancer has led to the identification of candidate biomarkers and regulatory genes. Discoveries from these genome-scale approaches may have applicability in the analysis of diagnostic prostate specimens...
  89. ncbi BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways
    Jie Zhou
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, People s Republic of China
    J Cell Physiol 200:89-98. 2004
    ....
  90. ncbi [Preliminary biomarker related to nasopharyngeal carcinoma filtered from the whole genome expression profiling involved in microdissection nasopharyngeal tissues]
    Zhong-Qi Liu
    Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:1-6. 2005
    ..CONCLUSION: Using the whole genome GeneChip to construct the expression profiling for the microdissected homogenesis tissue is effective to filter the candidate biomarker genes...
  91. ncbi Quantitative GSTP1 methylation levels correlate with Gleason grade and tumor volume in prostate needle biopsies
    Ming Zhou
    Department of Pathology, Otolaryngology-Head and Neck Surgery (Head and Neck Cancer Research Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 171:2195-8. 2004
    ..In addition, quantitative GSTP1 methylation also correlated with prostate cancer Gleason grade and cancer volume, suggesting that quantitative GSTP1 methylation may be of prognostic significance...
  92. ncbi Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues
    Wei Qiu
    Oncology and Molecular Endocrinology Research Center, Centre Hospitalier de l Université Laval Medical Center CHUL and Laval University, Sainte Foy, Quebec, Canada G1V 4G2
    Mol Endocrinol 18:1798-807. 2004
    ..These structures have provided a dynamic view of the enzyme reaction converting androstenedione to testosterone as well as valuable information for the development of potent enzyme inhibitors...
  93. ncbi Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    Toni K Choueiri
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:127-31. 2008
    ..The activity of sunitinib and sorafenib in non-clear cell histologies has not been evaluated...
  94. ncbi Cancer diagnosis using proteomic patterns
    Thomas P Conrads
    Mass Spectrometry Center, Biomedical Proteomics Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, MD 21702, USA
    Expert Rev Mol Diagn 3:411-20. 2003
    ..Hundreds of clinical samples per day can be analyzed utilizing this technology, which has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer...
  95. ncbi Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray
    Bicheng Zhang
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, China
    Genes Chromosomes Cancer 38:80-90. 2003
    ..Seventeen differentially expressed genes in NPC were obtained. Among these genes, we identified SPLUNC1 and LPLUNC1 to be down-expressed in NPC biopsies (34/48, 33/48)...
  96. ncbi Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis
    Haiyan Yang
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Exp Metastasis 21:719-35. 2004
    ....
  97. ncbi Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors
    Kenneth A Iczkowski
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32608, USA
    Hum Pathol 39:275-81. 2008
    ..For embryonal carcinoma, OCT3/4 was superior to PLAP and more specific than CD30. D2-40 is recommended to discriminate between seminoma and embryonal carcinoma...
  98. ncbi [Analysis of splicing variants in NASG 3'UTR, down-regulated in nasopharyngeal carcinoma, and its expression in multiple cancer tissues]
    Bi Cheng Zhang
    Cancer Research Institute, Xiangya Medical School, Central South University, Changsha, Hunan, PR China
    Ai Zheng 22:477-80. 2003
    ..This study was designed to analyze splicing variants in NASG 3'untranslated region (UTR) and its expression profiling in multiple cancer tissues...