Research Topics
| Youhua ZhangSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
AV nodal dual pathway electrophysiology and Wenckebach periodicityYouhua Zhang
Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cardiovasc Electrophysiol 22:1256-62. 2011..We have provided new evidence that, in addition, dual pathway (DPW) electrophysiology is directly involved in the manifestation of AV nodal Wenckebach phenomenon...
Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failureY Zhang
Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Int J Cardiol 73:157-62; discussion 163-4. 2000..Long-term sympathetic inhibition with clonidine treatment improved 1-year survival (50% vs. 22.6%, P<0.05) after surgery in this rat model of CHF...- Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing modelYouhua Zhang
Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, USA
Circ Heart Fail 2:692-9. 2009..We have investigated the impact of enhancing vagal tone (achieved through chronic cervical vagus nerve stimulation, [VNS]) on HF development in a canine high-rate ventricular pacing model... - Cardiac vagal stimulation eliminates detrimental tachycardia effects of dobutamine used for inotropic supportYouhua Zhang
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
Ann Thorac Surg 88:117-22. 2009.... - Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillationZoran B Popovic
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
Heart Rhythm 1:482-9. 2004..The aim of this study was to assess whether Frank-Starling mechanism has an independent effect on left ventricular (LV) performance in atrial fibrillation (AF)... - Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularityZoran B Popovic
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
Am J Physiol Heart Circ Physiol 283:H2706-13. 2002..We conclude that prolongation of the VCL during AF reduces the sensitivity of the LV performance parameters to irregularity... - Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillationShaowei Zhuang
Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 106:1853-8. 2002..It was hemodynamically superior to AVN ablation with either r-RVP or i-RVP, indicating that the benefits of preserving the physiological antegrade ventricular activation sequence outweigh the detrimental effect of irregularity... - Vagal denervation and atrial fibrillation inducibility: epicardial fat pad ablation does not have long-term effectsSeil Oh
Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, Ohio 44195, USA
Heart Rhythm 3:701-8. 2006..0%, 100% +/- 0.0%, and 95% +/- 11%, respectively). CONCLUSION: Radiofrequency fat pad ablation may not achieve long-term suppression of AF induction in this canine model... - Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation modelYouhua Zhang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Circulation 112:2904-11. 2005..This novel concept is an attractive alternative to other methods of rate control and may be applicable in a selected group of patients... 
Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocityJunko Asada-Kamiguchi
Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Eur J Echocardiogr 10:826-32. 2009..To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF)...- Determinants of LV diastolic function during atrial fibrillation: beat-to-beat analysis in acute dog experimentsTomotsugu Tabata
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Physiol Heart Circ Physiol 286:H145-52. 2004..This suggests that the major benefit of slower ventricular rate appears related to lengthening of LV filling interval, promoting subsequent higher peak systolic LVP and greater LV relaxation... - Achieving regular slow rhythm during atrial fibrillation without atrioventricular nodal ablation: selective vagal stimulation plus ventricular pacingYouhua Zhang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
Heart Rhythm 1:469-75. 2004..Rate regularization achieved by this approach was associated with pronounced hemodynamic benefits during AF... - The pseudorestrictive pattern of transmitral Doppler flow pattern after conversion of atrial fibrillation to sinus rhythm: is atrial or ventricular dysfunction to blame?Hirotsugu Yamada
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Am Soc Echocardiogr 17:813-8. 2004..Transient left ventricular diastolic dysfunction also effected the TMF velocity immediately after the conversion from AF to sinus rhythm, although it recovered faster than LA mechanical dysfunction... - Atrioventricular nodal fast pathway modification: mechanism for lack of ventricular rate slowing in atrial fibrillationYouhua Zhang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Research Building FF1-02, Cleveland, OH 44195, USA
Cardiovasc Res 61:45-55. 2004..This study highlights the usefulness of HE alternans as a novel tool to monitor dual pathway conduction during AF and to guide AVN modification... - Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulationYouhua Zhang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Physiol Heart Circ Physiol 282:H1102-10. 2002..We conclude that this novel method can be used to maintain slow anterograde conduction with best hemodynamics during AF... - Avoiding microbubbles formation during radiofrequency left atrial ablation versus continuous microbubbles formation and standard radiofrequency ablation protocols: comparison of energy profiles and chronic lesion characteristicsSeil Oh
Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cardiovasc Electrophysiol 17:72-7. 2006.... - Atrioventricular node functional remodeling induced by atrial fibrillationYouhua Zhang
Department of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
Heart Rhythm 9:1419-25. 2012..AF results in profound electrophysiological and structural remodeling in the atria as well as the sinus node. However, it is unknown whether AVN undergoes remodeling during AF... - How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imagingKenya Kusunose
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America
PLoS ONE 7:e40061. 2012..We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rates scale to heart size... - Ventricular rate control during atrial fibrillation and AV node modifications: past, present, and futureYouhua Zhang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Pacing Clin Electrophysiol 27:382-93. 2004..We are reviewing current clinical and newer experimental modalities aimed at enhancing the lifesaving function of this remarkable nodal structure... - Relationship between right cervical vagus nerve stimulation and atrial fibrillation inducibility: therapeutic intensities do not increase arrhythmogenesisYouhua Zhang
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Heart Rhythm 6:244-50. 2009..Taken as a surrogate of increased vagal tone, such observations suggest an arrhythmogenic role of VNS in AF. In contrast, VNS has been demonstrated to have profound therapeutic effects in heart failure and other ailments... - His electrogram alternans reveal dual atrioventricular nodal pathway conduction during atrial fibrillation: the role of slow-pathway modificationYouhua Zhang
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 107:1059-65. 2003..HE alternans provide a new insight into the mechanisms of AVN conduction and could guide AVN modification for ventricular rate control in AF clinically... - Novel robotic catheter remote control system: feasibility and safety of transseptal puncture and endocardial catheter navigationWalid Saliba
Section of Cardiac Electrophysiology and Pacing, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cardiovasc Electrophysiol 17:1102-5. 2006..CONCLUSIONS: Endocardial catheter navigation and mapping using the robotic catheter remote control is safe and feasible. Moreover, the CCS could be used to perform transseptal puncture and left atrial instrumentation... - Therapeutic effects of selective atrioventricular node vagal stimulation in atrial fibrillation and heart failureYouhua Zhang
Department of Molecular Cardiology, The Cleveland Clinic, Cleveland, Ohio, USA
J Cardiovasc Electrophysiol 24:86-91. 2013..Accordingly, this study was designed to evaluate the therapeutic effects of AVN-VS to control ventricular rate in AF and HF... - Arrhythmias and vagus nerve stimulationYouhua Zhang
Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Bld NE 6, 208, Cleveland, OH 44195, USA
Heart Fail Rev 16:147-61. 2011..Specifically, the focus is on VNS capability to become a therapeutic strategy along with important electrophysiological alterations that may constitute a potential arrhythmogenic substrate and become a clinical concern... - Recurrence of symptomatic atrial fibrillation after successful catheter ablation of atrioventricular accessory pathways: a multivariate regression analysisL Wang
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China
Int J Clin Pract 59:886-90. 2005..Older patients and patients with inducible AF after accessory pathway ablation are at an increased risk of AF recurrence. These patients should be closely monitored after successful ablation of atrioventricular accessory pathways... - His electrogram alternans reveal dual-wavefront inputs into and longitudinal dissociation within the bundle of HisY Zhang
Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA
Circulation 104:832-8. 2001..These findings provide further understanding of the mechanisms of dual-AVN electrophysiology... - The dual pathway electrophysiology of the atrioventricular conduction. A new look at an old phenomenonT N Mazgalev
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Minerva Cardioangiol 51:1-14. 2003.... - Stimulation by melittin of Na+-Ca2+ exchange current in ventricular myocytes of guinea pigsX M Zhang
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China
Acta Pharmacol Sin 22:10-4. 2001..01) and 320+/-97 (n=5, P < 0.05) respectively at a testing potential of +50 mV. CONCLUSION: The stimulating effect of Mel on I(Na-Ca) rather than the effect on I(Ca) contributes to the calcium overload of myocytes... - Short-term postural reflexes in diabetic patients with autonomic dysfunctionY Zhang
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Diabetologia 47:304-11. 2004..We investigated whether a detailed analysis of postural reflexes of patients during short-term head-up tilting and standing erect (both for 3 min) would provide useful clinical data... - Selective AV nodal vagal stimulation improves hemodynamics during acute atrial fibrillation in dogsD W Wallick
Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Physiol Heart Circ Physiol 281:H1490-7. 2001..The present study provides comprehensive evidence that slowing of the ventricular rate during AF by selective ganglionic stimulation of the vagal nerves that innervate the AVN successfully improved the hemodynamic responses... - Assessment of LV systolic function in atrial fibrillation using an index of preceding cardiac cyclesT Tabata
Section of Cardiovascular Imaging, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Physiol Heart Circ Physiol 281:H573-80. 2001.... - The role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan-injected ratsY Zhang
State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Medical Center of Fudan University, 138 Yi Xue Yuan Road, 200032, Shanghai, China
Pain 92:201-11. 2001..The excitability of dorsal horn WDR neurons and the sensitivity of the neurons to intrathecal 5-HT1A and 5-HT1B receptor agonists might increase following carrageenan-induced inflammation... - Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathwaysD W Benson
Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Clin Invest 104:1567-73. 1999..The coinheritance of NKX2.5 mutations with various congenital heart defects suggests that this transcription factor contributes to diverse cardiac developmental pathways... - Effects of intrinsic prostaglandins on the spontaneous contractile and electrical activity of the proximal renal pelvis of the guinea-pigY Zhang
Department of Physiology, Monash University, Clayton, Victoria, Australia
Br J Pharmacol 113:431-8. 1994..Keywords: Renal pelvis; action potentials; prostaglandins; indomethacin.. - [Effects of percutaneous transluminal coronary angioplasty and stenting on QT dispersion in patients with coronary heart disease]Y Zhang
Catheterization Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011, China
Hunan Yi Ke Da Xue Xue Bao 26:171-2. 2001..The degree in decreasing QTd and QTcd was associated with compensatory circulation in coronary artery... - Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscleT Tazzeo
Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
Eur Respir J 32:275-84. 2008.... - Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary arteryY Zhang
Firestone Institute for Respiratory Health, Father Sean O'Sullivan Research Centre, and Department of Medicine, McMaster University, St. Joseph's Healthcare, Hamilton, Ontario, L8N 4A6, Canada
J Pharmacol Exp Ther 305:1054-60. 2003..We conclude that 8-iso-prostaglandin E2 acts directly on the smooth muscle to increase K+ conductance, leading to membrane hyperpolarization and vasodilation... - Regional differences in nitrergic innervation of the smooth muscle of murine lower oesophageal sphincterY Zhang
Gastrointestinal Diseases Research Unit, Department of Physiology, Queen s University, Kingston, Ontario, Canada
Br J Pharmacol 153:517-27. 2008..Regional differences have been demonstrated in several species including humans. We investigated, for the first time in mice LES, regionally distinct physiological and pharmacological characteristics of the neuromusculature... - A wearable mobihealth care system supporting real-time diagnosis and alarmJ W Zheng
Institute of Medical Equipment, National Biological Protection Engineering Center, Tianjin, People s Republic of China
Med Biol Eng Comput 45:877-85. 2007..With advanced gpsOne technology, the patient can be located and rescued immediately whether he/she is indoors or outdoors in case of emergency... - Variable left ventricular activation pattern in patients with heart failure and left bundle branch blockJ W H Fung
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China
Heart 90:17-9. 2004..To determine the left ventricular (LV) activation pattern in patients with chronic heart failure and left bundle branch block (LBBB) on ECG... - Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentrationH Dong
Department of Physiology, University of Toronto, Toronto, ON, Canada
Diabetologia 49:697-705. 2006..05, n=5). CONCLUSIONS/INTERPRETATION: These findings indicate that activation of GABA(A)Rs in beta cells regulates insulin secretion in concert with changes in glucose levels... - Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivoX Y Zhao
Department of Pharmacology, Harbin Medical University, Harbin, PR China
Br J Pharmacol 154:105-13. 2008..QT interval prolongation and apoptosis have been implicated in the cardiotoxicity of As(2)O(3). The present study was designed to evaluate the effects of resveratrol on As(2)O(3)-induced apoptosis and cardiac injury...