Youhua Zhang

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi AV nodal dual pathway electrophysiology and Wenckebach periodicity
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 22:1256-62. 2011
  2. ncbi Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure
    Y Zhang
    Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Int J Cardiol 73:157-62; discussion 163-4. 2000
  3. ncbi Cardiac vagal stimulation eliminates detrimental tachycardia effects of dobutamine used for inotropic support
    Youhua Zhang
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
    Ann Thorac Surg 88:117-22. 2009
  4. doi Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, USA
    Circ Heart Fail 2:692-9. 2009
  5. ncbi Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillation
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Heart Rhythm 1:482-9. 2004
  6. ncbi Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularity
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 283:H2706-13. 2002
  7. ncbi Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillation
    Shaowei Zhuang
    Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:1853-8. 2002
  8. ncbi Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation model
    Youhua Zhang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 112:2904-11. 2005
  9. ncbi Vagal denervation and atrial fibrillation inducibility: epicardial fat pad ablation does not have long-term effects
    Seil Oh
    Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, Ohio 44195, USA
    Heart Rhythm 3:701-8. 2006
  10. pmc Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity
    Junko Asada-Kamiguchi
    Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Eur J Echocardiogr 10:826-32. 2009

Collaborators

Detail Information

Publications43

  1. doi AV nodal dual pathway electrophysiology and Wenckebach periodicity
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 22:1256-62. 2011
    ..We have provided new evidence that, in addition, dual pathway (DPW) electrophysiology is directly involved in the manifestation of AV nodal Wenckebach phenomenon...
  2. ncbi Sympathetic inhibition with clonidine prolongs survival in experimental chronic heart failure
    Y Zhang
    Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Int J Cardiol 73:157-62; discussion 163-4. 2000
    ..Long-term sympathetic inhibition with clonidine treatment improved 1-year survival (50% vs. 22.6%, P<0.05) after surgery in this rat model of CHF...
  3. ncbi Cardiac vagal stimulation eliminates detrimental tachycardia effects of dobutamine used for inotropic support
    Youhua Zhang
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
    Ann Thorac Surg 88:117-22. 2009
    ....
  4. doi Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, USA
    Circ Heart Fail 2:692-9. 2009
    ..We have investigated the impact of enhancing vagal tone (achieved through chronic cervical vagus nerve stimulation, [VNS]) on HF development in a canine high-rate ventricular pacing model...
  5. ncbi Frank-Starling mechanism contributes modestly to ventricular performance during atrial fibrillation
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Heart Rhythm 1:482-9. 2004
    ..The aim of this study was to assess whether Frank-Starling mechanism has an independent effect on left ventricular (LV) performance in atrial fibrillation (AF)...
  6. ncbi Slow rate during AF improves ventricular performance by reducing sensitivity to cycle length irregularity
    Zoran B Popovic
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 283:H2706-13. 2002
    ..We conclude that prolongation of the VCL during AF reduces the sensitivity of the LV performance parameters to irregularity...
  7. ncbi Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillation
    Shaowei Zhuang
    Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:1853-8. 2002
    ..We tested the hypothesis that, at comparable levels of VR slowing, AVN-VS provides hemodynamic benefits similar to those of ablation with pacemaker implantation...
  8. ncbi Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation model
    Youhua Zhang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 112:2904-11. 2005
    ..Thus, this study reports the first observations on the long-term efficacy and safety of this novel approach to control ventricular rate during AF in chronically instrumented dogs...
  9. ncbi Vagal denervation and atrial fibrillation inducibility: epicardial fat pad ablation does not have long-term effects
    Seil Oh
    Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, Ohio 44195, USA
    Heart Rhythm 3:701-8. 2006
    ..Major epicardial fat pads contain cardiac ganglionated plexi of the autonomic, predominantly vagal nerves. Vagal denervation may improve the success rate of atrial fibrillation (AF) treatment...
  10. pmc Non-invasive assessment of left ventricular relaxation during atrial fibrillation using mitral flow propagation velocity
    Junko Asada-Kamiguchi
    Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Eur J Echocardiogr 10:826-32. 2009
    ..To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF)...
  11. ncbi Determinants of LV diastolic function during atrial fibrillation: beat-to-beat analysis in acute dog experiments
    Tomotsugu Tabata
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 286:H145-52. 2004
    ..This suggests that the major benefit of slower ventricular rate appears related to lengthening of LV filling interval, promoting subsequent higher peak systolic LVP and greater LV relaxation...
  12. ncbi Achieving regular slow rhythm during atrial fibrillation without atrioventricular nodal ablation: selective vagal stimulation plus ventricular pacing
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Heart Rhythm 1:469-75. 2004
    ..The aim of this study was to achieve regular slow ventricular rhythm during atrial fibrillation (AF) without destroying the AV node (AVN)...
  13. ncbi The pseudorestrictive pattern of transmitral Doppler flow pattern after conversion of atrial fibrillation to sinus rhythm: is atrial or ventricular dysfunction to blame?
    Hirotsugu Yamada
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Soc Echocardiogr 17:813-8. 2004
    ..Transient left ventricular diastolic dysfunction also effected the TMF velocity immediately after the conversion from AF to sinus rhythm, although it recovered faster than LA mechanical dysfunction...
  14. ncbi Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulation
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 282:H1102-10. 2002
    ..We conclude that this novel method can be used to maintain slow anterograde conduction with best hemodynamics during AF...
  15. ncbi Atrioventricular nodal fast pathway modification: mechanism for lack of ventricular rate slowing in atrial fibrillation
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Research Building FF1 02, Cleveland, OH 44195, USA
    Cardiovasc Res 61:45-55. 2004
    ..This electrophysiological-morphological study was designed to address the role of selective FP ablation on AVN conduction during AF...
  16. ncbi Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy
    Kenya Kusunose
    Department of Cardiovascular Medicine, Cleveland Clinic, Heart and Vascular Institute, 9500 Euclid Avenue, Desk J1 5, Cleveland, OH 44195, USA
    Cardiovasc Ultrasound 11:43. 2013
    ..We hypothesized that TIC induces specific changes in LV strain distribution pattern...
  17. ncbi Avoiding microbubbles formation during radiofrequency left atrial ablation versus continuous microbubbles formation and standard radiofrequency ablation protocols: comparison of energy profiles and chronic lesion characteristics
    Seil Oh
    Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 17:72-7. 2006
    ..Radiofrequency (RF) energy parameters and chronic lesion characteristics associated with the microbubbles formation have not been yet fully elucidated...
  18. ncbi Atrioventricular node functional remodeling induced by atrial fibrillation
    Youhua Zhang
    Department of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
    Heart Rhythm 9:1419-25. 2012
    ..AF results in profound electrophysiological and structural remodeling in the atria as well as the sinus node. However, it is unknown whether AVN undergoes remodeling during AF...
  19. pmc How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging
    Kenya Kusunose
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e40061. 2012
    ..We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rates scale to heart size...
  20. ncbi Ventricular rate control during atrial fibrillation and AV node modifications: past, present, and future
    Youhua Zhang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 27:382-93. 2004
    ..We are reviewing current clinical and newer experimental modalities aimed at enhancing the lifesaving function of this remarkable nodal structure...
  21. doi Therapeutic effects of selective atrioventricular node vagal stimulation in atrial fibrillation and heart failure
    Youhua Zhang
    Department of Molecular Cardiology, The Cleveland Clinic, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 24:86-91. 2013
    ..Accordingly, this study was designed to evaluate the therapeutic effects of AVN-VS to control ventricular rate in AF and HF...
  22. doi Relationship between right cervical vagus nerve stimulation and atrial fibrillation inducibility: therapeutic intensities do not increase arrhythmogenesis
    Youhua Zhang
    Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart Rhythm 6:244-50. 2009
    ..Taken as a surrogate of increased vagal tone, such observations suggest an arrhythmogenic role of VNS in AF. In contrast, VNS has been demonstrated to have profound therapeutic effects in heart failure and other ailments...
  23. ncbi His electrogram alternans reveal dual atrioventricular nodal pathway conduction during atrial fibrillation: the role of slow-pathway modification
    Youhua Zhang
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:1059-65. 2003
    ..We have now applied this novel index to monitor dual-pathway conduction and the effects of SP modification during AF...
  24. ncbi Novel robotic catheter remote control system: feasibility and safety of transseptal puncture and endocardial catheter navigation
    Walid Saliba
    Section of Cardiac Electrophysiology and Pacing, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 17:1102-5. 2006
    ..The aims of this study were to demonstrate the safety and the feasibility of the robotic catheter remote control system (CCS) in endocardial navigation in all cardiac chambers, as well as facilitation of the transseptal puncture...
  25. doi Arrhythmias and vagus nerve stimulation
    Youhua Zhang
    Department of Molecular Cardiology and Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Bld NE 6, 208, Cleveland, OH 44195, USA
    Heart Fail Rev 16:147-61. 2011
    ..Specifically, the focus is on VNS capability to become a therapeutic strategy along with important electrophysiological alterations that may constitute a potential arrhythmogenic substrate and become a clinical concern...
  26. ncbi Recurrence of symptomatic atrial fibrillation after successful catheter ablation of atrioventricular accessory pathways: a multivariate regression analysis
    L Wang
    Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China
    Int J Clin Pract 59:886-90. 2005
    ..Older patients and patients with inducible AF after accessory pathway ablation are at an increased risk of AF recurrence. These patients should be closely monitored after successful ablation of atrioventricular accessory pathways...
  27. ncbi His electrogram alternans reveal dual-wavefront inputs into and longitudinal dissociation within the bundle of His
    Y Zhang
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA
    Circulation 104:832-8. 2001
    ..These findings provide further understanding of the mechanisms of dual-AVN electrophysiology...
  28. ncbi The dual pathway electrophysiology of the atrioventricular conduction. A new look at an old phenomenon
    T N Mazgalev
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Minerva Cardioangiol 51:1-14. 2003
    ....
  29. ncbi Stimulation by melittin of Na+-Ca2+ exchange current in ventricular myocytes of guinea pigs
    X M Zhang
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China
    Acta Pharmacol Sin 22:10-4. 2001
    ..01) and 320+/-97 (n=5, P < 0.05) respectively at a testing potential of +50 mV. CONCLUSION: The stimulating effect of Mel on I(Na-Ca) rather than the effect on I(Ca) contributes to the calcium overload of myocytes...
  30. ncbi Short-term postural reflexes in diabetic patients with autonomic dysfunction
    Y Zhang
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Diabetologia 47:304-11. 2004
    ..We investigated whether a detailed analysis of postural reflexes of patients during short-term head-up tilting and standing erect (both for 3 min) would provide useful clinical data...
  31. ncbi Selective AV nodal vagal stimulation improves hemodynamics during acute atrial fibrillation in dogs
    D W Wallick
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 281:H1490-7. 2001
    ..The present study provides comprehensive evidence that slowing of the ventricular rate during AF by selective ganglionic stimulation of the vagal nerves that innervate the AVN successfully improved the hemodynamic responses...
  32. ncbi Assessment of LV systolic function in atrial fibrillation using an index of preceding cardiac cycles
    T Tabata
    Section of Cardiovascular Imaging, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 281:H573-80. 2001
    ....
  33. ncbi The role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan-injected rats
    Y Zhang
    State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Medical Center of Fudan University, 138 Yi Xue Yuan Road, 200032, Shanghai, China
    Pain 92:201-11. 2001
    ..The excitability of dorsal horn WDR neurons and the sensitivity of the neurons to intrathecal 5-HT1A and 5-HT1B receptor agonists might increase following carrageenan-induced inflammation...
  34. pmc Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
    D W Benson
    Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Invest 104:1567-73. 1999
    ..The coinheritance of NKX2.5 mutations with various congenital heart defects suggests that this transcription factor contributes to diverse cardiac developmental pathways...
  35. pmc Effects of intrinsic prostaglandins on the spontaneous contractile and electrical activity of the proximal renal pelvis of the guinea-pig
    Y Zhang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 113:431-8. 1994
    ..Keywords: Renal pelvis; action potentials; prostaglandins; indomethacin..
  36. ncbi [Effects of percutaneous transluminal coronary angioplasty and stenting on QT dispersion in patients with coronary heart disease]
    Y Zhang
    Catheterization Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 26:171-2. 2001
    ..The degree in decreasing QTd and QTcd was associated with compensatory circulation in coronary artery...
  37. ncbi Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery
    Y Zhang
    Firestone Institute for Respiratory Health, Father Sean O Sullivan Research Centre, and Department of Medicine, McMaster University, St Joseph s Healthcare, Hamilton, Ontario, L8N 4A6, Canada
    J Pharmacol Exp Ther 305:1054-60. 2003
    ..We conclude that 8-iso-prostaglandin E2 acts directly on the smooth muscle to increase K+ conductance, leading to membrane hyperpolarization and vasodilation...
  38. pmc Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo
    X Y Zhao
    Department of Pharmacology, Harbin Medical University, Harbin, PR China
    Br J Pharmacol 154:105-13. 2008
    ..QT interval prolongation and apoptosis have been implicated in the cardiotoxicity of As(2)O(3). The present study was designed to evaluate the effects of resveratrol on As(2)O(3)-induced apoptosis and cardiac injury...
  39. pmc Regional differences in nitrergic innervation of the smooth muscle of murine lower oesophageal sphincter
    Y Zhang
    Gastrointestinal Diseases Research Unit, Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Br J Pharmacol 153:517-27. 2008
    ..Regional differences have been demonstrated in several species including humans. We investigated, for the first time in mice LES, regionally distinct physiological and pharmacological characteristics of the neuromusculature...
  40. ncbi A wearable mobihealth care system supporting real-time diagnosis and alarm
    J W Zheng
    Institute of Medical Equipment, National Biological Protection Engineering Center, Tianjin, People s Republic of China
    Med Biol Eng Comput 45:877-85. 2007
    ..With advanced gpsOne technology, the patient can be located and rescued immediately whether he/she is indoors or outdoors in case of emergency...
  41. pmc Variable left ventricular activation pattern in patients with heart failure and left bundle branch block
    J W H Fung
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Heart 90:17-9. 2004
    ..To determine the left ventricular (LV) activation pattern in patients with chronic heart failure and left bundle branch block (LBBB) on ECG...
  42. ncbi Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration
    H Dong
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Diabetologia 49:697-705. 2006
    ..However, the reported effects of GABA(A)R activation on insulin secretion from islet beta cells have been controversial...
  43. doi Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle
    T Tazzeo
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Eur Respir J 32:275-84. 2008
    ....