J B Young

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Bariatric surgery and cardiovascular outcomes: a systematic review
    Amanda R Vest
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 98:1763-77. 2012
  2. doi request reprint Commentary: Change we must: putting patients first with the institute model of academic health center organization
    James B Young
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Ohio, USA
    Acad Med 87:552-4. 2012
  3. doi request reprint Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry)
    James B Young
    Department of Cardiovascular Medicine, Heart Failure Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:223-30. 2008
  4. ncbi request reprint Perspectives on cardiac allograft vasculopathy
    J B Young
    Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure, Department of Cardiology Desk F 25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Atheroscler Rep 2:259-71. 2000
  5. ncbi request reprint Heart failure is a fever: the cytokine connection
    J B Young
    Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 67:801-3. 2000
  6. ncbi request reprint Angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, or both in chronic heart failure
    James B Young
    Case Western University, Cleveland, OH 44195, USA
    Heart Fail Clin 1:39-47. 2005
  7. ncbi request reprint Imaging patients with heart failure: expectations of the clinician
    James B Young
    Division of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Heart Fail Clin 2:107-15. 2006
  8. ncbi request reprint Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials
    James B Young
    Division of Medicine, The Cleveland Clinic Foundation and Kaufman Center for Heart Failure, 9500 Euclid Avenue T 13, Cleveland, OH 44195, USA
    Circulation 110:2618-26. 2004
  9. ncbi request reprint The global epidemiology of heart failure
    James B Young
    Department of Medicine, Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Med Clin North Am 88:1135-43, ix. 2004
  10. ncbi request reprint Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial
    James B Young
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:2685-94. 2003

Detail Information

Publications132 found, 100 shown here

  1. doi request reprint Bariatric surgery and cardiovascular outcomes: a systematic review
    Amanda R Vest
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 98:1763-77. 2012
    ..To quantify the impact of bariatric surgery on cardiovascular (CV) risk factors, and on cardiac structure and function...
  2. doi request reprint Commentary: Change we must: putting patients first with the institute model of academic health center organization
    James B Young
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Ohio, USA
    Acad Med 87:552-4. 2012
    ..The authors argue that this model better focuses on the patient as well as on the institution's academic charge. It is a concept that should be more widely adopted with deference to individual institutional culture and history...
  3. doi request reprint Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry)
    James B Young
    Department of Cardiovascular Medicine, Heart Failure Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:223-30. 2008
    ..Lower hemoglobin is associated with higher morbidity and mortality in hospitalized patients with HF...
  4. ncbi request reprint Perspectives on cardiac allograft vasculopathy
    J B Young
    Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure, Department of Cardiology Desk F 25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Atheroscler Rep 2:259-71. 2000
    ..In the future, better control of the allograft immunologic response will likely be the key to attenuating development of this form of atherosclerosis...
  5. ncbi request reprint Heart failure is a fever: the cytokine connection
    J B Young
    Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 67:801-3. 2000
    ..Several medications counter these effects in vitro, and some are in clinical testing...
  6. ncbi request reprint Angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, or both in chronic heart failure
    James B Young
    Case Western University, Cleveland, OH 44195, USA
    Heart Fail Clin 1:39-47. 2005
  7. ncbi request reprint Imaging patients with heart failure: expectations of the clinician
    James B Young
    Division of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Heart Fail Clin 2:107-15. 2006
  8. ncbi request reprint Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials
    James B Young
    Division of Medicine, The Cleveland Clinic Foundation and Kaufman Center for Heart Failure, 9500 Euclid Avenue T 13, Cleveland, OH 44195, USA
    Circulation 110:2618-26. 2004
    ..CHARM is a randomized, double-blind, placebo-controlled, multicenter, international trial program...
  9. ncbi request reprint The global epidemiology of heart failure
    James B Young
    Department of Medicine, Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Med Clin North Am 88:1135-43, ix. 2004
    ..Early identification of patients at risk for HF and asymptomatic patients with structural heart disease is critical if the human morbidity and mortality toll and the economic burden that HF causes is to be decreased...
  10. ncbi request reprint Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial
    James B Young
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:2685-94. 2003
    ....
  11. doi request reprint Hemodynamics, diuretics, and nesiritide: a retrospective VMAC analysis
    James B Young
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Cardiol 32:530-6. 2009
    ..Hypotension has been proposed as the cause of nesiritide-associated increases in serum creatinine (SCr); however, this hypothesis has not been tested...
  12. ncbi request reprint Risk factors for death after heart transplantation: does a single-center experience correlate with multicenter registries?
    J F McCarthy
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 65:1574-8; discussion 1578-9. 1998
    ..This study was performed to (1) evaluate pre-Tx factors affecting mortality in a single-center experience, and (2) compare these factors with risk factors obtained from multicenter registry reports...
  13. ncbi request reprint Angiotensin II receptors from peritransplantation through first-year post-transplantation and the risk of transplant coronary artery disease
    Mohammed Yousufuddin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 4195, USA
    J Am Coll Cardiol 43:1565-73. 2004
    ..We evaluated whether the angiotensin II (Ang II) receptors from perioperation through one-year post-transplantation predict the transplant coronary artery disease (TCAD) progression...
  14. ncbi request reprint The effect of combined Angiotensin-converting enzyme inhibition and calcium antagonism on allograft coronary vasculopathy validated by intravascular ultrasound
    Kursad Erinc
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH 44195, USA
    J Heart Lung Transplant 24:1033-8. 2005
    ..We evaluated the efficacy of angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists, and their combined use, on the development of coronary vasculopathy in hypertensive heart transplant recipients...
  15. ncbi request reprint High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound
    E M Tuzcu
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 103:2705-10. 2001
    ..Detailed, in vivo data on atherosclerosis in young individuals are limited. Intravascular ultrasonography provides a unique opportunity for in vivo characterization of early atherosclerosis in a clinically relevant context...
  16. ncbi request reprint Cellular rejection and rate of progression of transplant vasculopathy: a 3-year serial intravascular ultrasound study
    J Jimenez
    Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Heart Lung Transplant 20:393-8. 2001
    ..However, de novo lesions continue to develop every year. In patients with evidence of rejection, the rate of progression of transplant vasculopathy correlates with the severity of rejection...
  17. ncbi request reprint The influence of donor gender on allograft vasculopathy: evidence from intravascular ultrasound
    K Erinc
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Transplant Proc 36:3129-31. 2004
    ..Allograft vasculopathy is a major risk factor for mortality following cardiac transplantation. Several immune and nonimmune factors have been evaluated as risk factors for the development of coronary vasculopathy...
  18. ncbi request reprint Left ventricular reduction surgery with mitral valve repair
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S64-7. 2000
    ..Many questions remain to be answered, but many patients have demonstrated early subjective and objective improvement...
  19. ncbi request reprint Oral steroid pulse without taper for the treatment of asymptomatic moderate cardiac allograft rejection
    M H Park
    Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121 2483, USA
    J Heart Lung Transplant 18:1224-7. 1999
    ..This study analyzes the efficacy of 3-day 100-mg course of prednisone without a tapered regimen for the treatment of asymptomatic moderate cardiac allograft rejection...
  20. ncbi request reprint HLA sensitization in ventricular assist device recipients: does type of device make a difference?
    Ganesh S Kumpati
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 127:1800-7. 2004
    ....
  21. ncbi request reprint Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observations
    R C Starling
    George M and Linda H Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 36:2098-103. 2000
    ..The study was done to prospectively measure the echocardiographic, hemodynamic and clinical outcomes after partial left ventriculectomy (PLV)...
  22. ncbi request reprint Patients with mild heart failure worsen during withdrawal from digoxin therapy
    K F Adams
    Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, USA
    J Am Coll Cardiol 30:42-8. 1997
    ..We investigated whether patients with mild heart failure due to left ventricular systolic dysfunction were at risk of worsening during digoxin withdrawal...
  23. ncbi request reprint Brain natriuretic peptide levels do not correlate with acute cellular rejection in De Novo orthotopic heart transplant recipients
    James O O'Neill
    Kaufman Centre for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 24:416-20. 2005
    ..The use of brain natriuretic peptide levels as a surrogate marker for cellular rejection remains controversial, with conflicting data...
  24. ncbi request reprint Survival beyond 10 years following heart transplantation: The Cleveland Clinic Foundation experience
    V Ozduran
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Transplant Proc 37:4509-12. 2005
    ..Long-term survival after heart transplantation is a desirable although challenging goal...
  25. ncbi request reprint Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)
    A Deswal
    Winters Center for Heart Failure Research, Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 103:2055-9. 2001
    ..CONCLUSIONS: Cytokines and cytokine receptors are independent predictors of mortality in patients with advanced heart failure. Moreover, circulating levels of cytokines are modified by age, sex, and cause of heart failure...
  26. ncbi request reprint Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology?
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Heart Lung Transplant 19:1077-80. 2000
    ..A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate...
  27. ncbi request reprint Noninvasive assessment of cardiac mechanics and clinical outcome after partial left ventriculectomy
    Randolph M Setser
    Department of Radiology, The Cleveland Clinic Foundation, OH, USA
    Ann Thorac Surg 76:1576-85; discussion 1585-6. 2003
    ..Little is known about its effects on myocardial mechanics and their relation to clinical outcome...
  28. ncbi request reprint Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion
    K Fukamachi
    Department of Biomedical Engineering, The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 68:2181-4. 1999
    ..Implantable left ventricular assist device (LVAD) insertion complicated by early right ventricular (RV) failure has a poor prognosis and is generally unpredictable...
  29. ncbi request reprint Hypogammaglobulinemia after heart transplantation: impact of pre-emptive use of immunoglobulin replacement (CytoGam) on infection and rejection outcomes
    M H Yamani
    Departament of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Transpl Infect Dis 3:40-3. 2001
    ..001) and episodes of rejection (grade > or = 3; P = 0.03 and grade > or = 2; P = 0.04) compared with the control group...
  30. ncbi request reprint Device-based change in left ventricular shape: a new concept for the treatment of dilated cardiomyopathy
    P M McCarthy
    Department of Cardiology and Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 122:482-90. 2001
    ..We tested a unique new device, the Myosplint device (Myocor, Inc, Maple Grove, Minn), which is designed to change left ventricular shape, reduce left ventricular wall stress, and improve left ventricular systolic function...
  31. ncbi request reprint Hypogammaglobulinemia following cardiac transplantation: a link between rejection and infection
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Heart Lung Transplant 20:425-30. 2001
    ..IgG level may be a useful marker for identifying patients at high risk...
  32. ncbi request reprint Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation
    Mohammed Yousufuddin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure and Transplantation, The Cleveland Clinic Foundation, F 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 25:377-85. 2004
    ..We tested the hypothesis that cardiac angiotensin II (Ang II) receptor gene transcription may predict the development of transplant coronary artery disease (TCAD) following heart transplantation...
  33. ncbi request reprint Donor hepatitis-C seropositivity is an independent risk factor for the development of accelerated coronary vasculopathy and predicts outcome after cardiac transplantation
    Showkat A Haji
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 23:277-83. 2004
    ..We evaluated the hypothesis that donor HCV seropositivity predicts mortality and the development of coronary vasculopathy in cardiac transplant recipients...
  34. ncbi request reprint Neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy
    Soren Schenk
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 128:38-43. 2004
    ..We evaluated the neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy...
  35. doi request reprint Acute heart failure syndromes in patients with coronary artery disease early assessment and treatment
    James D Flaherty
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Am Coll Cardiol 53:254-63. 2009
    ..Prospective studies of the assessment and treatment of CAD in patients with AHFS are urgently needed...
  36. ncbi request reprint Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur J Heart Fail 9:83-91. 2007
    ..Limited comparative studies assessing the health-related quality of life (HRQL) in heart failure (HF) patients with preserved vs. low ejection fraction (LVEF) have been disparate...
  37. ncbi request reprint Permanent mechanical circulatory support with an implantable left ventricular assist device
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195, USA
    Ann Thorac Surg 63:1458-61. 1997
    ..He was discharged from the hospital 13 days after the operation, and 5 months postoperatively he had returned to New York Heart Association functional class II...
  38. ncbi request reprint Clinical predictors of worsening heart failure during withdrawal from digoxin therapy
    K F Adams
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, 27599 7075, USA
    Am Heart J 135:389-97. 1998
    ....
  39. ncbi request reprint Surgical therapy for dilated cardiomyopathy
    R C Starling
    Section of Heart Failure and Cardiac Transplant Medicine, George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio, USA
    Cardiol Clin 16:727-37. 1998
    ..Randomized, prospective controlled studies assessing LVAD therapy and cardiomyoplasty are in progress...
  40. ncbi request reprint Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts
    Nader M Fahmy
    The Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 75:2044-7. 2003
    ..Potential molecular differences between early and late rejection (grade > or =2) episodes were examined by testing chemokine and receptor-gene expression...
  41. ncbi request reprint Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 50:768-77. 2007
    ..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
  42. ncbi request reprint Equivalence of the bioimpedance and thermodilution methods in measuring cardiac output in hospitalized patients with advanced, decompensated chronic heart failure
    Nancy M Albert
    Division of Nursing, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Crit Care 13:469-79. 2004
    ..An accurate and reliable noninvasive method for determining cardiac output/cardiac index would be valuable for patients with acutely decompensated advanced systolic heart failure...
  43. ncbi request reprint Severe frequent ventricular ectopy after exercise as a predictor of death in patients with heart failure
    James O O'Neill
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 44:820-6. 2004
    ..The study was done to determine the prognostic importance of frequent ventricular ectopy in recovery after exercise among patients with systolic heart failure (HF)...
  44. ncbi request reprint B-type natriuretic peptide levels are not a surrogate marker for invasive hemodynamics during management of patients with severe heart failure
    J O O'Neill
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 149:363-9. 2005
    ..We sought to assess the utility of serial BNP measurements in patients with severe heart failure and attempted to correlate values with invasively derived data...
  45. ncbi request reprint Impact of lipid abnormalities in development and progression of transplant coronary disease: a serial intravascular ultrasound study
    S R Kapadia
    Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 38:206-13. 2001
    ..Therefore, maintenance of LDL cholesterol as close to pretransplant values as possible may help to limit the rate of progression of acquired allograft vasculopathy...
  46. ncbi request reprint Sudden cardiac death syndrome and pump dysfunction: the link
    J B Young
    Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S27-31. 2000
    ..Obviously, sudden cardiac death due to sudden heart block or asystole might be attenuated with this strategy...
  47. doi request reprint Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    William T Abraham
    Division of Cardiology, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 52:347-56. 2008
    ..The aim of this study was to develop a clinical model predictive of in-hospital mortality in a broad hospitalized heart failure (HF) patient population...
  48. ncbi request reprint Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants
    Nader M Fahmy
    The Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Transplantation 75:72-8. 2003
    ....
  49. ncbi request reprint Testing for B-type natriuretic peptide in the diagnosis and assessment of heart failure: what are the nuances?
    James B Young
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Cleve Clin J Med 71:S1-17. 2004
  50. ncbi request reprint Predictors of delivery of hospital-based heart failure patient education: a report from OPTIMIZE-HF
    Nancy M Albert
    Division of Nursing and George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Card Fail 13:189-98. 2007
    ....
  51. ncbi request reprint Analysis of immune markers in human cardiac allograft recipients and association with coronary artery vasculopathy
    Emilio D Poggio
    Department of Immunology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 24:1606-13. 2005
    ..Because coronary artery vasculopathy (CAV) is a common cause of late cardiac allograft loss in humans, there is a need to develop and test non-invasive surrogate markers capable of detecting and predicting this disease entity...
  52. ncbi request reprint Early and late rejection and HLA sensitization at the time of heart transplantation in patients bridged with left ventricular assist devices
    G V Gonzalez-Stawinski
    Department of Thoracic Surgery, Kaufman Center for Heart Failure and The Transplant Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplant Proc 37:1349-51. 2005
    ....
  53. ncbi request reprint Partial left ventriculectomy for dilated cardiomyopathy: is this an alternative to transplantation?
    A Franco-Cereceda
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Thorac Cardiovasc Surg 121:879-93. 2001
    ..To determine the late effectiveness of partial left ventriculectomy and risk factors for failure...
  54. ncbi request reprint Comparison of dobutamine-based and milrinone-based therapy for advanced decompensated congestive heart failure: Hemodynamic efficacy, clinical outcome, and economic impact
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 142:998-1002. 2001
    ..We sought to compare the clinical outcome and economic cost of dobutamine-based and milrinone-based therapy in patients with acute exacerbation of CHF...
  55. ncbi request reprint The looming polypharmacy crisis in the management of patients with heart failure. Potential solutions
    G S Francis
    Coronary Intensive Care Unit, Department of Cardiology, George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cardiol Clin 19:541-5. 2001
    ..This will not be an easy task, but the current model of rational drug development followed by a large megatrial is costly and not likely to be sustained indefinitely...
  56. ncbi request reprint Incidence and predictors of hyperkalemia in patients with heart failure: an analysis of the CHARM Program
    Akshay S Desai
    Department of Cardiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 50:1959-66. 2007
    ..We explored the incidence and predictors of hyperkalemia in a broad population of heart failure patients...
  57. ncbi request reprint The role of vitronectin receptor (alphavbeta3) and tissue factor in the pathogenesis of transplant coronary vasculopathy
    Mohamad H Yamani
    Department of Cardiology, Learner Research Institute, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 39:804-10. 2002
    ..This study was undertaken to test the hypothesis that transplant coronary vasculopathy (CV) is associated with increased myocardial protein expression of both tissue factor (TF) and integrin alphavbeta3...
  58. ncbi request reprint Statin use and risks of death or fatal rejection in the Heart Transplant Lipid Registry
    Audrey H Wu
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 95:367-72. 2005
    ..Statin therapy was significantly associated with lower risk of death and fatal rejection, benefits that were independent of lipid values...
  59. doi request reprint Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF
    Gregg C Fonarow
    Department of Medicine, UCLA University of California, Los Angeles Medical Center, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 168:847-54. 2008
    ..This study evaluated the association between precipitating factors identified at the time of HF hospital admission and subsequent clinical outcomes...
  60. doi request reprint Prognosis of patients removed from a transplant waiting list for medical improvement: implications for organ allocation and transplantation for status 2 patients
    Katherine J Hoercher
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 135:1159-66. 2008
    ....
  61. ncbi request reprint Ventricular assist devices and aggressive immunosuppression: looking beyond overall survival
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44121, USA
    J Heart Lung Transplant 25:613-8. 2006
    ..We hypothesized that allosensitized VAD patients have higher levels of immunosuppression and thus different morbidity and causes of mortality...
  62. ncbi request reprint Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation
    E Murat Tuzcu
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 45:1538-42. 2005
    ..The aim of this study was to determine whether angiographically silent early coronary intimal thickening could predict long-term morbidity and mortality...
  63. ncbi request reprint Early and midterm risk of coronary allograft vasculopathy in patients bridged to orthotopic heart transplantation with ventricular assist devices
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 79:1175-9. 2005
    ..To examine this, we obtained posttransplant coronary angiograms from a group of patients bridged with VAD and compared them to post transplant coronary angiograms of a non-VAD cohort...
  64. ncbi request reprint Influence of a performance-improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, 10833 LeConte Ave, Room 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 167:1493-502. 2007
    ..We sought to evaluate the effect of a national hospital-based initiative on quality of care in patients hospitalized with HF...
  65. ncbi request reprint Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 46:1029-35. 2005
    ..We evaluated chimerism and stromal cell-derived factor-1 (SDF-1) expression in response to peritransplant ischemic injury following human heart transplantation...
  66. ncbi request reprint The impact of donor gender on cardiac peri-transplantation ischemia injury
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 24:1741-4. 2005
    ..Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated...
  67. ncbi request reprint The impact of CytoGam on cardiac transplant recipients with moderate hypogammaglobulinemia: a randomized single-center study
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Heart Lung Transplant 24:1766-9. 2005
    ..However, the impact of Ig replacement in moderately hypogammaglobulinemic patients is unknown...
  68. doi request reprint Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:569-76. 2008
    ..This study sought to determine the characteristics and long-term prognosis of anemia in ambulatory patients with chronic heart failure...
  69. ncbi request reprint Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection
    Mohamad H Yamani
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 25:1283-9. 2006
    ..We hypothesized that recurrent acute rejection is associated with increased gene expression of AGTR1 in human heart transplantation...
  70. ncbi request reprint Contemporary outcomes of outpatients referred for cardiac transplantation evaluation to a tertiary heart failure center: impact of surgical alternatives
    Niall G Mahon
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Card Fail 10:273-8. 2004
    ..We sought to assess current disposition and outcomes of patients recently referred for transplant evaluation to a single high-throughput tertiary referral center...
  71. ncbi request reprint Ischemic heart disease and congestive heart failure in diabetic patients
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Med Clin North Am 88:1037-61, xi-xii. 2004
    ..Special consideration is given to new strategies for treating the adverse effects of abnormal glucose metabolism on the cardiovascular system...
  72. ncbi request reprint Myocardial ischemic-fibrotic injury after human heart transplantation is associated with increased progression of vasculopathy, decreased cellular rejection and poor long-term outcome
    Mohamad H Yamani
    Department of Cardiology, Kaufman Heart Failure Center, Cleveland, Ohio, USA
    J Am Coll Cardiol 39:970-7. 2002
    ..We sought to assess the influence of peritransplant ischemia and fibrosis on the development of allograft vasculopathy, acute cellular rejection and long-term outcome...
  73. pmc Plasma volume and outcome in pulmonary hypertension
    Karen B James
    Department of Cardiovascular Medicine, Cleveland Clinic, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Tex Heart Inst J 30:305-7. 2003
    ..Elevated plasma volume may be a useful prognosticator; further studies are needed to assess whether manipulation of plasma volume affects prognosis...
  74. ncbi request reprint Systemic activation of integrin alphaVbeta3 in donors with spontaneous intracerebral hemorrhage is associated with subsequent development of vasculopathy in the heart transplant recipient
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio, USA
    J Heart Lung Transplant 24:1014-8. 2005
    ..We hypothesized that donor ICH is associated with systemic activation of alpha(V)beta3 in the donor before transplantation...
  75. ncbi request reprint Sustained apoptosis in human cardiac allografts despite histologic resolution of rejection
    Sofia C Masri
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 76:859-64. 2003
    ..We investigated the occurrence of apoptosis during and after resolution of cardiac allograft rejection. Apoptosis could play different roles in graft survival depending on the target cells; thus, we also determined the cell types involved...
  76. ncbi request reprint Donor spontaneous intracerebral hemorrhage is associated with systemic activation of matrix metalloproteinase-2 and matrix metalloproteinase-9 and subsequent development of coronary vasculopathy in the heart transplant recipient
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 108:1724-8. 2003
    ..We hypothesized that donor intracerebral hemorrhage (ICH) is associated with activation of the metalloproteinases before transplantation that play a key role in the subsequent development of transplant vasculopathy...
  77. doi request reprint Novel implantable device to detect cardiac allograft rejection
    Tetsuya Horai
    Department of Biomedical Engineering, Heart and Vascular Institute, Cleveland Clinic, Ohio 44195, USA
    Circulation 120:S185-90. 2009
    ..This study determined the ability of the Soul Mate to detect early rejection of transplanted hearts...
  78. ncbi request reprint Acute vascular rejection is associated with up-regulation of vitronectin receptor (alphavbeta3), increased expression of tissue factor, and activation of the extracellular matrix metalloproteinase induction system
    Mohamad H Yamani
    Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 21:983-9. 2002
    ....
  79. ncbi request reprint The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure
    Niall G Mahon
    Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 40:1106-13. 2002
    ..The goal of this study was to determine the prognostic significance of estimated creatinine clearance (CrCl) in relation to 6-min walk distance in ambulatory patients with congestive heart failure (HF)...
  80. ncbi request reprint Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 41:1394-8. 2003
    ..We sought to define the characteristics of fluid retention after thiazolidinedione (TZD) initiation in patients with established heart failure (HF)...
  81. doi request reprint Utility of leflunomide in the treatment of complex cytomegalovirus syndromes
    Robin K Avery
    Department of Infectious Disease, Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA
    Transplantation 90:419-26. 2010
    ..Leflunomide, a drug for rheumatoid arthritis, has been reported to have anti-CMV activity. This study reports on its use in 17 transplant recipients with complex CMV syndromes who had failed or were intolerant to other therapies...
  82. ncbi request reprint Severe renal dysfunction complicating cardiogenic shock is not a contraindication to mechanical support as a bridge to cardiac transplantation
    Umesh N Khot
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Coll Cardiol 41:381-5. 2003
    ..This study investigated outcomes in patients with cardiogenic shock and severe renal dysfunction treated with ventricular assist devices (VAD) as a bridge to cardiac transplantation...
  83. ncbi request reprint Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient heart failure clinic
    Ritesh Gupta
    Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 147:79-83. 2004
    ..However, there is limited information regarding their use in clinical practice settings, and reasonable utilization targets for quality improvement initiatives have not been established...
  84. ncbi request reprint Plasma B-type natriuretic peptide levels in ambulatory patients with established chronic symptomatic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 108:2964-6. 2003
    ..The diagnostic and prognostic values of plasma B-type natriuretic peptide (BNP) testing are established. However, the range of plasma BNP levels present in the setting of chronic, stable systolic heart failure (HF) is unclear...
  85. ncbi request reprint Systemic up-regulation of angiotensin II type 1 receptor in cardiac donors with spontaneous intracerebral hemorrhage
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:1097-102. 2004
    ..397, CI = 1.243-15.553, adjusted p = 0.02). This is the first report to describe splenic up-regulation of AT1R in the presence of spontaneous ICH and its association with subsequent development of transplant vasculopathy...
  86. ncbi request reprint PET abnormalities in patients with nonischemic cardiomyopathy
    James O O'Neill
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine and Cardiothoracic Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    J Card Fail 10:244-9. 2004
    ..We sought to ascertain the prevalence of regional defects in DCM by multiple imaging modalities and to establish the relationship between QRS width and these defects...
  87. doi request reprint Sodium nitroprusside for advanced low-output heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:200-7. 2008
    ..This study was designed to examine the safety and efficacy of sodium nitroprusside (SNP) for patients with acute decompensated heart failure (ADHF) and low-output states...
  88. ncbi request reprint Acute cellular rejection following human heart transplantation is associated with increased expression of vitronectin receptor (integrin alphavbeta3)
    Mohamad H Yamani
    Department of Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Am J Transplant 2:129-33. 2002
    ..Acute cellular rejection, a process characterized by T-lymphocyte activation and release of inflammatory cytokines, is associated with increased expression of alphavbeta3...
  89. ncbi request reprint Increased beta-myosin heavy chain in acute cellular rejection following human heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH, USA
    Am J Transplant 2:386-8. 2002
    ..However, altered expression of beta-myosin heavy chain in human cardiac rejection has not been determined...
  90. ncbi request reprint Does acute cellular rejection correlate with cardiac allograft vasculopathy?
    Mohamad H Yamani
    Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 23:272-6. 2004
    ..We explored a possible association between acute cellular rejection and the extent of CAV, and we found a potential confounding variable that may obscure such an association...
  91. ncbi request reprint Impact of donor spontaneous intracranial hemorrhage on outcome after heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:257-61. 2004
    ..9%, p=0.0012). There was a trend towards an increased rate of allograft vasculopathy in the ICB group (competing risks adjusted hazard ratio 1.39, 95% CI 0.90-2.13, p = 0.14)...
  92. ncbi request reprint Myocardial ischemic injury after heart transplantation is associated with upregulation of vitronectin receptor (alpha(v)beta3), activation of the matrix metalloproteinase induction system, and subsequent development of coronary vasculopathy
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Circulation 105:1955-61. 2002
    ..Both vitronectin receptor (integrin alpha(v)beta3) and tissue factor play key roles in vascular endothelial cell injury. Matrix metalloproteinases (MMPs) are activated in ischemic injury models...
  93. ncbi request reprint Computerized scoring of histopathology for predicting coronary vasculopathy, validated by intravascular ultrasound
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Ohio 44195, USA
    J Heart Lung Transplant 21:850-9. 2002
    ..Allograft coronary vasculopathy results from a complex interplay between immunologic and non-immunologic factors. We devised a computerized biopsy scoring method based on histopathology to predict the development of coronary vasculopathy...
  94. doi request reprint Depression and clinical outcomes in heart failure: an OPTIMIZE-HF analysis
    Nancy M Albert
    Nursing Institute and George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Med 122:366-73. 2009
    ....
  95. ncbi request reprint Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of coronary vasculopathy
    Mohamad H Yamani
    Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 22:687-90. 2003
    ..We tested the hypothesis that Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and the subsequent development of coronary vasculopathy...
  96. ncbi request reprint Effects of fetal and neonatal environment on sympathetic nervous system development
    J B Young
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Diabetes Care 21:B156-60. 1998
    ....
  97. ncbi request reprint The HOPE study. Ramipril lowered cardiovascular risk, but vitamin E did not
    B J Hoogwerf
    Department of Endocrinology, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 67:287-93. 2000
    ..On the other hand, vitamin E in the doses and duration studied (400 IU/day for 4.5 years) did not lower risk significantly...
  98. ncbi request reprint An update on nesiritide for treatment of decompensated heart failure
    R E Hobbs
    The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Department of Cardiology, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Expert Opin Investig Drugs 10:935-42. 2001
    ..Beneficial haemodynamic effects correlated with symptomatic improvement in heart failure patients. Nesiritide appears to be an ideal first-line agent for treatment of patients with acutely decompensated heart failure...
  99. ncbi request reprint New therapeutic choices in the management of acute congestive heart failure
    J B Young
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Rev Cardiovasc Med 2:S19-24. 2001
    ..Intravenous administration of nesiritide, a recombinant human B-type natriuretic peptide, has been shown to produce favorable hemodynamic effects, including balanced vasodilation associated with a rapid improvement in clinical symptoms...
  100. ncbi request reprint Heart failure disease management: a team approach
    N M Albert
    Kaufman Center for Heart Failure, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 68:53-62; discussion 63-4. 2001
    ..This article reviews the principles of heart failure disease-management programs and cites evidence that they are beneficial...
  101. ncbi request reprint Healing the heart with ventricular assist device therapy: mechanisms of cardiac recovery
    J B Young
    Kaufman Center for Heart Failure, Section of Heart Failure and Cardiac Transplant Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 71:S210-9. 2001
    ..It is important to understand how ventricular assist device implantation in select advanced heart failure patients might precipitate recovery of depressed myocardial function...