Riqiang Yan

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1
    Donald B Carter
    Global Research and Development, Pfizer Inc, Kalamazoo, MI 49001, USA
    Mol Neurodegener 3:6. 2008
  2. pmc Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition
    Xiangdong Zhou
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    FASEB J 25:3146-56. 2011
  3. ncbi request reprint Reticulon proteins: emerging players in neurodegenerative diseases
    R Yan
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, 44195, USA
    Cell Mol Life Sci 63:877-89. 2006
  4. ncbi request reprint Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins
    Wanxia He
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Biol 363:625-34. 2006
  5. pmc Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites
    Qi Shi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 29:9163-73. 2009
  6. ncbi request reprint The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1
    Wanxia He
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 282:29144-51. 2007
  7. pmc BACE1 deficiency causes altered neuronal activity and neurodegeneration
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 30:8819-29. 2010
  8. pmc Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice
    Qi Shi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 33:3059-66. 2013
  9. pmc RTN/Nogo in forming Alzheimer's neuritic plaques
    Marguerite Prior
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurosci Biobehav Rev 34:1201-6. 2010
  10. pmc Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    FASEB J 22:2970-80. 2008

Collaborators

  • Allan Levey
  • Philip Wong
  • Grahame J Kidd
  • X Zhou
  • Christopher G Wilson
  • Jun Yang
  • Robert Miller
  • Q Shi
  • Marla Gearing
  • Bruce Trapp
  • Jinhe Li
  • Xiangyou Hu
  • Wanxia He
  • XiaoYang Luo
  • Marguerite Prior
  • Wendy B Macklin
  • Isam Qahwash
  • Xiaoying Tang
  • Donald B Carter
  • Alfredo Tomasselli
  • Yifeng Lu
  • Zhihong Jiang
  • Katherine Elyse Tsubota
  • Rita Schlanger
  • Sumiko Kiryu-Seo
  • Satya Yadav
  • Weizhen Shen
  • Wencheng Xiong
  • Denise D McKinley
  • Claudiu Diaconu
  • Jeffrey S Nye
  • Brenda R Ellerbrook
  • Edwige Dunn
  • Nancy C Stratman
  • Carol S Himes
  • Adele M Pauley
  • Timothy J Fleck
  • Hong Yi
  • Xinghua Yin
  • Caitlin W Hicks
  • Christopher Fisher
  • Xiang You Hu
  • Rolf F Kletzien
  • Ansi Chang
  • Jane Y Wu
  • Xiaochun Zhang
  • Hao Tang
  • Stefan Stamm
  • Necat Havlioglu

Detail Information

Publications23

  1. pmc Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1
    Donald B Carter
    Global Research and Development, Pfizer Inc, Kalamazoo, MI 49001, USA
    Mol Neurodegener 3:6. 2008
    ..This study provides an important structural clue for the rational design of drugs to inhibit processing of APP at the gamma-site without interfering with Notch processing...
  2. pmc Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition
    Xiangdong Zhou
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    FASEB J 25:3146-56. 2011
    ..0.76% of total measured area in APP(swe)/PS1ΔE9 mice). Our results demonstrate that down-regulation of NgR expression is a potential approach for inhibiting amyloid deposition in AD patients...
  3. ncbi request reprint Reticulon proteins: emerging players in neurodegenerative diseases
    R Yan
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, 44195, USA
    Cell Mol Life Sci 63:877-89. 2006
    ..In this review, we summarize the accumulated findings concerning the structural and functional aspects of RTNs and speculate on their linkage to the pathogenesis of neurodegenerative diseases...
  4. ncbi request reprint Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins
    Wanxia He
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Biol 363:625-34. 2006
    ..The knowledge from this study may potentially guide discovery of small molecules that can mimic the effect of RTN3 on the inhibition of BACE1 activity...
  5. pmc Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites
    Qi Shi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 29:9163-73. 2009
    ..Our results suggest that inhibition of RTN3 aggregation is likely to be beneficial by reducing both amyloid deposition and the formation RIDNs...
  6. ncbi request reprint The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1
    Wanxia He
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 282:29144-51. 2007
    ..Thus, the determination of RTN3 membrane topology may provide an important structural basis for our understanding of its cellular functions...
  7. pmc BACE1 deficiency causes altered neuronal activity and neurodegeneration
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 30:8819-29. 2010
    ..The knowledge from this study is crucial for the development of BACE1 inhibitors for Alzheimer's therapy and to the applicative study of epilepsy...
  8. pmc Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice
    Qi Shi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 33:3059-66. 2013
    ..Hence, we conclude that age-dependent RIDNs cannot be effectively cleared once they have formed, and we postulate that successful prevention of RIDN formation should be initiated before RTN3 aggregation...
  9. pmc RTN/Nogo in forming Alzheimer's neuritic plaques
    Marguerite Prior
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurosci Biobehav Rev 34:1201-6. 2010
    ..The presence of dystrophic neurites impairs cognition. Blocking abnormal RTN3 aggregation will increase the available RTN3 monomer and is therefore a promising therapeutic strategy for enhancing cognitive function in AD patients...
  10. pmc Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    FASEB J 22:2970-80. 2008
    ..Pharmacological inhibition of BACE1 should be carefully monitored to avoid alteration of signaling pathway that regulates remyelination...
  11. pmc Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    EMBO J 26:2755-67. 2007
    ..Together, we demonstrate that aggregation of RTN3 contributes to AD pathogenesis by inducing neuritic dystrophy. Inhibition of RTN3 aggregation is likely a therapeutic approach for reducing neuritic dystrophy...
  12. pmc Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination
    XiaoYang Luo
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 286:23967-74. 2011
    ..Thus, processing of Nrg1 by BACE1 appears to be more critical for regulating myelination. Our results imply that a significant inhibition of BACE1 could potentially impair Nrg1 signaling activity in vivo...
  13. pmc BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Rep 4:40-9. 2013
    ..Hence, BACE1 appears to function as a signaling protease that controls the balance of neurogenesis and astrogenesis via the Jag1-Notch pathway. ..
  14. ncbi request reprint Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
    Wanxia He
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Med 10:959-65. 2004
    ..Thus, changes in the expression of reticulon proteins in the human brain are likely to affect cellular amyloid-beta and the formation of amyloid plaques...
  15. pmc Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    FASEB J 27:1868-73. 2013
    ..Our results suggest that signaling activity other than Akt may also contribute to proper myelination in peripheral nerves...
  16. pmc The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function
    Qi Shi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 29:5108-15. 2009
    ..Collectively, these results suggest that blocking the formation of RIDNs may be a promising strategy to impede cognitive decline in the elderly and in AD patients...
  17. pmc Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice
    XiaoYang Luo
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio
    Biol Psychiatry 76:120-7. 2014
    ..This study aimed to determine whether increased expression of Nrg1 is beneficial for brain development and functions...
  18. ncbi request reprint Bace1 modulates myelination in the central and peripheral nervous system
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:1520-5. 2006
    ..Based upon these and previous studies, we postulate that neuronally enriched Bace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates myelination by means of phosphorylation of Akt in myelin-forming cells...
  19. pmc Targeting the β secretase BACE1 for Alzheimer's disease therapy
    Riqiang Yan
    Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Lancet Neurol 13:319-29. 2014
    ..The potential of therapeutic BACE1 inhibition might prove to be a watershed in the treatment of Alzheimer's disease. ..
  20. pmc Inhibition of BACE1 for therapeutic use in Alzheimer's disease
    XiaoYang Luo
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Clin Exp Pathol 3:618-28. 2010
    ..Although BACE1 inhibitors are expected to be safe in general, careful titration of drug dosage to avoid undesirable side effects in BACE1-directed AD therapy is also emphasized...
  21. ncbi request reprint Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1
    Isam Qahwash
    Cell and Molecular Biology, Protein Sciences, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 279:39010-6. 2004
    ....
  22. pmc Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta
    Zhihong Jiang
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:18997-9007. 2003
    ..Our results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 beta, suggesting that Tra2 beta may play a role in aberrant tau exon 10 alternative splicing and in the pathogenesis of tauopathies...
  23. ncbi request reprint SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production
    Jinhe Li
    Department of Neurobiology, Computer Aided Drug Design, Pharmacia Corporation, Kalamazoo, Michigan 49001, USA
    J Neurochem 82:1540-8. 2002
    ..Co-transfection of sel-10 and APP cDNAs in HEK293 cells leads to an alteration in the metabolism of APP and to an increase in the production of amyloid beta-peptide, the principal component of amyloid plaque in Alzheimer's disease...

Research Grants6

  1. Roles of Reticulon proteins in neurodegenerative disease
    Riqiang Yan; Fiscal Year: 2005
    ..We believe that results from this study will provide valuable insights into the molecular mechanisms of RTN3 and its family members in negatively modulating BACE1 activity. ..
  2. Roles of Reticulon proteins in neurodegenerative disease
    Riqiang Yan; Fiscal Year: 2006
    ..We believe that results from this study will provide valuable insights into the molecular mechanisms of RTN3 and its family members in negatively modulating BACE1 activity. ..
  3. Roles of Reticulon proteins in neurodegenerative disease
    Riqiang Yan; Fiscal Year: 2007
    ..We believe that results from this study will provide valuable insights into the molecular mechanisms of RTN3 and its family members in negatively modulating BACE1 activity. ..
  4. Roles of Reticulon proteins in neurodegenerative disease
    Riqiang Yan; Fiscal Year: 2009
    ..We believe that results from this study will provide valuable insights into the molecular mechanisms of RTN3 and its family members in negatively modulating BACE1 activity. ..
  5. Roles of reticulon proteins in neurodegenerative diseases
    Riqiang Yan; Fiscal Year: 2010
    ....