Valentin P Yakubenko

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc αMβ₂ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation
    Valentin P Yakubenko
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 108:544-54. 2011
  2. pmc The role of integrin alpha D beta2 (CD11d/CD18) in monocyte/macrophage migration
    Valentin P Yakubenko
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Exp Cell Res 314:2569-78. 2008
  3. ncbi request reprint Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Tatiana P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 42:9365-73. 2003
  4. ncbi request reprint Multiple binding sites in fibrinogen for integrin alphaMbeta2 (Mac-1)
    Valeryi K Lishko
    J J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Biol Chem 279:44897-906. 2004
  5. ncbi request reprint Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5)
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Blood 104:719-26. 2004
  6. pmc Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1
    Praveena S Thiagarajan
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Cardiovasc Res 99:494-504. 2013
  7. pmc From macrophage interleukin-13 receptor to foam cell formation: mechanisms for αMβ2 integrin interference
    Valentin P Yakubenko
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 288:2778-88. 2013
  8. pmc Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties
    Valentin P Yakubenko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Blood 107:1643-50. 2006
  9. ncbi request reprint Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 41:12942-51. 2002
  10. pmc IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages
    Ashish Bhattacharjee
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Free Radic Biol Med 54:1-16. 2013

Collaborators

Detail Information

Publications15

  1. pmc αMβ₂ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation
    Valentin P Yakubenko
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 108:544-54. 2011
    ..The alternative activation of monocytes by interleukin (IL)-13 and IL-4 is a significant component of the inflammatory response. The consequences of alternative activation in inflammatory diseases remain to be determined...
  2. pmc The role of integrin alpha D beta2 (CD11d/CD18) in monocyte/macrophage migration
    Valentin P Yakubenko
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Exp Cell Res 314:2569-78. 2008
    ....
  3. ncbi request reprint Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Tatiana P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 42:9365-73. 2003
    ..Thus, these data demonstrate the essential role of the P2, but not P1, sequence for binding of gamma C by the alpha(M)I-domain and suggest that the adhesive function of P2 depends on the minimal recognition motif NRLTIG...
  4. ncbi request reprint Multiple binding sites in fibrinogen for integrin alphaMbeta2 (Mac-1)
    Valeryi K Lishko
    J J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Biol Chem 279:44897-906. 2004
    ..This paradigm may have implications for mechanisms of promiscuity in ligand binding exhibited by integrin alphaMbeta2...
  5. ncbi request reprint Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5)
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Blood 104:719-26. 2004
    ..These findings identify Glu-Pg as an adhesive ligand for integrins alphaMbeta2 and alpha5beta1 and suggest that alpha5beta1 may participate in the binding of soluble Glu-Pg and assist in its activation...
  6. pmc Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1
    Praveena S Thiagarajan
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Cardiovasc Res 99:494-504. 2013
    ..Our hypothesis was that inflammation generates endogenous ligands for Dectin-1 that activate O₂⁻ production and thereby contributes to atherogenesis...
  7. pmc From macrophage interleukin-13 receptor to foam cell formation: mechanisms for αMβ2 integrin interference
    Valentin P Yakubenko
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 288:2778-88. 2013
    ..The discovery of this mechanism helps our understanding of the potential role of alternatively activated macrophages in atherogenesis and highlights the impact of integrin α(M)β(2) on this process...
  8. pmc Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties
    Valentin P Yakubenko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Blood 107:1643-50. 2006
    ....
  9. ncbi request reprint Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 41:12942-51. 2002
    ....
  10. pmc IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages
    Ashish Bhattacharjee
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Free Radic Biol Med 54:1-16. 2013
    ....
  11. ncbi request reprint The interplay between integrins alphaMbeta2 and alpha5beta1 during cell migration to fibronectin
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Exp Cell Res 283:116-26. 2003
    ..Because alpha(M)beta(2) binds numerous proteins in the extracellular matrix with a specificity overlapping that of the beta(1) integrins, the results suggest that alpha(M)beta(2) can affect the beta(1) integrin-mediated cell migration...
  12. pmc Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes
    Deena H Elsori
    Cleveland Clinic, Cleveland, OH 44195, USA
    J Leukoc Biol 90:599-611. 2011
    ....
  13. ncbi request reprint Identification of a novel binding site for platelet integrins alpha IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of fibrinogen
    Nataly P Podolnikova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Biol Chem 278:32251-8. 2003
    ..Thus, these data suggest that the P3 sequence in the gamma C-domain of fibrinogen defines a previously unknown recognition specificity of alpha IIb beta 3 and alpha 5 beta 1 and may function as a binding site for these integrins...
  14. pmc Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo
    Suman Kundu
    Department of Cell Biology, and Research Core Services, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    J Lipid Res 54:436-47. 2013
    ..Their effectiveness, often attributed to increasing EET levels, is probably influenced by the impairment of DHET formation and inhibition of chemotaxis...
  15. ncbi request reprint A molecular basis for integrin alphaMbeta 2 ligand binding promiscuity
    Valentin P Yakubenko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 277:48635-42. 2002
    ..These results suggest that alpha(M)(Lys(245)-Arg(261)) serves as a consensus binding site for interaction with a variety of distinct molecules and, thus, may define the degenerate recognition properties inherent to alpha(M)beta(2)...