Research Topics
| Steven E WilsonSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
Research Grants
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Detail Information
Publications
Long-term outcomes after photorefractive keratectomySteven E Wilson
Ophthalmology 113:1693-4. 2006- Synergistic effect of ethanol and mitomycin C on corneal stromaMarcelo V Netto
Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
J Refract Surg 24:626-32. 2008..To investigate the combined effects of ethanol and mitomycin C (MMC) application on the corneal stroma of rabbits that underwent photorefractive keratectomy (PRK)... 
Corneal myofibroblast biology and pathobiology: generation, persistence, and transparencySteven E Wilson
The Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Eye Res 99:78-88. 2012..Investigations of myofibroblast biology are likely to lead to safer pharmacological modulators of corneal wound healing and transparency...
Flaporhexis: rapid and effective technique to limit epithelial ingrowth after LASIK enhancementSteven E Wilson
Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cataract Refract Surg 38:2-4. 2012..This method consistently produces a smooth epithelial dissection and decreases the possibility that epithelium is retained beneath the flap...- Apoptosis in the initiation, modulation and termination of the corneal wound healing responseSteven E Wilson
The Cole Eye Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Eye Res 85:305-11. 2007.... - RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healingSteven E Wilson
Cole Eye Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
Invest Ophthalmol Vis Sci 45:2201-11. 2004..To examine the influx of monocytes into the cornea after epithelial scrape injury and the expression of chemokines that potentially regulate monocyte phenotype in cultured corneal fibroblasts and keratocytes in situ... - Clinical practice. Use of lasers for vision correction of nearsightedness and farsightednessSteven E Wilson
Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
N Engl J Med 351:470-5. 2004 - Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatmentSteven E Wilson
Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Ophthalmology 114:76-9. 2007..To report the resolution of symptoms and signs of chronic dry eye for at least 1 year after completion of a minimum 6-month course of topical 0.05% cyclosporine in a subgroup of patients from 2 practices... - Effect of femtosecond laser energy level on corneal stromal cell death and inflammationFabricio Witzel de Medeiros
Cleveland Clinic, Cole Eye Institute, Ohio 44195, USA
J Refract Surg 25:869-74. 2009..To analyze the effects of variations in femtosecond laser energy level on corneal stromal cell death and inflammatory cell influx following flap creation in a rabbit model... - Femtosecond laser and microkeratome corneal flaps: comparison of stromal wound healing and inflammationMarcelo V Netto
The Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 23:667-76. 2007..To examine early postoperative wound healing in rabbit corneas that had LASIK flaps formed with three different models (15 KHz, 30 KhZ, and 60 KHz) of a femtosecond laser compared with flaps formed with a microkeratome... - Topical interleukin-1 receptor antagonist inhibits inflammatory cell infiltration into the corneaW Michael Stapleton
Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Eye Res 86:753-7. 2008..Topical IL-1 receptor antagonist could be an effective adjuvant for clinical treatment of corneal conditions in which unwanted inflammation has a role in the pathophysiology of the disorder... - Corneal myofibroblast generation from bone marrow-derived cellsFlavia L Barbosa
Cole Eye Institute, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Exp Eye Res 91:92-6. 2010..This model, therefore, cannot exclude the possibility of myofibroblasts also developed from keratocytes and/or corneal fibroblasts... - A novel method for generating corneal haze in anterior stroma of the mouse eye with the excimer laserRajiv R Mohan
Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Exp Eye Res 86:235-40. 2008..This PTK technique for inducing haze in mouse cornea in vivo provides a useful model for studying wound healing and myofibroblast biology in transgenic mice... - Haze development after photorefractive keratectomy: mechanical vs ethanol epithelial removal in rabbitsFabricio Witzel de Medeiros
Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 24:923-7. 2008..To compare mechanical and ethanol epithelial removal with respect to myofibroblast development and haze formation after photorefractive keratectomy (PRK)... - Corneal stroma PDGF blockade and myofibroblast developmentHarmeet Kaur
Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Exp Eye Res 88:960-5. 2009..Stromal PDGF-B blockade during the early postoperative period following PRK decreases stromal alphaSMA+ myofibroblast generation. PDGF is an important modulator of myofibroblast development in the cornea... - Corneal myofibroblast viability: opposing effects of IL-1 and TGF beta1Harmeet Kaur
Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Exp Eye Res 89:152-8. 2009..TGF beta1 and IL-1 have opposing effects on myofibroblast viability and likely interact to modulate haze generation after corneal injury... - Stromal haze, myofibroblasts, and surface irregularity after PRKMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Exp Eye Res 82:788-97. 2006..Late apoptosis appears to have a role in the disappearance of myofibroblasts and haze over time... - Short-term cell death and inflammation after intracorneal inlay implantation in rabbitsMarcony R Santhiago
The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 28:144-9. 2012..To investigate the cell death and inflammatory response to insertion of the KAMRA inlay (AcuFocus Inc) for presbyopia... - Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbitsMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 22:562-74. 2006..However, a persistent decrease in keratocyte density in the anterior stroma could be a warning sign for future complications and treatment should be reserved for patients with significant risk of developing haze after PRK... - Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laserMarcella Q Salomao
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cataract Refract Surg 35:1756-60. 2009..To compare the incidence of laser in situ keratomileusis (LASIK)-associated dry eye and the need for postoperative cyclosporine A treatment after flap creation with a femtosecond laser and a mechanical microkeratome... - Corneal wound healing after ultraviolet-A/riboflavin collagen cross-linking: a rabbit studyMarcella Q Salomao
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 27:401-7. 2011..To investigate corneal wound healing following ultraviolet-A (UVA)/riboflavin corneal collagen cross-linking (CXL) in rabbit corneas... - Wavefront analysis comparison of LASIK outcomes with the femtosecond laser and mechanical microkeratomesFabricio W Medeiros
Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
J Refract Surg 23:880-7. 2007..To evaluate differences related to ocular aberrations after customized LASIK for myopia using three different microkeratomes... - Flap lift for LASIK retreatment in eyes with myopiaMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Ophthalmology 111:1362-7. 2004..It provided good uncorrected visual acuity, predictable results, good refractive stability, and few complications... - Differences in the early biomechanical effects of hyperopic and myopic laser in situ keratomileusisFabricio Witzel de Medeiros
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cataract Refract Surg 36:947-53. 2010.... - Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injuryShyam S Chaurasia
Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Exp Eye Res 89:133-9. 2009..The earliest precursors of myofibroblasts destined to express SMA and desmin are detectible by staining for vimentin at 1 week after surgery... - Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapyMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
Cornea 24:509-22. 2005..Recent advances in understanding the biologic and molecular processes that contribute to the healing response bring hope that safe and effective pharmacologic modulators of the corneal wound healing response may soon be developed... - Flap relift for retreatment after femtosecond laser-assisted LASIKMarcony R Santhiago
The Cleveland Clinic, Cleveland, OH, USA
J Refract Surg 28:482-7. 2012..To analyze the results of LASIK retreatment performed by relifting the original femtosecond laser-created flap... - Mitomycin C: biological effects and use in refractive surgeryMarcony R Santhiago
The Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Cornea 31:311-21. 2012..To provide an overview of the safety and efficacy of mitomycin C (MMC) as adjuvant therapy after refractive surgery procedures... - Femtosecond laser in laser in situ keratomileusisMarcella Q Salomao
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Cataract Refract Surg 36:1024-32. 2010..In this article, we review common considerations in management and complications of this step in femtosecond laser-LASIK and concentrate primarily on the IntraLase laser because most published studies relate to this instrument... - Use of mitomycin-C for phototherapeutic keratectomy and photorefractive keratectomy surgeryRavindra A Shah
The Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Curr Opin Ophthalmol 21:269-73. 2010..This review will highlight our understanding of the utility, mechanism of action, and safety profile of MMC... - Wavefront-guided ablation: evidence for efficacy compared to traditional ablationMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA, and Department of Ophthalmology, , , Brazil
Am J Ophthalmol 141:360-368. 2006..However, it is evident that wavefront-customized ablation holds a promising future and merits ongoing investigation... - Modulation transfer function and optical quality after bilateral implantation of a +3.00 D versus a +4.00 D multifocal intraocular lensMarcony R Santhiago
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44114, USA
J Cataract Refract Surg 38:215-20. 2012..00 diopter (D) addition (add) occurs at the expense of optical quality compared with the previous model with a +4.00 D add... - Wavefront analysis in normal refractive surgery candidatesMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
J Refract Surg 21:332-8. 2005..CONCLUSIONS: This study provides reference values for higher order aberrations in normal refractive surgery candidates. Wavefront analysis also proved to be a valuable tool for objectively measuring preoperative refractive error... - Gene therapy in the corneaRajiv R Mohan
The Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Mail Code i 31, Cleveland, OH 44195, USA
Prog Retin Eye Res 24:537-59. 2005..We will review the successes and obstacles impeding gene therapy approaches used for delivering genes into the cornea... - Cellular effects after laser in situ keratomileusis flap formation with femtosecond lasers: a reviewMarcony R Santhiago
Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Cornea 31:198-205. 2012..To provide an overview of the cellular effects of femtosecond laser in laser in situ keratomileusis flap formation... - Visual performance of an apodized diffractive multifocal intraocular lens with +3.00-d addition: 1-year follow-upMarcony R Santhiago
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44114, USA
J Refract Surg 27:899-906. 2011..00 diopters [D]) at the lens plane results in better intermediate visual acuity 1 year after surgery compared with a multifocal IOL with higher addition (+4.00 D)... - Indications for excimer laser surface ablationMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Refract Surg 21:734-41. 2005 - Reprint of "Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury"Shyam S Chaurasia
Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Exp Eye Res 89:590-6. 2009..The earliest precursors of myofibroblasts destined to express SMA and desmin are detectable by staining for vimentin at 1 week after surgery... - Biomechanics and wound healing in the corneaWilliam J Dupps
The Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, OH 44195, USA
Exp Eye Res 83:709-20. 2006.... - Corneal molecular and cellular biology update for the refractive surgeonMarcella Q Salomao
The Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Refract Surg 25:459-66. 2009..To review clinically relevant progress in understanding cellular and molecular interactions in the cornea that relate to refractive surgical outcomes in patients... - [Corneal wound healing response following different modalities of refractive surgical procedures]Marcelo Vieira Netto
Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
Arq Bras Oftalmol 68:140-9. 2005..The present text proposes a review of the corneal wound healing characteristics following different modalities of refractive surgical procedures... - Corneal wound healing relevance to wavefront guided laser treatmentsMarcelo V Netto
The Cole Eye Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Ophthalmol Clin North Am 17:225-31, vii. 2004.... - Expression of PDGF receptor-alpha in corneal myofibroblasts in situHarmeet Kaur
Cole Eye Institute, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Exp Eye Res 89:432-4. 2009..In vitro studies have suggested that PDGF is important in the development and viability of myofibroblasts after corneal injury. Expression of PDGFR-alpha in myofibroblasts supports these findings... - Agreement of physician treatment practices with the international task force guidelines for diagnosis and treatment of dry eye diseaseSteven E Wilson
Cleveland Clinic Cole Eye Institute, Cleveland, OH, USA
Cornea 26:284-9. 2007..To evaluate the clinical implementation of guidelines for the treatment of dysfunctional tear syndrome (DTS) developed by the International Task Force (ITF) of dry eye disease experts... - Inflammation: a unifying theory for the origin of dry eye syndromeSteven E Wilson
Cole Eye Institute, Cleveland Clinic Foundation, USA
Manag Care 12:14-9. 2003..An inflammatory mechanism apparently underlies the condition. This theory has been proven by use of immunomodulators that show efficacy in treating patients with dry eye syndrome... - Analysis of the keratocyte apoptosis, keratocyte proliferation, and myofibroblast transformation responses after photorefractive keratectomy and laser in situ keratomileusisSteven E Wilson
Department of Ophthalmology, University of Washington School of Medicine, Seattle, USA
Trans Am Ophthalmol Soc 100:411-33. 2002.... - Gene transfer into rabbit keratocytes using AAV and lipid-mediated plasmid DNA vectors with a lamellar flap for stromal accessRajiv R Mohan
Department of Ophthalmology, University of Washington School of Medicine, Box 356485, Seattle, WA 98195 6485, USA
Exp Eye Res 76:373-83. 2003..This is the first report to demonstrate selective gene transfer into keratocytes and would be highly useful in studying function and regulation of genes in vivo and may eventually furnish a tool for the treatment of corneal dystrophies... - Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformationSteven E Wilson
Department of Ophthalmology, University of Washington School of Medicine, Box 356485, 1959 Pacific Street, Seattle, WA 98195 6485, USA
Exp Eye Res 76:193-201. 2003..Epithelium-derived signals also participate in the generation and/or maintenance of myofibroblasts in the corneal stroma... - Corneal topographic and pachymetric screening of keratorefractive patientsRenato Ambrosio
Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
J Refract Surg 19:24-9. 2003..To review the incidence of corneal abnormalities detected in the preoperative examination, using videokeratography and pachymetry that excluded patients from laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK)... - Early pellucid marginal corneal degeneration: case reports of two refractive surgery candidatesRenato Ambrosio
Department of Ophthalmology, University of Washington, Seattle 98195, USA
Cornea 21:114-7. 2002..To report two refractive surgery candidates who demonstrated early corneal topographic findings of pellucid marginal degeneration... - Pellucid marginal corneal degenerationJúnior Renato Ambrósio
J Refract Surg 18:86-8. 2002 - Apoptosis in the cornea in response to epithelial injury: significance to wound healing and dry eyeSteven E Wilson
The Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, USA
Adv Exp Med Biol 506:821-6. 2002 - Bilateral marginal sterile infiltrates and diffuse lamellar keratitis after laser in situ keratomileusisRenato Ambrosio
Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
J Refract Surg 19:154-8. 2003..To report cases of acute bilateral catarrhal infiltrates in the early postoperative period after laser in situ keratomileusis (LASIK)... - Corneal injury. A relatively pure model of stromal-epithelial interactions in wound healingSteven E Wilson
Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA, USA
Methods Mol Med 78:67-81. 2003 - Loss of alpha3(IV) collagen expression associated with corneal keratocyte activationEmily Guerriero
UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Invest Ophthalmol Vis Sci 48:627-35. 2007..To determine whether changes in the expression of type IV alpha1, alpha2, or alpha3 collagen isoforms are stringently associated with corneal stromal cell activation... - Dry eye and corneal sensitivity after high myopic LASIKIlpo S Tuisku
Helsinki University Eye Hospital, Helsinki, Finland
J Refract Surg 23:338-42. 2007..To assess subjective symptoms and objective clinical signs of dry eye and investigate corneal sensitivity after high myopic LASIK... - Management of unsuccessful LASIK surgeryRenato Ambrosio
Instituto de Olhos Renato Ambrosio, Visare Personal Laser and Refracta RIO, Rio de Janeiro, Brazil
Compr Ophthalmol Update 8:125-41; discussion 143-4. 2007..This paper reviews the management of unsuccessful laser-assisted in situ keratomileusis (LASIK) procedures, focusing on significant advances related to wavefront-guided therapeutic ablations... - Influence of intraoperative epithelial defects on outcomes in LASIK for myopiaMatthew S Oliva
Department of Ophthalmology, University of Washington Seattle, Washington, USA
Am J Ophthalmol 137:244-9. 2004..CONCLUSIONS: Intraoperative epithelial defects during LASIK predispose eyes to increased wound healing, leading to myopic regression, irregular wound healing with loss of visual acuity, and increased need for enhancement procedures... - Correlation of pupil sizes measured with a mesopic infrared pupillometer and a photopic topographerLaura M Periman
Department of Ophthalmology, University of Washington, Seattle 98195, USA
J Refract Surg 19:555-9. 2003..Care should be taken when relying on topography pupil sizes and more accurate measurements of mesopic and scotopic pupil sizes should be obtained... - Corneal cells: chatty in development, homeostasis, wound healing, and diseaseSteven E Wilson
Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
Am J Ophthalmol 136:530-6. 2003..CONCLUSIONS: Cellular communications in the cornea are critical during development, homeostasis, and wound healing. Disorders of cellular communication likely contribute to many corneal diseases... - LASIK-associated dry eye and neurotrophic epitheliopathy: pathophysiology and strategies for prevention and treatmentRenato Ambrosio
Department of Ophthalmology, Fluminense Federal University, Niteroi, Brazil
J Refract Surg 24:396-407. 2008..To review the pathophysiology of LASIK-associated dry eye conditions and provide insights into prophylaxis to decrease the incidence of dry eye after LASIK and to treat the condition when it occurs... - Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRKRahul R Mohan
Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA 98195-6485, USA
Exp Eye Res 76:71-87. 2003.... - Wave-front analysis: are we missing something?Steven E Wilson
Am J Ophthalmol 136:340-2. 2003 - Pupil size in refractive surgery candidatesMarcelo V Netto
Department of Ophthalmology, University of Washington, Seattle, WA, USA
J Refract Surg 20:337-42. 2004..The Procyon pupillometer provides an objective method for measuring pupil size at controlled light levels with a permanent printed record... - Development of genetically engineered tet HPV16-E6/E7 transduced human corneal epithelial clones having tight regulation of proliferation and normal differentiationRajiv R Mohan
Department of Ophthalmology, School of Medicine, University of Washington, Seattle 98195 6485, USA
Exp Eye Res 77:395-407. 2003..The physical barrier established by the newly developed clones was determined by the transepithelial permeability to sodium fluorescein and transepithelial electrical resistance assays in the airlifted-stratified cultures... - Dysfunctional tear syndrome: a Delphi approach to treatment recommendationsAshley Behrens
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9278, USA
Cornea 25:900-7. 2006..To develop current treatment recommendations for dry eye disease from consensus of expert advice... - Surgery in patients with Fuchs'Renato Ambrosio
Ophthalmology 113:503; author reply 504. 2006 - Sporadic diffuse lamellar keratitis (DLK) after LASIKSteven E Wilson
Department of Ophthalmology, University of Washington School of Medicine, Box 356485, Seattle, WA 98195 6485, USA
Cornea 21:560-3. 2002..To examine the incidence of sporadic diffuse lamellar keratitis (DLK) in a large series of LASIK eyes and to suggest the hypothesis that the etiology of sporadic DLK differs from that of epidemic DLK... - Refractive surgery and cornea: the never-ending spiral of technologySteven E Wilson
Arch Ophthalmol 123:265-6. 2005
Research Grants
- Corneal Epithelial Growth Factors and ReceptorsSteven Wilson; Fiscal Year: 2009..The research design is histopathologic, cellular, and molecular investigations in corneas and cultured cells from animal models. ..
- Corneal Epithelial Growth Factors and ReceptorsSteven Wilson; Fiscal Year: 2007..The research design is histopathologic, cellular, and molecular investigations in corneas and cultured cells from animal models. ..
- CORNEAL EPITHELIAL CELL GROWTH FACTORS AND RECEPTORSSteven Wilson; Fiscal Year: 2004....
- CORNEAL EPITHELIAL CELL GROWTH FACTORS AND RECEPTORSSteven Wilson; Fiscal Year: 1999....
- Corneal Epithelial Growth Factors and ReceptorsSteven E Wilson; Fiscal Year: 2010..The research design is histopathological, cellular, and molecular investigations in corneas and cultured cells from animal models. ..