Research Topics
| Kai WangSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis modelKai Wang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 23:357-62. 2003..We assessed the influence of a selective P2Y(12)-receptor antagonist (AR-C69931MX), in conjunction with thrombolytic therapy, on the prevention of platelet aggregation and thrombus formation...- Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injuryKai Wang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 25:1584-9. 2005..This study was designed to determine whether P-selectin expression on platelet, endothelial, or both surfaces is critical to the inflammatory response and neointimal formation after arterial injury... - Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury modelKai Wang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cardiovasc Pharmacol 45:61-7. 2005..We conclude that celecoxib decreases the inflammatory response and intimal hyperplasia following vascular injury, possibly through inhibition of MCP-1 expression, implying a pivotal role of inflammation in the pathogenesis of restenosis... - Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis modelKai Wang
Experimental Animal Laboratory, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
Thromb Haemost 104:609-17. 2010.... - Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury modelKai Wang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
J Pharmacol Exp Ther 317:37-43. 2006.... - Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented modelKai Wang
Experimental Animal Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
Mol Ther 7:597-603. 2003..68 mm(2), P < 0.05). We concluded that efficient intramural adenovirus-mediated iNOS transfer can be achieved by using Infiltrator catheters. iNOS gene transfer significantly reduces neointimal hyperplasia following stent injury... - Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusionKai Wang
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Thromb Haemost 88:149-54. 2002..Thus, administration of rPSGL-Ig decreases myocardial injury and inflammatory response for at least 7 days after reperfusion of ischemic myocardium... - Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat modelZhongmin Zhou
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arterioscler Thromb Vasc Biol 22:1598-603. 2002.... - Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injuryZhongmin Zhou
Experimental Interventional Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 107:2238-43. 2003..CONCLUSIONS: These findings indicate that RAGE/ligand interaction plays a key role in neointimal formation after vascular injury irrespective of diabetes status and suggest a novel target to minimize neointimal hyperplasia... - Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker ratOlga I Stenina
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 107:3209-15. 2003..This increase in TSP-1 production may be a direct response of vascular cells to glucose... - Effect of anti-tumor necrosis factor-alpha polyclonal antibody on restenosis after balloon angioplasty in a rabbit atherosclerotic modelZhongmin Zhou
Department of Cardiology, The Cleveland Clinic Foundation, Desk F25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Atherosclerosis 161:153-9. 2002..Anti-TNF-alpha treatment was sufficient to neutralize tissue TNF-alpha activity, reduce inflammation, but did not inhibit neointimal formation following balloon angioplasty in a rabbit atherosclerotic model... - Alterations of regional myocardial function in a swine model of myocardial infarction assessed by echocardiographic 2-dimensional strain imagingJing Ping Sun
The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Am Soc Echocardiogr 20:498-504. 2007..This study attempted to apply radial strain, circumferential strain, radial displacement, and strain-based torsion analysis to differentiating the infarct, adjacent, and remote zones in a swine model of myocardial infarction... - The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heartYoshioki Satoh
Department of Medicine, Koshu Rehabilitation Hospital, Faefuki-city, Japan
J Pharmacol Sci 97:101-6. 2005..Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats... - Effects of granulocyte-colony stimulating factor on the repair of balloon-injured arteriesXiaoyan Wu
Department of Cardiology, Shandong Provincial Hospital, Shandong University, Shandong University, Jinan, China
Pathology 40:513-9. 2008.... - Endothelium-targeted gene and cell-based therapies for cardiovascular diseaseLuis G Melo
Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
Arterioscler Thromb Vasc Biol 24:1761-74. 2004.... - A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cellsRui Zhang
State Key Laboratory of Cancer Biology and Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, China
Cancer Biol Ther 7:547-54. 2008..Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies... - Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome modelHung Fat Tse
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
Circulation 114:1000-11. 2006..We hypothesized that overexpression of an engineered HCN construct via somatic gene transfer offers a flexible approach for fine-tuning cardiac pacing in vivo... - Enhanced immunization after intranasal coadministration of Escherichia coli heat-labile enterotoxin B subunit and human papillomavirus 16-L1 DNA vaccineJing Wang
Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute for Cancer Research, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710061, China
Chin Med J (Engl) 119:408-11. 2006 - [Construction of rAAV2-GPIIb/IIIa vector and test of its expression and function in vitro]Kai Wang
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:369-74. 2006..This result may provide a basis for application of rAAV2 vector in Glanzmann's thrombasthenia gene therapy in furture... - Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adultsDahui You
Louisiana State University, Department of Biological Sciences, Baton Rouge, USA
Respir Res 7:107. 2006.... - Effects of intravenous infusion of lipopolysaccharide on plasma micromineral, magnesium, and cytokine concentrations and serum cortisol concentrations in lactating goatsJiufeng Wang
College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
Am J Vet Res 68:529-34. 2007.... - In vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogsKai Wang
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
J Pharmacol Sci 103:207-13. 2007.... - Metabolic control of proteasome functionFengxue Zhang
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, USA
Physiology (Bethesda) 22:373-9. 2007..Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation... - Screening and identification of differentially expressed genes in myocardial ischaemia/reperfusion injury using suppression subtractive hybridizationYan Wei Liu
Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat Sen University, China
Acta Cardiol 63:213-9. 2008..Several mechanisms have been postulated for the pathogenesis of MI/R injury although little is known regarding the role of myocardial gene expression... - Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibitionHua hao Shen
Department of Respiratory Medicine, The Second Affiliated Hospital, Medical School of Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China
J Ethnopharmacol 116:363-9. 2008..The purpose of this study is to determine whether this herbal injection could suppress allergic-induced AHR and mucus hypersecretion in allergic mice... - Influential factors of thresholds for electrically evoked potentials elicited by intraorbital electrical stimulation of the optic nerve in rabbit eyesKai Wang
People Eye Centre of People s Hospital, Peking University, Xicheng District, Beijing, China
Vision Res 47:3012-24. 2007..Two equations were derived to predict electrical thresholds needed to elicit cortical responses... - Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortexShuzhang Yang
Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
Genome Biol 8:R247. 2007..Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances... - Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferationJing Zheng
Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
Biol Reprod 78:143-50. 2008.... - Different fates of donor mitochondrial DNA in bovine-rabbit and cloned bovine-rabbit reconstructed embryos during preimplantation developmentYan Jiang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Front Biosci 11:1425-32. 2006..Our results demonstrate that: 1) the fates of donor mtDNAs in bovine-rabbit and cloned bovine-rabbit reconstructed embryos were different; and 2) recipient mtDNAs replicate at blastocyst regardless of the difference of donor cells... - Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45Kai Wang
Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical School of Zhejiang University, Hangzhou 310031, China
Acta Pharmacol Sin 23:1013-7. 2002..Theophylline, rolipram, and acetamide-45 can inhibit the PDE4A activity. The expressed product in yeast cell GL62 may be used in the research work of PDE4 and its inhibitors... - [Some factors affecting in vitro development of porcine embryo reconstitution from somatic cells nuclear transfer]De Fu Zhang
Animal Husbandry and Veterinary Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106
Shi Yan Sheng Wu Xue Bao 36:49-53. 2003.... - Unusual topographical pattern of proximal astrogliosis around a cortical devascularizing lesionKai Wang
Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
J Neurosci Res 73:497-506. 2003..The proximal response was, instead, more remote and only at the base of the lesion, extending partly into the corpus callosum... - Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytesYing Chen
Center for Developmental Biology, Shanghai Second Medical University, Shanghai 200092, China
Cell Res 13:251-63. 2003..Thus, ntES cells derived from human somatic cells by NT to rabbit eggs retain phenotypes similar to those of conventional human ES cells, including the ability to undergo multilineage cellular differentiation... - Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injuryHaiyan Zhou
Department of Anesthesiology, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China
Chin Med J (Engl) 116:1532-4. 2003..To investigate the effects of magnesium sulfate on neuron apoptosis and the expressions of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury... - Gene and cell-based therapies for heart diseaseLuis G Melo
Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
FASEB J 18:648-63. 2004.... - Quantitative analysis of mitochondrial DNAs in macaque embryos reprogrammed by rabbit oocytesCai-Xia Yang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 25 Bei Si Huan Xi Lu, Haidian, Beijing 100080, China
Reproduction 127:201-5. 2004..The ratio of nuclear donor mtDNA to oocyte mtDNA dropped sharply from 2% at the 1-cell stage to 0.011% at the blastocyst stage. These results suggest that maternal mtDNA replicates after the morula stage... - Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimismLuis G Melo
Department of Physiology, Queen's University, 20 Stuart St, Kingston, Ontario K7L 3N6, Canada
Circulation 109:2386-93. 2004 - Vimentin-expressing proximal reactive astrocytes correlate with migration rather than proliferation following focal brain injuryKai Wang
Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Brain Res 1024:193-202. 2004.... - Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine modelAtsushi Sugiyama
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
J Pharmacol Sci 96:436-43. 2004.... - Halothane sensitizes the canine heart to pharmacological IKr blockadeAkira Takahara
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan
Eur J Pharmacol 507:169-77. 2005..Thus, the halothane-anesthetized canine model can be useful for predicting the in vivo I(Kr) blocking property of new drugs... - [Inducement effect of (DIPP-L-Trp)2-L-Lys-OCH3 on apoptosis of K562 cells through mitochondrial-dependent pathway]Feng Liu
Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, P. R. China
Ai Zheng 24:448-53. 2005..CONCLUSION: (DIPP-L-Trp) (2)-L-Lys-OCH(2) could induce apoptosis in K562 cells, which might relate with down-regulation of mitochondrial Delta Psi m and reduction of ROS production... - Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approachKai Wang
Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA, USA
Biophys J 89:3017-25. 2005..These findings are compared to currently available data from different species and allows for an evaluation of the aforementioned heart-failure scenario... - Construction of prophylactic human papillomavirus type 16 L1 capsid protein vaccine delivered by live attenuated Shigella flexneri strain sh42Xiao-feng Yang
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute for Cancer Research, Xi an Jiaotong University, Xi an 710061, China
Acta Biochim Biophys Sin (Shanghai) 37:743-50. 2005..This may be an effective strategy for the development of an HPV prophylactic oral vaccine... - Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmiasAkira Takahara
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Nakakoma-gun, Yamanashi 409-3898, Japan
Br J Pharmacol 147:634-41. 2006..These results suggest that long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect terfenadine-induced TdP... - Identification of differentially expressed genes in normal and malignant prostate by electronic profiling of expressed sequence tagsYan W Asmann
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Cancer Res 62:3308-14. 2002..In five of five Gleason score 6 cancer cases, CRISP-3 expression was increased >50 fold, whereas the expression of DAN was reduced by >80%...