Kai Wang

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 23:357-62. 2003
  2. ncbi request reprint Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 25:1584-9. 2005
  3. ncbi request reprint Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Pharmacol 45:61-7. 2005
  4. doi request reprint Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model
    Kai Wang
    Experimental Animal Laboratory, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Thromb Haemost 104:609-17. 2010
  5. ncbi request reprint Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
    J Pharmacol Exp Ther 317:37-43. 2006
  6. ncbi request reprint Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model
    Kai Wang
    Experimental Animal Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Ther 7:597-603. 2003
  7. ncbi request reprint Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Thromb Haemost 88:149-54. 2002
  8. ncbi request reprint Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model
    Zhongmin Zhou
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 22:1598-603. 2002
  9. ncbi request reprint Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury
    Zhongmin Zhou
    Experimental Interventional Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:2238-43. 2003
  10. ncbi request reprint Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:3209-15. 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 23:357-62. 2003
    ..We assessed the influence of a selective P2Y(12)-receptor antagonist (AR-C69931MX), in conjunction with thrombolytic therapy, on the prevention of platelet aggregation and thrombus formation...
  2. ncbi request reprint Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 25:1584-9. 2005
    ..This study was designed to determine whether P-selectin expression on platelet, endothelial, or both surfaces is critical to the inflammatory response and neointimal formation after arterial injury...
  3. ncbi request reprint Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Pharmacol 45:61-7. 2005
    ..We conclude that celecoxib decreases the inflammatory response and intimal hyperplasia following vascular injury, possibly through inhibition of MCP-1 expression, implying a pivotal role of inflammation in the pathogenesis of restenosis...
  4. doi request reprint Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model
    Kai Wang
    Experimental Animal Laboratory, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Thromb Haemost 104:609-17. 2010
    ....
  5. ncbi request reprint Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
    J Pharmacol Exp Ther 317:37-43. 2006
    ....
  6. ncbi request reprint Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model
    Kai Wang
    Experimental Animal Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Ther 7:597-603. 2003
    ..68 mm(2), P < 0.05). We concluded that efficient intramural adenovirus-mediated iNOS transfer can be achieved by using Infiltrator catheters. iNOS gene transfer significantly reduces neointimal hyperplasia following stent injury...
  7. ncbi request reprint Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion
    Kai Wang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Thromb Haemost 88:149-54. 2002
    ..Thus, administration of rPSGL-Ig decreases myocardial injury and inflammatory response for at least 7 days after reperfusion of ischemic myocardium...
  8. ncbi request reprint Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model
    Zhongmin Zhou
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 22:1598-603. 2002
    ....
  9. ncbi request reprint Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury
    Zhongmin Zhou
    Experimental Interventional Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:2238-43. 2003
    ..However, the role of RAGE/ligand interaction in neointimal hyperplasia after vascular injury remains unclear...
  10. ncbi request reprint Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:3209-15. 2003
    ..Thus, TSP-1 expression in the blood vessel wall may increase, providing a molecular link between diabetes and accelerated vascular lesion development...
  11. ncbi request reprint Effect of anti-tumor necrosis factor-alpha polyclonal antibody on restenosis after balloon angioplasty in a rabbit atherosclerotic model
    Zhongmin Zhou
    Department of Cardiology, The Cleveland Clinic Foundation, Desk F25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Atherosclerosis 161:153-9. 2002
    ..Anti-TNF-alpha treatment was sufficient to neutralize tissue TNF-alpha activity, reduce inflammation, but did not inhibit neointimal formation following balloon angioplasty in a rabbit atherosclerotic model...
  12. ncbi request reprint Alterations of regional myocardial function in a swine model of myocardial infarction assessed by echocardiographic 2-dimensional strain imaging
    Jing Ping Sun
    The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Soc Echocardiogr 20:498-504. 2007
    ..This study attempted to apply radial strain, circumferential strain, radial displacement, and strain-based torsion analysis to differentiating the infarct, adjacent, and remote zones in a swine model of myocardial infarction...
  13. ncbi request reprint The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart
    Yoshioki Satoh
    Department of Medicine, Koshu Rehabilitation Hospital, Faefuki city, Japan
    J Pharmacol Sci 97:101-6. 2005
    ..Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats...
  14. doi request reprint Effects of granulocyte-colony stimulating factor on the repair of balloon-injured arteries
    Xiaoyan Wu
    Department of Cardiology, Shandong Provincial Hospital, Shandong University, Shandong University, Jinan, China
    Pathology 40:513-9. 2008
    ....
  15. ncbi request reprint Endothelium-targeted gene and cell-based therapies for cardiovascular disease
    Luis G Melo
    Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
    Arterioscler Thromb Vasc Biol 24:1761-74. 2004
    ....
  16. ncbi request reprint A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells
    Rui Zhang
    State Key Laboratory of Cancer Biology and Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 7:547-54. 2008
    ..Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies...
  17. ncbi request reprint Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model
    Hung Fat Tse
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Circulation 114:1000-11. 2006
    ..We hypothesized that overexpression of an engineered HCN construct via somatic gene transfer offers a flexible approach for fine-tuning cardiac pacing in vivo...
  18. ncbi request reprint Enhanced immunization after intranasal coadministration of Escherichia coli heat-labile enterotoxin B subunit and human papillomavirus 16-L1 DNA vaccine
    Jing Wang
    Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute for Cancer Research, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710061, China
    Chin Med J (Engl) 119:408-11. 2006
  19. ncbi request reprint [Construction of rAAV2-GPIIb/IIIa vector and test of its expression and function in vitro]
    Kai Wang
    Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:369-74. 2006
    ..This result may provide a basis for application of rAAV2 vector in Glanzmann's thrombasthenia gene therapy in furture...
  20. pmc Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults
    Dahui You
    Louisiana State University, Department of Biological Sciences, Baton Rouge, USA
    Respir Res 7:107. 2006
    ....
  21. ncbi request reprint Effects of intravenous infusion of lipopolysaccharide on plasma micromineral, magnesium, and cytokine concentrations and serum cortisol concentrations in lactating goats
    Jiufeng Wang
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
    Am J Vet Res 68:529-34. 2007
    ....
  22. ncbi request reprint In vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogs
    Kai Wang
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    J Pharmacol Sci 103:207-13. 2007
    ....
  23. ncbi request reprint Metabolic control of proteasome function
    Fengxue Zhang
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, USA
    Physiology (Bethesda) 22:373-9. 2007
    ..Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation...
  24. ncbi request reprint Screening and identification of differentially expressed genes in myocardial ischaemia/reperfusion injury using suppression subtractive hybridization
    Yan Wei Liu
    Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat Sen University, China
    Acta Cardiol 63:213-9. 2008
    ..Several mechanisms have been postulated for the pathogenesis of MI/R injury although little is known regarding the role of myocardial gene expression...
  25. doi request reprint Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition
    Hua hao Shen
    Department of Respiratory Medicine, The Second Affiliated Hospital, Medical School of Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China
    J Ethnopharmacol 116:363-9. 2008
    ..The purpose of this study is to determine whether this herbal injection could suppress allergic-induced AHR and mucus hypersecretion in allergic mice...
  26. ncbi request reprint Influential factors of thresholds for electrically evoked potentials elicited by intraorbital electrical stimulation of the optic nerve in rabbit eyes
    Kai Wang
    People Eye Centre of People s Hospital, Peking University, Xicheng District, Beijing, China
    Vision Res 47:3012-24. 2007
    ..Two equations were derived to predict electrical thresholds needed to elicit cortical responses...
  27. pmc Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex
    Shuzhang Yang
    Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Biol 8:R247. 2007
    ..Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances...
  28. pmc Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    Jing Zheng
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
    Biol Reprod 78:143-50. 2008
    ....
  29. ncbi request reprint Different fates of donor mitochondrial DNA in bovine-rabbit and cloned bovine-rabbit reconstructed embryos during preimplantation development
    Yan Jiang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Front Biosci 11:1425-32. 2006
    ..Our results demonstrate that: 1) the fates of donor mtDNAs in bovine-rabbit and cloned bovine-rabbit reconstructed embryos were different; and 2) recipient mtDNAs replicate at blastocyst regardless of the difference of donor cells...
  30. ncbi request reprint Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45
    Kai Wang
    Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical School of Zhejiang University, Hangzhou 310031, China
    Acta Pharmacol Sin 23:1013-7. 2002
    ..To study the inductive expression of human phosphodiesterase 4A (hPDE4A) in yeast cell GL62 and investigate the inhibitory effects of theophylline, rolipram, and acetamide-45 on PDE4A activity of the expressed product in yeast cell GL62...
  31. ncbi request reprint [Some factors affecting in vitro development of porcine embryo reconstitution from somatic cells nuclear transfer]
    De Fu Zhang
    Animal Husbandry and Veterinary Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106
    Shi Yan Sheng Wu Xue Bao 36:49-53. 2003
    ....
  32. ncbi request reprint Unusual topographical pattern of proximal astrogliosis around a cortical devascularizing lesion
    Kai Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Neurosci Res 73:497-506. 2003
    ..The proximal response was, instead, more remote and only at the base of the lesion, extending partly into the corpus callosum...
  33. ncbi request reprint Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes
    Ying Chen
    Center for Developmental Biology, Shanghai Second Medical University, Shanghai 200092, China
    Cell Res 13:251-63. 2003
    ..Thus, ntES cells derived from human somatic cells by NT to rabbit eggs retain phenotypes similar to those of conventional human ES cells, including the ability to undergo multilineage cellular differentiation...
  34. ncbi request reprint Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury
    Haiyan Zhou
    Department of Anesthesiology, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China
    Chin Med J (Engl) 116:1532-4. 2003
    ..To investigate the effects of magnesium sulfate on neuron apoptosis and the expressions of caspase-3, bax and bcl-2 after cerebral ischemia-reperfusion injury...
  35. ncbi request reprint Gene and cell-based therapies for heart disease
    Luis G Melo
    Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    FASEB J 18:648-63. 2004
    ....
  36. ncbi request reprint Quantitative analysis of mitochondrial DNAs in macaque embryos reprogrammed by rabbit oocytes
    Cai Xia Yang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 25 Bei Si Huan Xi Lu, Haidian, Beijing 100080, China
    Reproduction 127:201-5. 2004
    ..The ratio of nuclear donor mtDNA to oocyte mtDNA dropped sharply from 2% at the 1-cell stage to 0.011% at the blastocyst stage. These results suggest that maternal mtDNA replicates after the morula stage...
  37. ncbi request reprint Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism
    Luis G Melo
    Department of Physiology, Queen s University, 20 Stuart St, Kingston, Ontario K7L 3N6, Canada
    Circulation 109:2386-93. 2004
  38. ncbi request reprint Vimentin-expressing proximal reactive astrocytes correlate with migration rather than proliferation following focal brain injury
    Kai Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Brain Res 1024:193-202. 2004
    ....
  39. ncbi request reprint Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model
    Atsushi Sugiyama
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    J Pharmacol Sci 96:436-43. 2004
    ....
  40. ncbi request reprint Halothane sensitizes the canine heart to pharmacological IKr blockade
    Akira Takahara
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    Eur J Pharmacol 507:169-77. 2005
    ..Thus, the halothane-anesthetized canine model can be useful for predicting the in vivo I(Kr) blocking property of new drugs...
  41. ncbi request reprint [Inducement effect of (DIPP-L-Trp)2-L-Lys-OCH3 on apoptosis of K562 cells through mitochondrial-dependent pathway]
    Feng Liu
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, P R China
    Ai Zheng 24:448-53. 2005
    ..This study was designed to investigate cell apoptosis induced by (O,O-diisopropyl phosphoryl-L-tryptophan)(2)-L-lysine methyl ester [(DIPP-L-Trp)(2)-L-Lys-OCH(3)], and its mechanism in K562 cells...
  42. pmc Excitation-contraction coupling gain and cooperativity of the cardiac ryanodine receptor: a modeling approach
    Kai Wang
    Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA, USA
    Biophys J 89:3017-25. 2005
    ..These findings are compared to currently available data from different species and allows for an evaluation of the aforementioned heart-failure scenario...
  43. ncbi request reprint Construction of prophylactic human papillomavirus type 16 L1 capsid protein vaccine delivered by live attenuated Shigella flexneri strain sh42
    Xiao Feng Yang
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute for Cancer Research, Xi an Jiaotong University, Xi an 710061, China
    Acta Biochim Biophys Sin (Shanghai) 37:743-50. 2005
    ..This may be an effective strategy for the development of an HPV prophylactic oral vaccine...
  44. pmc Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias
    Akira Takahara
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Nakakoma gun, Yamanashi 409 3898, Japan
    Br J Pharmacol 147:634-41. 2006
    ..These results suggest that long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect terfenadine-induced TdP...
  45. ncbi request reprint Identification of differentially expressed genes in normal and malignant prostate by electronic profiling of expressed sequence tags
    Yan W Asmann
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 62:3308-14. 2002
    ..In five of five Gleason score 6 cancer cases, CRISP-3 expression was increased >50 fold, whereas the expression of DAN was reduced by >80%...