Declan Walsh

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint What is palliative medicine? motivations and skills
    Declan Walsh
    Cleveland Clinic Taussig Cancer Institute, Department of Solid Tumor Oncology, Cleveland, OH, USA
    Am J Hosp Palliat Care 28:52-8. 2011
  2. ncbi request reprint The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients
    D Walsh
    Palliative Medicine Program, Department of Hematology Oncology, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Support Care Cancer 8:175-9. 2000
  3. ncbi request reprint Established and potential therapeutic applications of cannabinoids in oncology
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation M 76, Cleveland, OH 44195, USA
    Support Care Cancer 11:137-43. 2003
  4. ncbi request reprint Assessment of nutritional status and prognosis in advanced cancer: interleukin-6, C-reactive protein, and the prognostic and inflammatory nutritional index
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, Ohio, USA
    Support Care Cancer 11:60-2. 2003
  5. ncbi request reprint Long-term rectal administration of high-dose sustained-release morphine tablets
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Support Care Cancer 10:653-5. 2002
  6. ncbi request reprint Advances in opioid therapy and formulations
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 13:138-44. 2005
  7. ncbi request reprint Symptoms and prognosis in advanced cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue M 76, Cleveland, OH 44195, USA
    Support Care Cancer 10:385-8. 2002
  8. ncbi request reprint Symptom clustering in advanced cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 14:831-6. 2006
  9. ncbi request reprint Parenteral morphine prescribing patterns among inpatients with pain from advanced cancer: a prospective survey of intravenous and subcutaneous use
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Am J Hosp Palliat Care 23:353-9. 2006
  10. ncbi request reprint Oral morphine and respiratory function amongst hospice inpatients with advanced cancer
    T D Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Support Care Cancer 11:780-4. 2003

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint What is palliative medicine? motivations and skills
    Declan Walsh
    Cleveland Clinic Taussig Cancer Institute, Department of Solid Tumor Oncology, Cleveland, OH, USA
    Am J Hosp Palliat Care 28:52-8. 2011
    ..We also comment on current issues in regard to education and research, and development of comprehensive palliative care programs in the United States...
  2. ncbi request reprint The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients
    D Walsh
    Palliative Medicine Program, Department of Hematology Oncology, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Support Care Cancer 8:175-9. 2000
    ..Performance status was associated with 14 symptoms. Advanced cancer patients are polysymptomatic. Ten symptoms are highly prevalent. Symptom prevalence for 24 individual symptoms differs with age, or gender, or performance status...
  3. ncbi request reprint Established and potential therapeutic applications of cannabinoids in oncology
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation M 76, Cleveland, OH 44195, USA
    Support Care Cancer 11:137-43. 2003
    ..The use of cannabinoids should be continued in the areas indicated, and further studies are needed to evaluate other potential uses in clinical oncology...
  4. ncbi request reprint Assessment of nutritional status and prognosis in advanced cancer: interleukin-6, C-reactive protein, and the prognostic and inflammatory nutritional index
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, Ohio, USA
    Support Care Cancer 11:60-2. 2003
    ..Elevated IL-6 levels correlated with high PINI and CRP values. CRP, IL-6, and PINI should be considered in future research on nutritional status and prediction of prognosis in advanced cancer...
  5. ncbi request reprint Long-term rectal administration of high-dose sustained-release morphine tablets
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Support Care Cancer 10:653-5. 2002
    ..An illustrative case in a 72-year-old patient with prostate cancer is reported...
  6. ncbi request reprint Advances in opioid therapy and formulations
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 13:138-44. 2005
    ..Optimal opioid use should rely on individualized dose-finding approaches to enhance pain relief while limiting drug-related side effects and avoiding the common problems associated with opioid prescription in clinical practice...
  7. ncbi request reprint Symptoms and prognosis in advanced cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue M 76, Cleveland, OH 44195, USA
    Support Care Cancer 10:385-8. 2002
    ..The effects of dysphagia, early satiety and gender were equal and nearly of similar magnitude to performance status. Symptom and gender analysis should be included in all cancer treatment and symptom control studies...
  8. ncbi request reprint Symptom clustering in advanced cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 14:831-6. 2006
    ..This could result in improved quality of life for patients with advanced cancer and perhaps reduce polypharmacy, lessen drug side effects, and have pharmacoeconomic benefits...
  9. ncbi request reprint Parenteral morphine prescribing patterns among inpatients with pain from advanced cancer: a prospective survey of intravenous and subcutaneous use
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Am J Hosp Palliat Care 23:353-9. 2006
    ..Physicians should be knowledgeable about the appropriate and flexible use of different routes of administration for morphine and other opioids...
  10. ncbi request reprint Oral morphine and respiratory function amongst hospice inpatients with advanced cancer
    T D Walsh
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Support Care Cancer 11:780-4. 2003
    ..This may hinder adequate dosing in cancer pain. The study was conducted to examine the respiratory function of patients with advanced cancer receiving significant doses (>100 mg/24 h) of oral morphine...
  11. doi request reprint The intravenous to oral relative milligram potency ratio of morphine during chronic dosing in cancer pain
    Wael Lasheen
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, OH 44195, USA
    Palliat Med 24:9-16. 2010
    ..A potency ratio of 1:3 was safe as evaluated by common M side-effects, the dose also easy to calculate. The 1: 3 M IV to PO relative milligram potency ratio appears correct and practical for most patients over a wide M dose range...
  12. doi request reprint Consistency of symptom clusters in advanced cancer
    Jordanka Kirkova
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:342-6. 2010
    ..The primary purpose was to assess consistency of SCs between 2 independent data sets. A secondary aim was to evaluate whether use of a sentinel symptom might abbreviate assessment but retain acceptable accuracy...
  13. doi request reprint Components of the anorexia-cachexia syndrome: gastrointestinal symptom correlates of cancer anorexia
    Tugba Yavuzsen
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, M 76, Cleveland, OH 44195, USA
    Support Care Cancer 17:1531-41. 2009
    ..We surveyed cancer patients with anorexia to learn more about the relationship between anorexia and these symptoms...
  14. doi request reprint The relationship between symptom prevalence and severity and cancer primary site in 796 patients with advanced cancer
    Jordanka Kirkova
    Cleveland Clinic Taussig Cancer Institute, Department of Solid Tumor Oncology, The Harry R Horvitz Center for Palliative Medicine and Supportive Oncology, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 28:350-5. 2011
    ..Nine of 17, 6 of 14, and 6 of 12 were gastrointestinal symptoms. Symptoms which varied by PSGs can be included in cancer site-specific symptom assessment instruments...
  15. doi request reprint Cancer symptom clusters: clinical and research methodology
    Jordanka Kirkova
    Taussig Cancer Institute, Department of Solid Tumor Oncology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Palliat Med 14:1149-66. 2011
    ..We conducted a comprehensive clinical review of cancer symptom cluster studies to identify common symptom clusters (SC), explore their clinical relevance, and examine their research importance...
  16. ncbi request reprint Symptom evaluation in palliative medicine: patient report vs systematic assessment
    Jade Homsi
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, OH 44195, USA
    Support Care Cancer 14:444-53. 2006
    ..This study examined symptoms reported by patients after open-ended questioning vs those systematically assessed using a 48-question survey...
  17. doi request reprint Intermittent cancer pain: clinical importance and an updated cancer pain classification
    Wael Lasheen
    Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:182-6. 2010
    ..We report the characteristics of intermittent cancer pain. In addition, we propose a new clinically based classification...
  18. doi request reprint A comparative study of 2 sustained-release morphine preparations for pain in advanced cancer
    Jade Homsi
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 27:99-105. 2010
    ..Several sustained-release morphine (SRM) formulations are available internationally. This study compared 2 such products available in the United States, SR1 and SR2.Patients and..
  19. ncbi request reprint Acute inpatient palliative medicine in a cancer center: clinical problems and medical interventions--a prospective study
    Ruth Lagman
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 24:20-8. 2007
    ..An acute inpatient palliative medicine unit within a tertiary level medical center has a definable and important role in comprehensive cancer care...
  20. doi request reprint Errors in opioid prescribing: a prospective survey in cancer pain
    Philip E Shaheen
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 39:702-11. 2010
    ..Cancer pain is debilitating and has multidimensional consequences. It can be treated adequately in up to 90% of patients by following pain management guidelines. Nevertheless, inadequate pain control remains a global problem...
  21. doi request reprint Cancer symptom clusters: old concept but new data
    Jordanka Kirkova
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
    Am J Hosp Palliat Care 27:282-8. 2010
    ..Symptom clusters require further research before becoming part of routine medical symptom assessment and management...
  22. ncbi request reprint Respiratory function during parenteral opioid titration for cancer pain
    Bassam Estfan
    The Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Palliat Med 21:81-6. 2007
    ..The primary outcome measure was to measure changes in end-tidal CO(2) (ET-CO(2)) during opioid titration to pain control...
  23. doi request reprint Cancer-related fatigue: central or peripheral?
    Tugba Yavuzsen
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 38:587-96. 2009
    ..These data demonstrate that CRF patients exhibited greater central fatigue, indicated by shorter ET and less voluntary muscle recruitment during an SC relative to controls...
  24. pmc Methylphenidate side effects in advanced cancer: a retrospective analysis
    Wael Lasheen
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:16-23. 2010
    ..Methylphenidate (MP) is often recommended for symptom control in advanced cancer. Little is known about its side effects in frail adults. Objectives: To evaluate MP-associated symptoms or side effects (S/E)...
  25. ncbi request reprint Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Support Care Cancer 11:84-92. 2003
    ..Oxycodone's kappa receptor binding has little role in abuse or addiction. The cost of CR oxycodone is prohibitive for most American hospices...
  26. ncbi request reprint Common symptoms in advanced cancer
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, M76 Cleveland, OH 44195, USA
    Surg Clin North Am 85:237-55. 2005
    ..Constipation should be treated with laxatives and stool softeners. Both should start with the first opioid dose...
  27. doi request reprint Symptom severity and distress in advanced cancer
    Jordanka Kirkova
    Section of Palliative Medicine and Supportive Oncology, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
    Palliat Med 24:330-9. 2010
    ..Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress...
  28. doi request reprint Fatigue in advanced cancer: a prospective study
    Katherine Hauser
    Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 25:372-8. 2008
    ..Brain metastases and poor quality of life independently predicted severity. Hemoglobin level did not predict fatigue. Further studies are necessary to define the clinical features and relationships of fatigue...
  29. doi request reprint A day in the life: a case series of acute care palliative medicine--the Cleveland model
    Ruth Lagman
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
    Am J Hosp Palliat Care 25:24-32. 2008
    ..The cases illustrate the sophisticated medical care involved for each individual and the important skill sets of the palliative medicine specialist required to provide high-quality acute medical care for the very ill...
  30. doi request reprint Symptom clusters: myth or reality?
    Aynur Aktas
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
    Palliat Med 24:373-85. 2010
    ..Further research is warranted to establish universally accepted statistical methods and assessment tools for symptom cluster research...
  31. doi request reprint A pilot study of palliative medicine fellows' hospice home visits
    Laura K Shoemaker
    Cleveland Clinic Taussig Cancer Institute, Department of Solid Tumor Oncology, The Harry R Horvitz Center for Palliative Medicine, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 29:591-8. 2012
    ..Physicians provided both education and symptom management. Physician HVs are an important intervention. HVs were important in continuity of care, however, time-consuming, and incurred considerable travel, and professional time and costs...
  32. ncbi request reprint The clinical effects of music therapy in palliative medicine
    Lisa M Gallagher
    The Harry R Horvitz Center for Palliative Medicine A World Health Organization Demonstration Project, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, M76, Cleveland, OH 44195, USA
    Support Care Cancer 14:859-66. 2006
    ..This study was to objectively assess the effect of music therapy on patients with advanced disease...
  33. ncbi request reprint Communication in palliative medicine: a pilot study of a problem list to capture complex medical information
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Harry R Horvitz Chair in Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:365-71. 2004
    ..Based on this experience, we believe a problem list facilitates succinct communication of complex patient information essential to optimal patient care. Proposed modifications are discussed...
  34. doi request reprint Symptom variability during repeated measurement among hospice patients with advanced cancer
    Wael Lasheen
    Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Am J Hosp Palliat Care 26:368-75. 2009
    ..In this prospective study, we explored symptom variability in patients with cancer during repeated measurements...
  35. doi request reprint Opioid equianalgesic tables: are they all equally dangerous?
    Philip E Shaheen
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Center Institute, Cleveland, OH 44195, USA
    J Pain Symptom Manage 38:409-17. 2009
    ..Current information in equianalgesic tables is confusing for physicians, and dangerous to the public...
  36. doi request reprint The cancer anorexia-cachexia syndrome: myth or reality?
    Wael Lasheen
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH, USA
    Support Care Cancer 18:265-72. 2010
    ..In this study, we aimed to: (1) assess if CACS is a distinct clinical disorder, (2) identify the symptoms characteristic of CACS, (3) evaluate CACS impact on patient outcomes (symptom burden and survival time from referral)...
  37. ncbi request reprint A syllabus for fellowship education in palliative medicine
    Susan B Legrand
    Palliative Medicine Fellowship Program, The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 20:279-89. 2003
    ..This article outlines the syllabus developed for this fellowship, given what we believe to be the essential knowledge base for the field of palliative medicine...
  38. doi request reprint Bioelectrical impedance phase angle changes during hydration and prognosis in advanced cancer
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Center, Cleveland Clinic, Ohio 44195, USA
    Am J Hosp Palliat Care 26:180-7. 2009
    ..We wished to determine bioelectrical impedance (BIA) correlates before hydration or changes during hydration and determine if these changes were prognostically important...
  39. pmc Myoelectrical manifestation of fatigue less prominent in patients with cancer related fatigue
    Katarzyna Kisiel-Sajewicz
    Department of Biomedical Engineering, The Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America Department of Kinesiology, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland
    PLoS ONE 8:e83636. 2013
    ..The purpose of this study was to test this hypothesis by examining electromyographic (EMG) signal changes during fatiguing muscle performance...
  40. doi request reprint Lack of muscle contractile property changes at the time of perceived physical exhaustion suggests central mechanisms contributing to early motor task failure in patients with cancer-related fatigue
    Katarzyna Kisiel-Sajewicz
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA
    J Pain Symptom Manage 44:351-61. 2012
    ..Central fatigue plays a significant role, more than muscle (peripheral) fatigue, in contributing to early task failure in cancer-related fatigue (CRF)...
  41. doi request reprint Symptom prevalence in advanced cancer: age, gender, and performance status interactions
    Jordanka Kirkova
    Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, OH, USA
    Am J Hosp Palliat Care 29:139-45. 2012
    ..They should be included as important variables in clinical practice symptom research data...
  42. doi request reprint Opioid and adjuvant analgesics: compared and contrasted
    Mohammed Ilyas Ahmed Khan
    The Harry R Horvitz Center for Palliative Medicine, Section of Palliative Medicine and Supportive Oncology, Cleveland Clinic Taussig CancerInstitute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 28:378-83. 2011
    ..Abrupt discontinuation of an opioid after chronic repeated use for more than a few days will cause a withdrawal syndrome of variable severity. Adjuvant analgesics are an essential tool in cancer pain...
  43. ncbi request reprint All patient refined-diagnostic related group and case mix index in acute care palliative medicine
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Support Oncol 5:145-9. 2007
    ....
  44. ncbi request reprint The business of palliative medicine - part 5: service utilization in a comprehensive integrated program
    Bassam Estfan
    Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 24:211-8. 2007
    ..A comprehensive integrated palliative medicine program is necessary to fully meet the complex needs of those with advanced disease...
  45. doi request reprint Validation of a simplified anorexia questionnaire
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio, USA
    J Pain Symptom Manage 38:691-7. 2009
    ..Anorexia is a common symptom in cancer and is usually assessed by multiple questions and multidimensional questionnaires. A simplified questionnaire would be less burdensome to patients and abbreviate the process...
  46. ncbi request reprint Nausea and vomiting in advanced cancer: the Cleveland Clinic protocol
    Mona Gupta
    The Harry R Horvitz Center for Palliative Medicine, Section of Palliative Medicine and Supportive Oncology, Department of Solid Tumor Oncology, Cleveland Clinic Tausig Cancer Institute, Ohio, USA
    J Support Oncol 11:8-13. 2013
    ....
  47. doi request reprint A Phase II dose titration study of thalidomide for cancer-associated anorexia
    Mellar Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA
    J Pain Symptom Manage 43:78-86. 2012
    ..Several inflammatory cytokines appear to cause appetite loss in animal models. Thalidomide is an immunomodulatory drug that has been associated with improved appetite in those with HIV infections and cancer...
  48. doi request reprint A pilot study of taste changes among hospice inpatients with advanced cancer
    Fade A Mahmoud
    Cleveland Clinic Taussig Cancer Institute, Department of Solid Tumor Oncology, OH, USA
    Am J Hosp Palliat Care 28:487-92. 2011
    ..Both detection and recognition thresholds for these basic tastes were abnormal for the majority of participants. Reduced sensitivity for sweet and salt taste and altered perception for sour predominated in formal taste testing...
  49. doi request reprint Scopolamine for cancer-related nausea and vomiting
    Susan B Legrand
    Section of Palliative Medicine and Supportive Oncology, The Harry R Horvitz Center for Palliative Medicine, Cleveland, Ohio, USA
    J Pain Symptom Manage 40:136-41. 2010
    ..We present three cases that support the use of scopolamine in an etiologically based approach for management of nausea in advanced cancer...
  50. doi request reprint The business of palliative medicine--part 6: clinical operations in a comprehensive integrated program
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 28:75-81. 2011
    ..Structured and seamless clinical operations are important to ensure the best delivery of high-quality medical care and continuity for those affected by life-limiting illness...
  51. ncbi request reprint Early satiety in cancer patients: a common and important but underrecognized symptom
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 14:693-8. 2006
    ..The severity of anorexia correlates with the presence of early satiety. The sense of fullness limits nutritional intake. The symptom is poorly understood because most assessment questionnaires do not include early satiety...
  52. ncbi request reprint Complicated bereavement: a national survey of potential risk factors
    Julia Ellifritt
    Hospice of the Cleveland Clinic, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 20:114-20. 2003
    ..This would allow palliative care teams to allocate resources and services to those at the greatest risk for complicated bereavement...
  53. ncbi request reprint Controversies in pharmacotherapy of pain management
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    Lancet Oncol 6:696-704. 2005
    ....
  54. ncbi request reprint Gastrointestinal symptoms among inpatients with advanced cancer
    Seref Komurcu
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:351-5. 2002
    ..Findings support that gastrointestinal symptoms are very common in hospitalized patients with advanced cancer and that the frequency and type of symptoms differ with gender and gastrointestinal vs. nongastrointestinal primary site...
  55. ncbi request reprint Opioid rotation in cancer patients: pros and cons
    Bassam Estfan
    The Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Oncology (Williston Park) 19:511-6; discussion 516-8, 521-3, 527-8. 2005
    ..Weighing the advantages and disadvantages is essential prior to making a decision about opioid rotation selection...
  56. ncbi request reprint Systematic review of the treatment of cancer-associated anorexia and weight loss
    Tugba Yavuzsen
    Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 23:8500-11. 2005
    ..Literature databases were searched for randomized controlled trials of appetite stimulants in the treatment of cancer anorexia...
  57. ncbi request reprint The financial benefits of acute inpatient palliative medicine: an inter-institutional comparative analysis by all patient refined-diagnosis related group and case mix index
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, OH, USA
    J Support Oncol 3:313-6. 2005
    ..We conclude that an acute inpatient palliative medicine unit operating within a comprehensive integrated palliative medicine program is cost-effective in providing specialized care for people with advanced disease...
  58. ncbi request reprint A phase II study of hydrocodone for cough in advanced cancer
    Jade Homsi
    Harry R Horvitz Center for Palliative Medicine a World Health Organization demonstration project in palliative medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:49-56. 2002
    ..Cough is a common symptom in advanced cancer. The use of hydrocodone as an antitussive has not been studied previously in this setting. This study evaluates hydrocodone for cough in advanced cancer..
  59. ncbi request reprint The cancer anorexia-cachexia syndrome: a survey of the Prognostic Inflammatory and Nutritional Index (PINI) in advanced disease
    Kristine A Nelson
    The Harry R Horvitz Center for Palliative Medicine and The Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Pain Symptom Manage 24:424-8. 2002
    ..There was no significant association between the PINI and corticosteroid use, weight loss over time, age, or sex. These data indicate that the PINI is highly abnormal in our population. The CRP may be the most important value...
  60. ncbi request reprint Opioids in cancer pain: common dosing errors
    Romeen Kochhar
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Oncology (Williston Park) 17:571-5; discussion 575-6, 579. 2003
    ..This article describes these errors and offers strategies with which to improve outcomes for patients suffering with cancer pain...
  61. doi request reprint Symptom assessment in palliative medicine: complexities and challenges
    Jordanka Kirkova
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 27:75-83. 2010
    ..In this article, we discuss current methodological concepts of symptom assessment in clinical practice, specifically with reference to symptom questionnaires appropriate for palliative medicine...
  62. doi request reprint Comfort measures: practical care of the dying cancer patient
    Susan B Legrand
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, USA
    Am J Hosp Palliat Care 27:488-93. 2010
    ..Although protocols exist in other countries, there is no established protocol in the United States. We present a protocol for management of the dying that is clinically useful and review the existing evidence-base...
  63. ncbi request reprint The impact of a palliative medicine consultation service in medical oncology
    Jade Homsi
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, M76, Cleveland, OH 44195, USA
    Support Care Cancer 10:337-42. 2002
    ..3) Multiple interventions were suggested even at the initial consultation. (4) Important issues such as DNR (do not resuscitate) status, support system, treatment goals, and eligibility for hospice care had often not been addressed...
  64. ncbi request reprint Appetite and cancer-associated anorexia: a review
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Department of Hematology Medical Oncology, FCCP, Cleveland Clinic Foundation, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    J Clin Oncol 22:1510-7. 2004
    ..There have been few clinical trials and very little translational research on anorexia despite its prevalence in cancer...
  65. ncbi request reprint The efficacy and side effects of continuous infusion intravenous morphine (CIVM) for pain and symptoms due to advanced cancer
    Paul Glare
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:343-50. 2002
    ..Safety was suggested by the low incidence of dose-limiting side effects, most of which responded to dose reduction. Particularly noteworthy was the flexibility of CIVM with dose reduction in 20 percent...
  66. ncbi request reprint Cancer symptom assessment instruments: a systematic review
    Jordanka Kirkova
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 24:1459-73. 2006
    ..A variety of assessment instruments have been created to identify cancer symptoms. We reviewed systematically cancer symptom assessment instruments published in English...
  67. ncbi request reprint The business of palliative medicine--Part 2: The economics of acute inpatient palliative medicine
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:89-95. 2002
    ..In the future, an international CMI or APR-DRG will allow palliative inpatient units to compare disease severity, resource utilization, and outcome measures...
  68. ncbi request reprint Integration of palliative medicine into comprehensive cancer care
    Ruth Lagman
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, OH 44195, USA
    Semin Oncol 32:134-8. 2005
    ..Palliative medicine addresses all these issues and complements attempts to cure the disease; it is an essential part of modern comprehensive cancer care...
  69. pmc Weakening of functional corticomuscular coupling during muscle fatigue
    Qi Yang
    Department of Biomedical Engineering, The Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Brain Res 1250:101-12. 2009
    ..The purpose of this study was to address this issue by quantifying EEG-EMG coherence at times when muscles experienced minimal versus significant fatigue...
  70. doi request reprint Animal models of the cancer anorexia-cachexia syndrome
    Nabila Bennani-Baiti
    Section of Palliative Medicine and Suppportive Oncology, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Support Care Cancer 19:1451-63. 2011
    ..Animal models expand our understanding of its mechanisms. A review of cancer cachexia and anorexia animal models will help investigators make an informed choice of the study model...
  71. doi request reprint Symptom management: an important part of cancer care
    Laura K Shoemaker
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, Cleveland Clinic, USA
    Cleve Clin J Med 78:25-34. 2011
    ..We review the general principles of symptom management for fatigue, anorexia, constipation, dyspnea, nausea, and vomiting...
  72. ncbi request reprint Mechanisms of fatigue
    Mellar P Davis
    Lerner Medical College, Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Support Oncol 8:164-74. 2010
    ..This state-of-the-art review discusses these physiologic correlates of fatigue and the mechanisms described in a variety of chronic diseases...
  73. ncbi request reprint Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, 9500 Euclid Avenue R35, Cleveland OH 44195, USA
    Support Care Cancer 10:117-38. 2002
    ..In this review the pharmacology of rectally administered palliative medications is reviewed and the use of individual drugs is outlined...
  74. ncbi request reprint Cancer pain: how to measure the fifth vital sign
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 71:625-32. 2004
    ..Outpatient pain diaries and hospital recordings of pain severity with the vital signs facilitate communication. Part of the goal should be to improve function and quality of life...
  75. ncbi request reprint Epidemiology of cancer pain and factors influencing poor pain control
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:137-42. 2004
    ..Other factors include lack of physician education and failure to follow existing guidelines. Patients fear addiction, drug tolerance, and side effects. Despite adequate resources, pain is still undertreated...
  76. ncbi request reprint A phase II study of low-dose megestrol acetate using twice-daily dosing for anorexia in nonhormonally dependent cancer
    Kristine A Nelson
    Taussig Cancer Center, Cleveland Clinic Foundation, Ohio, USA
    Am J Hosp Palliat Care 19:206-10. 2002
    ..If this is not effective, considerable dose escalation is possible...
  77. ncbi request reprint Opioids, respiratory function, and dyspnea
    Susan B Legrand
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 20:57-61. 2003
    ..This article reviews current knowledge in the pathophysiology of dyspnea, proposed opioid mechanism of action, and evidence of efficacy...
  78. ncbi request reprint Communication of a cancer diagnosis: patients' perceptions of when they were first told they had cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 20:52-6. 2003
    ..A minority of women were significantly more unhappy than men about the manner in which they were told. Sophisticated techniques are available to help physicians impart bad news effectively and humanely...
  79. ncbi request reprint Palliative medicine in a United States cancer center: a prospective study
    John D Cowan
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:240-50. 2002
    ..a) To report the medical complexity of cancer and noncancer patients receiving palliative medicine (PM) consultation at a tertiary medical center and (b) to describe the consult recommendations madefor this group...
  80. ncbi request reprint The business of palliative medicine--part 4: Potential impact of an acute-care palliative medicine inpatient unit in a tertiary care cancer center
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine A World Health Organization Demonstration Project, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:217-21. 2004
    ..Our model predicted that 695 patients would be admitted to the acute-care palliative medicine unit in the first year of operation; 655 patients were actually admitted during this time...
  81. ncbi request reprint Visual analogue scales and assessment of quality of life in cancer
    Katherine Hauser
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    J Support Oncol 6:277-82. 2008
    ..Multi-item VAS QOL instruments vary in length and domains; they are useful in clinical trials enrolling patients with good performance status, but some are long and disease-specific...
  82. ncbi request reprint Dangerous nutrition? Calcium, vitamin D, and shark cartilage nutritional supplements and cancer-related hypercalcemia
    Ruth Lagman
    Department of Medical Oncology, Cleveland Clinic Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue M76, Cleveland, OH 44195, USA
    Support Care Cancer 11:232-5. 2003
    ..We report eight cases of hypercalcemia in cancer patients seen at the Cleveland Clinic Foundation in whom these nutritional supplements may have contributed to the prevalence or severity of hypercalcemia...
  83. doi request reprint The cough from hell: diazepam for intractable cough in a patient with renal cell carcinoma
    Bassam Estfan
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 36:553-8. 2008
    ..We present the case of a patient with renal cell carcinoma hospitalized for intractable cough that failed to respond adequately to usual treatments, but improved with diazepam...
  84. ncbi request reprint Morphine in cancer pain management: a practical guide
    Sinead Donnelly
    Harry R Horvitz Center for Palliative Medicine
    Support Care Cancer 10:13-35. 2002
    ..Guidelines for morphine administration are reviewed, and in particular those of the Harry R. Horvitz Center for Palliative Medicine are outlined...
  85. ncbi request reprint The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain
    Paul Glare
    The Harry R Horvitz Center for Palliative Medicine
    Am J Hosp Palliat Care 23:229-35. 2006
    ..Validated patient-based measures of opioid side effects are needed...
  86. ncbi request reprint The business of palliative medicine--Part 3: The development of a palliative medicine program in an academic medical center
    Kristine A Nelson
    Cancer Treatment Research Foundation, Arlington Heights, Illinois, USA
    Am J Hosp Palliat Care 20:345-52. 2003
    ..In this article, we describe the structure and development of the program and suggest future avenues for growth...
  87. ncbi request reprint Randomized clinical trial of an implantable drug delivery system
    Mellar P Davis
    J Clin Oncol 21:2800-1; author reply 2802-3. 2003
  88. ncbi request reprint A prospective study of the pathophysiology and clinical characteristics of pain in a palliative medicine population
    Terence Gutgsell
    Hospice of the Bluegrass and Hospice Care Center, St Joseph Hospital, Lexington, Kentucky, USA
    Am J Hosp Palliat Care 20:140-8. 2003
    ..Comprehensive studies rigorously evaluating characteristics of pain and response to treatment are a necessary first step toward more effective treatments for difficult pain syndromes...
  89. ncbi request reprint The efficacy and tolerability of long-term use of dronabinol in cancer-related anorexia: a case series
    Declan Walsh
    J Pain Symptom Manage 30:493-5. 2005
  90. ncbi request reprint End-of-life care costs
    Mellar P Davis
    J Palliat Med 7:713-4; author reply 714. 2004
  91. ncbi request reprint Can a soft diet prevent bowel obstruction in advanced pancreatic cancer?
    Paula McCallum
    Palliative Medicine Program, The Taussig Cancer Center, The Cleveland Clinic Foundation R 35, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Support Care Cancer 10:174-5. 2002
    ..Although many patients are advised to follow a high-fiber diet to avoid constipation, it seems that a soft diet such as that recommended after bowel surgery may well be more helpful in avoidance of intestinal obstruction...
  92. ncbi request reprint Deaths in an academic medical center
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine A World Heath Organization Demonstration Project, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Palliat Med 9:1260-3. 2006
    ..Invasive procedures were common. Forty-five percent of the predeath patient days were spent in intensive care units. Palliative medicine was involved in the care of 20% of all the decedents...
  93. ncbi request reprint Palatable message? Change the language!
    Susan B Legrand
    J Palliat Med 9:10-1; author reply 15. 2006
  94. ncbi request reprint Cancer symptom clusters--a dynamic construct
    Jordanka Kirkova
    Support Care Cancer 15:1011-3. 2007
  95. ncbi request reprint The pitfalls of a systematic MEDLINE review in palliative medicine: symptom assessment instruments
    Eoin Tiernan
    Department of Palliative Medicine, St Vincent s University Hospital, Dublin, Ireland
    Am J Hosp Palliat Care 24:181-4. 2007
    ..Related links searches are proposed in any systematic PubMed MEDLINE literature review in palliative medicine...
  96. ncbi request reprint Non-pharmacologic cancer pain management: a customized multidensity foam seating cushion
    Jason M Swoger
    J Support Oncol 4:209-10. 2006
  97. ncbi request reprint Autonomic nervous system dysfunction in advanced cancer
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, 9500 Euclid Ave, M76, Cleveland, Ohio 44195, USA
    Support Care Cancer 10:523-8. 2002
    ..These tests may help define the lesion better than these simple bedside tests. Further research with sophisticated ANS testing is needed to clearly define this paraneoplastic syndrome...
  98. ncbi request reprint End-of-Life care: the death of palliative medicine?
    Mellar P Davis
    J Palliat Med 5:813-4. 2002
  99. ncbi request reprint Cancer and chemotherapy-related upper gastrointestinal symptoms: the role of abnormal gastric motor function and its evaluation in cancer patients
    Kristine Nelson
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Support Care Cancer 10:455-61. 2002
    ..Because of the limitations of existing methods, new technology is frequently being evaluated. Radionuclide measurement is the current method of choice...
  100. ncbi request reprint Family distress in palliative medicine: a pilot study of the family APGAR scale
    Ruth D Powazki
    Department of Social Work, The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:392-6. 2002
    ..Completing the study later with a larger sample will provide information that will help the multidisciplinary team better meet the needs of both patient and family...
  101. doi request reprint Combining objective and subjective outcomes in cancer-related fatigue: illustrations from a single case report
    Dilara Seyidova Khoshknabi
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Palliat Med 11:829-33. 2008
    ..She remained at 10 mg twice daily for 8 months. Improvement in severe CRF (Brief Fatigue Inventory score) was associated with normalization of neurophysiologic tests...