Michael A Vogelbaum

..Future studies are needed to further improve outcomes, minimize toxicities and increase our understanding of this treatment modality...

..The goal in this retrospective study was to determine whether differences in doses to the margins of brain metastases affect the ability of SRS to achieve local control...

..New trials are being planned to investigate agents that can be coinfused with radiographic tracers, as well as novel catheters that avoid problems with backflow and potentially will provide more reliable drug distribution...

....

..As a result, overall survival is much more dependent on the status of the patient's systemic disease...

..Each speaker's presentation has been abstracted along with relevant references...

..Each speaker's talk has been abstracted and a list of relevant references has been compiled...

..Choroid plexus metastases (CPM) are uncommon lesions. Consequently, optimal management of CPM is uncertain. We summarize our experience with stereotactic radiosurgery (SRS) of CPM...

..Standard MRI techniques do not reliably discriminate between tumor progression and RN after treatment with SRS for brain metastases. Additional imaging modalities are warranted to aid in distinguishing between these diagnoses...

..To evaluate the outcomes for patients with Grade III meningiomas as defined by the 2007 World Health Organization standards...

..Erlotinib co administered with RT and temozolomide was not efficacious and had an unacceptable toxicity...

..The authors evaluated overall survival and factors predicting outcome in patients with ≥ 5 brain metastases who were treated with Gamma Knife surgery (GKS)...

..Our findings suggest that SRS alone may be a viable therapeutic option for patients with incidentally-discovered NSCLC brain metastases...

..To examine the outcomes of patients with five or more brain metastases treated in a single session with stereotactic radiosurgery (SRS)...

..To analyze factors affecting outcomes in breast cancer patients with brain metastases (BM) and characterize the role of HER2 status...

..Further studies are needed to fully delineate the significance of this molecular marker in patients with GBM...

..To assess the imaging and clinical outcomes of patients with single brainstem metastases treated with stereotactic radiosurgery (SRS)...

....

..This study was designed to evaluate the therapeutic effect of stereotactic radiosurgery (SRS) in patients aged > or =75 years who presented with brain metastasis...

..To investigate the relationship between the conformality index (CIn), heterogeneity index (HIn), and gradient index (GIn) and the development of toxicity in patients treated with Gamma Knife radiosurgery (GKRS) for intracranial meningiomas...

..The authors of further prospective studies may better determine the true value of the allelic loss of 1p and its implication for clinical decision making...

....

..RPA class 1 patients have a very favorable prognosis with a median survival of 21.4 months...

....

..Necrosis is a common feature of many brain tumors, including BM; however, the influence of tumor necrosis on treatment efficacy of SRS in women with breast cancer metastatic to the brain is unknown...

..We report the use of (111)indium-octreotide brain scintigraphy (OBS) for the non-invasive differentiation of meningiomas from other cranial dural-based pathology...

..Future studies will need to prospectively stratify patients according to the presence of deletions of chromosomes 1p and 19q...

..In this review, we describe the clinically available methods used to circumvent the blood brain barrier and summarize the results to date of ongoing and completed clinical trials...

..Prostate cancer metastatic to the brain is uncommon and has been associated historically with a poor prognosis. It has been suggested that SRS may be an effective treatment...

....

..A prospective study directly comparing surgery and SRS and further evaluating the significance of LMD in PFM is warranted...

..The activity at the dose and schedule used in this study, however, was modest and the study did not meet its efficacy endpoint...

..Their electron-dense, metallic cores suggest utility in other clinical imaging modalities...

....

..Using a large BM patient database, we assessed the impact of histologic subtypes on survival stratified by the GPA...

..The authors sought to determine the long-term tumor control and side effects of Gamma Knife radiosurgery (GKRS) in patients with vestibular schwannomas (VS)...

..CONCLUSIONS: For patients with good prognostic factors such as young age, good RPA characteristics and single metastasis, treatment with surgery or SRS offers the best chance for long-term survival...

..This review of the management of brain metastases focuses on whole brain radiation therapy, surgery, stereotactic radiosurgery, radiation sensitizers, and clinical trials...

..This prospective study demonstrates that GK is well tolerated with few patients developing major acute effects. Many patients are able to return to work shortly after GK...

..An estimated 24%-45% of patients with cancer develop brain metastases. Individualized estimation of survival for patients with brain metastasis could be useful for counseling patients on clinical outcomes and prognosis...

..These data help define a novel angiogenic axis that could be exploited for the treatment of human cancers and other diseases where excess angiogenesis occurs...

..The number of metastatic intracranial lesions should be included when determining the prognosis...

..In this review, we summarize the recent past of the clinical trials utilizing CED and discuss emerging technologies that will shape future CED trials...

..CONCLUSIONS: Survival of patients with cerebellar brain metastasis is comparable to that of patients with supratentorial brain metastasis using RPA classification. Aggressive multimodality therapy has a favorable impact on survival...

..The RANO group identified knowledge gaps relating to the definitions of tumor response and progression after the use of surgical or surgically based treatments...

..These results indicate that IL-4/IL-13 receptor-mediated Stat3 signaling may contribute to the pathogenesis of GBM cells by modulating the expression of the Bcl-2 family of antiapoptotic proteins...

..Therefore, targeting Stat3 signaling may provide a potential therapeutic intervention for GBM...

..Because invasion is a major cause of GBM morbidity, differentiation therapy may improve the clinical outcome...

....

..This article reviews the role of robotic technology in the context of neurosurgery...

..Additional larger prospective studies with appropriate patient stratification culminating in development of neurosurgical guidelines on AED prophylaxis in brain tumor patients is warranted...

..Tumors with expression of COX-2 by immunohistochemistry may, in theory, benefit from treatment with therapeutic agents that inhibit COX-2...

..Increased plasma levels of arginase and G-CSF may relate to MDSC suppressor function and MDSC expansion, respectively, in patients with glioma...

..Therefore, we determined (1) incidence and prevalence of, risk factors for, and survival after development of brain metastases following esophagectomy for esophageal cancer, and (2) their association with adjuvant therapy...

..A high degree of suspicion of intracranial metastasis should be maintained for patients who have known systemic cancer and are found incidentally to have a dural-based mass lesion...

..Larger prospective studies may better determine the true specificity of S100beta as a marker for BBB function and as an early detection or follow-up marker of brain tumors...

..Identifying a mechanistic pathway that can be targeted for pharmacologic intervention will have applied implications to developing novel and effective treatments of GBM...

..Interruption of this aberrant NF-kappaB activity may help reduce the spread of this infiltrative tumor...

..Finally, we discuss ongoing efforts to develop new trials to more definitively address important therapeutic questions...

..Our data indicate that IL-8 is necessary but not solely responsible for glioma cell invasion and mediates its effect in an autocrine manner...

..Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression...

..This feature may allow optical nanoparticles, such as quantum dots, to colocalize with brain tumors and serve as an optical aid in the surgical resection or biopsy of brain tumors...

..The use of anti-EGFR therapies against malignant brain tumors, although in its infancy, promises to yield exciting results as these new drugs probably will enhance the usefulness of existing therapies...

..These findings are significant in that therapeutic agents, which inhibit COX-2, are currently available and may play a role in the management of glioblastoma multiforme...

..Thus, IL-13R(alpha)2 acts as an inhibitor of IL-4-dependent signal transduction pathways via a novel mechanism that is independent of ligand binding...

..The incidence of brain metastases (BM) from colorectal cancer (CRC) is increasing, and the management of this previously rare complication at a single institution is reported...

..Standard neurosurgical drills, microscopes, and other equipment can be used safely in conjunction with this iMR imaging system...

..The primary end point of the study was local tumor control. The secondary end points included patient survival, distant brain recurrence, quality of life, and treatment toxicity...