Research Topics
| M A VogelbaumSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working GroupMichael A Vogelbaum
Brain Tumor and Neuro Oncology Center, Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
Neurosurgery 70:234-43; discussion 243-4. 2012..The RANO group identified knowledge gaps relating to the definitions of tumor response and progression after the use of surgical or surgically based treatments...
Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131Michael A Vogelbaum
Cleveland Clinic, Brain Tumor and NeuroOncology Center, Cleveland, OH 44195, USA
Neuro Oncol 11:167-75. 2009..Future studies will need to prospectively stratify patients according to the presence of deletions of chromosomes 1p and 19q...- Opportunities for clinical research in meningiomaMichael A Vogelbaum
Brain Tumor and NeuroOncology Center, Cleveland Clinic, Cleveland, OH 44195, USA
J Neurooncol 99:417-22. 2010..Finally, we discuss ongoing efforts to develop new trials to more definitively address important therapeutic questions... - Novel drug delivery strategies in neuro-oncologyDani S Bidros
Department of Neurological Surgery, Brain Tumor and NeuroOncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA
Neurotherapeutics 6:539-46. 2009..In this review, we describe the clinically available methods used to circumvent the blood brain barrier and summarize the results to date of ongoing and completed clinical trials... 
RPA classification has prognostic significance for surgically resected single brain metastasisRahul D Tendulkar
Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Int J Radiat Oncol Biol Phys 66:810-7. 2006..RPA class 1 patients have a very favorable prognosis with a median survival of 21.4 months...- Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institutionLewis A Rosenberg
Department of Radiation Oncology, Cleveland Clinic Foundation, OH 44195, USA
Int J Radiat Oncol Biol Phys 74:427-32. 2009..To evaluate the outcomes for patients with Grade III meningiomas as defined by the 2007 World Health Organization standards... - Future of convection-enhanced delivery in the treatment of brain tumorsDani S Bidros
Brain Tumor and NeuroOncology Center, Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, OH 44195, USA
Future Oncol 6:117-25. 2010..In this review, we summarize the recent past of the clinical trials utilizing CED and discuss emerging technologies that will shape future CED trials... - Five-year survivors of brain metastases: a single-institution report of 32 patientsSamuel T Chao
Department of Radiation Oncology, Brain Tumor Institute, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Int J Radiat Oncol Biol Phys 66:801-9. 2006..CONCLUSIONS: For patients with good prognostic factors such as young age, good RPA characteristics and single metastasis, treatment with surgery or SRS offers the best chance for long-term survival... - Brain metastases from esophageal cancer: a phenomenon of adjuvant therapy?Thomas W Rice
The Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
Ann Thorac Surg 82:2042-9, 2049.e1-2. 2006..Therefore, we determined (1) incidence and prevalence of, risk factors for, and survival after development of brain metastases following esophagectomy for esophageal cancer, and (2) their association with adjuvant therapy... - Convection enhanced delivery for treating brain tumors and selected neurological disorders: symposium reviewMichael A Vogelbaum
Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
J Neurooncol 83:97-109. 2007..Each speaker's presentation has been abstracted along with relevant references... - Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor marginMichael A Vogelbaum
Brain Tumor Institute and Departments of Biostatistics, Neurosurgery, and Radiation Oncology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Neurosurg 104:907-12. 2006..The goal in this retrospective study was to determine whether differences in doses to the margins of brain metastases affect the ability of SRS to achieve local control... - Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety resultsMichael A Vogelbaum
Brain Tumor and Neuro Oncology Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Neurosurgery 61:1031-7; discussion 1037-8. 2007.... - Stereotactic radiosurgical treatment of parenchymal brain metastases from prostate adenocarcinomaSe Hyuk Kim
The Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA
Surg Neurol 69:641-6; discussion 646. 2008..Prostate cancer metastatic to the brain is uncommon and has been associated historically with a poor prognosis. It has been suggested that SRS may be an effective treatment... - Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastasesNicholas F Marko
Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH 44195, USA
World Neurosurg 73:186-93; discussion e29. 2010.... - Gender, race, and survival: a study in non-small-cell lung cancer brain metastases patients utilizing the radiation therapy oncology group recursive partitioning analysis classificationGregory M M Videtic
Department of Radiation Oncology, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Int J Radiat Oncol Biol Phys 75:1141-7. 2009.... - Management of brain metastasesJohn H Suh
Brain Tumor and Neuro Oncology Center, Department of Radiation Oncology, T28, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Curr Neurol Neurosci Rep 9:223-30. 2009..This review of the management of brain metastases focuses on whole brain radiation therapy, surgery, stereotactic radiosurgery, radiation sensitizers, and clinical trials... - Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiformeDavid M Peereboom
Brain Tumor and Neuro Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
J Neurooncol 98:93-9. 2010..Erlotinib co administered with RT and temozolomide was not efficacious and had an unacceptable toxicity... - Salvage stereotactic radiosurgery effectively treats recurrences from whole-brain radiation therapySamuel T Chao
Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Cancer 113:2198-204. 2008.... - Convection enhanced delivery for the treatment of malignant gliomas: symposium reviewMichael A Vogelbaum
Brain Tumor Institute, Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Neurooncol 73:57-69. 2005..Each speaker's talk has been abstracted and a list of relevant references has been compiled... - Resectable brain metastasesMichael A Vogelbaum
Brain Tumor Institute ND40, Cleveland Clinic Foundation, Cleveland, OH, USA
J Clin Oncol 24:1289-94. 2006..As a result, overall survival is much more dependent on the status of the patient's systemic disease... - Update of stereotactic radiosurgery for brain tumorsJohn H Suh
Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Curr Opin Neurol 17:681-6. 2004..Future studies are needed to further improve outcomes, minimize toxicities and increase our understanding of this treatment modality... - Stereotactic radiosurgery for single brainstem metastases: the cleveland clinic experienceShlomo A Koyfman
Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, OH, USA
Int J Radiat Oncol Biol Phys 78:409-14. 2010..To assess the imaging and clinical outcomes of patients with single brainstem metastases treated with stereotactic radiosurgery (SRS)... - Cyclooxygenase-2 in oligodendroglial neoplasmsElias A Castilla
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer 98:1465-72. 2003..Tumors with expression of COX-2 by immunohistochemistry may, in theory, benefit from treatment with therapeutic agents that inhibit COX-2... - Epidermal growth factor receptor amplification does not have prognostic significance in patients with glioblastoma multiformeAimee L Quan
Department of Radiation Oncology, Brain Tumor Institute, The Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Int J Radiat Oncol Biol Phys 63:695-703. 2005..Further studies are needed to fully delineate the significance of this molecular marker in patients with GBM... - Posterior fossa metastases: aggressive treatment improves survivalAndrew A Kanner
Department of Neurosurgery, Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Stereotact Funct Neurosurg 81:18-23. 2003..CONCLUSIONS: Survival of patients with cerebellar brain metastasis is comparable to that of patients with supratentorial brain metastasis using RPA classification. Aggressive multimodality therapy has a favorable impact on survival... - Current concepts and newer developments in the treatment of malignant gliomasS B Omay
Cleveland Clinic Brain Tumor and Neuro Oncology Center, 9500 Euclid Avenue, Cleveland, OH 441 95, USA
Indian J Cancer 46:88-95. 2009..Further progress towards a cure for malignant gliomas will require a greater understanding of the underlying mechanisms driving the growth, and resistance to therapy, of these challenging tumors... - Posterior fossa metastases: risk of leptomeningeal disease when treated with stereotactic radiosurgery compared to surgeryVitaly E Siomin
Department of Neurosurgery, Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Neurooncol 67:115-21. 2004..A prospective study directly comparing surgery and SRS and further evaluating the significance of LMD in PFM is warranted... - Modern treatment of cerebral metastases: Integrated Medical Learning(SM) at CNS 2007Michael A Vogelbaum
Brain Tumor and Neuro Oncology Center, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Neurooncol 93:89-105. 2009.... - Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cellsShaik Ohidar Rahaman
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, OH 44195, USA
Oncogene 21:8404-13. 2002..Therefore, targeting Stat3 signaling may provide a potential therapeutic intervention for GBM... - S100beta as a predictor of brain metastases: brain versus cerebrovascular damageMichael A Vogelbaum
Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer 104:817-24. 2005.... - The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision makingAndrew A Kanner
The Brain Tumor Institute, The Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Neurosurg 104:542-50. 2006..The authors of further prospective studies may better determine the true value of the allelic loss of 1p and its implication for clinical decision making... - Stereotactic radiosurgical treatment of brain metastases in older patientsSe Hyuk Kim
The Brain Tumor and Neuro Oncology Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer 113:834-40. 2008..This study was designed to evaluate the therapeutic effect of stereotactic radiosurgery (SRS) in patients aged > or =75 years who presented with brain metastasis... - PTPmu suppresses glioma cell migration and dispersalAdam M Burgoyne
Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Neuro Oncol 11:767-78. 2009..Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression... - Mapping prosody: correlation of functional magnetic resonance imaging with intraoperative electrocorticography recordings in a patient with a right-sided temporooccipital glioma. Case illustrationNarendra Nathoo
Brain Tumor Institute, The Taussig Cancer Center, Cleveland, Ohio 44195, USA
J Neurosurg 103:930. 2005 - Cyclooxygenase-2 (COX-2) expression by immunohistochemistry in glioblastoma multiformeRichard A Prayson
Brain Tumor Center and the Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Ann Diagn Pathol 6:148-53. 2002..These findings are significant in that therapeutic agents, which inhibit COX-2, are currently available and may play a role in the management of glioblastoma multiforme... - Use of the Radiation Therapy Oncology Group recursive partitioning analysis classification system and predictors of survival in 19 women with brain metastases from ovarian carcinomaPhilip G Chen
Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer 104:2174-80. 2005..The number of metastatic intracranial lesions should be included when determining the prognosis... - Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatinPhilip A Klenotic
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Pathol 176:2039-50. 2010..These data help define a novel angiogenic axis that could be exploited for the treatment of human cancers and other diseases where excess angiogenesis occurs... - Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotypeBaisakhi Raychaudhuri
Brain Tumor Institute and Taussig Cancer Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Neurooncol 85:39-47. 2007..Interruption of this aberrant NF-kappaB activity may help reduce the spread of this infiltrative tumor... - Intracranial collision tumor mimicking an octreotide-SPECT positive and FDG-PET negative meningiomaAli Chahlavi
Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Clin Neurosci 12:720-3. 2005..A high degree of suspicion of intracranial metastasis should be maintained for patients who have known systemic cancer and are found incidentally to have a dural-based mass lesion... - IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cellsShaik Ohidar Rahaman
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer Res 62:1103-9. 2002..Thus, IL-13R(alpha)2 acts as an inhibitor of IL-4-dependent signal transduction pathways via a novel mechanism that is independent of ligand binding... - Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastomaBaisakhi Raychaudhuri
Brain Tumor and Neuro Oncology Center, Neurological Institute, Cleveland, OH, USA
Neuro Oncol 13:591-9. 2011..Increased plasma levels of arginase and G-CSF may relate to MDSC suppressor function and MDSC expansion, respectively, in patients with glioma... - Results of a survey of neurosurgical practice patterns regarding the prophylactic use of anti-epilepsy drugs in patients with brain tumorsVitaly Siomin
Department of Neurosurgery, The Cleveland Clinic Brain Tumor Institute, 9500 Euclid Avenue, ND-40, Cleveland, OH 44195, USA
J Neurooncol 74:211-5. 2005..Additional larger prospective studies with appropriate patient stratification culminating in development of neurosurgical guidelines on AED prophylaxis in brain tumor patients is warranted... - Quantum dots are phagocytized by macrophages and colocalize with experimental gliomasHeather Jackson
Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Neurosurgery 60:524-9; discussion 529-30. 2007..This feature may allow optical nanoparticles, such as quantum dots, to colocalize with brain tumors and serve as an optical aid in the surgical resection or biopsy of brain tumors... - In touch with robotics: neurosurgery for the futureNarendra Nathoo
Brain Tumor Institute and Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Neurosurgery 56:421-33; discussion 421-33. 2005..This article reviews the role of robotic technology in the context of neurosurgery...