Jacqueline Vitali

Summary

Affiliation: Cleveland State University
Country: USA

Publications

  1. pmc Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, OH 44115, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:527-34. 2012
  2. ncbi request reprint Crystal structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, Ohio 44115, USA
    Proteins 71:1324-34. 2008
  3. pmc Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, OH 44115, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:776-80. 2008
  4. pmc Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1
    Jacqueline Vitali
    W M Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nucleic Acids Res 30:1531-8. 2002

Research Grants

  1. Structural Studies of the Pyrimidine Pathway
    Jacqueline Vitali; Fiscal Year: 2004

Detail Information

Publications4

  1. pmc Structure of the catalytic chain of Methanococcus jannaschii aspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, OH 44115, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:527-34. 2012
    ..Additional biochemical studies of carbamoylation and the molecular organization of this enzyme in M. jannaschii will provide further insight into these points...
  2. ncbi request reprint Crystal structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, Ohio 44115, USA
    Proteins 71:1324-34. 2008
    ..8 A. The active site appears similar to Escherichia coli. Upon substrate binding, smaller changes in the global orientation of domains and larger conformational changes of the active site residues are expected as compared to E. coli...
  3. pmc Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form
    Jacqueline Vitali
    Department of Physics, Cleveland State University, Euclid Avenue at East 24th Street, Cleveland, OH 44115, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:776-80. 2008
    ..4 degrees between crystal forms. Moreover, there is also flexibility in the relative orientation of the trimers around their threefold axis in the complexes, with a difference of 4 degrees between crystal forms...
  4. pmc Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1
    Jacqueline Vitali
    W M Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nucleic Acids Res 30:1531-8. 2002
    ..These phenylalanines are critical for nucleic acid binding and the observed alternative side chain conformations may serve as a mechanism for regulating nucleic acid binding by RRM-containing proteins...

Research Grants1

  1. Structural Studies of the Pyrimidine Pathway
    Jacqueline Vitali; Fiscal Year: 2004
    ..Finally, understanding the means of extreme heat stability will allow us to engineer selected features in other aspartate transcarbamoylases to obtain enzymes with enhanced thermostability. ..