Niraj Varma

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Probability and magnitude of response to cardiac resynchronization therapy according to QRS duration and gender in nonischemic cardiomyopathy and LBBB
    Niraj Varma
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio Electronic address
    Heart Rhythm 11:1139-47. 2014
  2. ncbi request reprint Superiority of automatic remote monitoring compared with in-person evaluation for scheduled ICD follow-up in the TRUST trial - testing execution of the recommendations
    Niraj Varma
    J2 2 Cardiac Pacing and Electrophysiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 35:1345-52. 2014
  3. doi request reprint Variegated left ventricular electrical activation in response to a novel quadripolar electrode: visualization by non-invasive electrocardiographic imaging
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, OH, USA Electronic address
    J Electrocardiol 47:66-74. 2014
  4. pmc Same-day discovery of implantable cardioverter defibrillator dysfunction in the TRUST remote monitoring trial: influence of contrasting messaging systems
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Europace 15:697-703. 2013
  5. ncbi request reprint Telemedicine and cardiac implants: what is the benefit?
    Niraj Varma
    Cardiac Pacing and Electrophysiology, 9500 Euclid Avenue Desk J2 2, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur Heart J 34:1885-95. 2013
  6. doi request reprint Automatic remote home monitoring of implantable cardioverter defibrillator lead and generator function: a system that tests itself everyday
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Europace 15:i26-i31. 2013
  7. doi request reprint Electrical isolation of both left pulmonary veins by a single left atrial endocardial radiofrequency energy application: ablation of marshall bundle bypass
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 35:e325-9. 2012
  8. doi request reprint Alternative site pacing: accessing normal precordial activation: is it possible?
    Niraj Varma
    Cleveland Clinic, Cleveland, OH, USA
    J Electrocardiol 45:660-2. 2012
  9. doi request reprint Device features for managing patients with heart failure
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart Fail Clin 7:215-25, viii. 2011
  10. doi request reprint Role of the surface electrocardiogram in developing countries
    Niraj Varma
    Department of Cardiac Electrophysiology, University of Pittsburgh Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Electrocardiol 43:612-4. 2010

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Probability and magnitude of response to cardiac resynchronization therapy according to QRS duration and gender in nonischemic cardiomyopathy and LBBB
    Niraj Varma
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio Electronic address
    Heart Rhythm 11:1139-47. 2014
    ..QRS morphology and QRS duration (QRSd) determine cardiac resynchronization therapy (CRT) candidate selection but criteria require refinement...
  2. ncbi request reprint Superiority of automatic remote monitoring compared with in-person evaluation for scheduled ICD follow-up in the TRUST trial - testing execution of the recommendations
    Niraj Varma
    J2 2 Cardiac Pacing and Electrophysiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 35:1345-52. 2014
    ..To test recommended implantable cardioverter defibrillator (ICD) follow-up methods by 'in-person evaluations' (IPE) vs. 'remote Home Monitoring' (HM)...
  3. doi request reprint Variegated left ventricular electrical activation in response to a novel quadripolar electrode: visualization by non-invasive electrocardiographic imaging
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, OH, USA Electronic address
    J Electrocardiol 47:66-74. 2014
    ..This observation introduces an added level of complexity in the understanding CRT electrical action. Attention to this factor may influence response to electrical resynchronization therapy. ..
  4. pmc Same-day discovery of implantable cardioverter defibrillator dysfunction in the TRUST remote monitoring trial: influence of contrasting messaging systems
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Europace 15:697-703. 2013
    ..Assess whether automatic remote home monitoring (HM) permits same-day evaluation of implantable cardioverter defibrillator (ICD) system dysfunction...
  5. ncbi request reprint Telemedicine and cardiac implants: what is the benefit?
    Niraj Varma
    Cardiac Pacing and Electrophysiology, 9500 Euclid Avenue Desk J2 2, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur Heart J 34:1885-95. 2013
    ..Remote home monitoring reduces the volume of device clinic visits and provides early detection of patient and/or system problems. ..
  6. doi request reprint Automatic remote home monitoring of implantable cardioverter defibrillator lead and generator function: a system that tests itself everyday
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Europace 15:i26-i31. 2013
    ..These characteristics have significant ramifications for CIEDs in general and patient safety...
  7. doi request reprint Electrical isolation of both left pulmonary veins by a single left atrial endocardial radiofrequency energy application: ablation of marshall bundle bypass
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 35:e325-9. 2012
    ..This was delivered at a site recording a complex continuous electrogram (duration 100 ms), interpreted as the site of a single connection between LA and MB...
  8. doi request reprint Alternative site pacing: accessing normal precordial activation: is it possible?
    Niraj Varma
    Cleveland Clinic, Cleveland, OH, USA
    J Electrocardiol 45:660-2. 2012
    ..g., non-invasively with electrocardiographic imaging. In the future, pacing site selection individualized according to detailed biventricular activation effects may enhance outcomes with alternate site pacing...
  9. doi request reprint Device features for managing patients with heart failure
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart Fail Clin 7:215-25, viii. 2011
    ..This may facilitate management of large patient volumes and enable pre-emptive treatment to improve outcomes in these high-risk patients...
  10. doi request reprint Role of the surface electrocardiogram in developing countries
    Niraj Varma
    Department of Cardiac Electrophysiology, University of Pittsburgh Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Electrocardiol 43:612-4. 2010
    ..In China, ischemia monitoring with 12-lead Holters is performed due to lack of availability of a chest pain clinic. Innovative measures in electrocardiography are required for improving health care delivery in developing nations...
  11. doi request reprint Automatic remote monitoring of implantable cardioverter-defibrillator lead and generator performance: the Lumos-T Safely RedUceS RouTine Office Device Follow-Up (TRUST) trial
    Niraj Varma
    Cleveland Clinic, Cleveland, OH, USA
    Circ Arrhythm Electrophysiol 3:428-36. 2010
    ..These were prospectively evaluated and compared in the TRUST trial. The HM technology tested performed daily self-checks and databasing with rapid event notifications for out-of-range (including asymptomatic) conditions...
  12. ncbi request reprint Efficacy and safety of automatic remote monitoring for implantable cardioverter-defibrillator follow-up: the Lumos-T Safely Reduces Routine Office Device Follow-up (TRUST) trial
    Niraj Varma
    Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circulation 122:325-32. 2010
    ....
  13. pmc RV electrical activation in heart failure during right, left, and biventricular pacing
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 3:567-75. 2010
    ..To compare right ventricular (RV) activation during intrinsic conduction or pacing in heart failure (HF) patients...
  14. ncbi request reprint Therapeutic implications of automatic home monitoring of implantable cardiac devices
    Niraj Varma
    Niraj Varma, MD, PhD, FRCP Cardiac Electrophysiology Laboratory, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Treat Options Cardiovasc Med 11:366-72. 2009
    ..Remote monitoring likely will become incorporated into the standard of care in cardiac implantable electronic devices...
  15. doi request reprint Left ventricular conduction delays and relation to QRS configuration in patients with left ventricular dysfunction
    Niraj Varma
    Cardiac Electrophysiology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 103:1578-85. 2009
    ..Fewer than 25% of patients with RBBB(HF) demonstrated delays equivalent to those in patients with LBBB(HF.) These variations may affect efficacy to cardiac resynchronization therapy...
  16. ncbi request reprint Prevalence of cancelled shock therapy and relationship to shock delivery in recipients of implantable cardioverter-defibrillators assessed by remote monitoring
    Niraj Varma
    Department of Electrophysiology, Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 32:S42-6. 2009
    ..However, it is silent and has received little attention. Remote home monitoring (HM) with continuous surveillance and automatic daily data archiving allows investigation of CxTx...
  17. doi request reprint QRS prolongation induced by cardiac resynchronization therapy correlates with deterioration in left ventricular function
    John Rickard
    Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Blvd, Cleveland, OH 44122, USA
    Heart Rhythm 9:1674-8. 2012
    ..A subset of "nonresponders" experience deterioration in LV function following cardiac resynchronization therapy (CRT). Characteristics of this patient population, however, have not been studied...
  18. pmc Electrocardiographic imaging of cardiac resynchronization therapy in heart failure: observation of variable electrophysiologic responses
    Ping Jia
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 3:296-310. 2006
    ..Being an electrical approach, detailed electrical information during CRT is critical to resolving these issues. However, electrical data from patients have been limited because of the requirement for invasive mapping...
  19. doi request reprint Durability of the survival effect of cardiac resynchronization therapy by level of left ventricular functional improvement: fate of "nonresponders"
    John Rickard
    Division of Cardiology, The Johns Hopkins Hospital, Cleveland, Ohio Electronic address
    Heart Rhythm 11:412-6. 2014
    ....
  20. doi request reprint Normalization of left ventricular ejection fraction after cardiac resynchronization therapy also normalizes survival
    Mahesh Manne
    Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 36:970-7. 2013
    ..Our aim was to determine whether super-responders survival increases to levels comparable to the general population. We compared the survival of super-responders to the general population matched for age and sex...
  21. pmc Use of dabigatran for periprocedural anticoagulation in patients undergoing catheter ablation for atrial fibrillation
    Mohamed Bassiouny
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circ Arrhythm Electrophysiol 6:460-6. 2013
    ..We hypothesized that dabigatran can be safely used as an alternative to continuous warfarin for the periprocedural anticoagulation in PVI...
  22. pmc QRS narrowing is associated with reverse remodeling in patients with chronic right ventricular pacing upgraded to cardiac resynchronization therapy
    John Rickard
    Heart and Vascular Institute Cleveland Clinic, Cleveland, Ohio 44122, USA
    Heart Rhythm 10:55-60. 2013
    ..Little is known about the predictors of response in this population. We hypothesized that reversal of RVP-induced electrical dyssynchrony (indexed by QRS duration) by CRT would predict a favorable response...
  23. doi request reprint Remote monitoring of cardiovascular devices: a time and activity analysis
    Edmond M Cronin
    Section of Electrophysiology and Pacing, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44106, USA
    Heart Rhythm 9:1947-51. 2012
    ..Remote monitoring (RM) may be less time-consuming compared to in-office follow-up; however, its effect on the device clinic workflow has not been clarified...
  24. doi request reprint Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 60:592-8. 2012
    ..The goal of this study was to examine the relative impact of QRS morphology and duration in echocardiographic responses to cardiac resynchronization therapy (CRT) and clinical outcomes...
  25. doi request reprint Predictors of response to cardiac resynchronization therapy in patients with a non-left bundle branch block morphology
    John Rickard
    Heart and Vascular Institute Cleveland Clinic, Ohio, USA
    Am J Cardiol 108:1576-80. 2011
    ..66 to 0.94, p = 0.005). In patients with advanced heart failure and non-LBBB morphologies, a wider baseline QRS duration is an important determinant of enhanced reverse ventricular remodeling and improved long-term outcomes after CRT...
  26. pmc Implantable cardioverter-defibrillator FDA safety advisories: Impact on patient mortality and morbidity
    Jay Sengupta
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue J2 2, Cleveland, OH 44195, USA
    Heart Rhythm 9:1619-26. 2012
    ..Although estimated risks of ICD generators under advisory are low, dependency on ICD therapies to prevent sudden death justifies the assessment of long-term mortality...
  27. ncbi request reprint Left ventricular conduction delays induced by right ventricular apical pacing: effect of left ventricular dysfunction and bundle branch block
    Niraj Varma
    Cardiac Electrophysiology Laboratory, University Hospitals Case Western Reserve University, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 19:114-22. 2008
    ..RV apical pacing (RVP) may be deleterious, possibly by simulating LBBB, i.e., prolonging QRS duration (QRSd) and LV activation (LVAT). However, determinants of electrical delays are unknown...
  28. doi request reprint The QRS narrowing index predicts reverse left ventricular remodeling following cardiac resynchronization therapy
    John Rickard
    Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pacing Clin Electrophysiol 34:604-11. 2011
    ..The relationship between QRS narrowing and response to cardiac resynchronization therapy (CRT) has been controversial...
  29. ncbi request reprint Electrocardiographic imaging of patients with heart failure with left bundle branch block and response to cardiac resynchronization therapy
    Niraj Varma
    Cardiac Bioelectricity Research Department, Case Western Reserve University, Cleveland, OH, USA
    J Electrocardiol 40:S174-8. 2007
    ..To determine this, we used electrocardiographic imaging (ECGI), which maps epicardial ventricular excitation noninvasively...
  30. pmc Placebo CRT
    Niraj Varma
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 19:878. 2008
  31. ncbi request reprint Detection of atrial fibrillation by implanted devices with wireless data transmission capability
    Niraj Varma
    Cardiac Electrophysiology, University Hospitals Case Western Reserve University, Cleveland, Ohio, USA
    Pacing Clin Electrophysiol 28:S133-6. 2005
    ..Its application may overcome some current challenges in AF management by early notification and precise measurement of both AF burden and ventricular rate during AF...
  32. ncbi request reprint Alternation of QRS width and cycle length during a long RP' tachycardia: what is the mechanism?
    Anselma Intini
    Cardiac Electrophysiology Laboratory, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio
    Heart Rhythm 1:364-7. 2004
  33. ncbi request reprint Typical counterclockwise atrial flutter occurring despite absence of the inferior vena cava
    Niraj Varma
    Department of Cardiac Electrophysiology, Cleveland, Ohio 44118, USA
    Heart Rhythm 1:82-7. 2004
    ..The implications of this congenital abnormality on posterior barriers maintaining the atrial flutter circuit are discussed...
  34. doi request reprint Right pectoral implantable cardioverter defibrillators: role of the proximal (SVC) coil
    Niraj Varma
    University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA
    Pacing Clin Electrophysiol 31:1025-35. 2008
    ..However, SVC affects impedance, current flow, and shock waveform phase duration (PD), which exert independent DFT effects. Objective:Compare DFTs and shock characteristics in SVC On with SVC Off in right ICDs...
  35. doi request reprint Remote monitoring of cardiovascular implanted electronic devices: a paradigm shift for the 21st century
    Edmond M Cronin
    Department of Cardiovascular Medicine, Section of Electrophysiology and Pacing, Cleveland Clinic, J2 2, 9500 Euclid Avenue, Cleveland, OH 44106, USA
    Expert Rev Med Devices 9:367-76. 2012
    ..Remote monitoring platforms are also huge databases of patients and devices, offering unprecedented opportunities to investigate real-world outcomes. Here, the current status of the field is described and future directions are predicted...
  36. ncbi request reprint A Long RP' Interval Tachycardia: what is the mechanism?
    Anselma Intini
    Cardiac Electrophysiology Laboratory, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44118, USA
    J Cardiovasc Electrophysiol 14:1379-81. 2003
  37. ncbi request reprint 2:1 AV tracking during DDD pacing during high output ventricular stimulation
    Niraj Varma
    Cardiac Electrophysiology Laboratory, University Hospital of Case Western Reserve University, Cleveland, Ohio 44118, USA
    Heart Rhythm 1:123-5. 2004