Research Topics
| M F VaeziSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Quantitative methods to determine efficacy of treatment in achalasiaM F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Gastrointest Endosc Clin N Am 11:409-24, viii-ix. 2001..Recent data suggest that barium esophagram may be most practical and informative compared to manometry and scintigraphy in predicting treatment success in achalasia patients after therapy...- Extraesophageal manifestations of gastroesophageal reflux diseaseMichael F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Clin Cornerstone 5:32-8; discussion 39-40. 2003..Response to aggressive acid suppression is often the best indication of GERD etiology in a patient with extraesophageal symptoms... - Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect associationMichael F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Gastroenterol Hepatol 1:333-44. 2003..In this article we discuss the reasons for this controversy and highlight the recent data attempting to clarify this complex area... - Laryngitis and gastro-oesophageal reflux disease (GERD): improve laryngoscopic specificity, don't do pH monitoringM F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Dig Liver Dis 36:103-4. 2004 - Gastroesophageal reflux disease and the larynxMichael F Vaezi
Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Clin Gastroenterol 36:198-203. 2003..Hence, a multidisciplinary approach is often required in the optimum treatment of these patients... - Cost-assessment of alternative management strategies for achalasiaMarcelo F Vela
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Expert Opin Pharmacother 4:2019-25. 2003..We are therefore confronted with an increasing demand to justify the value of our therapeutic interventions, not only from the risk/benefit standpoint but also from the cost perspective [6,7]... 
Timed barium oesophagram: better predictor of long term success after pneumatic dilation in achalasia than symptom assessmentM F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Gut 50:765-70. 2002..Recently, we showed that symptom relief and objective oesophageal emptying are concordant in about 70% of patients, while up to 30% of achalasia patients report near complete symptom relief despite poor oesophageal emptying of barium...- Review article: the role of pH monitoring in extraoesophageal gastro-oesophageal reflux diseaseM F Vaezi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, TN, USA
Aliment Pharmacol Ther 23:40-9. 2006.... - Ambulatory gastric pH monitoring: proper probe placement and normal valuesW K Fackler
Center for Swallowing and Oesophageal Disorders, Cleveland Clinic Foundation, Cleveland, USA
Aliment Pharmacol Ther 15:1155-62. 2001..3%. CONCLUSION: The fundus is the optimal location to evaluate the presence of gastric acid; pH values are highly reproducible in this area. Normal values for percentage time gastric pH < 4 for a healthy population are now defined... - Duodenogastroesophageal reflux and methods to monitor nonacidic refluxM F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Med 111:160S-168S. 2001..Studies show that this may be accomplished by antireflux surgery or the use of proton pump inhibitors, which by reducing gastric volume, decrease the damaging potential of both acid and DGER... - Laryngeal disorders in patients with gastroesophageal reflux diseaseF Farrokhi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, TN, USA
Minerva Gastroenterol Dietol 53:181-7. 2007..In majority of those who are unresponsive to such therapy other causes of laryngeal irritation is considered. Surgical fundoplication is most effective in those who are responsive to acid suppressive therapy... - Extra-esophageal manifestations of gastroesophageal refluxF Farrokhi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Oral Dis 13:349-59. 2007..However, PPI-unresponsive patients usually have causes other than GERD for the extra-esophageal symptoms and signs... - New techniques in measuring nonacidic esophageal refluxM F Vaezi
Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Semin Thorac Cardiovasc Surg 13:255-64. 2001..Future studies in this area, however, will prove beneficial in identifying their role in diagnosis and management of patients with suspected nonacid reflux disease... - CON: Treatment with PPIs should not be preceded by pH monitoring in patients suspected of laryngeal refluxMichael F Vaezi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Gastroenterol 101:8-10. 2006 - Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope)Claudio F Milstein
The Voice Center, Head and Neck Institute, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Laryngoscope 115:2256-61. 2005.... - Correlation between symptoms and laryngeal signs in laryngopharyngeal refluxMohammed A Qadeer
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Laryngoscope 115:1947-52. 2005..In patients unresponsive to twice-daily proton-pump inhibitor therapy for 4 months, further aggressive therapy is unlikely to bring additional symptomatic benefit... - A physiologic clinical study of achalasia: should Dor fundoplication be added to Heller myotomy?Thomas W Rice
Center for Swallowing and Esophageal Disorders and the Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Cardiovasc Surg 130:1593-600. 2005..Therefore, we objectively studied the physiologic effects of adding Dor fundoplication to Heller myotomy... - Treatment of chronic posterior laryngitis with esomeprazoleMichael F Vaezi
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, OH, and the Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
Laryngoscope 116:254-60. 2006..To evaluate the efficacy of acid-suppressive therapy with the proton pump inhibitor esomeprazole on the signs and symptoms of chronic posterior laryngitis (CPL) in patients with suspected reflux laryngitis... - Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physiciansTasneem F Ahmed
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, OH, USA
Am J Gastroenterol 101:470-8. 2006..4) Our study highlights a need for cross communication and education between these two disciplines in understanding and treating GERD-related laryngitis better... - Surgical fundoplication in laryngopharyngeal reflux unresponsive to aggressive acid suppression: a controlled studyJason Swoger
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Clin Gastroenterol Hepatol 4:433-41. 2006..The argument of low volume or intermittent reflux as the cause of persistent laryngeal symptoms needs to be replaced with evaluation and therapy for other potential non-GERD causes... - Should we bravo?Michael F Vaezi
Gastroenterology 130:2238-9. 2006 - Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trialsMohammed A Qadeer
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Gastroenterol 101:2646-54. 2006..Validated diagnostic guidelines may facilitate the recognition of those patients most likely to respond favorably to PPI treatment... - Are there specific laryngeal signs for gastroesophageal reflux disease?Michael F Vaezi
Am J Gastroenterol 102:723-4. 2007 - Laryngeal manifestations of gastroesophageal reflux diseaseMichael F Vaezi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, C2104 MCN, Nashville, TN 37232, USA
Curr Gastroenterol Rep 10:271-7. 2008..Other causes of laryngeal irritation are considered in most of those who are unresponsive to such therapy. Surgical fundoplication is most effective in those who are responsive to acid-suppressive therapy... - Sore throat and a red hypopharynx: is it reflux?Michael F Vaezi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Clin Gastroenterol Hepatol 5:1379-82. 2007 - Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of responseWoosuk Park
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Laryngoscope 115:1230-8. 2005..More response was achieved at 4 months compared with 2 months. Therefore, aggressive acid suppression with BID PPI for at least 4 months is warranted for treatment of LPR... - Atypical manifestations of gastroesophageal reflux diseaseMichael F Vaezi
Clinical Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA
MedGenMed 7:25. 2005 - Dysphagia: a cost analysis of the diagnostic approachTuba Esfandyari
Department of Gastroenterology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Ohio 44195, USA
Am J Gastroenterol 97:2733-7. 2002.... - The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteersDouglas M Hicks
The Voice Center, Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Voice 16:564-79. 2002..Intraexaminer and interexaminer agreement information is provided. The traditional attribution of hypopharynx irritation signs to reflux is challenged; the need for improved diagnostic specificity is highlighted... - Sensitivity and specificity of reflux-attributed laryngeal lesions: experimental and clinical evidenceMichael F Vaezi
Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Med 115:97S-104S. 2003..Based on present data, we recommend aggressive acid suppression with twice-daily dosing of proton pump inhibitors for >or=4 months in these patients... - Laryngitis and gastroesophageal reflux disease: increasing prevalence or poor diagnostic tests?Michael F Vaezi
Am J Gastroenterol 99:786-8. 2004..GERD may be one cause of laryngeal signs and symptoms in a subgroup of patients but not in all those currently so suspected. Future, studies are needed in this area to better delineate this association... - "Refractory GERD": acid, nonacid, or not GERD?Michael F Vaezi
Am J Gastroenterol 99:989-90. 2004..quot; However, this term is poorly defined and has a different meaning in different countries. More importantly, the cause of "refractory GERD" is poorly understood... - Therapy Insight: gastroesophageal reflux disease and laryngopharyngeal refluxMichael F Vaezi
Division of Gastroenterology and Hepatology, Vanderbilt University Medical Center, Nashville, TN 37232 5280, USA
Nat Clin Pract Gastroenterol Hepatol 2:595-603. 2005..This review discusses the reasons for this controversy and highlights data that attempt to clarify this complex area... - The role of esophageal pH monitoring in symptomatic patients on PPI therapySamer Charbel
Departments of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Gastroenterol 100:283-9. 2005..01) than those on q.d. PPIs. CONCLUSIONS: 1) The likelihood of an abnormal esophageal pH for symptomatic GERD patients on b.i.d. PPI is very small. 2) In this group of patients failing b.i.d. PPIs causes other than GERD should be sought... - The role of pH monitoring in extraesophageal gastroesophageal reflux diseaseTasneem Ahmed
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Gastrointest Endosc Clin N Am 15:319-31. 2005..The clinical utility of pH monitoring in this patient population, however, remains controversial. In this article, the authors examine the role of pH monitoring in laryngitis, asthma, chronic cough, and NCCP... - American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1383-1391, 1391.e1-5. 2008 - Long-term effect of H2RA therapy on nocturnal gastric acid breakthroughWilliam K Fackler
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Gastroenterology 122:625-32. 2002..Because of H2RA tolerance, there is no difference in acid suppression between PPI twice daily and PPI twice daily + H2RA after 1 week of combination therapy... - Does diffuse esophageal spasm progress to achalasia? A prospective cohort studySayed Saeid Khatami
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Ohio 44195, USA
Dig Dis Sci 50:1605-10. 2005..1) Progression from DES to achalasia is uncommon. 2) DES patients with low esophageal body amplitude may develop increased simultaneous contractions over time. 3) DES remains an elusive diagnosis clinically and manometrically... - Idiopathic (primary) achalasiaFarnoosh Farrokhi
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Orphanet J Rare Dis 2:38. 2007..Although it cannot be permanently cured, excellent palliation is available in over 90% of patients... - Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence?Mohammed A Qadeer
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Ohio, USA
Laryngoscope 115:1877-81. 2005..Therefore, we conducted this study to identify potential effect of GERD and acid suppressive therapy on recurrences after larynx-preserving therapies... - Etiology and pathogenesis of achalasia: the current understandingWoosuk Park
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 100:1404-14. 2005..Further studies are needed to better understand the etiology and pathogenesis of achalasia-such an understanding will be important in developing safe, effective, and possibly curative therapy for achalasia... - Nocturnal acid breakthrough: clinical significance and correlation with esophageal acid exposureTina M Ours
Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 98:545-50. 2003..CONCLUSIONS: NAB is an isolated gastric phenomenon that is poorly controlled even with most aggressive acid suppressive therapy. Esophageal acid suppression and symptom control are not dependent on the degree of NAB elimination... - Esophageal impedance recording: clinical utility and limitationsWoosuk Park
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Curr Gastroenterol Rep 7:182-9. 2005..However, continued improvements in the software and increasing studies in different patient populations will aid in overcoming these limitations... - Laryngeal cancer and gastroesophageal reflux disease: a case-control studyMichael F Vaezi
Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tenn, USA
Am J Med 119:768-76. 2006..We aimed to better understand this relationship by conducting a matched case-control study... - The cost-effectiveness of treatment strategies for achalasiaMendel E Singer
Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA
Dig Dis Sci 47:1516-25. 2002..Further studies should examine the long-term relapse rates following treatment with Botox and more precisely determine the quality of life of symptomatic achalasia... - Predictors of outcome of pneumatic dilation in achalasiaKaveh Farhoomand
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Ohio, USA
Clin Gastroenterol Hepatol 2:389-94. 2004..CONCLUSIONS: (1) Young men have a greater failure rate with 3.0-cm PD than older men or women in general, and (2) graded PD in this group starting initially with the 3.0-cm balloon is more likely to fail... - Esophageal manometry: assessment of interpreter consistencyDevjit S Nayar
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Clin Gastroenterol Hepatol 3:218-24. 2005..Given their uncertain clinical implications, we must either redefine them or eliminate them from practice... - The role of gastric and duodenal agents in laryngeal injury: an experimental canine modelTalal Adhami
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 99:2098-106. 2004..ii) Duodenal agents do not play a significant role in causing laryngeal injury. (iii) Aggressive acid suppression should eliminate the injurious potential of any gastroduodenal refluxate... - Gastroesophageal reflux and laryngeal cancer: causation or association? A critical reviewMohammed A Qadeer
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA
Am J Otolaryngol 27:119-28. 2006..In this article, we address the current literature in a critical manner to facilitate the understanding of this subject and evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma... - Is GERD a risk factor for laryngeal cancer?Mohammed A Qadeer
Department of Internal Medicine, Cleveland Clinic Foundation, Case Western Reserve University, Cleveland, Ohio, USA
Laryngoscope 115:486-91. 2005..To evaluate the overall strength of the association of GERD with laryngeal cancer, we performed meta-analysis of the original studies in literature... - American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux diseasePeter J Kahrilas
Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1392-1413, 1413.e1-5. 2008