Affiliation: Cleveland Clinic Foundation
- Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trialsKen Uchino
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, Mail Code S80, Cleveland, OH 44195, USA
Arch Intern Med 172:397-402. 2012..We systematically evaluated the risk of MI or acute coronary syndrome (ACS) with the use of dabigatran...
- Transient ischemic attack after tissue plasminogen activator: aborted stroke or unnecessary stroke therapy?Ken Uchino
UPMC Stroke Institute, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Cerebrovasc Dis 29:57-61. 2010..The frequency with which intravenous thrombolysis for acute ischemic stroke results in normal clinical and radiographic status is currently unknown...
- Protocol adherence and safety of intravenous thrombolysis after telephone consultation with a stroke centerKen Uchino
University of Pittsburgh Medical Center Stroke Institute, Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Stroke Cerebrovasc Dis 19:417-23. 2010..Our findings indicate the need for improved protocol adherence for stroke thrombolysis in patients presenting to small community hospitals...
- Lower pretreatment cerebral blood volume affects hemorrhagic risks after intra-arterial revascularization in acute strokeArchit Bhatt
Department of Neurology, Division of Cerebrovascular Diseases, Michigan State University, East Lansing, Michigan, USA
Neurosurgery 63:874-8; discussion 878-9. 2008..We sought to determine whether pretreatment computed tomography perfusion parameters might help to identify patients at a higher risk of developing intracranial hemorrhage after intra-arterial stroke revascularization treatment...
- Safety, feasibility, and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulationRishi Gupta
Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Stroke 37:2562-6. 2006..We report our technical success rate and short-term restenosis rates after stenting with DESs in the intracranial and extracranial circulation...
- Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalizationRishi Gupta
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
Stroke 37:986-90. 2006..Endovascular therapies using mechanical and pharmacological modalities for large vessel occlusions in acute stroke are rapidly evolving. Our aim was to determine whether one modality is associated with higher recanalization rates...
- Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusionRishi Gupta
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
Stroke 37:2526-30. 2006..We hypothesized that patients with lower prethrombolysis cerebral blood flow (CBF) were at a higher risk of symptomatic ICH (sICH)...
- Endovascular treatment of basilar artery occlusion by manual aspiration thrombectomyBrian T Jankowitz
Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Neurointerv Surg 2:110-4. 2010..Intravenous and intra-arterial therapy have altered the natural history of this disease; however, clinical results remain poor. Therefore, exploring more aggressive and innovative management is warranted...
- Mechanical approaches combined with intra-arterial pharmacological therapy are associated with higher recanalization rates than either intervention alone in revascularization of acute carotid terminus occlusionRidwan Lin
Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA 15213, USA
Stroke 40:2092-7. 2009..Historically, pharmacological thrombolysis alone has low recanalization rates. We sought to determine whether adjunctive mechanical approaches achieve better vessel recanalization and functional outcome...
- Aortic dissection presenting as an acute ischemic stroke for thrombolysisKen Uchino
Department of Neurology, University of Texas Houston Medical School, Houston, TX, USA
J Neuroimaging 15:281-3. 2005..An experienced sonographer with skills to perform rapid intra- and extracranial examinations may help to change the treatment plan for acute stroke patients...
- Argatroban tPA stroke study: study design and results in the first treated cohortRebecca M Sugg
Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Arch Neurol 63:1057-62. 2006..Argatroban is a direct thrombin inhibitor that safely augments the benefit of rtPA in animal stroke models. There are no human data on this combination...
- Platelet C4d is associated with acute ischemic stroke and stroke severityNidhi Mehta
University of Pittsburgh School of the Health Sciences, University of Pittsburgh, PA, USA
Stroke 39:3236-41. 2008..We compared the prevalence of platelet C4d and investigated the clinical associations of platelet C4d in patients with acute ischemic stroke...
- Quantitative perihematomal blood flow in spontaneous intracerebral hemorrhage predicts in-hospital functional outcomeAshis H Tayal
Department of Neurology and University of Pittsburgh Medical Center Stroke Institute, University of Pittsburgh, Pittsburgh, PA, USA
Stroke 38:319-24. 2007..We correlated perihematomal CBF in a retrospective series of 42 subacute spontaneous intracerebral hemorrhage patients undergoing xenon computed tomography with in-hospital discharge status and mortality...
- Emergent stenting of extracranial internal carotid artery occlusion in acute stroke has a high revascularization rateTudor G Jovin
Department of Neurology, University of Pittsburgh Medical Center Stroke Institute, Pittsburgh, PA 15213, USA
Stroke 36:2426-30. 2005..In selected cases, revascularization with carotid artery stenting has been reported, but the safety, recanalization rate, and clinical outcomes in consecutive case series are not known...
- Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trialWilliam J Powers
Department of Neurology, Box 7025, Room 2131, 170 Manning Dr, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
JAMA 306:1983-92. 2011..Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically...
- Safety and feasibility of a lower dose intravenous TPA therapy for ischemic stroke beyond the first three hoursKen Uchino
Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
Cerebrovasc Dis 19:260-6. 2005..The risk/benefit ratio is more unfavorable beyond this time, but some patients might still benefit. We designed a pilot study with the hypothesis that lower dose TPA might be safe in selected patients treated beyond 3 h...
- Centenarian middle cerebral artery occlusion treated with intra-arterial mechanical embolectomyChristopher L Cummings
Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Neurointerv Surg 4:e23. 2012..The patient improved, and ultimately returned to a baseline modified Rankin Scale score of 3. With careful selection, elderly patients may benefit from acute stroke therapies and may be considered on a case by case basis...
- Moyamoya disease in Washington State and CaliforniaKen Uchino
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
Neurology 65:956-8. 2005..2 (95% CI: 1.3 to 2.4) for African Americans, and 0.5 (95% CI: 0.3 to 0.8) for Hispanics. The incidence of moyamoya in Washington and California was lower than reported in Japan, but the rate among US Asians is similar...