Mary J Thomassen

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Human alveolar macrophages and monocytes as a source and target for nitric oxide
    M J Thomassen
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195 5038, USA
    Int Immunopharmacol 1:1479-90. 2001
  2. ncbi request reprint Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis
    Mary Jane Thomassen
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195 5038, USA
    Autoimmunity 36:285-90. 2003
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma activity is deficient in alveolar macrophages in pulmonary sarcoidosis
    Daniel A Culver
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Cell Mol Biol 30:1-5. 2004
  4. ncbi request reprint Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, 9500 Euclid Avenue, Cleveland Clinic Foundation, Desk A90, Cleveland, OH 44195 5038
    Am J Respir Cell Mol Biol 29:677-82. 2003
  5. ncbi request reprint Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland, OH, USA
    J Autoimmun 26:37-41. 2006
  6. ncbi request reprint Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Immunol 114:79-85. 2005
  7. ncbi request reprint Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma)
    Barbara P Barna
    Department of Pulmonary, Allergy, and Critical Care Medicine, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Sarcoidosis Vasc Diffuse Lung Dis 23:93-100. 2006
  8. ncbi request reprint ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis
    Mary Jane Thomassen
    Program in Lung Cell Biology and Translational Research, Division of Pulmonary and Critical Care Medicine, East Carolina University, Greenville, NC, USA
    J Lipid Res 48:2762-8. 2007
  9. ncbi request reprint Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge
    Jiang Wu
    Biological Technologies and Inflammation Research, Wyeth, Cambridge, Massachusetts 02140, USA
    Mol Cell Proteomics 4:1251-64. 2005
  10. pmc Multiplexed particle-based anti-granulocyte macrophage colony stimulating factor assay used as pulmonary diagnostic test
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, 9500 Euclid Avenue, Cleveland Clinic Foundation, Desk A90, Cleveland, OH 44195 5038, USA
    Clin Diagn Lab Immunol 12:821-4. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Human alveolar macrophages and monocytes as a source and target for nitric oxide
    M J Thomassen
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195 5038, USA
    Int Immunopharmacol 1:1479-90. 2001
    ..Furthermore, such reactions may decrease the availability of NO for blocking inflammatory cytokine production. Thus, available data suggests that a multiplicity of factors affect NO regulatory properties in inflammatory situations...
  2. ncbi request reprint Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis
    Mary Jane Thomassen
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195 5038, USA
    Autoimmunity 36:285-90. 2003
    ..Based on these observations, we hypothesize that IL-10 may be an indicator of PAP clinical response to GM-CSF therapy...
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma activity is deficient in alveolar macrophages in pulmonary sarcoidosis
    Daniel A Culver
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Cell Mol Biol 30:1-5. 2004
    ....
  4. ncbi request reprint Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, 9500 Euclid Avenue, Cleveland Clinic Foundation, Desk A90, Cleveland, OH 44195 5038
    Am J Respir Cell Mol Biol 29:677-82. 2003
    ..Moreover, GM-CSF treatment of patients with PAP fully restores PPAR-gamma to healthy control levels. Based upon these novel findings, we hypothesize that GM-CSF regulates lung homeostasis via PPAR-gamma-dependent pathways...
  5. ncbi request reprint Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland, OH, USA
    J Autoimmun 26:37-41. 2006
    ..These studies are the first to suggest that activin A may play a role in autoimmune disease...
  6. ncbi request reprint Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Immunol 114:79-85. 2005
    ..Further, MCP-1 from PAP lung suppresses CCR2 expression in vitro, suggesting that in PAP, MCP-1 participates in an autocrine regulatory network in vivo...
  7. ncbi request reprint Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma)
    Barbara P Barna
    Department of Pulmonary, Allergy, and Critical Care Medicine, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Sarcoidosis Vasc Diffuse Lung Dis 23:93-100. 2006
    ....
  8. ncbi request reprint ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis
    Mary Jane Thomassen
    Program in Lung Cell Biology and Translational Research, Division of Pulmonary and Critical Care Medicine, East Carolina University, Greenville, NC, USA
    J Lipid Res 48:2762-8. 2007
    ..These findings document the existence of ABCG1 deficiency in human lung disease and highlight a critical role for ABCG1 in surfactant homeostasis...
  9. ncbi request reprint Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge
    Jiang Wu
    Biological Technologies and Inflammation Research, Wyeth, Cambridge, Massachusetts 02140, USA
    Mol Cell Proteomics 4:1251-64. 2005
    ..Importantly a large portion of these proteins and their expression changes were identified for the first time from BALF, thus providing new insights for finding novel pathological mediators and biomarkers of asthma...
  10. pmc Multiplexed particle-based anti-granulocyte macrophage colony stimulating factor assay used as pulmonary diagnostic test
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, 9500 Euclid Avenue, Cleveland Clinic Foundation, Desk A90, Cleveland, OH 44195 5038, USA
    Clin Diagn Lab Immunol 12:821-4. 2005
    ..In this report we present data to support anti-GM-CSF detection by a quantitative highly sensitive multiplexed particle-based assay which has the potential to be a clinical diagnostic test...
  11. ncbi request reprint Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health
    Hephzibah Rani S Tagaram
    Departments of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1052-63. 2007
    ..10) compared with culture-positive NCF (0.368 +/- 0.085). In summary, we developed and characterized an SP-A1 gene-specific antibody and used it to identify gene-specific SP-A content in BALFs as a function of age and lung health...
  12. ncbi request reprint Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor
    Tracey L Bonfield
    Department of Pulmonary, Allergy and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195 5038, USA
    J Leukoc Biol 79:133-9. 2006
    ..These data suggest that in the absence of GM-CSF, excess M-CSF in PAP may redirect alveolar macrophage activation, thus potentially contributing to elevated MMP expression in the lung...
  13. ncbi request reprint An inverse relationship between peroxisome proliferator-activated receptor gamma and allergic airway inflammation in an allergen challenge model
    Michiko Kobayashi
    Respiratory Disease, Wyeth Research, Cambridge, Massachusetts, USA
    Ann Allergy Asthma Immunol 95:468-73. 2005
    ..Peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression has not been evaluated in bronchoalveolar lavage (BAL) cells from allergic asthmatic patients...
  14. ncbi request reprint Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis
    Steve Meaney
    Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Lipid Res 45:2354-60. 2004
    ....
  15. pmc Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor
    Tracey L Bonfield
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44109, USA
    J Immunol 181:235-42. 2008
    ..Taken together, these data suggest that M-CSF is an important mediator of alveolar macrophage homeostasis, and that transcriptional control of M-CSF production is regulated by NF-kappaB and PPARgamma...
  16. ncbi request reprint PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195 5038, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1132-6. 2003
    ..1 and M-CSFR expression in alveolar macrophages compared with healthy control and PAP patients before GM-CSF therapy. These observations suggest that PU.1 is critical in the terminal differentiation of human alveolar macrophages...
  17. ncbi request reprint Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195 5038, USA
    Clin Immunol 105:342-50. 2002
    ..Together, these data support the hypothesis that PAP is an anti-GM-CSF autoimmune disease due to the development of antibodies, which results in the deactivation or neutralization of GM-CSF...
  18. ncbi request reprint Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis
    Tracey L Bonfield
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Respir Cell Mol Biol 27:481-6. 2002
    ..Further, using anti-GM-CSF as an indicator of pulmonary alveolar proteinosis may avoid the use of more invasive means of evaluating patients with pulmonary disease characterized by alveolar infiltrates...
  19. ncbi request reprint Nitric oxide attenuates beryllium-induced IFNgamma responses in chronic beryllium disease: evidence for mechanisms independent of IL-18
    Barbara P Barna
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Clin Immunol 103:169-75. 2002
    ..Data are the first to show that: (1) BE stimulates IL-18 as well as IFNgamma in CBD; (2) BE cytokine responses are NO-sensitive; and (3) NO down-regulation of IFNgamma involves other sites in addition to IL-18...
  20. ncbi request reprint The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in human alveolar macrophages
    Baisakhi Raychaudhuri
    Department of Pulmonary and Critical Care Medicine, Anatomic Pathology, and Cell Biology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195 5038, USA
    J Biol Chem 277:33344-8. 2002
    ..These data indicate that inflammatory mechanisms may be important in the pathogenesis of PPH and cytokine antagonism by blocking NFkappaB may contribute to the efficacy of TRE therapy in PPH...
  21. ncbi request reprint Nitric oxide blocks inflammatory cytokine secretion triggered by CD23 in monocytes from allergic, asthmatic patients and healthy controls
    Kholoud Wishah
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Ohio 44195 5038, USA
    Ann Allergy Asthma Immunol 89:78-82. 2002
    ..Our previous work suggested that NO may function in an anti-inflammatory capacity by downregulating endotoxin-stimulated cytokine production by alveolar macrophages and matured monocytes...
  22. ncbi request reprint An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis
    Saiprakash B Venkateshiah
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Ave, Mail Code A 90, Cleveland, OH 44109, USA
    Chest 130:227-37. 2006
    ..These data indicate that subcutaneous GM-CSF therapy is a promising alternative to WLL for symptomatic patients with PAP...
  23. pmc Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
    Jian Li
    Morphotek, Inc, 210 Welsh Pool Road, Exton, PA 19341, USA
    Proc Natl Acad Sci U S A 103:3557-62. 2006
    ..Moreover, these hybridoma cells have proven suitable for genetic optimization using the morphogenics process and have shown potential for large-scale manufacturing...
  24. ncbi request reprint Circulating monocytes from patients with primary pulmonary hypertension are hyporesponsive
    Baisakhi Raychaudhuri
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Immunol 104:191-8. 2002
    ..What remains unknown is how the reduced activation of monocytes in PPH is related to the pulmonary vascular lesion...
  25. ncbi request reprint Surfactant blocks lipopolysaccharide signaling by inhibiting both mitogen-activated protein and IkappaB kinases in human alveolar macrophages
    Baisakhi Raychaudhuri
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Cell Mol Biol 30:228-32. 2004
    ..Data are the first to show that surfactant may regulate lung homeostasis in part by inhibiting proinflammatory cytokine production through reduction of IKK and MAP kinase activity...
  26. ncbi request reprint Pulmonary sarcoidosis: new genetic clues and ongoing treatment controversies
    Daniel A Culver
    Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 71:88, 90, 92 passim. 2004
    ..Corticosteroid treatment is effective, but the optimal time to start, the dose, and the duration of treatment are controversial. We are just beginning to understand the genetic basis of sarcoidosis...
  27. ncbi request reprint Pulmonary alveolar proteinosis. Clinical manifestations and optimal treatment strategies
    Saiprakash B Venkateshiah
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Treat Respir Med 3:217-27. 2004
    ..Interventions directed at treating a relative GM-CSF deficiency by administration of GM-CSF or lowering the antibody level (i.e. by plasmapheresis or immunosuppression) may hold promise as future therapy for this rare disease...