Wh Wilson Tang

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure
    Alan H B Wu
    University of California at San Francisco, San Francisco, CA, USA
    Clin Chem 53:2086-96. 2007
  2. ncbi request reprint Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 16:635-40. 2010
  3. pmc Tolvaptan: the evidence for its therapeutic value in acute heart failure syndrome
    Arash Aghel
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Core Evid 3:31-43. 2008
  4. pmc Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension
    Samar Farha
    Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Respir Res 14:6. 2013
  5. pmc Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transl Res 162:26-33. 2013
  6. pmc Detectable subclinical myocardial necrosis is associated with cardiovascular risk in stable patients with diabetes
    W H Wilson Tang
    Cleveland Clinic, Cleveland, OH, USA
    Diabetes Care 36:1126-31. 2013
  7. doi request reprint Isolated left ventricular non-compaction controversies in diagnostic criteria, adverse outcomes and management
    Paaladinesh Thavendiranathan
    Department of Cardiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 99:681-9. 2013
  8. pmc Protein carbamylation in chronic systolic heart failure: relationship with renal impairment and adverse long-term outcomes
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 19:219-24. 2013
  9. pmc Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 111:465-70. 2013
  10. pmc Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 19:87-93. 2013

Research Grants

  1. Nitrative stress in heart failure
    Wai Hong Wilson Tang; Fiscal Year: 2010

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure
    Alan H B Wu
    University of California at San Francisco, San Francisco, CA, USA
    Clin Chem 53:2086-96. 2007
  2. ncbi request reprint Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 16:635-40. 2010
    ..Neurohormonal activation is a pathophysiological hallmark of acute and chronic heart failure (HF). The clinical significance of more recently discovered endogenous vasoactive hormones has not been well-characterized...
  3. pmc Tolvaptan: the evidence for its therapeutic value in acute heart failure syndrome
    Arash Aghel
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Core Evid 3:31-43. 2008
    ....
  4. pmc Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension
    Samar Farha
    Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Respir Res 14:6. 2013
    ....
  5. pmc Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: relation to severity of cardiac dysfunction
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transl Res 162:26-33. 2013
    ....
  6. pmc Detectable subclinical myocardial necrosis is associated with cardiovascular risk in stable patients with diabetes
    W H Wilson Tang
    Cleveland Clinic, Cleveland, OH, USA
    Diabetes Care 36:1126-31. 2013
    ..To investigate the relationship between different degrees of subclinical myocardial necrosis, glycemic control, and long-term adverse clinical outcomes within a stable patient population with diabetes mellitus...
  7. doi request reprint Isolated left ventricular non-compaction controversies in diagnostic criteria, adverse outcomes and management
    Paaladinesh Thavendiranathan
    Department of Cardiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 99:681-9. 2013
    ..In this review, we provide an overview of the current controversies in the clinical diagnosis of LVNC, and suggest a management approach...
  8. pmc Protein carbamylation in chronic systolic heart failure: relationship with renal impairment and adverse long-term outcomes
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 19:219-24. 2013
    ..We examine the relationship between plasma protein-bound homocitrulline (PBHCit) levels, a marker of protein lysine residue carbamylation, with cardiorenal function and long-term outcomes in chronic systolic heart failure (HF)...
  9. pmc Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 111:465-70. 2013
    ..82, 95% CI 3.82 to 30.6, p <0.001). In conclusion, an integrated assessment of cardiac biomarkers may provide independent prognostic value for long-term adverse clinical events in stable cardiac patients...
  10. pmc Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Card Fail 19:87-93. 2013
    ..Systemic alterations in arginine bioavailability occur in heart failure (HF) patients with more advanced myocardial dysfunction and poorer clinical outcomes, and they improve with beta-blocker therapy...
  11. doi request reprint Prognostic value of cardiac troponin in chronic stable heart failure: a systematic review
    Vijaiganesh Nagarajan
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 98:1778-86. 2012
    ..Elevation of cardiac troponins is noted in patients with chronic stable heart failure, but comparative prognostic value of different assay types is not established...
  12. pmc Threshold crossing of device-based intrathoracic impedance trends identifies relatively increased mortality risk
    Wai Hong Wilson Tang
    Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 33:2189-96. 2012
    ..The aim of this study is to examine the relationship between alterations in intrathoracic impedance and mortality risk in patients with implantable devices...
  13. doi request reprint Multispecialty approach: the need for heart failure disease management for refining cardiac resynchronization therapy
    W H Wilson Tang
    Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Heart Rhythm 9:S45-50. 2012
    ..Therefore, further investigations into HF disease management with a multispecialty approach, pre-CRT and post-CRT, are warranted...
  14. ncbi request reprint The role of aldosterone receptor antagonists in the management of heart failure: an update
    Vijaiganesh Nagarajan
    Department of Hospital Medicine, Cleveland Clinic, USA
    Cleve Clin J Med 79:631-9. 2012
    ..The benefits include a lower rate of death. Yet to be answered is whether the two drugs are clinically equivalent; another question is whether they may benefit everyone with symptomatic heart failure, including diastolic heart failure...
  15. pmc Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from
    Basem Abdelmalak
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 10:11. 2010
    ..We are studying three interventions that potentially modulate perioperative inflammation: corticosteroids, tight glucose control, and light anesthesia...
  16. ncbi request reprint PPARgamma agonists: safety issues in heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Diabetes Obes Metab 9:447-54. 2007
    ....
  17. ncbi request reprint Natriuretic peptides in screening for cardiac dysfunction
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart Fail Clin 2:323-32. 2006
  18. pmc Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Chem 57:33-9. 2011
    ..Myeloperoxidase (MPO) concentrations predict adverse clinical outcomes in the setting of acute coronary syndromes and heart failure, but the prognostic role of MPO in stable patients with known atherosclerotic burden is unclear...
  19. doi request reprint Epidemiology of anemia in heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Heart Fail Clin 6:271-8. 2010
    ..Different factors contribute to the development of anemia, including increasing age, renal insufficiency, hemodilution, chronic inflammation, and increasing heart failure disease severity...
  20. ncbi request reprint Glycemic control and treatment patterns in patients with heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Curr Cardiol Rep 9:242-7. 2007
    ..In-depth investigations of the role of current and emerging strategies of metabolic modulation are promising, although the precise therapeutic targets remain elusive...
  21. ncbi request reprint Collaboration among general cardiologists, heart failure specialists, and electrophysiologists: what are the barriers?
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA USA
    Am J Cardiol 99:41G-4G. 2007
    ..In the future, a "virtual clinic" model of patient care can only be realized with the successful incorporation of remotely accessed device data...
  22. ncbi request reprint Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 49:2364-70. 2007
    ..The purpose of this study was to explore the relationship between myeloperoxidase (MPO) and cardiac structure, performance, and prognosis...
  23. ncbi request reprint Biomarkers of risk stratification in congestive heart failure: North American view
    Wh Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Heart and Vascular Institute, The Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Biomark Med 3:443-52. 2009
    ..With healthcare cost on the rise in North America, clinical utility of biomarkers must demonstrate relative safety and potential incremental benefits to standard approaches...
  24. ncbi request reprint Pharmacologic therapy for acute heart failure
    W H Wilson Tang
    Cleveland Clinic, Cleveland, OH, USA
    Cardiol Clin 25:539-51; vi. 2007
    ..Several promising drugs are currently undergoing clinical development for the treatment of AHFS, although many of the clinical challenges remain unresolved...
  25. pmc A critical review of anti-adrenergic therapy in patients with heart failure and diabetes mellitus
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, OH 44195, USA
    Vasc Health Risk Manag 3:639-45. 2007
    ..This review summarizes what has been learned from clinical trial evidence regarding the benefits of anti-adrenergic drugs in diabetic patients with chronic heart failure...
  26. ncbi request reprint The metabolic approach in patients with heart failure: effects on left ventricle remodeling
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Pharm Des 15:850-6. 2009
    ..However, the appropriate candidate to receive such therapies and the appropriate targets of therapy remain unclear, which may warrant further investigations...
  27. doi request reprint Cardiorenal syndrome in decompensated heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart 96:255-60. 2010
    ..These revived concepts may support the role of novel renal-sparing approaches to salt and water removal and renal preservation, but better ways to distinguish haemodynamic versus other nephrotoxic aetiologies are needed...
  28. pmc Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure
    W H Wilson Tang
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 103:1269-74. 2009
    ..In conclusion, an independent association between increased MPO and the development of HF in apparently healthy elderly subjects was observed, particularly beyond MI and traditional cardiac risk factors...
  29. pmc Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure
    Wai Hong Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur Heart J 29:2506-13. 2008
    ..To investigate the association of arginine methylation with myocardial function and prognosis in chronic systolic heart failure patients...
  30. pmc Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, Cleveland, OH, USA
    J Am Coll Cardiol 53:2061-7. 2009
    ..We hypothesized that an integrated assessment of arginine with its catabolic products might better predict cardiovascular risks than arginine levels alone...
  31. pmc Subclinical myocardial necrosis and cardiovascular risk in stable patients undergoing elective cardiac evaluation
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 30:634-40. 2010
    ..Herein, we examine the relationship between different degrees of subclinical myocardial necrosis and long-term adverse clinical outcomes within a stable cardiac patient population with essentially normal renal function...
  32. doi request reprint Statin treatment for patients with heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Heart and Vascular Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nat Rev Cardiol 7:249-55. 2010
    ..The results from these studies and their implications for the timing of initiating statin therapy in this patient population are also discussed...
  33. doi request reprint Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:569-76. 2008
    ..This study sought to determine the characteristics and long-term prognosis of anemia in ambulatory patients with chronic heart failure...
  34. doi request reprint Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:370-3. 2008
    ..High plasma hs-CRP levels portend poor long-term outcomes, particularly in those with severe concomitant systolic and diastolic dysfunctions...
  35. pmc Measuring impedance in congestive heart failure: current options and clinical applications
    W H Wilson Tang
    Heart and Vascular Institute, Cleveland Clinic, OH 44195, USA
    Am Heart J 157:402-11. 2009
    ....
  36. ncbi request reprint Neurohormonal upregulation in heart failure
    W H Wilson Tang
    Case Western Reserve University, Cleveland, OH, USA
    Heart Fail Clin 1:1-9. 2005
  37. ncbi request reprint Aldosterone receptor antagonists in the medical management of chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Mayo Clin Proc 80:1623-30. 2005
    ..Theoretically, aldosterone receptor antagonists may also be beneficial in patients with more mild to moderate systolic heart failure or even in those with diastolic heart failure, although direct evidence is still lacking...
  38. doi request reprint Uncovering interim clinical events at the time of clinical encounter by reviewing intrathoracic impedance threshold crossings
    W H Wilson Tang
    Cleveland Clinic, Cleveland, Ohio, USA
    J Card Fail 17:893-8. 2011
    ..However, the usefulness of such information to direct patient encounter and enhance patient recall of relevant preceding clinical events at the point of care has not been carefully examined...
  39. ncbi request reprint Vasopressin receptor antagonists in the management of acute heart failure
    W H Wilson Tang
    Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Opin Investig Drugs 14:593-600. 2005
    ..Nevertheless, their comparative long-term safety and efficacy remains to be determined in large-scale clinical trials...
  40. ncbi request reprint Comparative sensitivities between different plasma B-type natriuretic peptide assays in patients with minimally symptomatic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Section of Heart Failure and Cardiac Transplantation Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Cornerstone 7:S18-24. 2005
    ..These findings suggest that there is a relationship between the decision statistics used in screening for left ventricular dysfunction and the type of diagnostic assay used...
  41. ncbi request reprint Impact of angiotensin-converting enzyme gene polymorphism on neurohormonal responses to high- versus low-dose enalapril in advanced heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 148:889-94. 2004
    ..The impact of angiotensin-converting enzyme (ACE) gene polymorphism on neurohormonal dose response to ACE inhibitor therapy is unclear...
  42. ncbi request reprint Ischemic heart disease and congestive heart failure in diabetic patients
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Med Clin North Am 88:1037-61, xi-xii. 2004
    ..Special consideration is given to new strategies for treating the adverse effects of abnormal glucose metabolism on the cardiovascular system...
  43. pmc Clinical and genetic association of serum ceruloplasmin with cardiovascular risk
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Desk J3 4, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 32:516-22. 2012
    ..Cp has recently been shown to possess nitric oxide (NO) oxidase catalytic activity, but its impact on long-term cardiovascular outcomes in stable cardiac patients has not been explored...
  44. ncbi request reprint Novel pharmacological treatments for heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Expert Opin Investig Drugs 12:1791-801. 2003
    ....
  45. ncbi request reprint Plasma B-type natriuretic peptide levels in ambulatory patients with established chronic symptomatic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 108:2964-6. 2003
    ..The diagnostic and prognostic values of plasma B-type natriuretic peptide (BNP) testing are established. However, the range of plasma BNP levels present in the setting of chronic, stable systolic heart failure (HF) is unclear...
  46. ncbi request reprint Evolving concepts in left ventricular systolic and diastolic remodeling: implications for therapy
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    Curr Cardiol Rep 6:200-4. 2004
    ..This implies that better characterization of this heterogeneous heart failure phenotype is desperately needed...
  47. ncbi request reprint The year in heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 46:2125-33. 2005
  48. ncbi request reprint Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 41:1394-8. 2003
    ..We sought to define the characteristics of fluid retention after thiazolidinedione (TZD) initiation in patients with established heart failure (HF)...
  49. pmc Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Ohio, USA
    Am J Cardiol 108:385-90. 2011
    ..However, we did not observe a relation between galectin-3 and echocardiographic or hemodynamic indexes...
  50. ncbi request reprint B-type natriuretic peptide: a critical review
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail 13:48-52. 2007
    ..The potential use of natriuretic peptide levels to monitor and guide patient management or detect subclinical disease states is currently under investigation...
  51. ncbi request reprint Risk stratification for patients undergoing nonurgent percutaneous coronary intervention using N-terminal pro-B-type natriuretic peptide: a Clopidogrel for the Reduction of Events During Observation (CREDO) substudy
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am Heart J 153:36-41. 2007
    ..The comparative prognostic values between NT-proBNP levels and left ventricular ejection fraction (LVEF) in the nonurgent PCI setting are unclear...
  52. ncbi request reprint The year in heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 48:2575-83. 2006
  53. pmc Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure
    W H Wilson Tang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Circ Heart Fail 4:59-64. 2011
    ..In the present study, we sought to determine the prognostic role of serum arylesterase activity in subjects with systolic heart failure, particularly in relation to established cardiac biomarkers...
  54. ncbi request reprint Plasma myeloperoxidase levels in patients with chronic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 98:796-9. 2006
    ..7, 95% confidence interval 3.6 to 371.1). In conclusion, in a cohort of patients with chronic HF, plasma MPO levels were elevated compared with those of normal controls and were associated with worsening functional class...
  55. doi request reprint Impact of left ventricular remodeling on diagnostic and prognostic value of tissue Doppler indices in chronic systolic heart failure
    W H Wilson Tang
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Card Fail 17:128-34. 2011
    ..We aim to examine the impact of left ventricular (LV) dimensions on the relationship between lateral and septal E/Ea in the determination of diastolic dysfunction patterns in the setting of chronic systolic heart failure (HF)...
  56. ncbi request reprint New approaches to detect and manage edema and renal insufficiency in heart failure
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 73:S14-9; discussion S30-3. 2006
    ..In addition, diuretic-sparing approaches to heart failure management, novel drug classes, new devices, and nonpharmacologic therapies are emerging to reduce reliance on diuretic therapy and manage edema with less renal compromise...
  57. ncbi request reprint Do thiazolidinediones cause heart failure? A critical review
    W H Wilson Tang
    Section of Heart Failure and Cardiac Transplantation, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 73:390-7. 2006
    ..TZDs have many benefits for patients with diabetes and can even be used cautiously in patients with mild heart failure, with careful monitoring of volume status...
  58. ncbi request reprint Glycemic control and treatment patterns in patients with heart failure
    W H Wilson Tang
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USA
    Heart Fail Monit 5:10-4. 2006
    ..Furthermore, there is a poor understanding of the relative contributions of glucose and fatty acids to the metabolism of the failing heart and a poor understanding of the pathogenesis of heart failure in patients with diabetes mellitus...
  59. ncbi request reprint In heart failure, all beta-blockers are not necessarily equal
    W H Wilson Tang
    The George M and Linda H Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 70:1081-7. 2003
    ..Given the overwhelming evidence of the benefit of carvedilol, metoprolol succinate, and bisoprolol in patients with heart failure, we should all strive to increase the use of these drugs in appropriate doses...
  60. pmc Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition
    Zeneng Wang
    Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 29:1383-91. 2009
    ..We examine the relationship of related posttranslational modification products of arginine methylation and coronary artery disease (CAD) phenotypes...
  61. ncbi request reprint Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient heart failure clinic
    Ritesh Gupta
    Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 147:79-83. 2004
    ..However, there is limited information regarding their use in clinical practice settings, and reasonable utilization targets for quality improvement initiatives have not been established...
  62. pmc Impact of left ventricular volume/mass ratio on diastolic function
    Adisai Buakhamsri
    Division of Cardiovascular Medicine, Department of Cardiology, Desk F 15, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 30:1213-21. 2009
    ..To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls...
  63. ncbi request reprint Emerging drugs for acute and chronic heart failure: current and future developments
    Stephen Y Chen
    Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Expert Opin Emerg Drugs 12:75-95. 2007
    ....
  64. doi request reprint Impact of myocardial function on cystatin C measurements in chronic systolic heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio 44195, USA
    J Card Fail 14:394-9. 2008
    ..The influence of myocardial function on plasma levels of cystatin C (CysC), a sensitive marker of renal function, in chronic systolic heart failure (HF) has not been well established...
  65. doi request reprint Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function?
    Wilfried Mullens
    Section of Heart Failure and Cardiac Transplantation, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:300-6. 2008
    ..This study sought to determine whether changes in intra-abdominal pressure (IAP) with aggressive diuretic or vasodilator therapy are associated with improvement in renal function in acute decompensated heart failure (ADHF)...
  66. pmc Right ventricular response to intensive medical therapy in advanced decompensated heart failure
    David Verhaert
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Heart Fail 3:340-6. 2010
    ..Our objective was to compare the clinical significance of changes in RV echocardiographic indices in response to intensive medical treatment in patients admitted to the hospital with acute decompensated heart failure (ADHF)...
  67. pmc Comprehensive peroxidase-based hematologic profiling for the prediction of 1-year myocardial infarction and death
    Marie Luise Brennan
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Ohio, USA
    Circulation 122:70-9. 2010
    ....
  68. doi request reprint Persistent hemodynamic benefits of cardiac resynchronization therapy with disease progression in advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:600-7. 2009
    ..Our aim was to determine the potential hemodynamic contributions of cardiac resynchronization therapy (CRT) in patients admitted for advanced decompensated heart failure...
  69. ncbi request reprint Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 53:765-73. 2009
    ..Our aim was to determine the feasibility and value of a protocol-driven approach to patients with cardiac resynchronization therapy (CRT) who did not exhibit a positive response long after implant...
  70. ncbi request reprint Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues
    Srinivasa R Kalidindi
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    Nat Clin Pract Cardiovasc Med 4:368-78. 2007
    ....
  71. ncbi request reprint Using echocardiography in cardiac resynchronization therapy
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Am Heart J 154:1011-20. 2007
    ..This manuscript reviews the current echocardiographic techniques available for guiding both patient selection and optimization of device programming following implantation...
  72. ncbi request reprint Outcomes of patients with stable heart failure undergoing elective noncardiac surgery
    Ye Olivia Xu-Cai
    Department of Hospital Medicine, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mayo Clin Proc 83:280-8. 2008
    ....
  73. ncbi request reprint Trends and treatment of heart failure developing after acute myocardial infarction
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart Hosp J 1:216-8. 2003
    ....
  74. ncbi request reprint Cardiac troponins in renal insufficiency and other non-ischemic cardiac conditions
    Gary S Francis
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, F25, Cleveland, Ohio 44195, USA
    Prog Cardiovasc Dis 47:196-206. 2004
    ..Last, monitoring cardiac troponins in cardiac transplant recipients and those receiving certain cardiotoxic chemotherapies may be of some diagnostic value, but clearly more experience and clinical research are needed...
  75. doi request reprint Sodium nitroprusside for advanced low-output heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:200-7. 2008
    ..This study was designed to examine the safety and efficacy of sodium nitroprusside (SNP) for patients with acute decompensated heart failure (ADHF) and low-output states...
  76. ncbi request reprint Mechanical dyssynchrony in advanced decompensated heart failure: relation to hemodynamic responses to intensive medical therapy
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Heart Rhythm 5:1105-10. 2008
    ..In patients with heart failure, the degree of intraventricular mechanical dyssynchrony (intra-VMD) at baseline may predict reversal of cardiac remodeling with cardiac resynchronization therapy (CRT)...
  77. pmc Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    Slava Epelman
    Department of Internal Medicine, Heart and Vascular Institute, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:750-4. 2008
    ..We sought to determine whether circulating soluble angiotensin-converting enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF)...
  78. ncbi request reprint Cardiac troponins in renal insufficiency: review and clinical implications
    Benjamin J Freda
    Department of Internal Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 40:2065-71. 2002
    ..It is possible that increases in serum troponin from baseline in patients with renal insufficiency admitted to hospital with acute coronary syndrome may signify myocardial necrosis. Further studies are needed to clarify this hypothesis...
  79. pmc Importance of venous congestion for worsening of renal function in advanced decompensated heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:589-96. 2009
    ..To determine whether venous congestion, rather than impairment of cardiac output, is primarily associated with the development of worsening renal function (WRF) in patients with advanced decompensated heart failure (ADHF)...
  80. ncbi request reprint Vasopressin receptor antagonists in heart failure
    Robert E Hobbs
    Department of Cardiovascular Medicine, Cleveland Clinic, OH, USA
    Recent Pat Cardiovasc Drug Discov 1:177-84. 2006
    ..We reviewed recent patents dealing with heart failure, hyponatremia, anti-diuretic hormone, and vasopressin antagonists...
  81. pmc Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    J Lipid Res 51:3055-61. 2010
    ..This supports the need to intensify lipid management in patients with elevated Lp(a) levels...
  82. ncbi request reprint Outcome of acute ST-segment elevation myocardial infarction in diabetics treated with fibrinolytic or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: lessons from the GUSTO V trial
    Hitinder S Gurm
    Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Coll Cardiol 43:542-8. 2004
    ....
  83. doi request reprint Long-term reverse remodeling with cardiac resynchronization therapy: results of extended echocardiographic follow-up
    David Verhaert
    Department of Cardiovascular Medicine, Section of Cardiac Imaging, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 55:1788-95. 2010
    ..The purpose of this study was to describe the long-term course of left ventricular remodeling induced by cardiac resynchronization therapy (CRT), adjusting for the confounding effect of patient loss due to disease...
  84. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure
    Arash Aghel
    Education Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Card Fail 16:49-54. 2010
    ..We sought to determine the relationship between admission serum NGAL levels and WRF in the setting of ADHF...
  85. ncbi request reprint National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine practice guidelines: Analytical issues for biomarkers of heart failure
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, Minn, USA
    Circulation 116:e95-8. 2007
  86. ncbi request reprint Insulin resistance in idiopathic dilated cardiomyopathy: a possible etiologic link
    Ronald M Witteles
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305 5406, USA
    J Am Coll Cardiol 44:78-81. 2004
    ..This study was designed to quantify the prevalence of abnormal glucose tolerance and insulin resistance in patients with idiopathic dilated cardiomyopathy (IDCM)...
  87. ncbi request reprint Vasopressin receptor antagonists: will the "vaptans" fulfill their promise?
    Gary S Francis
    JAMA 291:2017-8. 2004
  88. doi request reprint The ongoing search for a stratified medicine approach in heart failure
    W H Wilson Tang
    J Am Coll Cardiol 51:2310-2. 2008
  89. ncbi request reprint Pathophysiology of congestive heart failure
    Gary S Francis
    George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH, USA
    Rev Cardiovasc Med 4:S14-20. 2003
    ..More emphasis should be placed on recognition and correction of risk factors related to the development of heart failure...
  90. ncbi request reprint Beta-blockers and reverse remodeling: what are the implications?
    Gary S Francis
    Am Heart J 145:200-2. 2003
  91. ncbi request reprint Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options
    Ashish Aneja
    The Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    Am J Med 121:748-57. 2008
    ..Although glycemic control and early administration of neurohormonal antagonists remain the cornerstones of therapeutic approaches, newer treatment targets are currently being explored...
  92. ncbi request reprint Outcome of acute myocardial infarction in patients with prior coronary artery bypass grafting treated with combination reduced fibrinolytic therapy and abciximab
    Debabrata Mukherjee
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Cardiol 90:1198-203. 2002
    ..As in the overall trial, combination therapy in patients who underwent prior CABG led to a consistent reduction in key secondary complications of AMI, including recurrent ischemia and a trend toward reduced urgent revascularization...
  93. ncbi request reprint Prognostic evaluation of ambulatory patients with advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 101:1297-302. 2008
    ..0001). In conclusion, in ambulatory patients with advanced HF, hemodynamic and renal function assessments remain strong independent predictors of all-cause mortality...
  94. ncbi request reprint Biomarker screening for cardiac dysfunction: the more the merrier?
    W H Wilson Tang
    Am Heart J 152:1-3. 2006
  95. ncbi request reprint Why do patients fail to receive beta-blockers for chronic heart failure over time? A "real-world" single-center, 2-year follow-up experience of beta-blocker therapy in patients with chronic heart failure
    Anoop C Parameswaran
    Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 149:921-6. 2005
    ..The long-term compliance rate for beta-blocker drugs outside the context of a clinical trial has not been established...
  96. ncbi request reprint Plasma B-type natriuretic peptide levels predict postoperative atrial fibrillation in patients undergoing cardiac surgery
    Oussama M Wazni
    Center for Atrial Fibrillation, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 110:124-7. 2004
    ..Recently, B-type natriuretic peptide (BNP) has been reported to predict occurrence of nonpostoperative AF. This study evaluates whether elevated preoperative (preop) plasma BNP levels predict the occurrence of postop AF...
  97. ncbi request reprint National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure
    W H Wilson Tang
    Circulation 116:e99-109. 2007
  98. ncbi request reprint The difficult task of evaluating how to monitor patients with heart failure
    W H Wilson Tang
    J Card Fail 11:422-4. 2005
  99. ncbi request reprint Neurohormonal and clinical responses to high- versus low-dose enalapril therapy in chronic heart failure
    W H Wilson Tang
    Stanford University Medical School, Stanford, California, USA
    J Am Coll Cardiol 39:70-8. 2002
    ..We sought to compare the neurohormonal responses and clinical effects of long-term, high-dose versus low-dose enalapril in patients with chronic heart failure (CHF)...

Research Grants1

  1. Nitrative stress in heart failure
    Wai Hong Wilson Tang; Fiscal Year: 2010
    ....