Stephen Stohlman

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint NK cells regulate CD4 responses prior to antigen encounter
    Kennichi C Dowdell
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 171:234-9. 2003
  2. pmc Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system
    Maria Teresa P de Aquino
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, United States
    Virology 447:112-20. 2013
  3. pmc MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis
    Carine Savarin
    Department of Neurosciences NC 30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, U S A
    ASN Neuro 5:e00127. 2013
  4. pmc IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability
    Claudia Hindinger
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e42088. 2012
  5. pmc Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neuroinflammation 9:269. 2012
  6. pmc IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
    Carine Savarin
    Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neuroinflammation 9:104. 2012
  7. pmc Peritoneal macrophage from male and female SJL mice differ in IL-10 expression and macrophage maturation
    Shabbir Hussain
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    J Leukoc Biol 91:571-9. 2012
  8. pmc CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus
    Stephen A Stohlman
    Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Virol 82:2130-9. 2008
  9. ncbi request reprint Evidence for synaptic stripping by cortical microglia
    Bruce D Trapp
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Glia 55:360-8. 2007
  10. pmc Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis
    Shweta S Puntambekar
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6702-13. 2011

Research Grants

  1. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2004
  2. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2004
  3. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2004
  4. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2005
  5. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
  6. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2006
  7. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2005
  8. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2007
  9. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2003
  10. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 1999

Collaborators

  • Carine Savarin
  • Timothy W Phares
  • Richard Ransohoff
  • Jiehao Zhou
  • Cornelia C Bergmann
  • David R Hinton
  • Chandran Ramakrishna
  • Claudia Hindinger
  • Roscoe D Atkinson
  • John M Gonzalez
  • Roscoe Atkinson
  • Shabbir Hussain
  • Shweta S Puntambekar
  • Jun Zuo
  • Shuen Ing Tschen
  • Stefanie J Kirwin
  • Maria Teresa P de Aquino
  • Wendy B Macklin
  • Gabriel I Parra
  • Karen E Malone
  • Derek D C Ireland
  • Kevin B Walsh
  • Bruce D Trapp
  • Ludwig Hamo
  • Thomas E Lane
  • Roscoe A Atkinson
  • Babette Fuss
  • Audrey M Chen
  • Beatriz Parra
  • Kennichi C Dowdell
  • Norman W Marten
  • Christopher L Karp
  • Wendy Macklin
  • Maya Otto-Duessel
  • Grahame J Kidd
  • Gerson A Criste
  • Kimberley M Romero
  • Walid Jalabi
  • Jerome R Wujek
  • Matthew V Kotlajich
  • Xinghua Yin
  • Robert A Edwards
  • Kenichi C Dowdell
  • Jason B Hoskin
  • Jason Hoskin
  • Margaret E Burnett
  • Ni Feng
  • Nivedita Khanna
  • Cindy Kangas
  • Konechi C Dowdell
  • Kathryn V Holmes
  • Maureen Morrison
  • Daniel J Cua
  • Erlinda Kirkman
  • Ramakrishna Chandran
  • Shawn Morales
  • Mark J Shlomchik

Detail Information

Publications38

  1. ncbi request reprint NK cells regulate CD4 responses prior to antigen encounter
    Kennichi C Dowdell
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Immunol 171:234-9. 2003
    ..1-depleted males. The absence of a functional NK T cell population in SJL mice suggests that NK cells influence adaptive immunity before Ag exposure via alterations in APC activity...
  2. pmc Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system
    Maria Teresa P de Aquino
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, United States
    Virology 447:112-20. 2013
    ..However, their absence during acute infection alters the ability of the host to limit tissue damage. ..
  3. pmc MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis
    Carine Savarin
    Department of Neurosciences NC 30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, U S A
    ASN Neuro 5:e00127. 2013
    ..These data suggest an MMP-independent role of TIMP-1 in regulating CD4⁺ T cell access into the CNS parenchyma during acute JHMV encephalitis...
  4. pmc IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability
    Claudia Hindinger
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e42088. 2012
    ..These data indicate that astrocytes play a critical role in limiting CNS autoimmune disease dependent upon a neuroprotective signaling pathway mediated by engagement of IFN-γ receptors...
  5. pmc Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
    Timothy W Phares
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neuroinflammation 9:269. 2012
    ..However, the relative contribution of CD4 T cells to CD8 function in the CNS, in the absence of B7-H1, remains unclear...
  6. pmc IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
    Carine Savarin
    Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neuroinflammation 9:104. 2012
    ..These interactions have hindered the ability to distinguish the relative contributions of neutrophils, Th1 and Th17 cell-derived effector molecules from secondary mediators to tissue damage and morbidity...
  7. pmc Peritoneal macrophage from male and female SJL mice differ in IL-10 expression and macrophage maturation
    Shabbir Hussain
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    J Leukoc Biol 91:571-9. 2012
    ....
  8. pmc CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus
    Stephen A Stohlman
    Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Virol 82:2130-9. 2008
    ..Although the antiviral effector mechanism is initially independent of IFN-gamma secretion, sustained control of CNS virus replication by CD4(+) T cells requires IFN-gamma...
  9. ncbi request reprint Evidence for synaptic stripping by cortical microglia
    Bruce D Trapp
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Glia 55:360-8. 2007
    ..Since neuronal pathology was not a feature of either the acute or immune-mediated lesion, synaptic stripping by activated microglia may have neuroprotective consequences...
  10. pmc Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis
    Shweta S Puntambekar
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6702-13. 2011
    ..Moreover, a shift from predominant IL-10 production by CD25(+) CD4(+) T cells to CD25(-) CD4(+) T cells suggests that a transition to nonclassical regulatory T cells precedes and is retained during CNS viral persistence...
  11. ncbi request reprint Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells
    Chandran Ramakrishna
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Immunol 168:1204-11. 2002
    ..B cells themselves may also play a subtle role in modulating pathogenesis by influencing tropism...
  12. ncbi request reprint Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2
    Jiehao Zhou
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Viral Immunol 18:162-9. 2005
    ....
  13. ncbi request reprint Differential regulation of primary and secondary CD8+ T cells in the central nervous system
    Chandran Ramakrishna
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Immunol 173:6265-73. 2004
    ..These data suggest that an instructional program intrinsic to T cell differentiation, rather than Ag load or factors in the inflamed CNS, prominently regulate CD8+ T cell function...
  14. pmc Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells
    Cornelia C Bergmann
    Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Virol 78:1739-50. 2004
    ....
  15. pmc Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection
    Jiehao Zhou
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Virol 76:7374-84. 2002
    ..By contrast, MMP-9 protein activity was associated with the infiltration of neutrophils into the CNS. These data indicate an association between the magnitude of inflammatory gene expression within the CNS and viral virulence...
  16. ncbi request reprint The art of survival during viral persistence
    Stephen A Stohlman
    Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Neurovirol 8:53-8. 2002
    ..The low turnover of virus, T cells, and B cells constitute a unifying feature of persistent infection, illustrating the dichotomy between distinct immune effectors in regulating acute and persistent central nervous system infection...
  17. pmc Expression of the mouse hepatitis virus receptor by central nervous system microglia
    Chandran Ramakrishna
    Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Virol 78:7828-32. 2004
    ....
  18. ncbi request reprint Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation
    Cornelia C Bergmann
    Department of Neurology, Keck School of Medicine, University of California, Los Angeles, CA 90033, USA
    J Immunol 170:3204-13. 2003
    ..The data further imply that IFN-gamma plays a crucial role in pathogenesis by regulating the balance between virus replication in oligodendrocytes, CD8(+) T cell effector function, and demyelination...
  19. ncbi request reprint Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis
    Jiehao Zhou
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 170:3331-6. 2003
    ..These data suggest that infiltrating neutrophils are crucial for limiting virus replication during acute JHMV infection, contribute to the loss of blood brain barrier integrity and play a role in shaping adaptive immunity within the CNS...
  20. ncbi request reprint Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease
    Kevin B Walsh
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 179:1155-65. 2007
    ..These studies highlight that CXCL10 expression promotes protection from coronavirus-induced neurological and liver disease...
  21. pmc Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells
    Derek D C Ireland
    The Cleveland Clinic, 2500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 82:300-10. 2008
    ..By limiting early viral replication and tropism, IFN-I controls the balance of viral replication and immune control in favor of CD8 T-cell-mediated protective functions...
  22. pmc Control of central nervous system viral persistence by neutralizing antibody
    Chandran Ramakrishna
    Department of Neurology, USC Keck School of Medicine, Los Angeles, California 90033, USA
    J Virol 77:4670-8. 2003
    ....
  23. doi request reprint Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis
    Karen E Malone
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Glia 56:426-35. 2008
    ....
  24. ncbi request reprint IL-15-independent antiviral function of primary and memory CD8+ T cells
    Jun Zuo
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Virology 331:338-48. 2005
    ..However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function...
  25. pmc Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection
    Norman W Marten
    Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    J Virol 77:2775-8. 2003
    ..The data further suggest peripheral acquisition of cytolytic function, thus enhancing CD8+ -T-cell effector function upon cognate antigen recognition in the CNS...
  26. ncbi request reprint Recruitment kinetics and composition of antibody-secreting cells within the central nervous system following viral encephalomyelitis
    Shuen Ing Tschen
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 168:2922-9. 2002
    ..Lastly, altered antiviral ASC specificities following clearance of infectious virus suggest ongoing recruitment of peripheral memory cells and/or local B cell differentiation...
  27. ncbi request reprint Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis
    Ludwig Hamo
    Department of Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Glia 55:1169-77. 2007
    ..Furthermore, prolonged MHC expression subsequent to viral clearance implies a potential for ongoing presentation...
  28. ncbi request reprint Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes
    John M Gonzalez
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Glia 51:22-34. 2005
    ..This model will allow evaluation of oligodendrocyte responses to this critical cytokine during CNS inflammation...
  29. pmc Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitis
    Audrey M Chen
    Department of Neurology, University of Southern California Keck School of Medicine, 1333 San Pablo St, MCH 148, Los Angeles, CA 90033, USA
    J Virol 79:4700-8. 2005
    ..However, transient CNS retention and the absence of activation suggest that memory bystander CD8+ T cells may not overtly contribute to pathology in the absence of antigen recognition...
  30. pmc Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis
    Jiehao Zhou
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Virol 79:4764-73. 2005
    ....
  31. ncbi request reprint Astrocyte expression of a dominant-negative interferon-gamma receptor
    Claudia Hindinger
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Neurosci Res 82:20-31. 2005
    ..Transgenic mice with impaired astrocyte responsiveness to IFN-gamma provide a model for studying the selective astrocyte-dependent effects of this critical cytokine in CNS immunopathology...
  32. ncbi request reprint Coronavirus infection of the central nervous system: host-virus stand-off
    Cornelia C Bergmann
    Cleveland Clinic Foundation, Neurosciences, 9500 Euclid Avenue NC30, Cleveland, Ohio 44195, USA
    Nat Rev Microbiol 4:121-32. 2006
    ..Distinct from cytolytic effector mechanisms expressed during acute infection, non-lytic humoral immunity prevails in suppressing infectious virus during persistence...
  33. ncbi request reprint Vaccine-induced memory CD8+ T cells cannot prevent central nervous system virus reactivation
    Chandran Ramakrishna
    Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 176:3062-9. 2006
    ..These studies demonstrate that vaccine-induced T cell memory alone is unable to control persisting virus in a tissue with strict IFN-dependent MHC regulation, as evident in immune privileged sites...
  34. pmc Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination
    John M Gonzalez
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Pathol 168:796-804. 2006
    ..In addition, the absence of a correlation between increased oligodendroglial infection and the extent of demyelination suggests a complex pathobiology of myelin loss in which infection of oligodendroglia is required but not sufficient...
  35. ncbi request reprint Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells
    Jun Zuo
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Virology 350:206-15. 2006
    ..IL-15 and NK cells thus appear dispensable for anti-viral immunity and CNS pathogenesis during acute JHMV infection...
  36. ncbi request reprint Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis
    Stefanie J Kirwin
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 1333 San Pablo Ave, Los Angeles, CA 90033, USA
    J Neuroimmunol 178:30-9. 2006
    ..These data suggest that a peripheral Th2 cytokine environment influences both potential antigen presenting cells as well as recruitment and/or retention of neuroAg-specific Th2 CD4+ T cells...
  37. ncbi request reprint Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis
    Claudia Hindinger
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    J Neurosci Res 84:1225-34. 2006
    ..These data suggest that LXR agonists play an important protective role in the regulation of T-cell-mediated inflammatory disease of the central nervous system...
  38. ncbi request reprint CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS
    Shuen Ing Tschen
    Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Eur J Immunol 36:603-12. 2006
    ..These results confirm the CNS as a major ASC-supporting environment, even after resolution of viral infection and in the absence of chronic ongoing inflammation...

Research Grants23

  1. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2004
    ..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
  2. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2004
    ..abstract_text> ..
  3. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2004
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  4. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2005
    ..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
  5. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  6. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2006
    ..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
  7. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2005
    ..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
  8. Regulation of Gender Dependent EAE Susceptibility
    Stephen Stohlman; Fiscal Year: 2007
    ..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
  9. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2003
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  10. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 1999
    ....
  11. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2000
    ....
  12. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2000
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  13. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2001
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  14. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2002
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  15. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2002
    ..abstract_text> ..
  16. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..abstract_text> ..
  17. PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITY
    Stephen Stohlman; Fiscal Year: 2004
    ..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
  18. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..Funding is requested for continuation of Project 12 (Norman Marten), Project 2 (Stephen Stohlman) and Project 10 (Cornelia Bergmann) and for addition of a new project directed by Thomas Lane...
  19. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2003
    ..abstract_text> ..