Research Topics | Stephen StohlmanSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
NK cells regulate CD4 responses prior to antigen encounterKennichi C Dowdell
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
J Immunol 171:234-9. 2003..1-depleted males. The absence of a functional NK T cell population in SJL mice suggests that NK cells influence adaptive immunity before Ag exposure via alterations in APC activity...
Peritoneal macrophage from male and female SJL mice differ in IL-10 expression and macrophage maturationShabbir Hussain
Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Leukoc Biol 91:571-9. 2012....
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virusStephen A Stohlman
Department of Neurosciences NC30, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Virol 82:2130-9. 2008..Although the antiviral effector mechanism is initially independent of IFN-gamma secretion, sustained control of CNS virus replication by CD4(+) T cells requires IFN-gamma...- Evidence for synaptic stripping by cortical microgliaBruce D Trapp
Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Glia 55:360-8. 2007..Since neuronal pathology was not a feature of either the acute or immune-mediated lesion, synaptic stripping by activated microglia may have neuroprotective consequences... - Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitisShweta S Puntambekar
Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
J Virol 85:6702-13. 2011..Moreover, a shift from predominant IL-10 production by CD25(+) CD4(+) T cells to CD25(-) CD4(+) T cells suggests that a transition to nonclassical regulatory T cells precedes and is retained during CNS viral persistence... - Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2Jiehao Zhou
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Viral Immunol 18:162-9. 2005.... - Differential regulation of primary and secondary CD8+ T cells in the central nervous systemChandran Ramakrishna
Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
J Immunol 173:6265-73. 2004..These data suggest that an instructional program intrinsic to T cell differentiation, rather than Ag load or factors in the inflamed CNS, prominently regulate CD8+ T cell function... - Expression of the mouse hepatitis virus receptor by central nervous system microgliaChandran Ramakrishna
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Virol 78:7828-32. 2004.... - Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cellsCornelia C Bergmann
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Virol 78:1739-50. 2004.... - Mechanisms of central nervous system viral persistence: the critical role of antibody and B cellsChandran Ramakrishna
Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
J Immunol 168:1204-11. 2002..B cells themselves may also play a subtle role in modulating pathogenesis by influencing tropism... - Neutrophils promote mononuclear cell infiltration during viral-induced encephalitisJiehao Zhou
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Immunol 170:3331-6. 2003..These data suggest that infiltrating neutrophils are crucial for limiting virus replication during acute JHMV infection, contribute to the loss of blood brain barrier integrity and play a role in shaping adaptive immunity within the CNS... - Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulationCornelia C Bergmann
Department of Neurology, Keck School of Medicine, University of California, Los Angeles, CA 90033, USA
J Immunol 170:3204-13. 2003..The data further imply that IFN-gamma plays a crucial role in pathogenesis by regulating the balance between virus replication in oligodendrocytes, CD8(+) T cell effector function, and demyelination... - Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infectionJiehao Zhou
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Virol 76:7374-84. 2002..By contrast, MMP-9 protein activity was associated with the infiltration of neutrophils into the CNS. These data indicate an association between the magnitude of inflammatory gene expression within the CNS and viral virulence... - The art of survival during viral persistenceStephen A Stohlman
Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
J Neurovirol 8:53-8. 2002..The low turnover of virus, T cells, and B cells constitute a unifying feature of persistent infection, illustrating the dichotomy between distinct immune effectors in regulating acute and persistent central nervous system infection... - Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitisStefanie J Kirwin
Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 1333 San Pablo Ave, Los Angeles, CA 90033, USA
J Neuroimmunol 178:30-9. 2006..These data suggest that a peripheral Th2 cytokine environment influences both potential antigen presenting cells as well as recruitment and/or retention of neuroAg-specific Th2 CD4+ T cells... - Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitisClaudia Hindinger
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
J Neurosci Res 84:1225-34. 2006..These data suggest that LXR agonists play an important protective role in the regulation of T-cell-mediated inflammatory disease of the central nervous system... - Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitisLudwig Hamo
Department of Neuroscience, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Glia 55:1169-77. 2007..Furthermore, prolonged MHC expression subsequent to viral clearance implies a potential for ongoing presentation... - Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver diseaseKevin B Walsh
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
J Immunol 179:1155-65. 2007..These studies highlight that CXCL10 expression promotes protection from coronavirus-induced neurological and liver disease... - Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cellsDerek D C Ireland
The Cleveland Clinic, 2500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
J Virol 82:300-10. 2008..By limiting early viral replication and tropism, IFN-I controls the balance of viral replication and immune control in favor of CD8 T-cell-mediated protective functions... - Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitisKaren E Malone
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Glia 56:426-35. 2008.... - Recruitment kinetics and composition of antibody-secreting cells within the central nervous system following viral encephalomyelitisShuen-Ing Tschen
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Immunol 168:2922-9. 2002..Lastly, altered antiviral ASC specificities following clearance of infectious virus suggest ongoing recruitment of peripheral memory cells and/or local B cell differentiation... - Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cellsJun Zuo
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Virology 350:206-15. 2006..IL-15 and NK cells thus appear dispensable for anti-viral immunity and CNS pathogenesis during acute JHMV infection... - Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelinationJohn M Gonzalez
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
Am J Pathol 168:796-804. 2006..In addition, the absence of a correlation between increased oligodendroglial infection and the extent of demyelination suggests a complex pathobiology of myelin loss in which infection of oligodendroglia is required but not sufficient... - Vaccine-induced memory CD8+ T cells cannot prevent central nervous system virus reactivationChandran Ramakrishna
Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
J Immunol 176:3062-9. 2006..These studies demonstrate that vaccine-induced T cell memory alone is unable to control persisting virus in a tissue with strict IFN-dependent MHC regulation, as evident in immune privileged sites... - Control of central nervous system viral persistence by neutralizing antibodyChandran Ramakrishna
Department of Neurology, USC Keck School of Medicine, Los Angeles, California 90033, USA
J Virol 77:4670-8. 2003.... - IL-15-independent antiviral function of primary and memory CD8+ T cellsJun Zuo
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Virology 331:338-48. 2005..However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function... - Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytesJohn M Gonzalez
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
Glia 51:22-34. 2005..This model will allow evaluation of oligodendrocyte responses to this critical cytokine during CNS inflammation... - Virus-specific and bystander CD8 T cells recruited during virus-induced encephalomyelitisAudrey M Chen
Department of Neurology, University of Southern California Keck School of Medicine, 1333 San Pablo St, MCH 148, Los Angeles, CA 90033, USA
J Virol 79:4700-8. 2005..However, transient CNS retention and the absence of activation suggest that memory bystander CD8+ T cells may not overtly contribute to pathology in the absence of antigen recognition... - Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitisJiehao Zhou
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Virol 79:4764-73. 2005.... - Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infectionNorman W Marten
Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
J Virol 77:2775-8. 2003..The data further suggest peripheral acquisition of cytolytic function, thus enhancing CD8+ -T-cell effector function upon cognate antigen recognition in the CNS... - Astrocyte expression of a dominant-negative interferon-gamma receptorClaudia Hindinger
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
J Neurosci Res 82:20-31. 2005..Transgenic mice with impaired astrocyte responsiveness to IFN-gamma provide a model for studying the selective astrocyte-dependent effects of this critical cytokine in CNS immunopathology... - Coronavirus infection of the central nervous system: host-virus stand-offCornelia C Bergmann
Cleveland Clinic Foundation, Neurosciences, 9500 Euclid Avenue NC30, Cleveland, Ohio 44195, USA
Nat Rev Microbiol 4:121-32. 2006..Distinct from cytolytic effector mechanisms expressed during acute infection, non-lytic humoral immunity prevails in suppressing infectious virus during persistence... - CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNSShuen-Ing Tschen
Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Eur J Immunol 36:603-12. 2006..These results confirm the CNS as a major ASC-supporting environment, even after resolution of viral infection and in the absence of chronic ongoing inflammation...
Research Grants
- SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLSStephen Stohlman; Fiscal Year: 2005..abstract_text> ..
- PERSISTENT VIRUS ON CENTRAL NERVOUS SYSTEM IMMUNITYStephen Stohlman; Fiscal Year: 2004..The use of transgenic mice will determine the role of Ag expressed within defined CNS cell types, in the presence and absence of peripheral Ag. ..
- Regulation of Gender Dependent EAE SusceptibilityStephen Stohlman; Fiscal Year: 2007..These data will also provide the first evidence that NK and CD25 + T cells influence adaptive immunity prior to antigen encounter via alterations in APC function. ..
- DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTIONStephen Stohlman; Fiscal Year: 2007..Funding is requested for continuation of Project 12 (Norman Marten), Project 2 (Stephen Stohlman) and Project 10 (Cornelia Bergmann) and for addition of a new project directed by Thomas Lane...
- SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLSStephen Stohlman; Fiscal Year: 2000....