Randall C Starling

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi Advanced heart failure: transplantation, LVADs, and beyond
    Randall C Starling
    FACC, Kaufman Center for Heart Failure, Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 80:33-40. 2013
  2. ncbi Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial
    Randall C Starling
    The Cleveland Clinic, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 84:1236-42. 2007
  3. ncbi Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling
    Randall C Starling
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland, OH, USA
    Am J Transplant 4:2126-31. 2004
  4. ncbi Partial left ventriculectomy: sunrise or sunset?
    R C Starling
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, OH 44195, USA
    Eur J Heart Fail 1:313-7. 1999
  5. doi Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circul
    Randall C Starling
    Heart Failure and Cardiac Transplant Medicine, Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 57:1890-8. 2011
  6. ncbi Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observations
    R C Starling
    George M and Linda H Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 36:2098-103. 2000
  7. ncbi Systemic activation of integrin alphaVbeta3 in donors with spontaneous intracerebral hemorrhage is associated with subsequent development of vasculopathy in the heart transplant recipient
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio, USA
    J Heart Lung Transplant 24:1014-8. 2005
  8. ncbi The effect of combined Angiotensin-converting enzyme inhibition and calcium antagonism on allograft coronary vasculopathy validated by intravascular ultrasound
    Kursad Erinc
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH 44195, USA
    J Heart Lung Transplant 24:1033-8. 2005
  9. ncbi Angiotensin II receptors from peritransplantation through first-year post-transplantation and the risk of transplant coronary artery disease
    Mohammed Yousufuddin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 4195, USA
    J Am Coll Cardiol 43:1565-73. 2004
  10. doi Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009

Detail Information

Publications120 found, 100 shown here

  1. doi Advanced heart failure: transplantation, LVADs, and beyond
    Randall C Starling
    FACC, Kaufman Center for Heart Failure, Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 80:33-40. 2013
    ..Current mechanical circulatory assist devices improve quality of life in patients who are candidates...
  2. ncbi Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial
    Randall C Starling
    The Cleveland Clinic, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 84:1236-42. 2007
    ..However, long-term effects in patients with heart failure have not been reported...
  3. ncbi Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling
    Randall C Starling
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland, OH, USA
    Am J Transplant 4:2126-31. 2004
    ..5 mg/day, showed that the simulated BPAR rate (with TDM) was 21% versus 26% in the group with fixed dosing. Therefore, TDM in heart transplantation could optimize immunosuppressive efficacy and reduce treatment-related toxicity...
  4. ncbi Partial left ventriculectomy: sunrise or sunset?
    R C Starling
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, OH 44195, USA
    Eur J Heart Fail 1:313-7. 1999
    ..PLV does not yield outcomes equivalent to cardiac transplantation based on current selection criteria and requires further investigation to determine its role in the treatment of advanced heart failure...
  5. doi Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circul
    Randall C Starling
    Heart Failure and Cardiac Transplant Medicine, Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 57:1890-8. 2011
    ....
  6. ncbi Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observations
    R C Starling
    George M and Linda H Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 36:2098-103. 2000
    ..The study was done to prospectively measure the echocardiographic, hemodynamic and clinical outcomes after partial left ventriculectomy (PLV)...
  7. ncbi Systemic activation of integrin alphaVbeta3 in donors with spontaneous intracerebral hemorrhage is associated with subsequent development of vasculopathy in the heart transplant recipient
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio, USA
    J Heart Lung Transplant 24:1014-8. 2005
    ..We hypothesized that donor ICH is associated with systemic activation of alpha(V)beta3 in the donor before transplantation...
  8. ncbi The effect of combined Angiotensin-converting enzyme inhibition and calcium antagonism on allograft coronary vasculopathy validated by intravascular ultrasound
    Kursad Erinc
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH 44195, USA
    J Heart Lung Transplant 24:1033-8. 2005
    ..We evaluated the efficacy of angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists, and their combined use, on the development of coronary vasculopathy in hypertensive heart transplant recipients...
  9. ncbi Angiotensin II receptors from peritransplantation through first-year post-transplantation and the risk of transplant coronary artery disease
    Mohammed Yousufuddin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 4195, USA
    J Am Coll Cardiol 43:1565-73. 2004
    ..We evaluated whether the angiotensin II (Ang II) receptors from perioperation through one-year post-transplantation predict the transplant coronary artery disease (TCAD) progression...
  10. doi Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance
    Deborah H Kwon
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Heart Fail 11:937-44. 2009
    ....
  11. doi Relation of ventricular-vascular coupling to exercise capacity in ischemic cardiomyopathy: a cardiac multi-modality imaging study
    Raymond C Wong
    Department of Cardiovascular Medicine F15, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Int J Cardiovasc Imaging 26:151-9. 2010
    ..Ventricular-vascular coupling at rest may be a clinically important parameter in predicting exercise capacity in patients with advanced heart failure, and may become an additional target for therapeutic interventions...
  12. ncbi Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of coronary vasculopathy
    Mohamad H Yamani
    Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 22:687-90. 2003
    ..We tested the hypothesis that Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and the subsequent development of coronary vasculopathy...
  13. ncbi Does acute cellular rejection correlate with cardiac allograft vasculopathy?
    Mohamad H Yamani
    Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 23:272-6. 2004
    ..We explored a possible association between acute cellular rejection and the extent of CAV, and we found a potential confounding variable that may obscure such an association...
  14. ncbi Transplant vasculopathy is associated with increased AlloMap gene expression score
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 26:403-6. 2007
    ..2 +/- 3.9 vs 26.1 +/- 6.5, p < 0.001). There was a correlation of AlloMap score with time after transplantation (r = 0.31, p = 0.01). We found transplant vasculopathy to be associated with increased AlloMap score...
  15. ncbi Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts
    Nader M Fahmy
    The Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 75:2044-7. 2003
    ..Potential molecular differences between early and late rejection (grade > or =2) episodes were examined by testing chemokine and receptor-gene expression...
  16. doi Extent of left ventricular scar predicts outcomes in ischemic cardiomyopathy patients with significantly reduced systolic function: a delayed hyperenhancement cardiac magnetic resonance study
    Deborah H Kwon
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JACC Cardiovasc Imaging 2:34-44. 2009
    ....
  17. ncbi HLA sensitization in ventricular assist device recipients: does type of device make a difference?
    Ganesh S Kumpati
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 127:1800-7. 2004
    ....
  18. ncbi Duration of inotropic support after left ventricular assist device implantation: risk factors and impact on outcome
    Soren Schenk
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:447-54. 2006
    ....
  19. ncbi The impact of hypogammaglobulinemia on infection outcome in patients undergoing ventricular assist device implantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 25:820-4. 2006
    ..However, to our knowledge, quantitative immunoglobulin G (IgG) level determination and the impact of hypogammaglobulinemia (HGG) on infections after VAD implantation have not been evaluated before...
  20. ncbi Neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy
    Soren Schenk
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 128:38-43. 2004
    ..We evaluated the neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy...
  21. ncbi A comparative analysis between survivors and nonsurvivors with antibody mediated cardiac allograft rejection
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Surg Res 142:233-8. 2007
    ..The following study was conducted to determine differences between survivors and nonsurvivors who developed post heart transplant AMR...
  22. ncbi Systemic up-regulation of angiotensin II type 1 receptor in cardiac donors with spontaneous intracerebral hemorrhage
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:1097-102. 2004
    ..397, CI = 1.243-15.553, adjusted p = 0.02). This is the first report to describe splenic up-regulation of AT1R in the presence of spontaneous ICH and its association with subsequent development of transplant vasculopathy...
  23. ncbi Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 46:1029-35. 2005
    ..We evaluated chimerism and stromal cell-derived factor-1 (SDF-1) expression in response to peritransplant ischemic injury following human heart transplantation...
  24. ncbi The impact of donor gender on cardiac peri-transplantation ischemia injury
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 24:1741-4. 2005
    ..Cardiac allografts from female donors have been shown to be associated with increased risk of transplant vasculopathy. However, the influence of donor gender on peri-transplantation ischemic injury has not been evaluated...
  25. ncbi Noninvasive assessment of cardiac mechanics and clinical outcome after partial left ventriculectomy
    Randolph M Setser
    Department of Radiology, The Cleveland Clinic Foundation, OH, USA
    Ann Thorac Surg 76:1576-85; discussion 1585-6. 2003
    ..Little is known about its effects on myocardial mechanics and their relation to clinical outcome...
  26. ncbi Acute vascular rejection is associated with up-regulation of vitronectin receptor (alphavbeta3), increased expression of tissue factor, and activation of the extracellular matrix metalloproteinase induction system
    Mohamad H Yamani
    Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 21:983-9. 2002
    ....
  27. ncbi Brain natriuretic peptide levels do not correlate with acute cellular rejection in De Novo orthotopic heart transplant recipients
    James O O'Neill
    Kaufman Centre for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 24:416-20. 2005
    ..The use of brain natriuretic peptide levels as a surrogate marker for cellular rejection remains controversial, with conflicting data...
  28. doi Impact of mitral regurgitation on reverse remodeling and outcome in patients undergoing cardiac resynchronization therapy
    David Verhaert
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Cardiovasc Imaging 5:21-6. 2012
    ..We sought to evaluate the relationship between serial measurements of functional MR and reverse remodeling and outcomes in patients undergoing CRT...
  29. doi Sodium nitroprusside for advanced low-output heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:200-7. 2008
    ..This study was designed to examine the safety and efficacy of sodium nitroprusside (SNP) for patients with acute decompensated heart failure (ADHF) and low-output states...
  30. doi Decay-accelerating factor expression may provide immunoprotection against antibody-mediated cardiac allograft rejection
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 27:357-61. 2008
    ..Thus, we examined the role of DAF in the clinical presentation of antibody-mediated cardiac allograft rejection...
  31. ncbi Influence of different implantation techniques on long-term survival after orthotopic heart transplantation: an echocardiographic study
    Jing Ping Sun
    Department of Cardiology, The Cleveland Clinic Foundation, Norcross, GA 30308, USA
    J Heart Lung Transplant 26:1243-8. 2007
    ..The aim of this study was to compare OHT outcomes when using the bicaval technique vs the biatrial technique...
  32. ncbi Donor spontaneous intracerebral hemorrhage is associated with systemic activation of matrix metalloproteinase-2 and matrix metalloproteinase-9 and subsequent development of coronary vasculopathy in the heart transplant recipient
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 108:1724-8. 2003
    ..We hypothesized that donor intracerebral hemorrhage (ICH) is associated with activation of the metalloproteinases before transplantation that play a key role in the subsequent development of transplant vasculopathy...
  33. ncbi Impact of donor spontaneous intracranial hemorrhage on outcome after heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:257-61. 2004
    ..9%, p=0.0012). There was a trend towards an increased rate of allograft vasculopathy in the ICB group (competing risks adjusted hazard ratio 1.39, 95% CI 0.90-2.13, p = 0.14)...
  34. ncbi Donor or recipient hepatitis B seropositivity is associated with allograft vasculopathy
    Showkat A Haji
    Department of Cardiology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    J Heart Lung Transplant 25:294-7. 2006
    ..The current study hypothesized that hepatitis B (HBV) might be associated with accelerated vasculopathy...
  35. ncbi Ventricular assist devices and aggressive immunosuppression: looking beyond overall survival
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44121, USA
    J Heart Lung Transplant 25:613-8. 2006
    ..We hypothesized that allosensitized VAD patients have higher levels of immunosuppression and thus different morbidity and causes of mortality...
  36. ncbi Contemporary outcomes of outpatients referred for cardiac transplantation evaluation to a tertiary heart failure center: impact of surgical alternatives
    Niall G Mahon
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Card Fail 10:273-8. 2004
    ..We sought to assess current disposition and outcomes of patients recently referred for transplant evaluation to a single high-throughput tertiary referral center...
  37. ncbi Donor hepatitis-C seropositivity is an independent risk factor for the development of accelerated coronary vasculopathy and predicts outcome after cardiac transplantation
    Showkat A Haji
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 23:277-83. 2004
    ..We evaluated the hypothesis that donor HCV seropositivity predicts mortality and the development of coronary vasculopathy in cardiac transplant recipients...
  38. ncbi Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation
    Mohammed Yousufuddin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure and Transplantation, The Cleveland Clinic Foundation, F 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Heart J 25:377-85. 2004
    ..We tested the hypothesis that cardiac angiotensin II (Ang II) receptor gene transcription may predict the development of transplant coronary artery disease (TCAD) following heart transplantation...
  39. ncbi The impact of left ventricular reconstruction on survival in patients with ischemic cardiomyopathy
    James O O'Neill
    Department of Cardiovascular Medicine, Cleveland Clinic, Desk 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Cardiothorac Surg 30:753-9. 2006
    ..This procedure has been performed at the Cleveland Clinic Foundation since 1997. We assessed mortality, functional status, and predictors of outcome in these patients...
  40. ncbi Survival in patients with severe ischemic cardiomyopathy undergoing revascularization versus medical therapy: association with end-systolic volume and viability
    Deborah H Kwon
    Heart and Vascular Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Circulation 126:S3-8. 2012
    ..We sought to determine whether the contribution of viability as myocardial scar burden (SB) to predict revascularization outcomes could be modulated by end-systolic volume index (ESVi)...
  41. ncbi Computerized scoring of histopathology for predicting coronary vasculopathy, validated by intravascular ultrasound
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Ohio 44195, USA
    J Heart Lung Transplant 21:850-9. 2002
    ..Allograft coronary vasculopathy results from a complex interplay between immunologic and non-immunologic factors. We devised a computerized biopsy scoring method based on histopathology to predict the development of coronary vasculopathy...
  42. ncbi Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation
    E Murat Tuzcu
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 45:1538-42. 2005
    ..The aim of this study was to determine whether angiographically silent early coronary intimal thickening could predict long-term morbidity and mortality...
  43. ncbi Bench repair of donor aortic valve with minimal access orthotopic heart transplantation
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 80:313-5. 2005
    ..The postoperative period was uneventful. Follow-up at 4.5 years showed good results and no evidence of aortic regurgitation...
  44. ncbi Regional referral system for patients with acute mechanical support: experience at the Cleveland Clinic Foundation
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    ASAIO J 52:445-9. 2006
    ..Furthermore, there is a survival advantage when using long-term devices because this allows possible recovery or transplantation...
  45. doi Bridge to transplant experience: factors influencing survival to and after cardiac transplant
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 139:1295-305, 1305.e1-4. 2010
    ..Therefore, we investigated the complex interplay of duration of mechanical circulatory support and patient and device factors affecting survival on support, as well as survival after transplantation...
  46. doi Relation of mechanical dyssynchrony with underlying cardiac structure and performance in chronic systolic heart failure: implications on clinical response to cardiac resynchronization
    Wai Hong Wilson Tang
    Department of Cardiovascular Medicine, Section of Heart Failure and Cardiac Transplantation Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Europace 10:1370-4. 2008
    ..The aim of this study is to describe the relationship between ventricular mechanical dyssynchrony (VMD) and echocardiographic indices of cardiac remodelling...
  47. ncbi The effect of a donor's history of active substance on outcomes following orthotopic heart transplantation
    Kenneth J Shea
    Case Western Reserve School of Medicine, Cleveland, OH, United States
    Eur J Cardiothorac Surg 31:452-6; discussion 456. 2007
    ..To review the short-term and long-term outcomes of using heart donors with a history of substance abuse...
  48. ncbi Non-invasive evaluation of orthotopic heart transplant rejection by echocardiography
    Jing Ping Sun
    Cardiovascular Imaging Center and Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Heart Lung Transplant 24:160-5. 2005
    ..The purpose of this study was to identify demographic and echocardiographic factors associated with transplant rejection and develop a predictive model, which may reduce the number of cardiac biopsies...
  49. ncbi Survival is not compromised in donor hearts with echocardiographic abnormalities
    Nikolai Sopko
    Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    J Surg Res 143:141-4. 2007
    ..To determine the effect of heart donors with echocardiographic abnormalities on short and long-term outcomes on heart transplant recipients...
  50. ncbi Tissue synchronization imaging and optimal left ventricular pacing site in cardiac resynchronization therapy
    Ross T Murphy
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 97:1615-21. 2006
    ..In conclusion, pacing at the site of maximal mechanical delay was associated with reverse remodeling. Individually tailored LV lead positioning should be considered before CRT...
  51. doi Impact of myocardial function on cystatin C measurements in chronic systolic heart failure
    W H Wilson Tang
    Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Ohio 44195, USA
    J Card Fail 14:394-9. 2008
    ..The influence of myocardial function on plasma levels of cystatin C (CysC), a sensitive marker of renal function, in chronic systolic heart failure (HF) has not been well established...
  52. doi Persistent hemodynamic benefits of cardiac resynchronization therapy with disease progression in advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:600-7. 2009
    ..Our aim was to determine the potential hemodynamic contributions of cardiac resynchronization therapy (CRT) in patients admitted for advanced decompensated heart failure...
  53. ncbi Myocardial ischemic injury after heart transplantation is associated with upregulation of vitronectin receptor (alpha(v)beta3), activation of the matrix metalloproteinase induction system, and subsequent development of coronary vasculopathy
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Circulation 105:1955-61. 2002
    ..Both vitronectin receptor (integrin alpha(v)beta3) and tissue factor play key roles in vascular endothelial cell injury. Matrix metalloproteinases (MMPs) are activated in ischemic injury models...
  54. ncbi Residual high incidence of ventricular arrhythmias after left ventricular reconstructive surgery
    James O O'Neill
    Department of Cardiovascular Medicine, Section of Heart Failure and Cardiac Transplant Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 130:1250-6. 2005
    ....
  55. pmc Prognostic role of pulmonary arterial capacitance in advanced heart failure
    Matthias Dupont
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circ Heart Fail 5:778-85. 2012
    ..We examined the determinants, prognostic role, and response to treatment of pulmonary arterial capacitance (PAC, ratio of stroke volume over pulmonary pulse pressure), in relation to pulmonary vascular resistance (PVR) in heart failure...
  56. ncbi Coronary angiography for follow-up of heart transplant recipients: insights from TIMI frame count and TIMI myocardial perfusion grade
    Nezihi Baris
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 26:593-7. 2007
    ....
  57. ncbi Importance of treadmill exercise time as an initial prognostic screening tool in patients with systolic left ventricular dysfunction
    Eileen Hsich
    Department of Cardiovascular Medicine, Cleveland Clinic and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circulation 119:3189-97. 2009
    ..We sought to determine whether treadmill exercise time may be of value as an initial prognostic screening tool in ambulatory patients with impaired systolic function who are referred for cardiopulmonary exercise testing...
  58. ncbi Risks and outcomes of acute kidney injury requiring dialysis after cardiac transplantation
    Janet M Boyle
    Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Kidney Dis 48:787-96. 2006
    ..Risk factors for postoperative acute kidney injury (AKI) are well described in nontransplantation settings. Data regarding risks and consequences of AKI after cardiac transplantation are unclear...
  59. ncbi Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection
    Mohamad H Yamani
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 25:1283-9. 2006
    ..We hypothesized that recurrent acute rejection is associated with increased gene expression of AGTR1 in human heart transplantation...
  60. doi Prognostic evaluation of ambulatory patients with advanced heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 101:1297-302. 2008
    ..0001). In conclusion, in ambulatory patients with advanced HF, hemodynamic and renal function assessments remain strong independent predictors of all-cause mortality...
  61. doi Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function?
    Wilfried Mullens
    Section of Heart Failure and Cardiac Transplantation, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 51:300-6. 2008
    ..This study sought to determine whether changes in intra-abdominal pressure (IAP) with aggressive diuretic or vasodilator therapy are associated with improvement in renal function in acute decompensated heart failure (ADHF)...
  62. doi Prognosis of patients removed from a transplant waiting list for medical improvement: implications for organ allocation and transplantation for status 2 patients
    Katherine J Hoercher
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 135:1159-66. 2008
    ....
  63. ncbi Sustained apoptosis in human cardiac allografts despite histologic resolution of rejection
    Sofia C Masri
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 76:859-64. 2003
    ..We investigated the occurrence of apoptosis during and after resolution of cardiac allograft rejection. Apoptosis could play different roles in graft survival depending on the target cells; thus, we also determined the cell types involved...
  64. pmc Importance of venous congestion for worsening of renal function in advanced decompensated heart failure
    Wilfried Mullens
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 53:589-96. 2009
    ..To determine whether venous congestion, rather than impairment of cardiac output, is primarily associated with the development of worsening renal function (WRF) in patients with advanced decompensated heart failure (ADHF)...
  65. ncbi Severe renal dysfunction complicating cardiogenic shock is not a contraindication to mechanical support as a bridge to cardiac transplantation
    Umesh N Khot
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Coll Cardiol 41:381-5. 2003
    ..This study investigated outcomes in patients with cardiogenic shock and severe renal dysfunction treated with ventricular assist devices (VAD) as a bridge to cardiac transplantation...
  66. ncbi Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants
    Nader M Fahmy
    The Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Transplantation 75:72-8. 2003
    ....
  67. doi Long-term reverse remodeling with cardiac resynchronization therapy: results of extended echocardiographic follow-up
    David Verhaert
    Department of Cardiovascular Medicine, Section of Cardiac Imaging, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Coll Cardiol 55:1788-95. 2010
    ..The purpose of this study was to describe the long-term course of left ventricular remodeling induced by cardiac resynchronization therapy (CRT), adjusting for the confounding effect of patient loss due to disease...
  68. ncbi Partial left ventriculectomy for dilated cardiomyopathy: is this an alternative to transplantation?
    A Franco-Cereceda
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Thorac Cardiovasc Surg 121:879-93. 2001
    ..To determine the late effectiveness of partial left ventriculectomy and risk factors for failure...
  69. pmc Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury
    Karen Keslar
    Department of Immunology, The Cleveland Clinic, Cleveland, OH, USA
    Transplantation 86:1319-21. 2008
    ....
  70. ncbi Cardiac allograft vasculopathy: an update
    Ilke Sipahi
    Kaufman Center for Heart Failure, Cleveland, OH 44195, USA
    Heart Fail Clin 3:87-95. 2007
    ..A better understanding of CAV is needed to develop targeted preventive therapies. Ongoing research in native atherosclerosis and vascular biology may provide answers within the next decade...
  71. pmc Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
    Sathyamangla V Naga Prasad
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:27487-99. 2009
    ..Importantly, using network analysis we have identified a limited number of key functional targets that may regulate expression of the myriad proteins in heart failure and could be potential therapeutic targets...
  72. doi Application of the Seattle Heart Failure Model in ambulatory patients presented to an advanced heart failure therapeutics committee
    Eiran Z Gorodeski
    Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Heart Fail 3:706-14. 2010
    ..We sought to assess the predictive value of the Seattle Heart Failure Model (SHFM) when applied to ambulatory patients with advanced heart failure (HF) presented to an advanced HF therapeutics committee at a tertiary care US institution...
  73. doi Management of left ventricular assist devices after surgery: bridge, destination, and recovery
    Maria M Mountis
    Department of Medicine, Heart and Vascular Institute, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Curr Opin Cardiol 24:252-6. 2009
    ..The purpose of this review is to discuss the perioperative and long-term management of MCS patients...
  74. pmc An emerging population: kidney transplant candidates who are placed on the waiting list after liver, heart, and lung transplantation
    Titte R Srinivas
    Department of Nephrology and Hypertension, Glickman Urologic and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue Q7, Cleveland, OH 44195, USA
    Clin J Am Soc Nephrol 5:1881-6. 2010
    ..ESRD has an adverse impact on patients who have had previous nonrenal solid-organ transplants (NRTxs; liver, heart, lung) and may be referred for a kidney transplant (KTx)...
  75. doi Outcomes associated with nesiritide administration for acute decompensated heart failure in the emergency department observation unit: a single center experience
    Joseph F Styron
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Congest Heart Fail 15:103-7. 2009
    ..The use of nesiritide for acute decompensated heart failure in the emergency department observation unit is not associated with mortality or readmission differences compared with standard therapy alone...
  76. ncbi Long-term prognostic value of peak oxygen consumption in women versus men with heart failure and severely impaired left ventricular systolic function
    Eileen Hsich
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 100:291-5. 2007
    ..In conclusion, in this large cohort, peak VO(2) predicted survival in women and men whether or not coronary artery disease was present, but an interaction was noted between coronary artery, gender, and survival...
  77. ncbi Long-term outcomes and clinical predictors for pacing after cardiac transplantation
    Daniel J Cantillon
    Department of Cardiovascular Medicine, Cleveland Clinic, Sydell and Arnold Miller Family Heart and Vascular Institute, Cleveland, OH 44195, USA
    J Heart Lung Transplant 28:791-8. 2009
    ..This study evaluated the predictors for PPM requirement, long-term outcomes, and influence of implant timing and device programming on prognosis after cardiac transplant...
  78. ncbi The role of vitronectin receptor (alphavbeta3) and tissue factor in the pathogenesis of transplant coronary vasculopathy
    Mohamad H Yamani
    Department of Cardiology, Learner Research Institute, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 39:804-10. 2002
    ..This study was undertaken to test the hypothesis that transplant coronary vasculopathy (CV) is associated with increased myocardial protein expression of both tissue factor (TF) and integrin alphavbeta3...
  79. ncbi Acute cellular rejection following human heart transplantation is associated with increased expression of vitronectin receptor (integrin alphavbeta3)
    Mohamad H Yamani
    Department of Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Am J Transplant 2:129-33. 2002
    ..Acute cellular rejection, a process characterized by T-lymphocyte activation and release of inflammatory cytokines, is associated with increased expression of alphavbeta3...
  80. ncbi Tricuspid valve repair for biopsy-induced regurgitation in a heart transplant recipient
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Desk F 25, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Heart Valve Dis 14:264-7. 2005
    ..At a four-years post-transplant evaluation, she was in NYHA functional class I, with preserved ventricular function and trivial TR. She has been followed closely because of post-transplant coronary artery disease...
  81. ncbi The impact of CytoGam on cardiac transplant recipients with moderate hypogammaglobulinemia: a randomized single-center study
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Heart Lung Transplant 24:1766-9. 2005
    ..However, the impact of Ig replacement in moderately hypogammaglobulinemic patients is unknown...
  82. ncbi Minimally invasive left ventricular epicardial lead placement: surgical techniques for heart failure resynchronization therapy
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Ann Thorac Surg 79:1536-44; discussion 1536-44. 2005
    ..This study aims to determine perioperative and early postoperative outcome of minimally invasive left ventricular lead placement as a management strategy for heart failure, comparing minithoracotomy and endoscopic approaches...
  83. ncbi Increased beta-myosin heavy chain in acute cellular rejection following human heart transplantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, OH, USA
    Am J Transplant 2:386-8. 2002
    ..However, altered expression of beta-myosin heavy chain in human cardiac rejection has not been determined...
  84. ncbi Persistent abnormal left ventricular systolic torsion in dilated cardiomyopathy after partial left ventriculectomy
    Randolph M Setser
    Department of Radiology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Thorac Cardiovasc Surg 126:48-55. 2003
    ....
  85. ncbi Heart transplantation: a magnified model of heart-brain interactions
    Mohamad H Yamani
    Section of Heart Failure and Cardiac Transplant Medicine, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 74:S110-3. 2007
    ....
  86. ncbi Worldwide clinical experience with the CorCap Cardiac Support Device
    Randall C Starling
    Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Card Fail 10:S225-33. 2004
    ..The Acorn CorCap CSD received CE mark approval in Europe in 2001 and has been available to a small number of centers in a Limited Market Release Surveillance Study (LMRSS)...
  87. ncbi Management of acute decompensated heart failure in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail . 2003
    ....
  88. ncbi Myocardial ischemic-fibrotic injury after human heart transplantation is associated with increased progression of vasculopathy, decreased cellular rejection and poor long-term outcome
    Mohamad H Yamani
    Department of Cardiology, Kaufman Heart Failure Center, Cleveland, Ohio, USA
    J Am Coll Cardiol 39:970-7. 2002
    ..We sought to assess the influence of peritransplant ischemia and fibrosis on the development of allograft vasculopathy, acute cellular rejection and long-term outcome...
  89. ncbi Permanent mechanical circulatory support with an implantable left ventricular assist device
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195, USA
    Ann Thorac Surg 63:1458-61. 1997
    ..He was discharged from the hospital 13 days after the operation, and 5 months postoperatively he had returned to New York Heart Association functional class II...
  90. ncbi Hypogammaglobulinemia after heart transplantation: impact of pre-emptive use of immunoglobulin replacement (CytoGam) on infection and rejection outcomes
    M H Yamani
    Departament of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Transpl Infect Dis 3:40-3. 2001
    ..001) and episodes of rejection (grade > or = 3; P = 0.03 and grade > or = 2; P = 0.04) compared with the control group...
  91. ncbi Surgical therapy for dilated cardiomyopathy
    R C Starling
    Section of Heart Failure and Cardiac Transplant Medicine, George M and Linda H Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio, USA
    Cardiol Clin 16:727-37. 1998
    ..Randomized, prospective controlled studies assessing LVAD therapy and cardiomyoplasty are in progress...
  92. ncbi Comparison of dobutamine-based and milrinone-based therapy for advanced decompensated congestive heart failure: Hemodynamic efficacy, clinical outcome, and economic impact
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 142:998-1002. 2001
    ..We sought to compare the clinical outcome and economic cost of dobutamine-based and milrinone-based therapy in patients with acute exacerbation of CHF...
  93. ncbi Hypogammaglobulinemia following cardiac transplantation: a link between rejection and infection
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Heart Lung Transplant 20:425-30. 2001
    ..IgG level may be a useful marker for identifying patients at high risk...
  94. doi The effect of recipient hepatitis C virus infection on outcomes following heart transplantation
    A E Shafii
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Transplant Proc 42:1784-7. 2010
    ..Insufficient data exist on the clinical course of hepatitis C virus (HCV) infection in heart transplant (HT) recipients. Our study reports the outcomes of heart transplantation in pretransplantation HCV-positive (HCV+) recipients...
  95. ncbi Cellular rejection and rate of progression of transplant vasculopathy: a 3-year serial intravascular ultrasound study
    J Jimenez
    Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Heart Lung Transplant 20:393-8. 2001
    ..However, de novo lesions continue to develop every year. In patients with evidence of rejection, the rate of progression of transplant vasculopathy correlates with the severity of rejection...
  96. ncbi Left ventricular reduction surgery with mitral valve repair
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S64-7. 2000
    ..The earliest "learning curve" experience with this relatively unstudied operation warrants careful investigation. Many questions remain to be answered, but many patients have demonstrated early subjective and objective improvement...
  97. ncbi Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion
    K Fukamachi
    Department of Biomedical Engineering, The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 68:2181-4. 1999
    ..Implantable left ventricular assist device (LVAD) insertion complicated by early right ventricular (RV) failure has a poor prognosis and is generally unpredictable...
  98. ncbi Early and late rejection and HLA sensitization at the time of heart transplantation in patients bridged with left ventricular assist devices
    G V Gonzalez-Stawinski
    Department of Thoracic Surgery, Kaufman Center for Heart Failure and The Transplant Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplant Proc 37:1349-51. 2005
    ....
  99. ncbi Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: evidence from intravascular ultrasound
    M H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplant Proc 36:2564-6. 2004
    ..We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations...
  100. ncbi Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology?
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Heart Lung Transplant 19:1077-80. 2000
    ..A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate...
  101. ncbi Post-transplant ischemic injury is associated with up-regulated AlloMap gene expression
    M H Yamani
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Clin Transplant 21:523-5. 2007
    ..The AlloMap gene expression test is used for the non-invasive detection of rejection. However, the impact of early post-transplant ischemic injury on subsequent AlloMap gene expression analysis has not been evaluated before...