G R Stark

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi How cells respond to interferons
    G R Stark
    Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Annu Rev Biochem 67:227-64. 1998
  2. ncbi Forward genetics in mammalian cells: functional approaches to gene discovery
    G R Stark
    Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Hum Mol Genet 8:1925-38. 1999
  3. ncbi Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
    H Nguyen
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:33361-8. 2001
  4. ncbi Association of STATs with relatives and friends
    M Chatterjee-Kishore
    Dept of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Trends Cell Biol 10:106-11. 2000
  5. ncbi Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1
    M Chatterjee-Kishore
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44145, USA
    J Biol Chem 275:20406-11. 2000
  6. ncbi Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
    X Li
    Department of Molecular Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Cell Biol 17:2048-56. 1997
  7. ncbi Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha
    M R Rani
    Department of Neurosciences, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 271:22878-84. 1996
  8. ncbi Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1
    S J Haque
    Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 94:8563-8. 1997
  9. ncbi Stat1-independent regulation of gene expression in response to IFN-gamma
    C V Ramana
    Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 98:6674-9. 2001
  10. ncbi Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha
    X Li
    Department of Molecular Biology, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 271:5790-4. 1996

Collaborators

  • S J Haque
  • J M Smith
  • Q Wu
  • A Agarwal
  • J E Darnell
  • X Li
  • C V Ramana
  • M Chatterjee-Kishore
  • M R Rani
  • W R Taylor
  • N Sizemore
  • R M Ransohoff
  • H Nguyen
  • M L Agarwal
  • E B Albrecht
  • F van den Akker
  • S Leung
  • J Bayes
  • A R Asthagiri
  • M Hamilton
  • Y Han
  • A H Schonthal
  • S S Sathe
  • A Singh
  • M P Gil
  • J D DiDonato
  • A Wolfman
  • R D Schreiber
  • S E DePrimo
  • J Galante
  • M K Agarwal
  • L J Bean
  • A B Hunyady
  • T E Patterson
  • D Leaman
  • G R Foster

Detail Information

Publications16

  1. ncbi How cells respond to interferons
    G R Stark
    Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Annu Rev Biochem 67:227-64. 1998
    ....
  2. ncbi Forward genetics in mammalian cells: functional approaches to gene discovery
    G R Stark
    Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Hum Mol Genet 8:1925-38. 1999
    ..Here we review a broad range of techniques that have been used to alter gene expression randomly in mammalian cells, with examples of specific discoveries that have resulted from these applications of forward genetics...
  3. ncbi Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
    H Nguyen
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:33361-8. 2001
    ....
  4. ncbi Association of STATs with relatives and friends
    M Chatterjee-Kishore
    Dept of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Trends Cell Biol 10:106-11. 2000
    ..This review explores the diverse protein-protein interactions that underlie the multiple functions of the STATs...
  5. ncbi Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1
    M Chatterjee-Kishore
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44145, USA
    J Biol Chem 275:20406-11. 2000
    ..E1A interferes with the formation of this complex by occupying domains of Stat1 that bind to IRF1. These results reveal how adenovirus infection attenuates LMP2 expression, thereby interfering with the presentation of viral antigens...
  6. ncbi Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
    X Li
    Department of Molecular Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Cell Biol 17:2048-56. 1997
    ..Upon activation, the IFNAR1 subunit is phosphorylated on Tyr-466, allowing the SH2 domain of STAT2 to bind to it; this is followed by the sequential phosphorylation of STAT2 and STAT1...
  7. ncbi Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha
    M R Rani
    Department of Neurosciences, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 271:22878-84. 1996
    ....
  8. ncbi Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1
    S J Haque
    Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 94:8563-8. 1997
    ..Inhibition or deletion of PTP activity results in constitutive activation of cytokine signaling pathways...
  9. ncbi Stat1-independent regulation of gene expression in response to IFN-gamma
    C V Ramana
    Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 98:6674-9. 2001
    ....
  10. ncbi Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha
    X Li
    Department of Molecular Biology, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 271:5790-4. 1996
    ..Deletion analysis reveals that the C-terminal domain of STAT2 is important for transcriptional activation mediated by both STAT1-STAT2 heterodimers and ISGF3...
  11. ncbi A role for NF-kappa B in the induction of beta-R1 by interferon-beta
    M R Rani
    Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:44365-8. 2001
    ..These results provide a novel insight into the role of NF-kappaB in the transcriptional response to IFN-beta...
  12. ncbi Act1, an NF-kappa B-activating protein
    X Li
    Departments of Immunology and Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 97:10489-93. 2000
    ..Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling...
  13. ncbi p130/E2F4 binds to and represses the cdc2 promoter in response to p53
    W R Taylor
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:1998-2006. 2001
    ..These observations suggest that p53 represses the cdc2 promoter by inducing p21/waf1, which inhibits cyclin-dependent kinase activity, enhancing the binding of p130 and E2F4, which together bind to and repress the cdc2 promoter...
  14. ncbi Regulation of p53 expression by the RAS-MAP kinase pathway
    M L Agarwal
    Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, OH 44195, USA
    Oncogene 20:2527-36. 2001
    ..We conclude that MAP kinase-dependent pathways help to regulate p53 levels by regulating the expression of p53 mRNA...
  15. ncbi Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
    N Sizemore
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Cell Biol 19:4798-805. 1999
    ..Therefore, IL-1 stimulates the PI3K-dependent phosphorylation and transactivation of NF-kappaB, a process quite distinct from the liberation of NF-kappaB from its cytoplasmic inhibitor IkappaB...
  16. ncbi Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe
    E B Albrecht
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Biol Cell 11:873-86. 2000
    ..In the case of the 225-kb amplicon, the breaks may lead to a hairpin structure, which is then replicated to form a double-stranded linear amplicon, or to a cruciform structure, which is then resolved to yield the same amplicon...