Jonathan Smith

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Expression of the carrier protein apolipoprotein D in the mouse inner ear
    Michael S Hildebrand
    Department of Gene Identification and Expression, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hear Res 200:102-14. 2005
  2. ncbi request reprint Drug library screen to identify compounds that decrease secreted Abeta from a human cell line
    Enakshi Chakrabarti
    Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Curr Alzheimer Res 2:255-9. 2005
  3. ncbi request reprint Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities
    Dao Quan Peng
    Department of Cell Biology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:33775-84. 2005
  4. ncbi request reprint Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan
    Jonathan D Smith
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 26:597-603. 2006
  5. ncbi request reprint Quantitative trait locus mapping for atherosclerosis susceptibility
    Jonathan Smith
    Department of Cell Biology, The Clevelanf Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Opin Lipidol 14:499-504. 2003
  6. ncbi request reprint In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice
    Jonathan D Smith
    Rockefeller University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:117-22. 2003
  7. ncbi request reprint Drug discovery: estrogen-related compounds in mouse models of Alzheimer's disease
    Jonathan D Smith
    Department of Cell Biology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Neurosci 24:145-7. 2004
  8. ncbi request reprint ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I
    Jonathan D Smith
    Department of Cell Biology NC10, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Lipid Res 45:635-44. 2004
  9. ncbi request reprint Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice
    Jonathan D Smith
    Department of Cell Biology, Cleveland Clinic Foundation, Ohio, 44195, USA
    Mamm Genome 17:220-9. 2006
  10. ncbi request reprint Apolipoprotein A-I lysine modification: effects on helical content, lipid binding and cholesterol acceptor activity
    Gregory Brubaker
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1761:64-72. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Expression of the carrier protein apolipoprotein D in the mouse inner ear
    Michael S Hildebrand
    Department of Gene Identification and Expression, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hear Res 200:102-14. 2005
    ..The mouse was found to have a hearing threshold that was not significantly different to the control strain...
  2. ncbi request reprint Drug library screen to identify compounds that decrease secreted Abeta from a human cell line
    Enakshi Chakrabarti
    Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Curr Alzheimer Res 2:255-9. 2005
    ....
  3. ncbi request reprint Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities
    Dao Quan Peng
    Department of Cell Biology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:33775-84. 2005
    ..Thus, tyrosine modification of apoAI is not required for its MPO-mediated inhibition of cholesterol acceptor activity...
  4. ncbi request reprint Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan
    Jonathan D Smith
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 26:597-603. 2006
    ..This study aimed to determine the genetic regions associated with strain effects on lesion area...
  5. ncbi request reprint Quantitative trait locus mapping for atherosclerosis susceptibility
    Jonathan Smith
    Department of Cell Biology, The Clevelanf Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Opin Lipidol 14:499-504. 2003
    ..This review describes an unbiased genetic mapping method called quantitative trait locus mapping and progress in using this method to identify genes that alter atherosclerosis susceptibility in mice...
  6. ncbi request reprint In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice
    Jonathan D Smith
    Rockefeller University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:117-22. 2003
    ....
  7. ncbi request reprint Drug discovery: estrogen-related compounds in mouse models of Alzheimer's disease
    Jonathan D Smith
    Department of Cell Biology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Neurosci 24:145-7. 2004
    ..In this position paper, we review these data, along with our own--using estrogens in a transgenic mouse model of AD--and introduce our current working hypothesis and research...
  8. ncbi request reprint ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I
    Jonathan D Smith
    Department of Cell Biology NC10, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Lipid Res 45:635-44. 2004
    ..Finally, we could not reproduce a two-step effect on lipid efflux using conditioned medium from ABCA1-expressing cells pretreated with cyclodextrin...
  9. ncbi request reprint Transcriptome profile of macrophages from atherosclerosis-sensitive and atherosclerosis-resistant mice
    Jonathan D Smith
    Department of Cell Biology, Cleveland Clinic Foundation, Ohio, 44195, USA
    Mamm Genome 17:220-9. 2006
    ..The combination of this expression profiling data with the genetic method of quantitative trait locus mapping should give powerful insights into the genes that affect atherosclerosis susceptibility in mice...
  10. ncbi request reprint Apolipoprotein A-I lysine modification: effects on helical content, lipid binding and cholesterol acceptor activity
    Gregory Brubaker
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1761:64-72. 2006
    ....
  11. ncbi request reprint Identification of the cAMP-responsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements
    Wilfried Le Goff
    Dept of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 26:527-33. 2006
    ..To determine the mechanism by which expression of the murine ABCA1 gene is highly induced by cAMP analogues...
  12. ncbi request reprint Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux
    Jonathan D Smith
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:17797-803. 2002
    ..Although ABCA1 induction was associated with a small increase in cell surface PS, these results argue against the notion that this cell surface PS is sufficient to mediate cellular apoAI binding and lipid efflux...
  13. ncbi request reprint Identification of atherosclerosis-modifying genes: pathogenic insights and therapeutic potential
    Jonathan D Smith
    Cleveland Clinic Lerner College of Medicine, Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Expert Rev Cardiovasc Ther 4:703-9. 2006
    ..This review will summarize the methods and results thus far in the identification of atherosclerosis-modifier genes...
  14. ncbi request reprint Decreased atherosclerosis in mice deficient in tumor necrosis factor-alpha receptor-II (p75)
    Unni M Chandrasekharan
    Arterioscler Thromb Vasc Biol 27:e16-7. 2007
  15. pmc Large disk intermediate precedes formation of apolipoprotein A-I-dimyristoylphosphatidylcholine small disks
    Keng Zhu
    Department of Cell Biology, Cleveland Clinic, Ohio 44195, USA
    Biochemistry 46:6299-307. 2007
    ..Thus, the formation of small apoA-I lipid disks proceeds through the formation of a large disk intermediate...
  16. ncbi request reprint Direct electrochemical evaluation of plasma membrane cholesterol in live mammalian cells
    Dechen Jiang
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Am Chem Soc 129:11352-3. 2007
  17. pmc Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
    Zhenglong Wang
    Program for Vascular Biology and Therapeutics and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    J Clin Invest 118:195-204. 2008
    ..These results demonstrate what we believe to be a novel role for PLC activity in promoting macrophage survival in atherosclerotic plaques and identify PLC beta3 as a potential target for treatment of atherosclerosis...
  18. pmc Sex specific gene regulation and expression QTLs in mouse macrophages from a strain intercross
    Jeffrey M Bhasin
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 3:e1435. 2008
    ..A powerful way to identify genes for complex traits it to combine genetic and genomic methods. Many trait quantitative trait loci (QTLs) for complex traits are sex specific, but the reason for this is not well understood...
  19. pmc ApoE promotes the proteolytic degradation of Abeta
    Qingguang Jiang
    Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Neuron 58:681-93. 2008
    ..GW3965 treatment also reversed contextual memory deficits. These data demonstrate a mechanism through which ApoE facilitates the clearance of Abeta from the brain and suggest that LXR agonists may represent a novel therapy for AD...
  20. pmc Apolipoprotein A-I tryptophan substitution leads to resistance to myeloperoxidase-mediated loss of function
    Dao Quan Peng
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 28:2063-70. 2008
    ..We tried to determine which residues mediated this inactivation and create an oxidant-resistant apoAI variant...
  21. ncbi request reprint Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages
    Lemin Zheng
    Department of Cell Biology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 280:38-47. 2005
    ....
  22. pmc A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse
    Hayes M Dansky
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021, USA
    Genetics 160:1599-608. 2002
    ..In summary, two independently performed crosses between C57BL/6 and FVB/N Apoe-deficient mice have revealed several previously unreported atherosclerosis susceptibility loci that are distinct from loci linked to lipoprotein levels...
  23. ncbi request reprint Ovariectomy of young mutant amyloid precursor protein transgenic mice leads to increased mortality
    Justine A Levin-Allerhand
    The Rockefeller University, New York, NY 10021, USA
    J Mol Neurosci 19:163-6. 2002
    ..Previous studies have demonstrated increased mortality in mice overexpressing mutant or wildtype APP independent of A beta accumulation; thus, estrogen withdrawal may potentiate this phenotype associated with APP overexpression...
  24. pmc Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro
    Zhongmin Zhou
    Laboratory of Alzheimer Research, Department of Neurology and Neuroscience, Cornell University Medical College, New York, USA
    Mol Med 8:376-81. 2002
    ....
  25. ncbi request reprint 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice
    Justine A Levin-Allerhand
    The Rockefeller University, New York, NY, USA
    J Alzheimers Dis 4:449-57. 2002
    ..The increased efficacy of 17alpha-estradiol versus 17beta-estradiol may help to develop safe and effective therapeutics...
  26. ncbi request reprint Confirmation of the microsomal triglyceride transfer protein genetic effect on lipids in young African American men from the CARDIA study
    Suh Hang Hank Juo
    Arterioscler Thromb Vasc Biol 23:912-3. 2003
  27. pmc Supervised principal component analysis for gene set enrichment of microarray data with continuous or survival outcomes
    Xi Chen
    Department of Quantitative Health Sciences, The Cleveland Clinic, 9500 Euclid Ave Cleveland, OH 44195, USA
    Bioinformatics 24:2474-81. 2008
    ..PCA is an effective method for reducing high dimensionality and capture variations in gene expression values. However, one limitation with PCA is that the latent variable identified by the first PC may be unrelated to outcome...
  28. ncbi request reprint Potential use of estrogen-like drugs for the prevention of Alzheimer's disease
    Jonathan D Smith
    Department of Cell Biology, NC10, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Neurosci 20:277-81. 2003
    ..It is not known whether this combination of hormones or the late age at which the therapy was administered was responsible for the adverse outcome...
  29. ncbi request reprint Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I
    Wilfried Le Goff
    Department of Cell Biology NC10, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 24:2155-61. 2004
    ..In this study, we analyzed the effect of the immunosuppressant cyclosporin A on the ABCA1-mediated lipid effluxes reactions...
  30. ncbi request reprint Identification of a novel enhancer of brain expression near the apoE gene cluster by comparative genomics
    Ping Zheng
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Biochim Biophys Acta 1676:41-50. 2004
    ..These studies demonstrate that comparative sequence analysis is a successful strategy to predict candidate regulatory regions in vivo, although they do not imply that this element controls apoE expression physiologically...
  31. ncbi request reprint Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits
    Jun Yao
    Department of Psychiatry, New York University, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 90:1011-8. 2004
    ....
  32. pmc Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
    Lemin Zheng
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Invest 114:529-41. 2004
    ..They also suggest a potential mechanism for MPO-dependent generation of a proatherogenic dysfunctional form of HDL in vivo...
  33. ncbi request reprint Insight into ABCG1-mediated cholesterol efflux
    Jonathan D Smith
    Arterioscler Thromb Vasc Biol 26:1198-200. 2006
  34. ncbi request reprint Apolipoproteins and aging: emerging mechanisms
    Jonathan D Smith
    Lab Biochem Gen and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Ageing Res Rev 1:345-65. 2002
    ..One variant of apoE (E4) is associated with increased risk for heart disease, stroke and Alzheimer's disease (AD). In addition, some of the potential mechanisms for the observed effects of apoE on aging will be discussed...
  35. ncbi request reprint The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor
    Matthew L Brown
    Department of Medicine, Division of Gerontology and Geriatrics, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    J Lipid Res 43:1181-91. 2002
    ....
  36. ncbi request reprint Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis
    Wilfried Le Goff
    Department of Cell Biology NC10, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Lipid Res 47:51-8. 2006
    ....
  37. pmc A novel folding intermediate state for apolipoprotein A-I: role of the amino and carboxy termini
    Eitan Gross
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Biophys J 90:1362-70. 2006
    ..Our findings suggest that the N-terminus of apoAI stabilizes the native state of the protein by increasing the Eyring energy barrier for the N --> I(equil) unfolding transition; whereas the carboxyl terminus destabilizes that state...
  38. pmc Dietary methionine effects on plasma homocysteine and HDL metabolism in mice
    Wanda Velez-Carrasco
    Department of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021, USA
    J Nutr Biochem 19:362-70. 2008
    ..Mice on methionine diets had >20% decreased body weights and decreased HDL-C levels. An HDL turnover study demonstrated that the HDL-C production rate was significantly reduced in mice fed the methionine diet...
  39. ncbi request reprint Safe and effective method for chronic 17beta-estradiol administration to mice
    Justine A Levin-Allerhand
    Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Contemp Top Lab Anim Sci 42:33-5. 2003
    ....
  40. ncbi request reprint Quantitative assay for mouse atherosclerosis in the aortic root
    Julie Baglione
    Department of Cell Biology, The Cleveland Clinic Foundation, OH, USA
    Methods Mol Med 129:83-95. 2006
    ..Here, we provide the detailed methods for the quantitative analysis of mouse aortic root lesion area...