N G Smedira

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Postcardiotomy mechanical support: risk factors and outcomes
    N G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio, USA
    Ann Thorac Surg 71:S60-6; discussion S82-5. 2001
  2. doi request reprint Bridge to transplant experience: factors influencing survival to and after cardiac transplant
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 139:1295-305, 1305.e1-4. 2010
  3. ncbi request reprint Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study
    Nicholas G Smedira
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:686-92. 2006
  4. ncbi request reprint Invited commentary
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Thorac Surg 81:76-7. 2006
  5. ncbi request reprint Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:558-564.e4. 2006
  6. ncbi request reprint Clinical experience with 202 adults receiving extracorporeal membrane oxygenation for cardiac failure: survival at five years
    N G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 122:92-102. 2001
  7. ncbi request reprint Risk factors for death after heart transplantation: does a single-center experience correlate with multicenter registries?
    J F McCarthy
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 65:1574-8; discussion 1578-9. 1998
  8. ncbi request reprint Long-term results of the Carpentier-Edwards pericardial aortic valve: a 12-year follow-up
    M K Banbury
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 66:S73-6. 1998
  9. ncbi request reprint Noninvasive assessment of mitral inertness [correction of inertance]: clinical results with numerical model validation
    M S Firstenberg
    The Cleveland Clinic Foundation, Cleveland, USA
    Comput Cardiol 28:613-6. 2001
  10. ncbi request reprint Left ventricular reduction surgery with mitral valve repair
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S64-7. 2000

Detail Information

Publications92

  1. ncbi request reprint Postcardiotomy mechanical support: risk factors and outcomes
    N G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio, USA
    Ann Thorac Surg 71:S60-6; discussion S82-5. 2001
    ..The need for postcardiotomy mechanical support is uncommon, with an incidence of 0.5%...
  2. doi request reprint Bridge to transplant experience: factors influencing survival to and after cardiac transplant
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 139:1295-305, 1305.e1-4. 2010
    ..Therefore, we investigated the complex interplay of duration of mechanical circulatory support and patient and device factors affecting survival on support, as well as survival after transplantation...
  3. ncbi request reprint Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study
    Nicholas G Smedira
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:686-92. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin in off-pump coronary artery bypass grafting...
  4. ncbi request reprint Invited commentary
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Thorac Surg 81:76-7. 2006
  5. ncbi request reprint Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:558-564.e4. 2006
    ..To compare explantation for structural valve deterioration in nonelderly patients after aortic valve replacement with stented bovine pericardial and cryopreserved allograft valves...
  6. ncbi request reprint Clinical experience with 202 adults receiving extracorporeal membrane oxygenation for cardiac failure: survival at five years
    N G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 122:92-102. 2001
    ....
  7. ncbi request reprint Risk factors for death after heart transplantation: does a single-center experience correlate with multicenter registries?
    J F McCarthy
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 65:1574-8; discussion 1578-9. 1998
    ..This study was performed to (1) evaluate pre-Tx factors affecting mortality in a single-center experience, and (2) compare these factors with risk factors obtained from multicenter registry reports...
  8. ncbi request reprint Long-term results of the Carpentier-Edwards pericardial aortic valve: a 12-year follow-up
    M K Banbury
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 66:S73-6. 1998
    ..Mean age was 64.2+/-10.8 years (range, 22 to 95 years); 190 (61.3%) were men. Isolated valve replacement was performed in 135 patients (43.5%). There were 18 hospital deaths (5.8%), none of them valve related...
  9. ncbi request reprint Noninvasive assessment of mitral inertness [correction of inertance]: clinical results with numerical model validation
    M S Firstenberg
    The Cleveland Clinic Foundation, Cleveland, USA
    Comput Cardiol 28:613-6. 2001
    ..98x - 0.045, r=0.90) and the results of numerical modeling (y=0.96x - 0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography...
  10. ncbi request reprint Left ventricular reduction surgery with mitral valve repair
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S64-7. 2000
    ..The earliest "learning curve" experience with this relatively unstudied operation warrants careful investigation. Many questions remain to be answered, but many patients have demonstrated early subjective and objective improvement...
  11. ncbi request reprint Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitation
    M S Firstenberg
    The Cleveland Clinic Foundation, Cleveland, USA
    Comput Cardiol 28:177-80. 2001
    ..1%), and was best predicted by (r=0.97, p<0.01) %delta(fSV)[correction of fVS]=34[MRa initial] - 46[MRa final] -0.5[elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs...
  12. ncbi request reprint Is anterior leaflet repair always necessary in repair of bileaflet mitral valve prolapse?
    A M Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 68:820-3; discussion 824. 1999
    ..This study was undertaken to evaluate the effectiveness of a strategy of posterior leaflet resection and annuloplasty alone for patients with bileaflet prolapse and no anterior chordal rupture or severe anterior chordal elongation...
  13. ncbi request reprint Color M-mode Doppler flow propagation velocity is a preload insensitive index of left ventricular relaxation: animal and human validation
    M J Garcia
    Cardiovascular Imaging Center, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 35:201-8. 2000
    ..To determine the effect of preload in color M-mode Doppler flow propagation velocity (v(p))...
  14. ncbi request reprint The atherosclerotic aorta at aortic valve replacement: surgical strategies and results
    A M Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Thorac Cardiovasc Surg 120:957-63. 2000
    ..2%) patients had a severely atherosclerotic ascending aorta and required hypothermic circulatory arrest to facilitate aortic valve replacement. They form the study group...
  15. ncbi request reprint Short-term hemodynamic performance of the mitral Carpentier-Edwards PERIMOUNT pericardial valve. Carpentier-Edwards PERIMOUNT Investigators
    M S Firstenberg
    Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 71:S285-8. 2001
    ..Despite known echocardiographic limitations, the PERIMOUNT mitral valves exhibit similar hemodynamics to other prosthetic valves...
  16. ncbi request reprint Mitral inertance in humans: critical factor in Doppler estimation of transvalvular pressure gradients
    S Nakatani
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195
    Am J Physiol Heart Circ Physiol 280:H1340-5. 2001
    ..65, P < 0.0001). Because mitral inertance causes the velocity to lag significantly behind the actual pressure gradient, it needs to be considered when assessing diastolic filling and the pressure difference across normal mitral valves...
  17. doi request reprint Correlation of donor-specific antibodies, complement and its regulators with graft dysfunction in cardiac antibody-mediated rejection
    C D Tan
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Am J Transplant 9:2075-84. 2009
    ..03). We conclude that a panel of C4d and C3d is diagnostically more useful than C4d alone in the evaluation of AMR. CD55 and CD59 may play a protective role in patients with evidence of complement activation...
  18. doi request reprint The effect of recipient hepatitis C virus infection on outcomes following heart transplantation
    A E Shafii
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Transplant Proc 42:1784-7. 2010
    ..Insufficient data exist on the clinical course of hepatitis C virus (HCV) infection in heart transplant (HT) recipients. Our study reports the outcomes of heart transplantation in pretransplantation HCV-positive (HCV+) recipients...
  19. ncbi request reprint Implantable LVAD insertion in patients with previous heart surgery
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 44195, USA
    J Heart Lung Transplant 19:S95-100. 2000
    ..In conclusion adjustment of standard LVAD implant technique can successfully manage most problems posed by patients with previous heart surgery...
  20. ncbi request reprint Hypogammaglobulinemia following cardiac transplantation: a link between rejection and infection
    M H Yamani
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Heart Lung Transplant 20:425-30. 2001
    ..IgG level may be a useful marker for identifying patients at high risk...
  21. ncbi request reprint Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observations
    R C Starling
    George M and Linda H Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 36:2098-103. 2000
    ..The study was done to prospectively measure the echocardiographic, hemodynamic and clinical outcomes after partial left ventriculectomy (PLV)...
  22. ncbi request reprint Permanent mechanical circulatory support with an implantable left ventricular assist device
    P M McCarthy
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195, USA
    Ann Thorac Surg 63:1458-61. 1997
    ..He was discharged from the hospital 13 days after the operation, and 5 months postoperatively he had returned to New York Heart Association functional class II...
  23. ncbi request reprint Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion
    K Fukamachi
    Department of Biomedical Engineering, The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 68:2181-4. 1999
    ..Implantable left ventricular assist device (LVAD) insertion complicated by early right ventricular (RV) failure has a poor prognosis and is generally unpredictable...
  24. ncbi request reprint Attrition from heart transplant waiting list for patients on ventricular assist devices is not affected by desensitization strategies
    G V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue F24, Cleveland, OH 44195, USA
    Transplant Proc 39:1571-2. 2007
    ..The following study was conducted to ascertain the relationship between desensitization therapies and attrition rate from the waiting list for VAD patients...
  25. ncbi request reprint Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operation
    N Moazami
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 72:1933-7; discussion 1937-9. 2001
    ..CONCLUSIONS: In select patients with acute ischemic stroke after recent cardiac operation, intraarterial thrombolysis appears to be reasonably safe and may lead to neurologic recovery...
  26. ncbi request reprint Venovenous extracorporeal life support for patients after cardiotomy
    N G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195 0002, USA
    ASAIO J 43:M444-6. 1997
    ..V-V ECLS is a useful alternative to open sternotomy for ventilatory induced hemodynamic compromise post cardiotomy, especially in patients with LVADs...
  27. ncbi request reprint Off-pump reoperative coronary artery bypass grafting by thoracotomy: patient selection and operative technique
    F M Azoury
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 71:1959-63. 2001
    ..This is the approach of choice in cases of reoperative CABG to the circumflex system when resternotomy or CPB are undesirable, and the culprit coronary vessels are accessible through a thoracotomy...
  28. ncbi request reprint Early and late rejection and HLA sensitization at the time of heart transplantation in patients bridged with left ventricular assist devices
    G V Gonzalez-Stawinski
    Department of Thoracic Surgery, Kaufman Center for Heart Failure and The Transplant Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplant Proc 37:1349-51. 2005
    ....
  29. ncbi request reprint Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart
    M L Ogletree-Hughes
    Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 104:881-6. 2001
    ..This indicates that functional impairment of cardiac muscle in human heart failure is reversible...
  30. ncbi request reprint A novel miniature ventricular assist device for hemodynamic support
    M Takagaki
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Ohio 44195, USA
    ASAIO J 47:412-6. 2001
    ..Despite its small diameter, the enabler significantly improved the hemodynamics of failing hearts and may potentially serve as a means of peripheral left ventricular support. Further study is warranted...
  31. ncbi request reprint Relationship between early diastolic intraventricular pressure gradients, an index of elastic recoil, and improvements in systolic and diastolic function
    M S Firstenberg
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 104:I330-5. 2001
    ..38[%DeltaIVPG]-8.39, r=0.85). CONCLUSIONS: Improvements in LV function also increase IVPGs. These changes in IVPGs, suggestive of increases in LV suction and elastic recoil, correlate directly with improvements in LV relaxation and ESV...
  32. ncbi request reprint Steep left ventricle to aortic root angle and hypertrophic obstructive cardiomyopathy: study of a novel association using three-dimensional multimodality imaging
    D H Kwon
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Heart 95:1784-91. 2009
    ..Some patients with HCM have a steeper left ventricle to aortic root angle than controls...
  33. ncbi request reprint Outcome of patients with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation and septal myectomy surgery
    J X Qin
    Cardiovascular Imaging Center, Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 38:1994-2000. 2001
    ..However, there are benefits and drawbacks for each therapeutic method that must be counterbalanced when deciding on treatment for LVOT obstruction...
  34. ncbi request reprint Asymmetry of systolic anterior motion of the mitral valve in patients with hypertrophic obstructive cardiomyopathy: a real-time three-dimensional echocardiographic study
    Jong Min Song
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 19:1129-35. 2006
    ..In conclusion, systolic anterior motion of the mitral valve develops predominantly in the medial side, resulting in laterally located narrow left ventricular outflow tract opening in patients with hypertrophic obstructive cardiomyopathy...
  35. ncbi request reprint Surgery for permanent atrial fibrillation: impact of patient factors and lesion set
    A Marc Gillinov
    Atrial Fibrillation Innovation Center AFIC, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Ann Thorac Surg 82:502-13; discussion 513-4. 2006
    ..Whether a complete Cox-maze procedure is needed to ablate permanent atrial fibrillation in patients undergoing concomitant cardiac surgery is unknown. Our objective was to assess the effectiveness of different lesion sets in such patients...
  36. ncbi request reprint Regional referral system for patients with acute mechanical support: experience at the Cleveland Clinic Foundation
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    ASAIO J 52:445-9. 2006
    ..Furthermore, there is a survival advantage when using long-term devices because this allows possible recovery or transplantation...
  37. ncbi request reprint Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation
    Monvadi B Srichai
    Center for Integrated Non Invasive Cardiovascular Imaging of Department of Radiology Section of Cardiovascular Imaging, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:75-84. 2006
    ....
  38. ncbi request reprint Occurrence and risk factors for reintervention after coronary artery bypass grafting
    Joseph F Sabik
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue Desk F24, Cleveland, Ohio 44195, USA
    Circulation 114:I454-60. 2006
    ..Reintervention after coronary artery bypass grafting (CABG) is common. We sought to determine its occurrence and identify patient characteristics and operative techniques that influence the need or bias for reintervention...
  39. ncbi request reprint Failure modes of the Carpentier-Edwards pericardial bioprosthesis in the aortic position
    Eric E Roselli
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Valve Dis 15:421-7; discussion 427-8. 2006
    ..Modes of failure of the Perimount bioprostheses have not been characterized. Thus, the study aim was to classify their failure modes, to compare their rates of occurrence, and to relate these to patient age...
  40. ncbi request reprint Ventricular assist devices and aggressive immunosuppression: looking beyond overall survival
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44121, USA
    J Heart Lung Transplant 25:613-8. 2006
    ..We hypothesized that allosensitized VAD patients have higher levels of immunosuppression and thus different morbidity and causes of mortality...
  41. ncbi request reprint Allocating hearts
    Nicholas G Smedira
    J Thorac Cardiovasc Surg 131:775-6. 2006
  42. ncbi request reprint Determinants of ischemic mitral regurgitation in patients with chronic anterior wall myocardial infarction: a real time three-dimensional echocardiography study
    Jong Min Song
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Echocardiography 23:650-7. 2006
    ..We sought to elucidate the geometric determinants of ischemic mitral regurgitation (IMR) in patients with chronic anterior myocardial infarction (MI)...
  43. ncbi request reprint The impact of hypogammaglobulinemia on infection outcome in patients undergoing ventricular assist device implantation
    Mohamad H Yamani
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 25:820-4. 2006
    ..However, to our knowledge, quantitative immunoglobulin G (IgG) level determination and the impact of hypogammaglobulinemia (HGG) on infections after VAD implantation have not been evaluated before...
  44. ncbi request reprint Extended use of extracorporeal membrane oxygenation after lung transplantation
    David P Mason
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 132:954-60. 2006
    ....
  45. ncbi request reprint The effect of a donor's history of active substance on outcomes following orthotopic heart transplantation
    Kenneth J Shea
    Case Western Reserve School of Medicine, Cleveland, OH, United States
    Eur J Cardiothorac Surg 31:452-6; discussion 456. 2007
    ..To review the short-term and long-term outcomes of using heart donors with a history of substance abuse...
  46. doi request reprint Prognosis of patients removed from a transplant waiting list for medical improvement: implications for organ allocation and transplantation for status 2 patients
    Katherine J Hoercher
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 135:1159-66. 2008
    ....
  47. doi request reprint Mitral valve abnormalities in hypertrophic cardiomyopathy: echocardiographic features and surgical outcomes
    Ryan K Kaple
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 85:1527-35, 1535.e1-2. 2008
    ..This study was conducted to define the echocardiographic features of MV pathology in patients with HCM and relate these to repairability of the MV, MV procedures performed, durability of repair, and survival...
  48. doi request reprint Decay-accelerating factor expression may provide immunoprotection against antibody-mediated cardiac allograft rejection
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Heart Lung Transplant 27:357-61. 2008
    ..Thus, we examined the role of DAF in the clinical presentation of antibody-mediated cardiac allograft rejection...
  49. doi request reprint Diagnostic value of left ventricular outflow area in patients with hypertrophic cardiomyopathy: a real-time three-dimensional echocardiographic study
    Shota Fukuda
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 21:789-95. 2008
    ..However, its clinical value is unknown...
  50. ncbi request reprint Current effectiveness and risks of isolated septal myectomy for hypertrophic obstructive cardiomyopathy
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 85:127-33. 2008
    ..However, it is being challenged by a less-invasive alternative: alcohol septal ablation. This study examined the clinical effectiveness and risks of isolated septal myectomy for HOCM...
  51. ncbi request reprint Orthotopic heart transplantation through minimally invasive approach
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue F24, Cleveland, OH 44195, USA
    Asian Cardiovasc Thorac Ann 15:446-8. 2007
    ..The procedure was considered safe with adequate exposure, minimal postoperative pain medication requirements, acceptable operative times, and good long-term outcome...
  52. ncbi request reprint Left ventricular torsional mechanics after left ventricular reconstruction surgery for ischemic cardiomyopathy
    Randolph M Setser
    Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 134:888-96. 2007
    ..Therefore, we have computed left ventricular rotation and torsion in patients undergoing left ventricular reconstruction to determine its effects on these quantitative measures of myocardial mechanics...
  53. ncbi request reprint A comparative analysis between survivors and nonsurvivors with antibody mediated cardiac allograft rejection
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Surg Res 142:233-8. 2007
    ..The following study was conducted to determine differences between survivors and nonsurvivors who developed post heart transplant AMR...
  54. ncbi request reprint Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: results of the "EVOLUTION OFF" trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum, Berlin, Germany
    Anesth Analg 103:540-4. 2006
    ..These results suggest that bivalirudin, given according to the current protocol, provides reliable and effective anticoagulation during off-pump coronary artery bypass graft surgery...
  55. ncbi request reprint Does right thoracotomy increase the risk of mitral valve reoperation?
    Lars G Svensson
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 134:677-82. 2007
    ..The study objective was to determine whether a right thoracotomy approach increases the risk of mitral valve reoperation...
  56. ncbi request reprint Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery:the NAPA Trial
    Robert M Mentzer
    Division of Cardiothoracic Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 49:716-26. 2007
    ..The purpose of this study was to determine the role nesiritide might play in patients with left ventricular dysfunction undergoing coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB)...
  57. ncbi request reprint Cardiac surgery after mediastinal radiation: extent of exposure influences outcome
    Albert S Y Chang
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 133:404-13. 2007
    ..Mediastinal radiation for thoracic malignancies uses multiple treatment fields and doses. We investigated whether more extensive radiation exposure is associated with more hospital complications and worse survival after cardiac surgery...
  58. ncbi request reprint Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 83:572-7. 2007
    ....
  59. ncbi request reprint Aortic allograft valve reoperation: surgical challenges and patient risks
    Edward R Nowicki
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 86:761-768.e2. 2008
    ..Aortic valve allograft reoperation is a challenge for the surgeon and a risk to the patient. We examined our experience to identify these challenges and risks...
  60. ncbi request reprint A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study
    Cornelius M Dyke
    Carolina Cardiovascular and Thoracic Surgery Associates, Gaston Memorial Hospital, Gastonia, NC 28056, USA
    J Thorac Cardiovasc Surg 131:533-9. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin as an alternative to heparin with protamine reversal in on-pump cardiac surgery...
  61. ncbi request reprint Effectiveness of atrial fibrillation surgery in patients with hypertrophic cardiomyopathy
    Michael S Chen
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    Am J Cardiol 93:373-5. 2004
    ..The Maze procedure, with concomitant septal myectomy if indicated, appears to be feasible in patients with hypertrophic cardiomyopathy and refractory atrial fibrillation...
  62. ncbi request reprint Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting
    Andreas Koster
    Department of Anesthesia, Deutsches Herrzentrum, Berlin, Germany
    Am J Cardiol 93:356-9. 2004
    ..Our data provide the first evidence of clinical feasibility of anticoagulation with bivalirudin during cardiopulmonary bypass...
  63. ncbi request reprint Conduction system abnormalities in patients with obstructive hypertrophic cardiomyopathy following septal reduction interventions
    Jian Xin Qin
    Department of Cardiovascular Medicine, Cleveland, Ohio 44195, USA
    Am J Cardiol 93:171-5. 2004
    ..0001). Thus, RBBB often develops after PTSMA and LBBB is very frequently produced by myectomy. A possible requirement of a permanent pacemaker should always be considered before intervention when patients have preexisting RBBB or LBBB...
  64. ncbi request reprint Primary adenocarcinoma in a donor lung: evaluation and surgical management
    Erik A K Beyer
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
    J Heart Lung Transplant 22:1174-7. 2003
    ..The tumor was treated surgically. A lingular sparing left upper lobe bisegmental lung resection was performed...
  65. ncbi request reprint Importance of mitral valve repair associated with left ventricular reconstruction for patients with ischemic cardiomyopathy: a real-time three-dimensional echocardiographic study
    Jian Xin Qin
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Circulation 108:II241-6. 2003
    ..This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-time 3-dimensional echocardiography (3DE)...
  66. ncbi request reprint Images in cardiovascular medicine. Epicardial real-time 3-dimensional echocardiography during septal myectomy for obstructive hypertrophic cardiomyopathy
    Patrick J Nash
    Department of Cardiovascular Medicine, Desk F15, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circulation 108:e54-5. 2003
  67. ncbi request reprint A case of fatal West Nile virus meningoencephalitis associated with receipt of blood transfusions after open heart surgery
    Wendy S Armstrong
    Department of Infectious Disease, Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 76:605-7. 2003
    ..Individuals undergoing procedures with high blood product transfusion requirements, such as cardiac surgery or organ transplantation, may be at higher risk of this nosocomial infection during epidemics...
  68. ncbi request reprint The Carbomedics Top Hat supraannular aortic valve: a multicenter study
    A Marc Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 75:1175-80. 2003
    ..Five institutions pooled their clinical experiences to evaluate early outcome in patients with this prosthesis...
  69. ncbi request reprint Mechanical treatment of heart failure: the growing role of LVADs and artificial hearts
    Hassan W Nemeh
    Department of Thoracic and Cardiovascular Surgery, Loyola University Medical Center, Maywood, Ill 60153, USA
    Cleve Clin J Med 70:223-6, 229-33. 2003
    ..More exciting, mechanical assistance may provide an opportunity for a damaged heart to recover some function. Still, despite the promise, the use of these devices raises some difficult cost-benefit and ethical questions...
  70. ncbi request reprint Comparison of left ventricular diastolic function in obstructive hypertrophic cardiomyopathy in patients undergoing percutaneous septal alcohol ablation versus surgical myotomy/myectomy
    Marta Sitges
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 91:817-21. 2003
    ..Thus, diastolic function indexes obtained by echocardiography changed after septal reduction interventions in patients with obstructive HC; this change was similar to that after surgical myectomy and ASR...
  71. ncbi request reprint Do left ventricular assist device (LVAD) bridge-to-transplantation outcomes predict the results of permanent LVAD implantation?
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 74:2051-62; discussion 2062-3. 2002
    ..We review our experience in order to compare the BTTx lessons learned with the outcomes and goals of permanent implants...
  72. ncbi request reprint Severe renal dysfunction complicating cardiogenic shock is not a contraindication to mechanical support as a bridge to cardiac transplantation
    Umesh N Khot
    Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Coll Cardiol 41:381-5. 2003
    ..This study investigated outcomes in patients with cardiogenic shock and severe renal dysfunction treated with ventricular assist devices (VAD) as a bridge to cardiac transplantation...
  73. ncbi request reprint Quantitation and distribution of beta-tubulin in human cardiac myocytes
    Louise A Aquila-Pastir
    Department of Cardiovascular Medicine, Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Mol Cell Cardiol 34:1513-23. 2002
    ..Although the functional implications of this finding in the human heart remain to be explored, data from animal studies suggest that increased beta-tubulin protein contributes to cardiac dysfunction...
  74. ncbi request reprint Microwave ablation of atrial fibrillation during mitral valve operations
    A Marc Gillinov
    Ann Thorac Surg 74:1259-61. 2002
    ..Microwave creates lines of conduction block by thermal damage and subsequent scar formation. We describe a rapid and simple technique for microwave ablation of atrial fibrillation in patients having mitral valve operations...
  75. ncbi request reprint Edge-to-edge (Alfieri) mitral repair: results in diverse clinical settings
    Sunil K Bhudia
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 77:1598-606. 2004
    ..Objectives of this study were to demonstrate causes of MR amenable to edge-to-edge repair and to determine safety, obstructive potential, and durability of edge-to-edge repair...
  76. ncbi request reprint Radial artery bypass grafts have an increased occurrence of angiographically severe stenosis and occlusion compared with left internal mammary arteries and saphenous vein grafts
    Umesh N Khot
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 109:2086-91. 2004
    ..The radial artery has been increasingly used in CABG. However, angiographic outcome data have been limited...
  77. ncbi request reprint Influence of patient characteristics and arterial grafts on freedom from coronary reoperation
    Joseph F Sabik
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:90-8. 2006
    ..We sought to identify patient characteristics and operative factors that predict the need for or bias toward reoperative coronary artery bypass grafting...
  78. ncbi request reprint Small intestinal submucosa intracardiac patch: an experimental study
    Michael Rosen
    Cleveland Clinic Foundation Department of General Surgery, Cleveland, OH 44195, USA
    Surg Innov 12:227-31. 2005
    ..Further study with small intestinal submucosa in an intracardiac position is warranted...
  79. ncbi request reprint Bench repair of donor aortic valve with minimal access orthotopic heart transplantation
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 80:313-5. 2005
    ..The postoperative period was uneventful. Follow-up at 4.5 years showed good results and no evidence of aortic regurgitation...
  80. ncbi request reprint Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 129:1391-4. 2005
    ..This study was conducted to assess the effects of the currently suggested protocol for bivalirudin on hemostatic activation during cardiopulmonary bypass with and without cardiotomy suction...
  81. ncbi request reprint Early and midterm risk of coronary allograft vasculopathy in patients bridged to orthotopic heart transplantation with ventricular assist devices
    Gonzalo V Gonzalez-Stawinski
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 79:1175-9. 2005
    ..To examine this, we obtained posttransplant coronary angiograms from a group of patients bridged with VAD and compared them to post transplant coronary angiograms of a non-VAD cohort...
  82. ncbi request reprint Tricuspid valve repair for biopsy-induced regurgitation in a heart transplant recipient
    Jose L Navia
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Desk F 25, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Heart Valve Dis 14:264-7. 2005
    ..At a four-years post-transplant evaluation, she was in NYHA functional class I, with preserved ventricular function and trivial TR. She has been followed closely because of post-transplant coronary artery disease...
  83. ncbi request reprint Use of the Alfieri edge-to-edge technique to eliminate left ventricular outflow tract obstruction caused by mitral systolic anterior motion
    A Marc Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 78:e92-3. 2004
    ..This reduced the gradient across the left ventricular outflow tract to 10 mm Hg and eliminated the mitral regurgitation, which enabled successful separation from cardiopulmonary bypass...
  84. ncbi request reprint HLA sensitization in ventricular assist device recipients: does type of device make a difference?
    Ganesh S Kumpati
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 127:1800-7. 2004
    ....
  85. ncbi request reprint Contemporary outcomes of outpatients referred for cardiac transplantation evaluation to a tertiary heart failure center: impact of surgical alternatives
    Niall G Mahon
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Card Fail 10:273-8. 2004
    ..We sought to assess current disposition and outcomes of patients recently referred for transplant evaluation to a single high-throughput tertiary referral center...
  86. ncbi request reprint Usefulness of real-time three-dimensional echocardiography for evaluation of myectomy in patients with hypertrophic cardiomyopathy
    Jian Xin Qin
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 94:964-6. 2004
    ..4 +/- 0.7 vs 5.1 +/- 1.2 cm(2), p <0.01), significantly increased after myectomy (4.8 +/- 1.8 cm2, p <0.01) and was associated with a reduction of the pressure gradient at rest from 63 +/- 41 to 15 +/- 5 mm Hg (p <0.01)...
  87. ncbi request reprint Surgical advances in heart and lung transplantation
    Eric E Roselli
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Anesthesiol Clin North America 22:789-807. 2004
    ..This article focuses on the more recent surgical advances in donor selection and management, procurement and implantation, and the impact of these advances on patient outcome...
  88. ncbi request reprint Does off-pump coronary surgery reduce morbidity and mortality?
    Joseph F Sabik
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Thorac Cardiovasc Surg 124:698-707. 2002
    ..To compare hospital outcomes of on-pump and off-pump coronary artery bypass surgery...
  89. ncbi request reprint Left main dissection and thrombosis in a young athlete
    L Todd Justice
    Division of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0200, USA
    Cardiol Rev 13:260-2. 2005
    ..With successful surgical intervention, the patient made an uneventful recovery. This case is discussed and the literature reviewed...
  90. ncbi request reprint Evaluation of left ventricular outflow tract area after septal reduction in obstructive hypertrophic cardiomyopathy: a real-time 3-dimensional echocardiographic study
    Marta Sitges
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am Heart J 150:852-8. 2005
    ..We aimed to analyze the change in LVOT area after septal reduction interventions in patients with obstructive HC using RT3DE...
  91. ncbi request reprint Duration of inotropic support after left ventricular assist device implantation: risk factors and impact on outcome
    Soren Schenk
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:447-54. 2006
    ....
  92. ncbi request reprint Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients
    Yoshie Ochiai
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 106:I198-202. 2002
    ..Prediction of RV failure after LVAD placement would lead to more precise patient selection and optimal device selection...