Arun D Singh

..To investigate the molecular pathology underlying BIGH3-related corneal dystrophies (CDs) and to further delineate genotype-phenotype specificity...

..The management of primary acquired melanosis, nevi and conjunctival melanomas involves various modalities used either alone or concomitantly depending on the size and extent of the lesion...

..Use of periocular steroid during plaque brachytherapy may prevent radiation maculopathy over the short term. Newer designs and techniques of delivering radiation to the eye need to be explored...

..To compare fluorescence in situ hybridization (FISH) using a centromeric probe for chromosome 3 (CEP3) and 3p26 locus-specific probe with single-nucleotide polymorphism array (SNP-A) analysis in the detection of high-risk uveal melanoma...

..To report on the clinical features of eccrine hidrocystoma involving the eyelid...

..To compare detection rates of drusen and subretinal fluid by Fourier domain optical coherence tomography (FD OCT) and orange pigment by fundus autofluorescence (FAF) with ophthalmoscopy in indeterminate choroidal melanocytic lesions...

..However, it is not known whether the primary tumor cells maintain these aggressive attributes at the metastatic sites...

..Because the randomized design of the COMS was unique, no attempt is made to make any comparison with the results of previous non-controlled studies...

..In general, the survival with metastatic uveal melanoma is poor, with a median survival of less than 6 months...

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..Diffuse choroidal hemangiomas are usually evident at birth and generally occur as a part of neuro-oculo-cutaneous hemangiomatosis (Sturge-Weber syndrome)...

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..This article discusses primary lymphoma of the central nervous system, which is a variant of extranodal non-Hodgkin's lymphoma that arises from specific sites such as the brain, spinal cord, meninges, or eyes...

..To estimate the risk of malignant transformation of a choroidal nevus in the white population...

..To evaluate clinical features at presentation of small choroidal melanocytic lesions that were predictive of growth...

..In an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality...

..To evaluate published methods of estimating choroidal melanoma volume...

..This article reviews the clinical genetics, cytogenetics, and molecular genetic aspects of uveal melanoma...

..To determine trends in incidence, treatment, and survival with primary uveal melanoma in the United States over a 36-year period from 1973 to 2008...

..To describe the clinical course and ancillary findings of 3 patients with choroidal melanoma who inadvertently received multiple intravitreal injections of bevacizumab for a presumed diagnosis of choroidal neovascular membrane...

..To generate a vision prognostication model after plaque brachytherapy for uveal melanoma...

..FISH is a widely available, versatile technology, and when performed optimally has the potential to be a valuable tool for determining the prognosis of uveal melanoma...

..Monosomy 3, one such variable, can be determined using fluorescence in situ hybridization, either on enucleated samples, fine-needle aspiration biopsy, or tumor sample obtained by vitrector...

..To report the optical coherence tomographic features differentiating choroidal nevus from choroidal melanoma by 3D spectral-domain optical coherence tomography (SD-OCT) and OCT characteristics of other choroidal tumors...

..To determine whether the computed dosimetry of a new ophthalmic plaque, EP917, when compared with the standard Collaborative Ocular Melanoma Study (COMS) plaques, could reduce radiation exposure to vision critical structures of the eye...

..To describe breast cancer as a source of choroidal metastasis in men and highlight the diagnostic and treatment modalities...

..Single-centre consecutive interventional case series by retrospective chart review to evaluate the efficacy of verteporfin (Visudyne™) photodynamic therapy (PDT) of retinal capillary haemangioma (RCH)...

..The authors report anterior segment optical coherence tomography and ultrasound biomicroscopic features in two patients with iris arteriovenous malformation...

..The newer clinical data along with emerging radiobiological data indicate that radiotherapy is likely to play a greater role in melanoma management and should be considered as a treatment option...

..Clinical trials of some of these approaches have been initiated in patients with metastatic uveal melanoma as well as in the adjuvant setting after primary therapy...

..However, more research on the biology of uveal melanoma as well as improvements upon the current technologies are needed...

..To image and measure iris tumors with optical coherence tomography (OCT)...

..It is recommended that patients with oculo(dermal) melanocytosis be followed for the occurrence of uveal melanoma...

..This case highlights the importance of complete ocular evaluation and proper imaging modalities in children presenting with orbital cellulitis...

..abstract:..

..To evaluate genotype/phenotype correlations in individuals with astrocytic hamartoma (AH) and retinal achromic patch (AP) in the setting of tuberous sclerosis complex (TSC)...

..The stage is set to translate the advances made in understanding the molecular characteristics of uveal melanoma in order to identify and test clinically useful blood biomarkers of tumor dissemination and/or progression...

..Our case emphasizes the importance of a thorough examination of the anophthalmic socket, including upper and lower lid eversion...

..5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient...

..In the past this has been challenging. Herein, we describe a case of Sturge-Weber Syndrome with diffuse choroidal hemangioma which was successfully treated with low dose lens-sparing external beam radiotherapy...

..In the following review, we examine physiologic, epidemiological, and genetic data in order to determine the role of sunlight exposure in the pathogenesis of uveal melanoma...

..This comparison shows that, for tumours not exceeding 5 mm in thickness, the use of (106)Ru plaques has the potential to reduce the radiation dose to nearby normal structures and possibly lower the risk of radiation-induced visual loss...

..In conclusion, measurement of blood levels of β2M in patients with primary uveal melanoma may have prognostic value and may help guide surveillance and adjuvant therapy recommendations...

..To report on the development of visually significant maculopathy associated with blood-brain barrier disruption (BBBD) therapy for the treatment of central nervous system (CNS) lymphoma...

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..In this article, we review the clinical and histopathological findings of a sporadic plexiform pigmented schwannoma involving the iris, ciliary body, and the choroid...

..For the first time, histopathology from enucleation specimens provides a clinicopathologic disease correlation with focal abnormalities in the inner nuclear and outer plexiform layers...

..The 2 cases illustrate the widely varying clinical characteristics of this elusive disease...

..To our knowledge, this is the first such case reported in a child. Although this cyst has been described in the occipital and frontal bones, this is the first description of occurrence in the sphenoid bone...

..To describe the history and clinical presentation of a case of conjunctival lichen planus simulating ocular surface squamous neoplasia (OSSN)...

..We also report a case of an iris varix, confirmed by histopathological and immunohistochemical examination. Comparative features of each subtype of vascular anomaly are discussed...

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..The clinical signs and symptoms, histopathologic findings, and radiographic features of orbital amyloidosis are discussed...

..In this review, the Zimmerman-McLean-Foster hypothesis is explored in the light of current clinical, epidemiological, statistical, and experimental evidence...

..To evaluate efficacy of verteporfin ocular photodynamic therapy (PDT) in treatment of 10 patients with a symptomatic circumscribed choroidal haemangioma...

..To describe clinical, ultrasound biomicroscopy (UBM), and histopathologic characteristics of benign melanocytic tumors of the ciliary body...

..3 per million) in the United States is similar to that reported from European countries. The age-adjusted incidence rate of uveal melanoma has remained stable for the past 25 years...

..Laser photocoagulation and cryotherapy are the mainstays of treatment in most cases. Early detection of RCH and treatment before the onset of severe visual loss is recommended...

..CONCLUSIONS: Advances made in the local methods of treatment of primary uveal melanoma have not led to an improvement in survival. Systemic approaches to management of uveal melanoma are warranted...

..Transpupillary thermotherapy can cause damaging effects to the retina, leading to visual loss shortly after treatment...

..In conclusion, multifocal choroidal melanoma is rare and may be related to underlying ocular melanocytosis...

..The indications for chemoreduction, thermochemotherapy, and thermotherapy for retinoblastoma remain under investigation...

..To report the results of genetic testing for von Hippel-Lindau (VHL) disease in patients presenting with solitary retinal capillary hemangioma (RCH)...

..CONCLUSION: Postenucleation adjuvant therapy is safe and effective in significantly reducing the occurrence of metastasis in patients with retinoblastoma manifesting histopathologic high-risk characteristics...

..The contralateral orbit can be the site of late metastasis from choroidal melanoma. In rare instances, an orbital metastasis can be completely removed surgically without subjecting the patient to orbital irradiation...

..This review provides an update on the current management of advanced retinoblastoma...