Roy Silverstein

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Venous thrombosis in the elderly: more questions than answers
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Blood 110:3097-101. 2007
  2. pmc Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, NC10, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Trans Am Clin Climatol Assoc 121:206-20. 2010
  3. ncbi CD36-TSP-HRGP interactions in the regulation of angiogenesis
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Curr Pharm Des 13:3559-67. 2007
  4. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
  5. pmc Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36
    Roy L Silverstein
    Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:S27-30. 2009
  6. ncbi A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002
  7. pmc Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice
    Arunima Ghosh
    Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
    J Clin Invest 118:1934-43. 2008
  8. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
  9. pmc A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein
    Kan Chen
    Program in Cell Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Circ Res 102:1512-9. 2008
  10. pmc Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL
    Sangeeta R Kashyap
    Department of Endocrinology, Diabetes and Metabolism, Endocrinology Institute, Lerner Research Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Obesity (Silver Spring) 17:2142-8. 2009

Collaborators

Detail Information

Publications32

  1. ncbi Venous thrombosis in the elderly: more questions than answers
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Blood 110:3097-101. 2007
  2. pmc Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, NC10, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Trans Am Clin Climatol Assoc 121:206-20. 2010
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development in athero-thrombotic disorders...
  3. ncbi CD36-TSP-HRGP interactions in the regulation of angiogenesis
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Curr Pharm Des 13:3559-67. 2007
    ..The tripartite interactions among CD36, TSR domains and HRGP in tissues may play an important role in regulating physiological and pathological angiogenesis...
  4. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development...
  5. pmc Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36
    Roy L Silverstein
    Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:S27-30. 2009
    ..CD36 deficiency in mice is associated with inhibition of thrombus formation and with a reduction in microparticle accumulation in thrombi. Targeting CD36 is a promising avenue for the treatment of atheroinflammatory disorders...
  6. ncbi A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002
    ..Collectively, our data suggest that formation of this novel family of oxidized phospholipids participates in CD36-mediated recognition of oxidized lipoproteins and foam cell formation in vivo...
  7. pmc Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice
    Arunima Ghosh
    Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
    J Clin Invest 118:1934-43. 2008
    ..These results provide what we believe to be a novel role for CD36 in thrombosis...
  8. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
    ..These findings show that a specific CD36-dependent signaling pathway initiated by oxLDL is necessary for foam cell formation and identify potential targets for antiatherosclerosis therapy...
  9. pmc A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein
    Kan Chen
    Program in Cell Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Circ Res 102:1512-9. 2008
    ....
  10. pmc Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL
    Sangeeta R Kashyap
    Department of Endocrinology, Diabetes and Metabolism, Endocrinology Institute, Lerner Research Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Obesity (Silver Spring) 17:2142-8. 2009
    ..05) and not with FFA levels or brachial artery dilation. These data support a role for FFAs in induction of insulin resistance and provide a link to atherogenic mechanisms mediated by expression of scavenger receptor CD36...
  11. pmc Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
    Eugene A Podrez
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Med 13:1086-95. 2007
    ..Thus, interactions of platelet CD36 with specific endogenous oxidized lipids play a crucial role in the well-known clinical associations between dyslipidemia, oxidant stress and a prothrombotic phenotype...
  12. pmc A novel broadband impedance method for detection of cell-derived microparticles
    Vadim Lvovich
    The Cleveland Clinic Foundation, Department of Biomedical Engineering ND20, 9500 Euclid Ave, Cleveland, OH 44195, United States
    Biosens Bioelectron 26:444-51. 2010
    ..This study also demonstrated that standard laboratory methods such as flow cytometry underestimate MP concentrations, especially those with smaller average sizes, by as much as a factor of 2-40...
  13. pmc CD36: implications in cardiovascular disease
    Maria Febbraio
    Cleveland Clinic, Lerner Research Institute, Department of Cell Biology, NC 10, 9500 Euclid Avenue, Cleveland, OH 44195, United States
    Int J Biochem Cell Biol 39:2012-30. 2007
    ..This review focuses on CD36 in cardiovascular disease-what we know, and what we have yet to learn...
  14. ncbi Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis
    Maria Febbraio
    Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 24:2333-8. 2004
    ..In previous work, we demonstrated that CD36 absence was protective against lesion formation. The current objective was to determine whether absence of macrophage CD36 alone was protective...
  15. pmc Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells
    Michael E Greenberg
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Exp Med 203:2613-25. 2006
    ..Collectively, these results identify oxPS-CD36 interactions on macrophages as potential participants in a broad range of physiologic processes where macrophage-mediated engulfment of apoptotic cells is involved...
  16. pmc TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009
    ..Thus, lung APC subsets differ in TLR expression, which may determine differences in responses to Mtb...
  17. pmc Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis
    Jason O Robertson
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA
    Thromb Res 123:644-52. 2009
    ..The aim of this study was to define the role of platelet surface LRP8 in thrombosis...
  18. pmc Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin
    Philip A Klenotic
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Pathol 176:2039-50. 2010
    ..These data help define a novel angiogenic axis that could be exploited for the treatment of human cancers and other diseases where excess angiogenesis occurs...
  19. pmc CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima
    Young Mi Park
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Invest 119:136-45. 2009
    ..This may induce trapping of macrophages in the arterial intima and promote atherosclerosis...
  20. pmc CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs
    Wei Li
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 120:3996-4006. 2010
    ..These data suggest that CD36-mediated downregulation of antioxidant systems in VSMCs may contribute to its prothrombotic, proinflammatory, and atherogenic effects...
  21. pmc Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions
    Mingjiang Sun
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol Chem 281:4222-30. 2006
    ....
  22. ncbi The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia
    Sunghee Cho
    Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:2504-12. 2005
    ..The data unveil a previously unrecognized role of CD36 in ischemia-induced ROS production and brain injury. Modulation of CD36 signaling may provide a new strategy for the treatment of ischemic stroke...
  23. ncbi Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2
    Oscar B Goodman
    Urologic Oncology Research Laboratory, Department of Urology, Weil Medical College of Cornell University New York Presbyterian Hospital, New York, NY 10021, USA
    J Biol Chem 281:33597-605. 2006
    ..These data indicate that neprilysin proteolytically inactivates fibroblast growth factor-2, resulting in negative regulation of angiogenesis...
  24. ncbi CD36: a critical anti-angiogenic receptor
    Ronit Simantov
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Front Biosci 8:s874-82. 2003
    ..Several in vivo models support the role of the TSP/CD36 system in angiogenesis and tumor growth and provide evidence that the CD36 antiangiogenic pathway offers attractive therapeutic targets...
  25. pmc Biological surgery: synergetic angiogenic therapy using coadministration of two progenitor cell populations
    Wei Li
    Circ Res 103:684-6. 2008
  26. ncbi CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages
    Samir N Patel
    Department of Medicine, University of Toronto, Ontario, Canada
    J Infect Dis 189:204-13. 2004
    ..These studies support the use of these rodent models to examine PE-CD36 interactions...
  27. doi Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 134:556-67. 2008
    ..The goal of this study is to investigate further the role of Cd36 in hepatic steatosis...
  28. ncbi EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions
    Sylvie Marleau
    Faculty of Pharmacy and Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Quebec, Canada
    FASEB J 19:1869-71. 2005
    ..Our results suggest that EP 80317, as a CD36 ligand, might be a prototype for a novel class of anti-atherosclerotic agents...
  29. ncbi A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization
    Jongcheol Ahn
    Department of Medicine, Division of Hematology and Medical Oncology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Cell Sci 118:1725-31. 2005
    ..These data suggest that alternative splicing of the GLG1 gene transcript might regulate the function of its product...
  30. pmc CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum
    Todd G Smith
    Department of Medicine, University of Toronto, Toronto M5S 1A5, Ontario, Canada
    Infect Immun 71:393-400. 2003
    ....
  31. pmc The face of TSR revealed: an extracellular signaling domain is exposed
    Roy L Silverstein
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Cell Biol 159:203-6. 2002
    ..The novel layered fold motif described brings great insight into how the complicated functions of TSP-1 and related molecules are affected...
  32. pmc Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo
    Qi Ling
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 113:38-48. 2004
    ..These data establish annexin II as a regulator of cell surface plasmin generation and reveal that impaired endothelial cell fibrinolytic activity constitutes a barrier to effective neoangiogenesis...

Research Grants14

  1. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy Silverstein; Fiscal Year: 2009
    ....
  2. Oxidized Phospholipids in Vascular Pathobiology
    Roy Silverstein; Fiscal Year: 2007
    ..An Administrative Core and 2 scientific cores, "Analytic and Synthetic Chemistry" and "Monocyte/Macrophage Cell Biology" strengthen the Program by providing well characterized, uniform-quality cellular, animal, and chemical reagents. ..
  3. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  4. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2001
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  5. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2000
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  6. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 1999
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  7. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2010
    ....