B Shen

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Clinical approach to diseases of ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:2796-807. 2005
  2. doi request reprint A proposed classification of ileal pouch disorders and associated complications after restorative proctocolectomy
    Bo Shen
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 6:145-58; quiz 124. 2008
  3. doi request reprint Evaluation of tissue eosinophilia in the pouch and afferent limb in patients with restorative proctocolectomy
    Bo Shen
    Pouchitis Clinic, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 14:744-9. 2008
  4. pmc Rifaximin for maintenance therapy in antibiotic-dependent pouchitis
    Bo Shen
    The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Gastroenterol 8:26. 2008
  5. doi request reprint Endoscopic treatment for pill bezoars after continent ileostomy
    L Lian
    Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Dig Liver Dis 41:e26-8. 2009
  6. doi request reprint Bacteriology in the etiopathogenesis of pouchitis
    Bo Shen
    Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dig Dis 30:351-7. 2012
  7. pmc A new category of autoinflammatory disease associated with NOD2 gene mutations
    Qingping Yao
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Arthritis Res Ther 13:R148. 2011
  8. doi request reprint Acute and chronic pouchitis--pathogenesis, diagnosis and treatment
    Bo Shen
    Department of Gastroenterology and Hepatology A31, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44915, USA
    Nat Rev Gastroenterol Hepatol 9:323-33. 2012
  9. ncbi request reprint Diagnosis and management of Crohn's disease of the ileal pouch
    Y Li
    Department of Gastroenterology, Peking Union Medical College, Beijing, China
    Minerva Gastroenterol Dietol 58:123-35. 2012
  10. ncbi request reprint [Diagnosis and treatment of pouchitis and pouch dysfunction]
    Lei Lian
    Department of Gastroenterology, Cleveland Clinic Foundation, Weston, USA
    Zhonghua Wei Chang Wai Ke Za Zhi 15:412-21. 2012

Research Grants

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Clinical approach to diseases of ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:2796-807. 2005
    ..Accurate diagnosis and classification are important for appropriate management. Endoscopic evaluation is the most important tool for the diagnosis and differential diagnosis...
  2. doi request reprint A proposed classification of ileal pouch disorders and associated complications after restorative proctocolectomy
    Bo Shen
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 6:145-58; quiz 124. 2008
    ..Accurate diagnosis and classification of the disease conditions are imperative for proper management and prognosis...
  3. doi request reprint Evaluation of tissue eosinophilia in the pouch and afferent limb in patients with restorative proctocolectomy
    Bo Shen
    Pouchitis Clinic, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 14:744-9. 2008
    ..The aim of this study was to assess whether tissue eosinophilia was associated with disease status of ileal pouches...
  4. pmc Rifaximin for maintenance therapy in antibiotic-dependent pouchitis
    Bo Shen
    The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Gastroenterol 8:26. 2008
    ..This historical cohort open-label study investigated the efficacy and tolerability of rifaximin in maintaining symptomatic and endoscopic remission in patients with antibiotic-dependent pouchitis...
  5. doi request reprint Endoscopic treatment for pill bezoars after continent ileostomy
    L Lian
    Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Dig Liver Dis 41:e26-8. 2009
    ..Pill bezoar in the pouch is rare. However, patients with continent ileostomy should be advised to avoid taking hard-to-dissolve foods and medications...
  6. doi request reprint Bacteriology in the etiopathogenesis of pouchitis
    Bo Shen
    Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dig Dis 30:351-7. 2012
    ..Pouchitis is the most common long-term complication in ulcerative colitis that follows restorative proctocolectomy. Clinical evidence suggests that dysbiosis plays a key role in its pathogenesis...
  7. pmc A new category of autoinflammatory disease associated with NOD2 gene mutations
    Qingping Yao
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Arthritis Res Ther 13:R148. 2011
    ..This study characterized a cohort of patients with similar phenotypes and nucleotide oligomerization domain 2 (NOD2) gene mutations...
  8. doi request reprint Acute and chronic pouchitis--pathogenesis, diagnosis and treatment
    Bo Shen
    Department of Gastroenterology and Hepatology A31, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44915, USA
    Nat Rev Gastroenterol Hepatol 9:323-33. 2012
    ..Secondary causes of pouchitis, such as ischaemia, NSAID use, the presence of concurrent primary sclerosing cholangitis and other systemic immune-mediated disorders, should be evaluated and properly managed...
  9. ncbi request reprint Diagnosis and management of Crohn's disease of the ileal pouch
    Y Li
    Department of Gastroenterology, Peking Union Medical College, Beijing, China
    Minerva Gastroenterol Dietol 58:123-35. 2012
    ..A multidisciplinary approach with gastroenterologists, colorectal surgeons, gastrointestinal pathologists and radiologists for proper medical, endoscopic, and surgical treatment is advocated...
  10. ncbi request reprint [Diagnosis and treatment of pouchitis and pouch dysfunction]
    Lei Lian
    Department of Gastroenterology, Cleveland Clinic Foundation, Weston, USA
    Zhonghua Wei Chang Wai Ke Za Zhi 15:412-21. 2012
    ..While management of antibiotic-dependent or antibiotic-refractory pouchitis has been challenging, secondary etiology for pouchitis should be evaluated and modified, if possible...
  11. doi request reprint Prediction of late-onset pouch failure in patients with restorative proctocolectomy with a nomogram
    Bo Shen
    Digestive Disease Institute and Department of Quantitative Health Science, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Crohns Colitis 6:198-206. 2012
    ..Accurate risk assessment is critical for making proper evaluation and treatment. Information on factors that may reliably predict pouch failure for the patients requiring referral to a specialized care unit is minimal...
  12. ncbi request reprint Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice
    B Shen
    Department of Gastroenteorology Hepatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 22:721-8. 2005
    ..However, this agent has not been studied in the US, and its applicability in routine clinical practice has not been evaluated...
  13. doi request reprint Crohn's disease of the ileal pouch: reality, diagnosis, and management
    Bo Shen
    Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 15:284-94. 2009
    ..It is advisable to inform ulcerative colitis patients before the surgery of the potential risk for Crohn's disease along with other inflammatory and noninflammatory complications...
  14. ncbi request reprint Combined ciprofloxacin and tinidazole therapy in the treatment of chronic refractory pouchitis
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 50:498-508. 2007
    ..The aim of this study was to assess the efficacy and safety of a combination therapy of ciprofloxacin and tinidazole in patients with chronic refractory pouchitis compared with mesalamine therapy...
  15. doi request reprint Diagnostic value of esophagogastroduodenoscopy in patients with ileal pouch-anal anastomosis
    Bo Shen
    Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 15:395-401. 2009
    ..The aim was to estimate the prevalence of upper gastrointestinal (GI) diseases detected by EGD and to assess factors associated with the abnormal EGD findings...
  16. ncbi request reprint Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 4:81-9; quiz 2-3. 2006
    ..The aim of this study was to assess risk factors for inflammatory and noninflammatory diseases of IPAA in a tertiary care setting...
  17. doi request reprint Association between immune-associated disorders and adverse outcomes of ileal pouch-anal anastomosis
    Bo Shen
    Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic, Ohio 44195, USA
    Am J Gastroenterol 104:655-64. 2009
    ..The aim of the study was to determine whether coexisting AD in patients with ileal pouches increases the risk for chronic antibiotic-refractory pouchitis (CARP) and other inflammatory conditions of the pouch...
  18. doi request reprint Risk factors for low bone mass in patients with ulcerative colitis following ileal pouch-anal anastomosis
    Bo Shen
    Pouchitis Clinic, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 104:639-46. 2009
    ..There are few data on BMD in UC patients with IPAA. The aim of the study was to assess the prevalence and risk factors associated with low BMD in UC patients after IPAA...
  19. ncbi request reprint Clostridium difficile-associated pouchitis
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology Desk A30, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Dig Dis Sci 51:2361-4. 2006
    ..Clostridium difficile-associated pouchitis is rare. However, Clostridium difficile infection should be excluded in patients with chronic refractory pouchitis...
  20. ncbi request reprint Clinical features of ileal pouch polyps in patients with underlying ulcerative colitis
    Benjamin J Schaus
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 50:832-8. 2007
    ..Polypoid lesions rarely occur in the ileal pouch in ulcerative colitis patients after restorative proctocolectomy. Clinical features, malignant potential, and management of pouch polyps have not been characterized...
  21. doi request reprint Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosis
    Bo Shen
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 17:1890-900. 2011
    ..The aim of this study was to compare endoscopic and histologic inflammation in the afferent limb (prepouch ileum) and pouch between IPAA patients with and without PSC...
  22. ncbi request reprint Clinical features and quality of life in patients with different phenotypes of Crohn's disease of the ileal pouch
    Bo Shen
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Dis Colon Rectum 50:1450-9. 2007
    ..The clinical features of inflammatory, fibrostenotic, and fistulizing Crohn's disease have not been characterized...
  23. ncbi request reprint Effect of withdrawal of nonsteroidal anti-inflammatory drug use on ileal pouch disorders
    Bo Shen
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology Desk A30, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Dig Dis Sci 52:3321-8. 2007
    ..05). Patients with pouch disorders who regularly used NSAIDs appeared to benefit from the complete cessation of such agents, suggesting an association between NSAID use and pouch disorders...
  24. ncbi request reprint Collagenous pouchitis
    B Shen
    Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Dig Liver Dis 38:704-9. 2006
    ....
  25. doi request reprint Administration of adalimumab in the treatment of Crohn's disease of the ileal pouch
    B Shen
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 29:519-26. 2009
    ..Crohn's disease (CD) of the pouch can develop in patients with ileal pouch-anal anastomosis (IPAA). Scant data are available on the treatment of this disease entity...
  26. doi request reprint Efficacy and safety of endoscopic treatment of ileal pouch strictures
    Bo Shen
    Departments of Gastroenterology and Colorectal Surgery, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Inflamm Bowel Dis 17:2527-35. 2011
    ..The aim was to evaluate endoscopic balloon therapy of pouch strictures in inflammatory bowel disease (IBD) patients with ileal pouches and to identify risk factors for pouch failure for those patients...
  27. ncbi request reprint Pouchitis: a spectrum of diseases
    Bo Shen
    Department of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Curr Gastroenterol Rep 7:404-11. 2005
    ..Although the majority of patients with pouchitis respond to antibiotic therapy, a subset of these patients cannot achieve remission by means of antibiotics and thus require anti-inflammatory or immunosuppressive treatment...
  28. doi request reprint The efficacy and tolerability of AST-120 (spherical carbon adsorbent) in active pouchitis
    Bo Shen
    Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Gastroenterol 104:1468-74. 2009
    ..The aim of this pilot trial was to evaluate the efficacy and tolerability of AST-120 in the treatment of active pouchitis...
  29. pmc Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch
    Bo Shen
    Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 15:163-70. 2009
    ..CD of the pouch was often observed in patients with a family history of CD. The purpose was to determine whether the family history of CD increased the risk for CD of the pouch in patients who underwent restorative proctocolectomy...
  30. ncbi request reprint Endoscopic and histologic evaluation together with symptom assessment are required to diagnose pouchitis
    B Shen
    Department of Gastroenterology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Gastroenterology 121:261-7. 2001
    ..Pouchitis often is diagnosed based on symptoms alone. In this study, we evaluate whether symptoms correlate with endoscopic and histologic findings in patients with ulcerative colitis and an ileal pouch-anal anastomosis...
  31. ncbi request reprint A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis
    B Shen
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Inflamm Bowel Dis 7:301-5. 2001
    ..Ciprofloxacin should be considered as one of the first-line therapies for acute pouchitis...
  32. ncbi request reprint Cytokeratin expression patterns in noncardia, intestinal metaplasia-associated gastric adenocarcinoma: implication for the evaluation of intestinal metaplasia and tumors at the esophagogastric junction
    Bo Shen
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 94:820-31. 2002
    ....
  33. ncbi request reprint Managing medical complications and recurrence after surgery for Crohn's disease
    Bo Shen
    Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Gastroenterol Rep 10:606-11. 2008
    ..Disease monitoring and appropriate prophylaxis are necessary in patients at high risk...
  34. ncbi request reprint Diagnosis and treatment of patients with pouchitis
    Bo Shen
    Department of Gastroenterology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Drugs 63:453-61. 2003
    ..For patients with chronic pouchitis that is resistant to antibacterials, therapy with anti-inflammatory agents and immunomodulators is often required...
  35. doi request reprint Natural history of Crohn's disease in patients who underwent intentional restorative proctocolectomy with ileal pouch-anal anastomosis
    B Shen
    Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 31:745-53. 2010
    ..Crohn's disease is generally considered a relative contraindication for restorative proctocolectomy with ileal pouch anastomosis (IPAA). The natural history of IPAA in these patients has not well been defined...
  36. ncbi request reprint Impact of preoperative infliximab use on postoperative infectious complications in ulcerative colitis: the price we have to pay?
    Bo Shen
    Digestive Disease Institute Desk A31, Cleveland Clinic, 9500 Euclid Ave Cleveland, OH 44195, USA
    Inflamm Bowel Dis 14:1019-21. 2008
  37. doi request reprint Risk factors for pouch failure in patients with different phenotypes of Crohn's disease of the pouch
    Bo Shen
    Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 14:942-8. 2008
    ..Risk factors for pouch failure in these patients are yet to be identified. The aim of the study was to assess risk factors associated with pouch failure in patients with CD of the pouch...
  38. ncbi request reprint In vivo colonoscopic optical coherence tomography for transmural inflammation in inflammatory bowel disease
    Bo Shen
    Department of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Clin Gastroenterol Hepatol 2:1080-7. 2004
    ..We performed an in vivo colonoscopic OCT in patients with a clinical diagnosis of CD or UC using the previously established, histology-correlated OCT imaging criterion...
  39. ncbi request reprint Ex vivo histology-correlated optical coherence tomography in the detection of transmural inflammation in Crohn's disease
    Bo Shen
    Department of Gastroenterology Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Gastroenterol Hepatol 2:754-60. 2004
    ..The aims of this study were to perform histology-correlated OCT on surgical specimens of CD and UC and to determine its diagnostic accuracy...
  40. ncbi request reprint Optical coherence tomography in the gastrointestinal tract
    Bo Shen
    Department of Gastroenterology Hepatology, Cleveland Clinic Foundation, Desk A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastrointest Endosc Clin N Am 14:555-71, x. 2004
    ..The evolution of endoscopic ultrasonography has provided an additional dimension to the clinical application of modern endoscopy and imaging technology...
  41. doi request reprint Pyloric gland metaplasia and pouchitis in patients with ileal pouch-anal anastomoses
    R Kariv
    Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 31:862-73. 2010
    ..Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated...
  42. doi request reprint Do preoperative factors predict subsequent diagnosis of Crohn's disease after ileal pouch-anal anastomosis for ulcerative or indeterminate colitis?
    G B Melton
    Digestive Disease Institute, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Colorectal Dis 12:1026-32. 2010
    ....
  43. doi request reprint Clinical features of ileal pouch-anal anastomosis in African American patients with underlying ulcerative colitis
    L Moore
    Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 30:385-91. 2009
    ..The prevalence of inflammatory bowel disease in African Americans appears to be increasing. The data on differences in disease behavior and severity between the races have been conflicting...
  44. doi request reprint Preoperative colorectal neoplasia increases risk for pouch neoplasia in patients with restorative proctocolectomy
    Revital Kariv
    Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastroenterology 139:806-12, 812.e1-2. 2010
    ..We characterized features, risk factors, and outcomes of pouch neoplasia in patients with inflammatory bowel disease in a historical cohort study...
  45. doi request reprint Secondary pouchitis: those with identifiable etiopathogenetic or triggering factors
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 105:51-64. 2010
    ..Careful evaluation of these secondary causes of pouchitis that may contribute to resistance to antibiotics should be performed before the introduction of next-line medical therapy...
  46. ncbi request reprint Impact of orthotopic liver transplant for primary sclerosing cholangitis on chronic antibiotic refractory pouchitis
    Katherine Freeman
    Digestive Disease Center, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 6:62-8. 2008
    ..The aims of this study were to compare the frequency of chronic antibiotic-refractory pouchitis (CARP) in PSC patients with or without OLT and to assess potential risk factors for CARP in these patients...
  47. doi request reprint Gender of the patient may influence perioperative and long-term complications after restorative proctocolectomy
    M Rottoli
    Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Colorectal Dis 14:336-41. 2012
    ..Gender-related differences in preoperative characteristics and early and long-term outcome for patients undergoing ileal pouch anal anastomosis (IPAA) have not previously been well studied...
  48. doi request reprint Infliximab in ulcerative colitis is associated with an increased risk of postoperative complications after restorative proctocolectomy
    I J Mor
    Digestive Diseases Institute, A30, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1202-7; discussion 1207-10. 2008
    ..Our goals were to determine the rate of postoperative complications in infliximab-treated ulcerative colitis patients undergoing restorative proctocolectomy and to determine whether three-stage procedures are more often necessary...
  49. ncbi request reprint Medical management of postoperative complications of inflammatory bowel disease: pouchitis and Crohn's disease recurrence
    J P Achkar
    Department of Gastroenterology, The Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Gastroenterol Rep 3:484-90. 2001
    ..Increasing evidence suggests that postoperative medical therapy has the potential to decrease the risk of postoperative Crohn's disease recurrence...
  50. doi request reprint Evaluation of association between precolectomy thrombocytosis and the occurrence of inflammatory pouch disorders
    Lei Lian
    Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 52:1912-8. 2009
    ..The aim of this study was to evaluate the associations between precolectomy routine laboratory tests, including platelet counts, and occurrences of inflammatory pouch disorders...
  51. doi request reprint Laboratory tests for patients with ileal pouch-anal anastomosis: clinical utility in predicting, diagnosing, and monitoring pouch disorders
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:2606-15. 2009
    ....
  52. ncbi request reprint A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease Department of Gastroenterology, I H Page Center for Health Outcomes Research, Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 98:2460-7. 2003
    ..Cost-effectiveness of these strategies has not been compared. The aim of this study was to compare cost-effectiveness of different clinical approaches for patients with symptoms suggestive of pouchitis...
  53. ncbi request reprint Endoscopic balloon dilation of ileal pouch strictures
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:2340-7. 2004
    ..Endoscopic balloon dilation has been successfully used in patients with Crohn's strictures at the small intestine and colon. There are no published trials on endoscopic balloon therapy of ileal pouch strictures...
  54. doi request reprint Clinical implication of false-positive celiac serology in patients with ileal pouch
    Lei Lian
    Departments of Colorectal Surgery and Gastroenterology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 53:1446-51. 2010
    ..The clinical utility of celiac serology in patients with ileal pouches is unknown. The aim of this study was to investigate the clinical implications of false-positive celiac serology in patients with ileal pouches...
  55. doi request reprint Diagnostic yield of colonoscopy for constipation as the sole indication
    E C Obusez
    Lerner College of Medicine, Department of Gastroenterology and the Cleveland Clinic, Cleveland, Ohio 44195, USA
    Colorectal Dis 14:585-91. 2012
    ..The study was carried out to assess the prevalence of abnormal pathology on colonoscopy and to assess the risk factors for colonic neoplasia in patients with constipation but without 'high risk symptoms'...
  56. doi request reprint Asymmetric endoscopic inflammation of the ileal pouch: a sign of ischemic pouchitis?
    Bo Shen
    Pouchitis Clinic, Departmentsof Gastroenterology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 16:836-46. 2010
    ..The aim was to describe a disease phenotype of the ileal pouch with an endoscopic appearance suggestive of ischemia...
  57. ncbi request reprint Risk factors for clinical phenotypes of Crohn's disease of the ileal pouch
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 101:2760-8. 2006
    ..The clinical presentations of CD of the pouch are inflammatory, fibrostenotic, and fistulizing. Risk factors for clinical phenotypes of CD of the pouch have not been characterized...
  58. ncbi request reprint Surgical outcome in patients with primary sclerosing cholangitis undergoing ileal pouch-anal anastomosis: a case-control study
    Emre Gorgun
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Surgery 138:631-7; discussion 637-9. 2005
    ....
  59. doi request reprint Long-term outcomes with ileal pouch-anal anastomosis and Crohn's disease: pouch retention and implications of delayed diagnosis
    Genevieve B Melton
    Digestive Disease Institute, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Surg 248:608-16. 2008
    ..To assess long-term outcomes after ileal pouch-anal anastomosis (IPAA) in Crohn's disease (CD)...
  60. doi request reprint Clinical features and management of postoperative pouch bleeding after ileal pouch-anal anastomosis (IPAA)
    Lei Lian
    Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Gastrointest Surg 12:1991-4. 2008
    ..The clinical features of postoperative bleeding from the ileal pouch-anal anastomosis(IPAA) vary and its management can be difficult. There is no published literature regarding pouch bleeding and its treatment...
  61. doi request reprint Use of infliximab within 3 months of ileocolonic resection is associated with adverse postoperative outcomes in Crohn's patients
    Kweku A Appau
    The Cleveland Clinic Foundation, Cleveland, OH, USA
    J Gastrointest Surg 12:1738-44. 2008
    ..Our aim was to evaluate 30-day postoperative outcomes for Crohn's patients treated with infliximab within 3 months prior to ileocolonic resection...
  62. ncbi request reprint Differentiating risk factors for acute and chronic pouchitis
    Jean Paul Achkar
    Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A30, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 3:60-6. 2005
    ..The clinical course and medical therapy are different between acute pouchitis and chronic pouchitis. The aim of this study was to determine if there are predictors of risk for acute vs. chronic pouchitis...
  63. doi request reprint Outcome of salvage surgery for ileal pouches referred with a diagnosis of Crohn's disease
    Kelly A Garrett
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 52:1967-74. 2009
    ..The purpose of our study is to evaluate the presentation, treatment, and outcomes of patients with a potential misdiagnosis of Crohn's disease who have undergone redo ileal pouch-anal anastomosis...
  64. doi request reprint Outcomes for patients undergoing continent ileostomy after a failed ileal pouch-anal anastomosis
    Lei Lian
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 52:1409-14; discussion 4414-6. 2009
    ..The aim of this study is to investigate outcomes for patients undergoing continent ileostomy after a failed ileal pouch-anal anastomosis at our institution...
  65. ncbi request reprint Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis
    Mansour A Parsi
    Department of Gastroenterology, Center for Inflammatory Bowel Disease, Cleveland Clinic Foundation, Desk A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 126:1280-6. 2004
    ..Distinction among these entities requires pouch endoscopy and biopsy. Noninvasive means of diagnosis are preferable...
  66. ncbi request reprint Treatment of rectal cuff inflammation (cuffitis) in patients with ulcerative colitis following restorative proctocolectomy and ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology, Anatomic Pathology, and Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:1527-31. 2004
    ..Despite its advantages, the procedure normally leaves a 1-2 cm of anal transitional zone or rectal cuff, which is susceptible to recurrence of residual UC or cuffitis. Cuffitis can cause symptoms mimicking pouchitis...
  67. ncbi request reprint A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal
    Steven D Wexner
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
    Dis Colon Rectum 49:792-809. 2006
  68. ncbi request reprint Comprehensive evaluation of inflammatory and noninflammatory sequelae of ileal pouch-anal anastomoses
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio
    Am J Gastroenterol 100:93-101. 2005
    ..Symptomatology, endoscopy, histology, and the Cleveland Global QOL and the Irritable Bowel Syndrome-QOL scores were compared among the groups...
  69. ncbi request reprint A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal
    Steven D Wexner
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL, USA
    Surg Endosc 20:1147-60. 2006
  70. pmc Clostridium difficile infection and inflammatory bowel disease: understanding the evolving relationship
    Udayakumar Navaneethan
    Victor W Fazio Center for Inflammatory Bowel Disease, Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, The Cleveland Clinic A31, 9500 Euclid Ave, Cleveland, OH 44195, United States
    World J Gastroenterol 16:4892-904. 2010
    ..For CDI in the setting of underlying IBD, vancomycin appears to be more efficacious than metronidazole. Randomized controlled trials are required to clearly define the appropriate management for CDI in patients with IBD...
  71. doi request reprint Enterochromaffin cell hyperplasia in irritable pouch syndrome
    Bo Shen
    Pouchitis Clinic, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 103:2293-300. 2008
    ..The aim of the study was to assess EC cell hyperplasia and alterations in the mucosal immune cells in IPS...
  72. ncbi request reprint The challenge of irritable bowel syndrome: creating an alliance between patient and physician
    B Shen
    Department of Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 68:224-5, 229-33, 236-7. 2001
    ..We describe a stepwise approach to management, including judicious use of invasive tests, and setting realistic treatment goals that address the dominant symptoms, their severity, and psychosocial factors...
  73. doi request reprint Fulminant Clostridium difficile-associated pouchitis with a fatal outcome
    Bo Shen
    Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Nat Rev Gastroenterol Hepatol 6:492-5. 2009
    ..Management. Intravenous hydration, aggressive therapy with oral and intravenous antibiotics, supportive care, hemodialysis, and intubation...
  74. ncbi request reprint Irritable pouch syndrome: a new category of diagnosis for symptomatic patients with ileal pouch-anal anastomosis
    Bo Shen
    Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:972-7. 2002
    ..This study was designed to assess the etiology of bowel symptoms using the Pouchitis Disease Activity Index (PDAI)...
  75. doi request reprint Evaluation of endoscopic and imaging modalities in the diagnosis of structural disorders of the ileal pouch
    Linda Tang
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 16:1526-31. 2010
    ..The aims of this study were to compare these imaging techniques to each other and to optimize diagnosis of pouch disorders by using a combination of these diagnostic modalities...
  76. doi request reprint Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:2467-75. 2009
    ..The aim of this study was to evaluate the prevalence and to identify risk factors for abnormal LFTs in patients with IPAA and underlying IBD...
  77. doi request reprint Pros and cons of antibiotic therapy for pouchitis
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 3:547-59. 2009
    ..The risks and benefits should be carefully balanced in patients who require long-term antibiotic therapy, and safe, efficacious, non-antibiotic-based agents are needed...
  78. pmc Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract
    B Shen
    Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Pathol 58:687-94. 2005
    ..Paneth cells (PCs), characterised by cytoplasmic eosinophilic granules, are found in a subset of IM at these sites, but histology may not accurately detect them...
  79. ncbi request reprint Are we moving forward in the biological treatment of Crohn's disease? Time will tell
    Ioannis Oikonomou
    Center for Inflammatory Bowel Disease, Department of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Inflamm Bowel Dis 12:147-9. 2006
  80. doi request reprint Ileal pouch prolapse: prevalence, management, and outcomes
    Myles R Joyce
    Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue A30, Cleveland, OH 44195, USA
    J Gastrointest Surg 14:993-7. 2010
    ..The study aim is to review the prevalence, management, and outcomes for patients diagnosed with ileal pouch prolapse after restorative proctocolectomy...
  81. doi request reprint Application of wireless capsule endoscopy for the evaluation of iron deficiency anemia in patients with ileal pouches
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, OH, USA
    J Clin Gastroenterol 42:897-902. 2008
    ..Persistent anemia has been observed in patients with ileal pouches, for which identification of etiology can be challenging...
  82. ncbi request reprint What are the caveats to using sodium phosphate agents for bowel preparation?
    Rohit Makkar
    Department of General Internal Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 75:173-6. 2008
  83. doi request reprint Successful endoscopic needle knife therapy combined with topical doxycycline injection of chronic sinus at ileal pouch-anal anastomosis
    Y Li
    Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
    Colorectal Dis 14:e197-9. 2012
    ..The aim was to present a novel technique with a combining endoscopic doxycycline injection and needle knife therapy for a sinus at the ileoanal anastomosis...
  84. ncbi request reprint A review of diabetic gastropathy
    B Shen
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Compr Ther 27:56-9. 2001
    ..Management of diabetic gastropathy involves dietary modifications, pharmacological agents, and occasionally, alternative feeding methods...
  85. ncbi request reprint Risk factors for anemia in patients with ileal pouch-anal anastomosis
    Ioannis K Oikonomou
    Department of Gastroenterology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 50:69-74. 2007
    ..The identification of the underlying causes can be challenging. This study was designed to define the prevalence and to identify etiologic factors for anemia in this patient population...
  86. ncbi request reprint Modified pouchitis disease activity index: a simplified approach to the diagnosis of pouchitis
    Bo Shen
    Center for Inflammatory Bowel Disease, Cleveland, Ohio, USA
    Dis Colon Rectum 46:748-53. 2003
    ..The aim of the present study was to determine whether omitting histologic evaluation from the pouchitis disease activity index significantly affects the sensitivity and specificity of diagnostic criteria for pouchitis...
  87. doi request reprint Impact of narcotic use on the requirement for colectomy in inpatients with ulcerative colitis
    Lei Lian
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 53:1295-300. 2010
    ..The effect of narcotic use in the disease course of ulcerative colitis has not been studied. The aim of the study was to evaluate the impact of narcotic use on the requirement for colectomy in inpatients with ulcerative colitis...
  88. ncbi request reprint Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues
    Jan Wehkamp
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Tupper Hall Room 3146, 95616 8645, USA
    FEBS Lett 580:5344-50. 2006
    ....
  89. ncbi request reprint A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal
    Steven D Wexner
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Fla
    Gastrointest Endosc 63:894-909. 2006
  90. ncbi request reprint ASGE guideline: modifications in endoscopic practice for the elderly
    Waqar A Qureshi
    American Society for Gastrointestinal Endoscopy, 1520 Kensington Road, Ste 202, Oak Brook, IL 60523, USA
    Gastrointest Endosc 63:566-9. 2006
  91. ncbi request reprint ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease
    Jonathan A Leighton
    American Society for Gastrointestinal Endoscopy, 1520 Kensington Road, Ste 202, Oak Brook, IL 60523, USA
    Gastrointest Endosc 63:558-65. 2006
  92. ncbi request reprint Pouchitis
    En da Yu
    Department of Colorectal Surgery, Shangai Changai Hospital, Shangai 200438, China
    World J Gastroenterol 13:5598-604. 2007
    ..The majority of patients respond favorably to antibiotic therapy. However, management of chronic antibiotic-refractory pouchitis remains a challenge...
  93. ncbi request reprint Can we immunogenotypically and immunophenotypically profile patients who are at risk for pouchitis?
    Bo Shen
    Am J Gastroenterol 99:442-4. 2004
  94. ncbi request reprint Modifications in endoscopic practice for pediatric patients
    Kenneth K Lee
    Gastrointest Endosc 67:1-9. 2008
  95. doi request reprint Role of endoscopy in the bariatric surgery patient
    Michelle A Anderson
    Gastrointest Endosc 68:1-10. 2008
  96. ncbi request reprint Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:279-82. 2004
    ..The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity...
  97. pmc Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    Jan Wehkamp
    Department of Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
    Proc Natl Acad Sci U S A 102:18129-34. 2005
    ..Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease...
  98. ncbi request reprint The homeobox gene GLABRA2 affects seed oil content in Arabidopsis
    Bo Shen
    Pioneer Hi Bred International, A DuPont Company, 7300 NW 62nd Ave, Johnston, IOW, 50131, USA
    Plant Mol Biol 60:377-87. 2006
    ..The result indicates that in addition to its known function in trichome and root hair development, GLABRA2 is involved in the control of seed oil accumulation...
  99. ncbi request reprint ASGE guideline: colorectal cancer screening and surveillance
    Raquel E Davila
    American Society for Gastrointestinal Endoscopy, 1520 Kensington Road, Ste 202, Oak Brook, IL 60523, USA
    Gastrointest Endosc 63:546-57. 2006
  100. ncbi request reprint Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Am Chem Soc 124:9729-36. 2002
    ..The presence and position of an isovaleryl group in the terminal mannose (Man-B) in 3-5 are critical for retaining antibacterial potency...
  101. pmc Orthotopic liver transplantation as a rescue operation for recurrent hepatocellular carcinoma after partial hepatectomy
    Zhuo Shao
    Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 14:4370-6. 2008
    ....

Research Grants1

  1. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..