Klaus Sellheyer

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint "Hidradenitis suppurativa" is acne inversa! An appeal to (finally) abandon a misnomer
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Dermatol 44:535-40. 2005
  2. doi request reprint Ber-EP4 enhances the differential diagnostic accuracy of cytokeratin 7 in pagetoid cutaneous neoplasms
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cutan Pathol 35:366-72. 2008
  3. ncbi request reprint Histopathologic evaluation of alopecias
    Klaus Sellheyer
    Departments of Dermatology and Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Dermatopathol 28:236-59. 2006
  4. ncbi request reprint Differences in biopsy techniques of actinic keratoses by plastic surgeons and dermatologists: a histologically controlled pilot study
    Klaus Sellheyer
    Department of Anatomic Pathology, Section of Dermatopathology, The Cleveland Clinic Foundation, OH 44195, USA
    Arch Dermatol 142:455-9. 2006
  5. ncbi request reprint When to ask your dermatopathologist to evaluate for surgical margins and when not: a matter of confusion for dermatologists and dermatopathologists alike
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Acad Dermatol 52:1095-7. 2005
  6. ncbi request reprint "Lesion," "rule out...," and other vagaries of filling out pathology requisition forms
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Acad Dermatol 52:914-5. 2005
  7. ncbi request reprint A retrospective biopsy study of the clinical diagnostic accuracy of common skin diseases by different specialties compared with dermatology
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 52:823-30. 2005
  8. ncbi request reprint Evaluation of surgical margins in melanocytic lesions: a survey among 152 dermatopathologists
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cutan Pathol 32:293-9. 2005
  9. ncbi request reprint DNA microarrays: from structural genomics to functional genomics. The applications of gene chips in dermatology and dermatopathology
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 51:681-92; quiz 693-6. 2004
  10. ncbi request reprint Mechanisms of laser hair removal: could persistent photoepilation induce vitiligo or defects in wound repair?
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dermatol Surg 33:1055-65. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint "Hidradenitis suppurativa" is acne inversa! An appeal to (finally) abandon a misnomer
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Dermatol 44:535-40. 2005
    ..We suggest that the term "hidradenitis suppurativa" for this disease should (finally) be abandoned in favour of "acne inversa"...
  2. doi request reprint Ber-EP4 enhances the differential diagnostic accuracy of cytokeratin 7 in pagetoid cutaneous neoplasms
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cutan Pathol 35:366-72. 2008
    ..Here we report its application in the differential diagnosis of cutaneous pagetoid neoplasms...
  3. ncbi request reprint Histopathologic evaluation of alopecias
    Klaus Sellheyer
    Departments of Dermatology and Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Dermatopathol 28:236-59. 2006
    ..This review also discusses important pathogenetic concepts, such as stem cell failure...
  4. ncbi request reprint Differences in biopsy techniques of actinic keratoses by plastic surgeons and dermatologists: a histologically controlled pilot study
    Klaus Sellheyer
    Department of Anatomic Pathology, Section of Dermatopathology, The Cleveland Clinic Foundation, OH 44195, USA
    Arch Dermatol 142:455-9. 2006
    ..To compare differences in biopsy techniques of actinic keratoses between dermatologists and plastic surgeons...
  5. ncbi request reprint When to ask your dermatopathologist to evaluate for surgical margins and when not: a matter of confusion for dermatologists and dermatopathologists alike
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Acad Dermatol 52:1095-7. 2005
  6. ncbi request reprint "Lesion," "rule out...," and other vagaries of filling out pathology requisition forms
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Acad Dermatol 52:914-5. 2005
  7. ncbi request reprint A retrospective biopsy study of the clinical diagnostic accuracy of common skin diseases by different specialties compared with dermatology
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 52:823-30. 2005
    ..With the recent trend for nondermatologists to treat dermatologic disorders, this retrospective biopsy study reviews the accuracy of the clinical diagnosis of physicians of different specialties performing surgical dermatologic procedures...
  8. ncbi request reprint Evaluation of surgical margins in melanocytic lesions: a survey among 152 dermatopathologists
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cutan Pathol 32:293-9. 2005
    ..Although guidelines are established for reporting tissue specimens of melanomas, such guidelines are not available for reporting surgical margins of benign melanocytic lesions...
  9. ncbi request reprint DNA microarrays: from structural genomics to functional genomics. The applications of gene chips in dermatology and dermatopathology
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 51:681-92; quiz 693-6. 2004
    ..cDNA microarrays will shape the diagnostic approach of the dermatology and the dermatopathology of the future and may lead to new therapeutic options...
  10. ncbi request reprint Mechanisms of laser hair removal: could persistent photoepilation induce vitiligo or defects in wound repair?
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dermatol Surg 33:1055-65. 2007
    ..Current laser hair removal modalities achieve a long-term but not persistent (irreversible) hair loss...
  11. doi request reprint The ventral proximal nail fold: stem cell niche of the nail and equivalent to the follicular bulge--a study on developing human skin
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 39:835-43. 2012
    ..The areas of proliferative activity were additionally examined using labeling with Ki-67...
  12. doi request reprint Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Acad Dermatol 63:93-113. 2010
    ..Whereas keratinocytic bulge stem cells are well characterized, comparably little is known about cutaneous mesenchymal stem cells. The follicular connective tissue sheath is proposed as a niche for dermal stem cells...
  13. doi request reprint Basaloid tumors in nevus sebaceus revisited: the follicular stem cell marker PHLDA1 (TDAG51) indicates that most are basal cell carcinomas and not trichoblastomas
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 40:455-62. 2013
    ..Therefore, we explored its usefulness in basaloid neoplasms developing in NS...
  14. doi request reprint The concept of the onychodermis (specialized nail mesenchyme): an embryological assessment and a comparative analysis with the hair follicle
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 40:463-71. 2013
    ..The onychodermis expresses CD10 with remarkable specificity. Herein, we compare adult and fetal human hair follicles with fetal nail organs in an attempt to draw analogies for the mesenchyme associated with both adnexal structures...
  15. doi request reprint Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 38:415-9. 2011
    ..The distribution pattern differs only in early embryogenesis, when nestin but not SOX2 is also expressed throughout the entire interfollicular dermis. We speculated that DFSP would not only be nestin-positive but also SOX2-positive...
  16. doi request reprint The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 40:363-70. 2013
    ....
  17. doi request reprint Does the peritumoral stroma of basal cell carcinoma recapitulate the follicular connective tissue sheath?
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 38:551-9. 2011
    ..This study examines the expression of this neuroepithelial stem cell protein in trichoblastoma/trichoepithelioma and in basal cell carcinoma (BCC), which is increasingly being viewed as follicular in nature...
  18. doi request reprint Expression pattern of GATA-3 in embryonic and fetal human skin suggests a role in epidermal and follicular morphogenesis
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 37:357-61. 2010
    ..While the expression profile of GATA-3 is delineated for the mouse, little is known about its expression in the adult human hair follicle and no studies are published about its distribution during human cutaneous embryogenesis...
  19. doi request reprint Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 38:542-50. 2011
    ..In the current study, we examined the expression of a recently characterized follicular stem cell marker, PHLDA1 (pleckstrin homology-like domain, family A, member 1), also known as TDAG51 (T-cell death-associated gene 51)...
  20. doi request reprint Cutaneous mesenchymal stem cells: status of current knowledge, implications for dermatopathology
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 37:624-34. 2010
    ....
  21. doi request reprint Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 37:362-70. 2010
    ....
  22. doi request reprint Skin mesenchymal stem cells: prospects for clinical dermatology
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Acad Dermatol 63:859-65. 2010
    ..In line with the cancer stem cell hypothesis, the potential contributions to dermatopathology include a conceptual understanding of mesenchymal skin-based neoplasms as evolving from a genetically altered dermal stem cell clone...
  23. doi request reprint Stem cell markers can help identify adnexal tumor differentiation when evaluated in the context of morphology: methodology matters
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 38:460-74. 2011
    ..A combined approach of modern morphology with basic science holds potential to advance one important aspect of our field further with the final goal of logically classifying adnexal tumors based on stem cell biology...
  24. ncbi request reprint What causes acne inversa (or hidradenitis suppurativa)?--the debate continues
    Klaus Sellheyer
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Cutan Pathol 35:701-3. 2008
  25. ncbi request reprint Basal cell (trichoblastic) carcinoma common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: A clue to the adnexa
    Klaus Sellheyer
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Am Acad Dermatol 58:158-67. 2008
    ..Basal cell carcinoma (BCC) is still viewed by many dermatologists as a tumor of the interfollicular epidermis, although references were made early in the dermatopathologic literature to the resemblance of BCC to the hair follicle...
  26. doi request reprint Solitary plaque on the scalp as a primary manifestation of Hodgkin lymphoma: a case report and review of the literature
    Ibrahim Khalifeh
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Cutan Pathol 36:80-5. 2009
    ..In either case, primary or secondary cutaneous Hodgkin disease is an extreme rarity. The literature is critically reviewed...
  27. doi request reprint A case of recurrent pseudolymphomatous folliculitis: A mimic of cutaneous lymphoma
    Eun Ji Kwon
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
    J Am Acad Dermatol 60:994-1000. 2009
    ....
  28. ncbi request reprint Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments
    Kesha J Buster
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Ave S, EFH Set 414, Birmingham, AL 35294 0009, USA
    Cutis 92:83-7. 2013
    ..Although IVIG did not prevent our patient's death, further studies are needed to determine its clinical utility in the treatment of this rare disorder. ..
  29. ncbi request reprint Nail stem cells
    Klaus Sellheyer
    Department of Dermatology A61, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Dtsch Dermatol Ges 11:235-9. 2013
    ..Therefore, examining fetal material offers unique advantages. In the following mini-review, our current knowledge on nail stem cells is summarized and analogies to the hair follicle stem cells are drawn...
  30. ncbi request reprint Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma
    Dieter Krahl
    Institut für Dermatohistologie, Heidelberg, Germany
    J Cutan Pathol 34:782-7. 2007
    ..In this study, we report its application in the differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and basal cell carcinoma...
  31. ncbi request reprint Dermatofibroma: upregulation of syndecan-1 expression in mesenchymal tissue
    Klaus Sellheyer
    The Jefferson Center for Dermatopathology, Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Dermatopathol 25:392-8. 2003
    ....
  32. ncbi request reprint Pathogenesis of solar elastosis: synthesis or degradation?
    Klaus Sellheyer
    The Jefferson Center for Dermatopathology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    J Cutan Pathol 30:123-7. 2003