Brian P Rubin

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Diagnosis of gastrointestinal stromal tumors: a consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Int J Surg Pathol 10:81-9. 2002
  2. ncbi request reprint The gene expression profile of extraskeletal myxoid chondrosarcoma
    Subbaya Subramanian
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA
    J Pathol 206:433-44. 2005
  3. ncbi request reprint KIT mutations in GIST
    Jonathan A Fletcher
    Brigham and Women s Hospital, 75 Francis Street, Thorn 5, Boston, MA 02115, USA
    Curr Opin Genet Dev 17:3-7. 2007
  4. pmc SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    Hongzhe Li
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Breast Cancer Res 9:R1. 2007
  5. ncbi request reprint Pathology of soft tissue sarcoma
    Brian P Rubin
    Department of Anatomic Pathology, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Natl Compr Canc Netw 5:411-8. 2007
  6. ncbi request reprint Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions
    Brian P Rubin
    Departments of Anatomic Pathology and Molecular Genetics, Taussig Cancer Center and Lerner Research Institute, The Cleveland Clinic L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Skeletal Radiol 36:267-8. 2007
  7. ncbi request reprint Gastrointestinal stromal tumour
    Brian P Rubin
    Department of Anatomic Pathology, Taussig Cancer Center and the Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Lancet 369:1731-41. 2007
  8. doi request reprint Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma
    Joshua Weaver
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 22:66-70. 2009
  9. ncbi request reprint Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall
    Maggie M Lam
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Int J Gynecol Pathol 25:288-92. 2006
  10. doi request reprint Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience
    Munir R Tanas
    Department of Pathology, Cleveland Clinic, Ohio, USA
    Arch Pathol Lab Med 134:1797-803. 2010

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Diagnosis of gastrointestinal stromal tumors: a consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Int J Surg Pathol 10:81-9. 2002
    ....
  2. ncbi request reprint The gene expression profile of extraskeletal myxoid chondrosarcoma
    Subbaya Subramanian
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA
    J Pathol 206:433-44. 2005
    ..Small molecule inhibitors for PPARG exist and PPARG could be a potential therapeutic target for EMC...
  3. ncbi request reprint KIT mutations in GIST
    Jonathan A Fletcher
    Brigham and Women s Hospital, 75 Francis Street, Thorn 5, Boston, MA 02115, USA
    Curr Opin Genet Dev 17:3-7. 2007
    ..Alternately, the mutant kinase proteins can be targeted using HSP90 inhibitors, which result in degradation of activated KIT and/or PDGFRA, or using KIT transcriptional repressors, such as flavopiridol...
  4. pmc SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    Hongzhe Li
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Breast Cancer Res 9:R1. 2007
    ..Whether SirT1 regulates the IGF-1 signaling for mammary gland development and function, however, is not clear. In the present study, this role of SirT1 was examined by studying SirT1-deficient mice...
  5. ncbi request reprint Pathology of soft tissue sarcoma
    Brian P Rubin
    Department of Anatomic Pathology, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Natl Compr Canc Netw 5:411-8. 2007
    ....
  6. ncbi request reprint Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions
    Brian P Rubin
    Departments of Anatomic Pathology and Molecular Genetics, Taussig Cancer Center and Lerner Research Institute, The Cleveland Clinic L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Skeletal Radiol 36:267-8. 2007
  7. ncbi request reprint Gastrointestinal stromal tumour
    Brian P Rubin
    Department of Anatomic Pathology, Taussig Cancer Center and the Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Lancet 369:1731-41. 2007
    ..The important interplay between the molecular genetics of gastrontestinal stromal tumour and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumours...
  8. doi request reprint Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma
    Joshua Weaver
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 22:66-70. 2009
    ..However, lack of MDM2 immunoexpression would rule out the possibility of inflammatory well-differentiated liposarcoma...
  9. ncbi request reprint Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall
    Maggie M Lam
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Int J Gynecol Pathol 25:288-92. 2006
    ..Thus, it is imperative to consider EGISTs in the differential diagnosis of mesenchymal neoplasms in the vulvovaginal/rectovaginal septum...
  10. doi request reprint Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience
    Munir R Tanas
    Department of Pathology, Cleveland Clinic, Ohio, USA
    Arch Pathol Lab Med 134:1797-803. 2010
    ..Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH)...
  11. doi request reprint Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma?
    Joshua Weaver
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mod Pathol 23:1301-6. 2010
    ....
  12. doi request reprint Gastrointestinal stromal tumor: advances in diagnosis and management
    Deepa T Patil
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 135:1298-310. 2011
    ....
  13. doi request reprint Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 23:93-7. 2010
    ..Finally, we discuss some of the potential pitfalls of this technique, including confusion with other mesenchymal neoplasms containing rearrangement of EWSR1, in particular Ewing's sarcoma/PNET...
  14. doi request reprint The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens
    Karen J Fritchie
    Dept of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 137:229-39. 2012
    ..Awareness of the variety of histologic patterns is critical to avoid misdiagnosis, especially in small biopsy specimens...
  15. doi request reprint Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge
    Mandi P Sachdeva
    Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Dermatopathol 31:423-6. 2009
    ..When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas...
  16. doi request reprint Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 22:1196-200. 2009
    ..Recognition of these atypical fibroblasts/myofibroblasts may help in avoiding the potential pitfall of misdiagnosing them as well-differentiated liposarcoma...
  17. doi request reprint Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model
    Sachiko Ohshima-Hosoyama
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX, USA
    J Pediatr Hematol Oncol 34:116-21. 2012
    ..Thus, tandutinib may be an agent of interest for sonic hedgehog-driven medulloblastoma if a synergistic drug combination can be identified...
  18. pmc Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)
    Anu Gupta
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 107:14333-8. 2010
    ..Thus, combining imatinib with autophagy inhibition represents a potentially valuable strategy to promote GIST cytotoxicity and to diminish both cellular quiescence and acquired resistance in GIST patients...
  19. doi request reprint Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms
    Joshua Weaver
    Pathology and Laboratory Medicine Institute, Cleveland Clinic and the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 21:943-9. 2008
    ....
  20. doi request reprint Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma
    Munir R Tanas
    Department of Molecular Genetics and Anatomic Pathology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Transl Med 3:98ra82. 2011
    ..The chimeric WWTR1/CAMTA1 transcription factor may represent a therapeutic target for EHE and offers the opportunity to shed light on the functions of two poorly characterized proteins...
  21. doi request reprint The phosphatidyl inositol 3-kinase pathway is central to the pathogenesis of Kit-activated melanoma
    Ruixia Liang
    Department of Molecular Genetics, Cleveland Clinic, Lerner Research Institute, Taussig Cancer Center, Cleveland, OH, USA
    Pigment Cell Melanoma Res 24:714-23. 2011
    ..These studies validate this Kit L575P-activated model of melanoma and establish the PI3K pathway as a dominant signaling pathway downstream of Kit in melanoma...
  22. ncbi request reprint Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis
    Kimberly H Allison
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Clin Pathol 124:685-92. 2005
    ..However, identification of a benign precursor or origin from a nerve may be the most definitive way to properly classify these rare lesions...
  23. doi request reprint Prognosticators in thigh soft tissue sarcomas
    Anne E Newcomer
    Case Western Reserve University Medical School, Cleveland, Ohio, USA
    J Surg Oncol 103:85-91. 2011
    ..In sarcoma patients the roles of smoking history, family cancer history, and leukoreduced blood transfusions have not been studied and the effect of preoperative radiation on blood loss has not been examined...
  24. ncbi request reprint Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm
    Brigitte K Nixon
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Mod Pathol 18:1121-6. 2005
    ..Although this is a rare neoplasm, it is important to consider intravascular large B-cell lymphoma in the differential diagnosis of vascular lesions containing intravascular neoplastic cells...
  25. doi request reprint Epithelioid hemangioma-a rare scrotal tumor of childhood
    Anthony N Avallone
    Glickman Urological and Kidney Foundation, Cleveland, Ohio 44111, USA
    Urology 80:707-9. 2012
    ..The presented case represents only the third published occurrence of scrotal involvement, the second in a pediatric patient, and exhibited the unusual presentation as a scrotal wall mass rather than a visible skin lesion...
  26. pmc Gastrointestinal stromal tumors: molecular mechanisms and targeted therapies
    Erinn Downs-Kelly
    Departments of Anatomic and Molecular Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA
    Patholog Res Int 2011:708596. 2011
    ..This review will briefly touch on the clinicopathological features of GIST, while the majority of the review will focus on the clinical and treatment ramifications of KIT and PDGFRA mutations found in GIST...
  27. ncbi request reprint Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases
    Kimberly H Allison
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Surg Pathol 28:298-307. 2004
    ..Immunohistochemistry with vascular markers, CK20, and S-100 protein may be helpful in differentiating angiosarcoma from carcinoma and melanoma...
  28. pmc Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma
    Brian P Rubin
    Department of Anatomic Pathology, Taussig Cancer Center and Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cancer Cell 19:177-91. 2011
    ..Thus, sarcoma phenotype is strongly influenced by cell of origin and mutational profile...
  29. pmc Malignant neuroectodermal tumor with melanocytic and rhabdomyoblastic differentiation
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Rare Tumors 1:e26. 2009
    ....
  30. ncbi request reprint Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication
    Mikelle D Bassett
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, Washington 98195, USA
    Cancer 103:409-16. 2005
    ..The authors examined their single institutional experience and correlated their classification with clinical features and outcome...
  31. ncbi request reprint Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
    Brian P Rubin
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Lab Invest 86:981-6. 2006
    ..This paper focuses on what is known about mechanisms of resistance in the treatment of solid tumors by small molecule kinase inhibitors...
  32. pmc A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:690-5. 2006
    ....
  33. ncbi request reprint Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002
    ....
  34. ncbi request reprint Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    Brian P Rubin
    Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    J Clin Oncol 20:3586-91. 2002
    ..We investigated the response of dermatofibrosarcoma protuberans to the tyrosine kinase inhibitor imatinib mesylate...
  35. ncbi request reprint Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy
    Scott M Schuetze
    Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA
    Cancer 103:339-48. 2005
    ..Serial FDG-PET scans were taken to determine the correlation between FDG uptake and patient outcomes in patients receiving multimodality treatment of extremity sarcomas...
  36. doi request reprint Epithelioid sarcoma: the University of Washington experience
    Patrick S Wolf
    University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Surg 196:407-12. 2008
    ..Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes. We reviewed our experience with adjuvant therapy in patients with this disease...
  37. ncbi request reprint Keratin-positive Ewing's sarcoma: an ultrastructural study of 12 cases
    Amitabh Srivastava
    Department of Pathology, Tufts New England Medical Center, Boston, MA 02114, USA
    Int J Surg Pathol 13:43-50. 2005
    ..This study shows that keratin-positive EWS/PNETs have evidence of epithelial differentiation ultrastructurally, and may possibly represent a more aggressive subset of the EWS/PNET group of tumors...
  38. pmc Mitotic recombination as evidence of alternative pathogenesis of gastrointestinal stromal tumours in neurofibromatosis type 1
    Douglas R Stewart
    J Med Genet 44:e61. 2007
    ..Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut)...
  39. doi request reprint Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement
    Ilan Weinreb
    Department of Pathology and Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada
    J Cutan Pathol 35:855-60. 2008
    ..Pleomorphic AFH should be included in the differential diagnosis of atypical mesenchymal tumors of skin and superficial subcutis and molecular testing may prove helpful in this regard...
  40. ncbi request reprint Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    Michael C Heinrich
    Department of Medicine, Division of Hematology Oncology, Oregon Health Sciences University and Portland VA Medical Center, USA
    Hum Pathol 33:484-95. 2002
    ..These cytogenetic aberrations are undoubtedly important in GIST pathogenesis, but currently they do not play a key role as diagnostic adjuncts...
  41. ncbi request reprint FDG PET imaging guided re-evaluation of histopathologic response in a patient with high-grade sarcoma
    Cheryl B Vernon
    Department of Radiology Division of Nuclear Medicine, University of Washington, Seattle, Washington, USA
    Skeletal Radiol 32:139-42. 2003
    ..Evaluating the heterogeneity of the tumor at baseline and after response to therapy can provide insight into prognosis and treatment planning...
  42. ncbi request reprint A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E
    Brian P Rubin
    Department of Pathology, University of Washington Medical Center, Seattle, Washington 98195, USA
    Cancer Res 65:6631-9. 2005
    ....
  43. ncbi request reprint Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors
    Brian P Rubin
    Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Arch Pathol Lab Med 130:1616-29. 2006
  44. ncbi request reprint Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 28:1-30. 2004
    ..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO...
  45. ncbi request reprint TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies
    Jefferson Terry
    Genetic Pathology Evaluation Centre, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 4E6
    Am J Surg Pathol 31:240-6. 2007
    ..Our findings establish TLE as a robust immunohistochemical marker for synovial sarcoma, and may have implications for understanding the biology of synovial sarcoma and for developing experimental therapies for this cancer...
  46. ncbi request reprint Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Surg Pathol 29:1025-33. 2005
    ....
  47. pmc Determination of stromal signatures in breast carcinoma
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    PLoS Biol 3:e187. 2005
    ..Our findings suggest that the host stromal response varies significantly among carcinomas and that gene expression patterns characteristic of soft tissue tumors can be used to discover new markers for normal connective tissue cells...
  48. ncbi request reprint Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans
    Robert B West
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Surg Pathol 28:1063-9. 2004
    ..stanford.edu/tma_portal/apod/). We conclude that Apo D is strongly expressed in DFSPs and neural lesions and may be useful in differentiating DFSP from fibrous histiocytoma...