Affiliation: Cleveland Clinic Foundation
- Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrationsK Robinson
Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
Circulation 94:2743-8. 1996..A high level of total plasma homocysteine is a risk factor for atherosclerosis, which is an important cause of death in renal failure. We evaluated the role of this as a risk factor for vascular complications of end-stage renal disease...
- Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC GroupK Robinson
Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA
Circulation 97:437-43. 1998..This study was performed to explore the interrelationships between homocysteine, B vitamins, and vascular diseases and to evaluate the role of these vitamins as risk factors for atherosclerosis...
- Homocysteinemia and vascular disease in end-stage renal diseaseV W Dennis
Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Ohio, USA
Kidney Int Suppl 57:S11-7. 1996..The mechanism by which high homocysteine concentrations might cause vascular damage in patients with renal failure remains unclear...
- Hyperhomocysteinemia: detection, risk assessment, and treatmentV W Dennis
Department of Nephrology and Hypertension, Cleveland Clinic Foundation, OH 44195, USA
Curr Opin Nephrol Hypertens 6:483-8. 1997..Current models favor direct angiotoxicity involving endothelial and vascular smooth muscle cells, and impaired thrombolysis. Folic acid reduces hyperhomocysteinemia and thus provides an opportunity for risk-factor modification...
- Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular diseaseR Poddar
Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 103:2717-23. 2001..This suggests that L-homocysteine may contribute to the initiation and progression of vascular disease by promoting leukocyte recruitment...