Richard M Ransohoff

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. Ransohoff R, Trebst C. Surprising pleiotropy of nerve growth factor in the treatment of experimental autoimmune encephalomyelitis. J Exp Med. 2000;191:1625-30 pubmed
  2. Evans T, Barkauskas D, Myers J, Hare E, You J, Ransohoff R, et al. High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Exp Neurol. 2014;254:109-20 pubmed publisher
    ..Understanding the in vivo cellular interactions involved in secondary axonal injury may lead to clinical treatment candidates involving modulation of destructive infiltrating blood monocytes. ..
  3. Katsumoto A, Lu H, Miranda A, Ransohoff R. Ontogeny and functions of central nervous system macrophages. J Immunol. 2014;193:2615-21 pubmed publisher
    ..In this article, we discuss the physiology of microglia and the functions of monocytes in CNS pathology. We address the roles of microglia and monocytes in neurodegenerative diseases as an example of CNS pathology. ..
  4. Ransohoff R. Chemokines in neurological trauma models. Ann N Y Acad Sci. 2002;961:346-9 pubmed
  5. Takeshita Y, Obermeier B, Cotleur A, Sano Y, Kanda T, Ransohoff R. An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture. J Neurosci Methods. 2014;232:165-72 pubmed publisher
    ..This model provides reproducible assays for leukocyte transmigration with robust results, which will enable further defining the relationships among leukocytes and the cellular elements of the BBB. ..
  6. Ransohoff R, Wei T, Pavelko K, Lee J, Murray P, Rodriguez M. Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence. J Virol. 2002;76:2217-24 pubmed
    ..Our observations indicated that chemokine expression in the CNS in this chronic viral disorder was intrinsic to the CNS innate immune response to infection and was not governed by elements of the adaptive immune system. ..
  7. Cardona A, Li M, Liu L, Savarin C, Ransohoff R. Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. J Leukoc Biol. 2008;84:587-94 pubmed publisher
    ..We also propose novel functions of chemokine receptors during demyelination/remyelination, and developmental processes. ..
  8. Ransohoff R. Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity. 2009;31:711-21 pubmed publisher
    ..The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development. ..
  9. Ransohoff R, Cardona A. The myeloid cells of the central nervous system parenchyma. Nature. 2010;468:253-62 pubmed publisher
    ..Excessive or chronic inflammatory responses can, however, be harmful. How microglia balance these demands, and how their behaviour can be modified to ameliorate disorders of the central nervous system, is becoming clear. ..

More Information

Publications15

  1. Ransohoff R. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci. 2012;15:1074-7 pubmed publisher
  2. Ransohoff R, Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol. 2012;12:623-35 pubmed publisher
    ..Furthermore, we propose a new model to explain how antigen-specific T cell responses occur in the CNS. ..
  3. Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher
    ..Together our data suggest a cell-autonomous role of microglia, and identify TNF? as the responsible cytokine, in promoting neuronal CCEs in the pathogenesis of AD. ..
  4. Ransohoff R. A mighty mouse: building a better model of multiple sclerosis. J Clin Invest. 2006;116:2313-6 pubmed
    ..The studies describe an important new model for MS research. ..
  5. Ransohoff R, Brown M. Innate immunity in the central nervous system. J Clin Invest. 2012;122:1164-71 pubmed publisher
  6. Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch A, Cialic R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med. 2014;211:1533-49 pubmed publisher
    ..Distinguishing tissue-resident macrophages from infiltrating monocytes will point toward new strategies to treat disease and promote repair in diverse inflammatory pathologies in varied organs...