Richard A Prayson

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Dual Pathology in Rasmussen's Encephalitis: A Report of Coexistent Focal Cortical Dysplasia and Review of the Literature
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Case Report Pathol 2012:569170. 2012
  2. doi request reprint Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature
    Richard A Prayson
    Cleveland Clinic, Cleveland, OH, USA
    Clin Neuropathol 32:298-302. 2013
  3. doi request reprint Utilization of frozen sections in the evaluation of chronic epilepsy-related cases
    Richard A Prayson
    Cleveland Clinic, Section Head Neuropathology, CCLCM, OH 44195, USA
    Ann Diagn Pathol 17:145-9. 2013
  4. doi request reprint Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Pathol 43:1113-8. 2012
  5. ncbi request reprint Clinicopathologic findings in mesial temporal sclerosis treated with gamma knife radiotherapy
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 11:22-6. 2007
  6. ncbi request reprint The utility of MIB-1/Ki-67 immunostaining in the evaluation of central nervous system neoplasms
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Adv Anat Pathol 12:144-8. 2005
  7. doi request reprint Coexistent pathology in chronic epilepsy patients with neoplasms
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 23:1097-103. 2010
  8. doi request reprint Ki-67 immunoreactivity in type II malformations of cortical development
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 16:357-61. 2008
  9. doi request reprint Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma
    Richard A Prayson
    Department of Anatomic Pathology and Brain Tumor Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 18:422-8. 2010
  10. doi request reprint Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 13:36-40. 2009

Detail Information

Publications102 found, 100 shown here

  1. pmc Dual Pathology in Rasmussen's Encephalitis: A Report of Coexistent Focal Cortical Dysplasia and Review of the Literature
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Case Report Pathol 2012:569170. 2012
    ..type IIA, ILAE type IIA). The literature on dual pathology in the setting of Rasmussen's encephalitis is reviewed...
  2. doi request reprint Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature
    Richard A Prayson
    Cleveland Clinic, Cleveland, OH, USA
    Clin Neuropathol 32:298-302. 2013
    ..A Ki-67 labeling index of 1.9% was observed. The literature on gliofibromas arising in the spinal cord is reviewed. ..
  3. doi request reprint Utilization of frozen sections in the evaluation of chronic epilepsy-related cases
    Richard A Prayson
    Cleveland Clinic, Section Head Neuropathology, CCLCM, OH 44195, USA
    Ann Diagn Pathol 17:145-9. 2013
    ..Some epilepsy-associated pathology, such as focal cortical dysplasia, may be difficult to diagnose at the time of frozen section and such cases may not be an ideal target for intraoperative frozen section consultation...
  4. doi request reprint Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Pathol 43:1113-8. 2012
    ..Histologically, these multinodular tumors appear to maintain distinct areas with features of each tumor and foci where the 2 patterns are merged. A subset of composite tumors are associated with adjacent focal cortical dysplasia...
  5. ncbi request reprint Clinicopathologic findings in mesial temporal sclerosis treated with gamma knife radiotherapy
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 11:22-6. 2007
    ..Treatment of individuals with MTS via GKR may not always be adequate in controlling seizures. Radiation therapy effect may contribute to persistent seizures after GKR in some patients with MTS...
  6. ncbi request reprint The utility of MIB-1/Ki-67 immunostaining in the evaluation of central nervous system neoplasms
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Adv Anat Pathol 12:144-8. 2005
    ..Utilization of cell proliferation markers in the evaluation of tumors can be potentially useful in this endeavor. This review focuses on issues surrounding the utilization of MIB-1 or Ki-67 antibody in the evaluation of CNS neoplasms...
  7. doi request reprint Coexistent pathology in chronic epilepsy patients with neoplasms
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 23:1097-103. 2010
    ..Coexistent pathology may account for the incidence of recurrent or residual epilepsy in patients who undergo tumor resection...
  8. doi request reprint Ki-67 immunoreactivity in type II malformations of cortical development
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 16:357-61. 2008
    ..The proliferating cells appear to be primarily astrocytic and endothelial in nature and suggest that these lesions are not static. Dysmorphic neurons and balloon cells in MCD were not observed to stain with Ki-67...
  9. doi request reprint Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma
    Richard A Prayson
    Department of Anatomic Pathology and Brain Tumor Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 18:422-8. 2010
    ....
  10. doi request reprint Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 13:36-40. 2009
    ..The glioblastomatous component of the tumor demonstrated glial fibrillary acidic protein immunoreactivity. A Ki-67 labeling index of 18.9% was noted in the initial resection. The literature on similar-appearing lesions is reviewed...
  11. doi request reprint Diagnostic challenges in the evaluation of chronic epilepsy-related surgical neuropathology
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic, Section of Neuropathology, Cleveland, Ohio 44195, USA
    Am J Surg Pathol 34:e1-13. 2010
    ..Differential diagnostic difficulties will be examined...
  12. doi request reprint Tumours arising in the setting of paediatric chronic epilepsy
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pathology 42:426-31. 2010
    ..This study reviews one institution's 20 year experience with tumours arising in this clinical setting...
  13. ncbi request reprint Epidermal growth factor receptor is not amplified in schwannomas
    Richard A Prayson
    Department of Anatomic Pathology L25, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 11:326-9. 2007
    ....
  14. ncbi request reprint Epidermal growth factor receptor amplification does not have prognostic significance in patients with glioblastoma multiforme
    Aimee L Quan
    Department of Radiation Oncology, Brain Tumor Institute, The Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 63:695-703. 2005
    ..The purpose of this study is to determine the prognostic significance of EGFR amplification in patients with GBM treated at the Cleveland Clinic Foundation...
  15. doi request reprint Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institution
    Lewis A Rosenberg
    Department of Radiation Oncology, Cleveland Clinic Foundation, OH 44195, USA
    Int J Radiat Oncol Biol Phys 74:427-32. 2009
    ..To evaluate the outcomes for patients with Grade III meningiomas as defined by the 2007 World Health Organization standards...
  16. ncbi request reprint Neuronal nitric oxide synthase expression in resected epileptic dysplastic neocortex
    Jorge A González-Martínez
    Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosurg 110:343-9. 2009
    ..The expression of neuronal nitric oxide synthase (nNOS), and its relation to this subunit NR2B in epileptic dysplastic tissue has never been addressed...
  17. ncbi request reprint The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making
    Andrew A Kanner
    The Brain Tumor Institute, The Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg 104:542-50. 2006
    ..Anaplastic oligodendrogliomas with allelic loss of 1p have been associated with chemosensitivity and a longer patient survival period...
  18. ncbi request reprint Cyclooxygenase-2 in oligodendroglial neoplasms
    Elias A Castilla
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 98:1465-72. 2003
    ..Although increased expression of cyclooxygenase-2 (COX-2) has been described in association with a variety of neoplasms, including tumors of astrocytic derivation, limited data are available on COX-2 expression in oligodendrogliomas...
  19. ncbi request reprint Oligoastrocytoma presenting with intractable epilepsy
    Girish K Hiremath
    Department of Neurosurgery, Cleveland Clinic Foundation, OH 44195, USA
    Epileptic Disord 9:315-22. 2007
    ..Oligoastrocytomas (OA) are mixed gliomas with distinct oligodendroglial and astrocytic neoplastic components. Very little about OA has been reported in the intractable epilepsy population...
  20. ncbi request reprint Increased expression of 5-lipoxygenase in high-grade astrocytomas
    Narendra Nathoo
    Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurosurgery 58:347-54; discussion 347-54. 2006
    ..In this study, we investigated whether 5-LO is expressed in human astrocytomas and what effect its expression may have on patient outcome...
  21. doi request reprint The role of adjuvant radiation therapy in the treatment of spinal myxopapillary ependymomas
    Samuel T Chao
    Department of Radiation Oncology Brain Tumor and Neuro Oncology Center, Cleveland, Ohio 44195, USA
    J Neurosurg Spine 14:59-64. 2011
    ..the goal in this study was to determine the role of radiation therapy (RT) in the treatment of spinal myxopapillary ependymomas (MPEs)...
  22. doi request reprint Repeated molecular testing in gliomas: a retrospective study of 53 cases
    Dipti Mahajan
    Institute of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Clin Pathol 132:118-24. 2009
    ..Hence, there seems to be no indication for reflex repeated 1p/19q or EGFR testing in gliomas at the time of repeated biopsy or resection...
  23. doi request reprint Seizure outcome and its predictors after temporal lobe epilepsy surgery in patients with normal MRI
    Joanna S Fong
    Department of Neurology, Cleveland Clinic Epilepsy Center, Neurological Institute, Cleveland, Ohio 44195, USA
    Epilepsia 52:1393-401. 2011
    ..To characterize seizure outcomes following temporal lobe epilepsy (TLE) surgery in patients with normal preoperative brain magnetic resonance imaging (MRI)...
  24. doi request reprint Microscopic thrombi in anaplastic astrocytoma predict worse survival?
    Nicholas F Prayson
    Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Diagn Pathol 15:389-93. 2011
    ..There was no correlation between the presence of intratumoral thrombi and the development of DVT...
  25. pmc Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme
    Weifen F Zeng
    The Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Pathol 60:218-21. 2007
    ..These results suggest that Aurora B may be a prognostic feature of impaired survival and a novel therapeutic target in some patients...
  26. doi request reprint Interobserver and intraobserver reproducibility in focal cortical dysplasia (malformations of cortical development)
    Wendy A Chamberlain
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Epilepsia 50:2593-8. 2009
    ..The purpose of this study was to analyze inter- and intraobserver agreement among eight experienced neuropathologists (NPs) with respect to this classification system...
  27. ncbi request reprint Interobserver variability in determining MIB-1 labeling indices in oligodendrogliomas
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Ann Diagn Pathol 7:9-13. 2003
    ..Further improvement of concordance may theoretically be attainable by further training and discussion among observers...
  28. ncbi request reprint Pathologic findings associated with invasive EEG monitoring for medically intractable epilepsy
    Joanna S Fong
    Departments of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Clin Pathol 138:506-10. 2012
    ..The most common pathologic changes related to invasive monitoring were chronic inflammation and contusion/infarct...
  29. ncbi request reprint Immunohistochemical expression of cyclooxygenase 2 in follicular carcinomas of the thyroid
    Denise M Haynik
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 129:736-41. 2005
    ..Studies in this area are potentially significant, since therapeutic agents that inhibit COX-2 are currently available and could play a role in treatment...
  30. ncbi request reprint Role of MIB1 in predicting survival in patients with glioblastomas
    Shaye I Moskowitz
    Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Neurooncol 76:193-200. 2006
    ..An independent role of MIB1 analysis for survival prediction and clinical management within histologic grades has not been clearly proven...
  31. ncbi request reprint Symptomatic pituitary metastases from renal cell carcinoma
    Thottathil Gopan
    Department of Endocrinology and Metabolism, Desk A53 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Pituitary 10:251-9. 2007
    ..MRI shows contrast enhancement, stalk involvement, sclerosis and/or erosion of sella and presence of vascular flow voids. Combined treatment using decompressive surgery and stereotactic radiotherapy may result in better outcomes...
  32. doi request reprint Integrated molecular analysis suggests a three-class model for low-grade gliomas: a proof-of-concept study
    Nicholas F Marko
    Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH, USA
    Genomics 95:16-24. 2010
    ....
  33. ncbi request reprint Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Hum Pathol 35:317-21. 2004
    ..This suggests that the protoplasmic astrocytoma is a distinct entity from low-grade oligodendroglioma. Similar to other low-grade astrocytomas, only a minority of tumors show evidence of cyclooxygenase-2 and Bcl-2 immunoreactivity...
  34. ncbi request reprint Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord
    Clifford G Robinson
    Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Radiat Oncol Biol Phys 63:91-100. 2005
    ..To determine survival and changes in neurologic function and Karnofsky performance status (KPS) in a series of patients treated for low-grade astrocytoma of the spinal cord during the past two decades...
  35. doi request reprint Serum IGF-1 in the diagnosis of acromegaly and the profile of patients with elevated IGF-1 but normal glucose-suppressed growth hormone
    Sreevidya K Subbarayan
    Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, Ohio, USA
    Endocr Pract 18:817-25. 2012
    ....
  36. ncbi request reprint Gliosarcoma with infratemporal fossa extension. Case report
    Burak Sade
    Brain Tumor Institute, and Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg 105:904-7. 2006
    ..The effect of skull base involvement to the overall treatment and outcome of patients with gliosarcomas would be difficult to determine given the rare occurrence of these lesions in such locations...
  37. ncbi request reprint Concurrent lymphocytic hypophysitis and pituitary adenoma. Case report and review of the literature
    Shaye I Moskowitz
    Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosurg 105:309-14. 2006
    ..This is the first documented case of LyH in the setting of a null-cell pituitary adenoma. The authors review the related literature and outline potential mechanisms for the concurrent development of LyH and a pituitary adenoma...
  38. doi request reprint Aurora B kinase expression in ependymal neoplasms
    Sarah E Gibson
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 16:274-8. 2008
    ..In contrast to astrocytomas, elevated Aurora B expression in higher-grade ependymomas does not seem to correlate with clinical course, although it may be a potential target of Aurora kinase inhibitors...
  39. ncbi request reprint Immunohistochemical expression of cathepsin D in meningiomas
    Elias A Castilla
    Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 119:123-8. 2003
    ..Cathepsin D expression by immunohistochemical analysis was identified in the majority (88% [76/86]) of meningiomas studied. A greater degree of immunoreactivity was observed in the WHO grade I group...
  40. ncbi request reprint An algorithmic approach to the brain biopsy--part II
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arch Pathol Lab Med 130:1639-48. 2006
    ..They can assist pathologists-in-training in developing orderly, sequential, and logical thinking skills when confronting difficult cases...
  41. ncbi request reprint HER-2/neu expression in glioblastoma multiforme
    Denise M Haynik
    Cleveland Clinic Foundation, Cleveland, OH, USA
    Appl Immunohistochem Mol Morphol 15:56-8. 2007
    ..Studies in this area are potentially significant owing to the role of recombinant monoclonal anti-HER-2/neu antibody traztuzumab (Herceptin) in the treatment of tumors...
  42. doi request reprint The expanding family of glioneuronal tumors
    Daniela S Allende
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Adv Anat Pathol 16:33-9. 2009
    ..These tumors are relatively infrequent lesions, and because of that, they can be challenging to diagnose for the practicing pathologist. In this article, we summarize the clinical and pathologic findings of these new lesions...
  43. ncbi request reprint Brain-invasive solitary fibrous tumor of the meninges: report of a case
    Elias A Castilla
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Surg Pathol 10:217-21. 2002
    ..Focal infiltration into the underlying brain parenchyma was observed. The tumor was CD34 positive and EMA negative...
  44. ncbi request reprint Gliomatosis cerebri: treatment results with radiotherapy alone
    Mohamed A Elshaikh
    Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Cancer 95:2027-31. 2002
    ..The optimal therapeutic strategy is not well established. The impact of radiotherapy on survival in patients with GC remains undefined...
  45. doi request reprint Chromosome 1p and 19q deletions in glioblastoma multiforme
    David Kaneshiro
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 17:512-6. 2009
    ..Deletions on chromosomes 1p and 19q have been shown to correlate with prognosis and chemosensitivity in anaplastic oligodendrogliomas. In glioblastoma multiforme (GBM), the impact on prognosis of these alterations in GBM is unclear...
  46. ncbi request reprint Pituicytoma
    Robert J Kowalski
    Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 8:290-4. 2004
    ..An MIB-1 labeling index of 1.1% was observed. The tumor was subtotally resected and recurred 11 months after the initial surgery. The literature on this rare tumor will be reviewed and differential diagnosis discussed...
  47. ncbi request reprint Molecular diagnostic techniques for the clinical evaluation of gliomas
    Todd W Kelley
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Diagn Mol Pathol 14:1-8. 2005
    ....
  48. ncbi request reprint Frozen section discrepancy in the evaluation of central nervous system tumors
    Thomas P Plesec
    Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 131:1532-40. 2007
    ..Frozen section also provides an accurate preliminary diagnosis; however, certain lesions are recognized to cause diagnostic challenges at FS...
  49. ncbi request reprint Seizure outcome after temporal lobectomy in temporal lobe cortical dysplasia
    Teeradej Srikijvilaikul
    Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 44:1420-4. 2003
    ..To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD...
  50. doi request reprint Focal cortical dysplasia type II (malformations of cortical development) aberrantly expresses apoptotic proteins
    Wendy A Chamberlain
    Department of Pathology and Laboratory Medicine, Neuropathology Section, Cleveland Clinic, Cleveland, OH 44195, USA
    Appl Immunohistochem Mol Morphol 16:471-6. 2008
    ....
  51. doi request reprint Acromegaly with negative pituitary MRI and no evidence of ectopic source: the role of transphenoidal pituitary exploration?
    Sameera Daud
    Department of Endocrinology, Cleveland Clinic, Cleveland, OH 44195, USA
    Pituitary 14:414-7. 2011
    ..This approach may avoid long term medical treatment with its associated cost...
  52. ncbi request reprint A 65-year-old woman with a left occipital lobe tumor. Diffuse large B-Cell, primary central nervous system lymphoma
    Sean J Nagel
    Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 130:e96-9. 2006
  53. doi request reprint Pediatric pituitary adenomas
    Christopher Webb
    Department of Anatomic Pathology L25, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:77-80. 2008
    ..Pituitary adenomas are relatively rare occurrences in the pediatric population, and there are few studies documenting the profile of these tumors in this age group...
  54. doi request reprint Brain tumors in adults with medically intractable epilepsy
    Richard A Prayson
    Departmentof Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 136:557-63. 2011
    ..Gangliogliomas are the most commonly encountered neoplasms. Coexistent focal cortical dysplasia may be observed in a significant minority of tumors, suggesting a possible developmental origin for some of these neoplasms...
  55. ncbi request reprint Poor correlation of serum alpha-subunit concentration and magnetic resonance imaging following pituitary surgery in patients with nonfunctional pituitary macroadenomas
    Maria M Pineyro
    Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Endocr Pract 14:452-7. 2008
    ..To review the clinical utility of measuring serum alpha-subunit as a marker for residual tumor in a group of patients with surgically resected nonfunctional pituitary adenomas...
  56. ncbi request reprint Chromosome 1p allelic loss by fluorescence in situ hybridization is not observed in dysembryoplastic neuroepithelial tumors
    Richard A Prayson
    Department of Neurological Surgery, Cleveland Clinic Foundation, OH 44195, USA
    Am J Clin Pathol 118:512-7. 2002
    ..LOH on chromosome 1p may be a useful differential diagnostic feature (favoring oligodendroglioma) in a subset of cases in which specimen fragmentation or size raises the differential diagnosis of DNT vs oligodendroglioma...
  57. doi request reprint Spinal carcinoid metastasis with dural invasion
    Sean J Nagel
    Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio, USA
    World Neurosurg 76:478.e7-478.e11. 2011
    ..To present the unusual finding of a lumbar intradural carcinoid metastasis in a 67-year-old man with a primary thymic carcinoid diagnosed 16 years before presentation...
  58. doi request reprint Frozen section discrepancy in the evaluation of nonneoplastic central nervous system samples
    Thomas P Plesec
    Cleveland Clinic Lerner College of Medicine, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Diagn Pathol 13:359-66. 2009
    ..Nonneoplastic lesions are often more challenging than neoplastic lesions at FS, particularly because they are less commonly sampled for FS and, therefore, less familiar to pathologists...
  59. doi request reprint Microscopic thrombi in glioblastoma multiforme do not predict the development of deep venous thrombosis
    Nicholas F Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 13:291-6. 2009
    ..3%) of patients with GBM. There was no correlation between the number of microscopic thrombi and the subsequent development of DVT in patients with GBM. Patients who developed DVT did not appear to have a worse survival...
  60. ncbi request reprint Collision of a syncytial meningioma and malignant astrocytoma
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 6:44-8. 2002
    ..Focally, infiltration of the meningioma by astrocytoma was observed. Differential diagnostic issues are considered and the literature reviewed...
  61. ncbi request reprint Cyclooxygenase-2 (COX-2) expression by immunohistochemistry in glioblastoma multiforme
    Richard A Prayson
    Brain Tumor Center and the Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 6:148-53. 2002
    ..These findings are significant in that therapeutic agents, which inhibit COX-2, are currently available and may play a role in the management of glioblastoma multiforme...
  62. ncbi request reprint Increased expression of 5-lipoxygenase in glioblastoma multiforme
    Mladen Golubic
    Brain Tumor Institute, Cleveland Clinic Foundation, OH 44195, USA
    Adv Exp Med Biol 525:205-8. 2003
  63. ncbi request reprint Cortical dysplasia in extratemporal lobe intractable epilepsy: a study of 52 cases
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 7:139-46. 2003
    ..improved seizure control was obtained in approximately three fourths of patients after resection; and (5). seizures associated with balloon cell dysplasia were less successfully managed with surgery...
  64. ncbi request reprint Comparison of proliferation indices in glioblastoma multiforme by whole tissue section vs tissue microarray
    Andres G Chiesa-Vottero
    Division of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Clin Pathol 120:902-8. 2003
    ....
  65. ncbi request reprint Optic nerve choristoma
    Angela Spencer
    Department of Neurology, Cleveland Clinic, Weston, FL 33331 3609, USA
    Ann Diagn Pathol 9:93-5. 2005
    ..We report a case of an optic nerve choristoma arising in a 24-year-old woman. The lesion was marked by a disordered admixture of smooth muscle tissue and optic nerve tissue. The literature on optic nerve choristoma is reviewed...
  66. ncbi request reprint The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia
    Gabriel Moddel
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Brain Res 1046:10-23. 2005
    ..NR2B may constitute a target for new diagnostic and pharmacotherapeutic approaches...
  67. ncbi request reprint Fascin expression in 90 patients with glioblastoma multiforme
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 9:307-11. 2005
    ..Higher grade tumors generally expressed a greater degree of fascin staining. There was no obvious correlation with the extent of staining and survival among glioblastoma multiforme. Fascin may play a role in tumor cell infiltration...
  68. ncbi request reprint Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Am J Clin Pathol 117:776-82. 2002
    ..The pathologicfindings may be only focally present, and missed, if diagnosis is made or confirmed with biopsy alone. Most lymphoid cells have a T-cell immunophenotype, with a predominance of CD8+ cells in most cases...
  69. ncbi request reprint Immunohistochemical expression of Bcl-2, Bcl-x, and Bax in follicular carcinomas of the thyroid
    Denise M Haynik
    Cleveland Clinic Foundation, Cleveland, OH, USA
    Appl Immunohistochem Mol Morphol 14:417-21. 2006
    ..All recurrent and fatal tumors were negative for bcl-2. These data suggest that the loss of bcl-2 expression may correlate with poorer prognosis...
  70. ncbi request reprint Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the lateral ventricle
    Todd W Kelley
    Division of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Leuk Lymphoma 46:1423-7. 2005
    ..This rare case provides insight into the pathophysiology of MALT lymphomas...
  71. doi request reprint Fatal parasitic meningoencephalomyelitis caused by Halicephalobus deletrix : a case report and review of the literature
    Sarah L Ondrejka
    Department of Pathology and Laboratory Medicine, Cleveland Clinic, Ohio 44195, USA
    Arch Pathol Lab Med 134:625-9. 2010
    ..Although extremely rare, this organism needs to be considered in the differential diagnosis of human helminthic infection of the central nervous system...
  72. pmc The pathobiology of glioma tumors
    Candece L Gladson
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Annu Rev Pathol 5:33-50. 2010
    ....
  73. doi request reprint Rathke's cleft cyst presenting as bilateral abducens nerve palsy
    Vinni Grover
    Department of Endocrinology, Diabetes and Metabolism, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Pituitary 14:395-9. 2011
    ..Surgical excision resulted in near complete resolution of the bilateral 6th nerve palsy. Rathke's cleft cysts are an unusual cause of bilateral sixth nerve palsy and represent a potential cause of cranial neuropathy...
  74. ncbi request reprint Fatal West Nile Virus infection after rituximab/fludarabine--induced remission for non-Hodgkin's lymphoma
    Steven D Mawhorter
    Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Lymphoma Myeloma 6:248-50. 2005
    ..We present a case in which serology results were persistently negative because the patient was immunocompromised following lymphoma treatment. The role of humoral immunity in resolution of WNV is also discussed...
  75. ncbi request reprint JC virus chromogenic in situ hybridization in brain biopsies from patients with and without PML
    Gary W Procop
    Division of Pathology and Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Diagn Mol Pathol 15:70-3. 2006
    ..CISH seems to be a useful tool for the detection of the JC virus in brain biopsies from patients with PML, and is more accessible because a commercial probe is available...
  76. doi request reprint Development of a synergistic case-based microanatomy curriculum
    Jennifer M McBride
    Department of Surgery, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anat Sci Educ 1:102-5. 2008
    ....
  77. ncbi request reprint Metastatic epithelioid sarcoma to the brain: palisaded necrosis mimicking glioblastoma multiforme
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 6:302-6. 2002
    ..2; the tumor did not stain with glial fibrillary acidic protein antibody. The literature is reviewed and the morphologic distinction between metastatic epithelioid sarcoma and other central nervous system neoplasms is discussed...
  78. doi request reprint Ultrastructural abnormalities of respiratory cilia: a 25-year experience
    Thomas P Plesec
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 132:1786-91. 2008
    ..Ciliary dyskinesia is a rare, but significant, cause of chronic respiratory infections, and transmission electron microscopy is a critical adjunct to making the diagnosis...
  79. ncbi request reprint Pathologic characteristics of the cortical dysplasias
    Richard A Prayson
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurosurg Clin N Am 13:17-25, vii. 2002
    ..The pathologic associations of neurocutaneous disorders, neoplasms, and hippocampal sclerosis with cortical dysplasia also are discussed...
  80. ncbi request reprint Pathologic quiz case: a 3-year-old boy with new-onset partial seizures
    Ajay Gupta
    Department of Child Neurology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arch Pathol Lab Med 126:379-80. 2002
  81. ncbi request reprint Detection of polyoma virus in brain tissue of patients with progressive multifocal leukoencephalopathy by real-time PCR and pyrosequencing
    Rose C Beck
    Division of Pathology and Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Diagn Mol Pathol 13:15-21. 2004
    ..Both the LightCycler and pyrosequencing assays are useful for confirming JCV in brain biopsies from patients with PML, but variant JCVs may require supplementary methods to confirm JCV infection...
  82. ncbi request reprint Pathologic quiz case. Intraventricular mass in a 31-year-old man
    George M Corcoran
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Arch Pathol Lab Med 126:497-8. 2002
  83. ncbi request reprint Necrotizing neurosarcoidosis of the cranial base resembling an en plaque sphenoid wing meningioma: case report
    Samuel Tobias
    Department of Neurosurgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Neurosurgery 51:1290-4; discussion 1294. 2002
    ..Two cases of neurosarcoidosis (NS) with NSG with concomitant systemic disease have been described previously. We present an unusual case of primary NS-NSG that resembled an en plaque cranial base meningioma...
  84. ncbi request reprint Clinicopathologic findings in patients with infantile hemiparesis and epilepsy
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Pathol 35:734-8. 2004
    ..Hippocampal sclerosis was encountered in 2 patients, suggesting that a subset of cortical dysplasias and hippocampal sclerosis may be caused by an in utero ischemic event...
  85. ncbi request reprint Thyroid transcription factor-1 staining is useful in identifying brain metastases of pulmonary origin
    Alan L Prok
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland OH 44195, USA
    Ann Diagn Pathol 10:67-71. 2006
    ..None of the 50 glioblastoma multiform was positive for TTF-1. This study indicates that TTF-1 may be useful in evaluating metastatic carcinomas of unknown primary and TTF-1 immunoreactivity may be indicative of a lung or thyroid primary...
  86. ncbi request reprint Expression of cyclo-oxygenase-2 in ependymal tumors
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Neuropathology 26:422-8. 2006
    ..COX-2 inhibitors may play a role in treatment of the subset of ependymal tumors that demonstrate increased expression. COX-2 staining did not reliably predict tumor behavior...
  87. ncbi request reprint West Nile virus meningoencephalitis: MR imaging findings
    Kalliopi A Petropoulou
    Department of Radiology, Section of Neuroradiology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    AJNR Am J Neuroradiol 26:1986-95. 2005
    ..The purpose of this study was to review the spectrum of MR imaging findings for WNV meningoencephalomyelitis and investigate whether any of the findings correlates with clinical presentation of flaccid paralysis...
  88. doi request reprint Suprasellar spindle cell lipoma
    Krista L Pekarski
    Cleveland Clinic Foundation, Institute of Pathology, Cleveland, OH 44195, USA
    Ann Diagn Pathol 13:173-5. 2009
    ..The spindle cells and vasculature demonstrated focal positivity with CD34 antibody. There was no evidence of lipoblasts, mitoses, necrosis, or osseous tissue...
  89. ncbi request reprint Apoptotic and proliferative markers in chordomas: a study of 26 tumors
    Sony Kilgore
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Ann Diagn Pathol 6:222-8. 2002
    ..Cyclin D1, MIB-1, p53, and bcl-2 immunostaining does not appear to improve one's ability to predict behavior versus routine light microscopy...
  90. ncbi request reprint Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma
    Min Wang
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Medical School, Houston, Texas, USA
    J Neuropathol Exp Neurol 64:875-81. 2005
    ..Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal...
  91. ncbi request reprint An algorithmic approach to the brain biopsy--part I
    B K Kleinschmidt-Demasters
    Department of Pathology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B216, Denver, CO 80262, USA
    Arch Pathol Lab Med 130:1630-8. 2006
    ..They can assist pathologists-in-training in developing orderly, sequential, and logical thinking skills when confronting difficult cases...
  92. ncbi request reprint Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature
    Arie Perry
    Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
    Brain Pathol 15:55-65. 2005
    ..In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories...
  93. ncbi request reprint Pathologic quiz case: an 11-year-old boy with intractable seizures. Meningioangiomatosis
    Stanley Krolczyk
    Department of Neurology, Cleveland Clinic Florida, Westin, USA
    Arch Pathol Lab Med 127:e349-50. 2003
  94. ncbi request reprint 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 17:9-14. 2004
    ....
  95. ncbi request reprint A 12-year-old girl with seizures and dementia
    Peter Widdess-Walsh
    Brain Pathol 17:464-5, 474. 2007
  96. ncbi request reprint Cerebellar paraganglioma
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Ann Diagn Pathol 8:219-23. 2004
    ..Morphologic and immunohistochemical features of the neoplasm are discussed and literature is reviewed regarding involvement of the central nervous system by paraganglioma...
  97. doi request reprint Diagnosis of malignant glioma: role of neuropathology
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University Hospital, G 169, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    J Neurooncol 89:287-311. 2008
  98. ncbi request reprint Cell proliferation and tumors of the central nervous system. Part 1: Evaluation of mitotic activity
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Neuropathol Exp Neurol 61:501-9. 2002
    ..This paper reviews factors that affect the identification of mitotic figures and the determination of mitosis counts. The role mitosis evaluation plays in the evaluation of certain neoplasms of the central nervous system is discussed...
  99. ncbi request reprint Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 14:297-303. 2004
    ..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics...
  100. ncbi request reprint Fibrin glue system for adjuvant brachytherapy of brain tumors with 188Re and 186Re-labeled microspheres
    Urs O Hafeli
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Eur J Pharm Biopharm 65:282-8. 2007
    ....
  101. ncbi request reprint Cell proliferation and tumors of the central nervous system, part II: radiolabeling, cytometric, and immunohistochemical techniques
    Richard A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Neuropathol Exp Neurol 61:663-72. 2002
    ..Factors that affect these methodologies and their practical application to routine practice of diagnostic neuropathology will be explored...