Research Topics
Genomes and Genes | EDWARD FRANKLIN PLOWSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Macrophage gene expression and foam cell formation are regulated by plasminogenRiku Das
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
Circulation 127:1209-18, e1-16. 2013..Deciphering the molecular and cellular processes that govern macrophage foam cell formation is critical to understanding the basic mechanisms underlying atherosclerosis and other vascular pathologies...- So many plasminogen receptors: why?Edward F Plow
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic, Cleveland, OH 44195, USA
J Biomed Biotechnol 2012:141806. 2012..Furthermore, several different plasminogen receptors can be used to support the same cellular response, such as inflammatory cell migration. Here, we discuss the perplexing issue: why are there so many different Plg-Rs?.. - miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancerKatarzyna Augoff
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH, USA
Mol Cancer 11:5. 2012..The molecular mechanisms that lead to the loss of miR-31 and the activation of its pro-metastatic target genes during these specific steps of the invasion-metastasis cascade are however unknown... - Integrin alpha(M)beta(2)-mediated cell migration to fibrinogen and its recognition peptidesC B Forsyth
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, and the Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Exp Med 193:1123-33. 2001..Taken together, these data define specific molecular requirements for alpha(M)beta(2) to mediate cell migration to Fg derivatives and assign a novel proinflammatory activity to the P2 peptide... 
The functions of plasminogen in cardiovascular diseaseEdward F Plow
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Trends Cardiovasc Med 14:180-6. 2004..Dissection of these mechanisms represents a future challenge toward understanding the roles of Plg in vivo...- Vitronectin: back into the spotlightE F Plow
Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Thromb Haemost 3:873-4. 2005 - AlphaIIbbeta3 and its antagonism at the new millenniumE F Plow
Department of Molecular Cardiology, Cleveland Clinic Foundation, OH 44195, USA
Thromb Haemost 86:34-40. 2001..As illustrated by these two examples, there is still much to be learned about alphaIIbbeta3 if we are to fully appreciate its functions and its potential as a therapeutic target... - Kindling the flame of integrin activation and function with kindlinsEdward F Plow
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
Curr Opin Hematol 16:323-8. 2009..However, in-vivo data on the functions of the kindlins and their mechanisms of action have been lacking... - Identification of the binding site for fibrinogen recognition peptide gamma 383-395 within the alpha(M)I-domain of integrin alpha(M)beta2V P Yakubenko
Joseph J. Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
J Biol Chem 276:13995-4003. 2001.... - Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon alpha(4)beta(1)-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectinV P Yakubenko
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute of The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Exp Cell Res 260:73-84. 2000.... - Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoproteinT V Byzova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Exp Cell Res 254:299-308. 2000..The constitutive activation of alpha(V)beta(3) on neoplastic cells may contribute to tumor growth and metastatic potential... - Activation of alphaVbeta3 on vascular cells controls recognition of prothrombinT V Byzova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cell Biol 143:2081-92. 1998..The capacity of alphaVbeta3 to interact with prothrombin may play a significant role in the maintenance of hemostasis; and, at a general level, ligand selection by alphaVbeta3 may be controlled by the activation state of this integrin... - The ligand recognition specificity of beta3 integrinsK Suehiro
Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 271:10365-71. 1996.... - Proteolysis regulates exposure of the IIICS-1 adhesive sequence in plasma fibronectinT P Ugarova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
Biochemistry 35:10913-21. 1996..The adhesive function of the CS-1 region in intact Fn appears to be suppressed by the native conformation of the molecule... - Selective inhibition of factor Xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosisF A Nicolini
Department of Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, Ohio, USA
Blood Coagul Fibrinolysis 7:39-48. 1996..These findings highlight the potential adverse effects of unchecked thrombin generation in the setting of thrombolytic therapy... - Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarctionE J Topol
Cleveland Clinic Foundation, Cleveland, Ohio, USA
Circulation 104:2641-4. 2001..Recent advances in high-throughput genomics technology have expanded our ability to catalogue allelic variants in large sets of candidate genes related to premature coronary artery disease... - A discrete site modulates activation of I domains. Application to integrin alphaMbeta2L Zhang
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 271:29953-7. 1996..In support of this hypothesis, several naturally occurring mutations that activate von Willebrand factor map to the same loops of its I(A) domain... - Role of platelets in restenosis after percutaneous coronary revascularizationH Le Breton
Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195 5066, USA
J Am Coll Cardiol 28:1643-51. 1996..Considerable further study is necessary to unravel the effects of platelets on the restenosis process... - Platelet integrin alpha(IIb)beta(3): activation mechanismsY Q Ma
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
J Thromb Haemost 5:1345-52. 2007..Among them, talin appears to be a critical trigger of alpha(IIb)beta(3) activation, but other binding partners, which function as activators or suppressors, are likely to act as co-regulators of integrin activation... - A mechanism for modulation of cellular responses to VEGF: activation of the integrinsT V Byzova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
Mol Cell 6:851-60. 2000..Thus, integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses... - Platelet GPIIb-IIIa blockersE J Topol
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
Lancet 353:227-31. 1999..With attention to heparin dose the risk of bleeding is not a major concern with these agents. The GPIIb-IIIa blockers are taking the clinician and patient out of the era of aspirin monotherapy when platelet inhibition is required... - Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIFL Zhang
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 272:17558-64. 1997..Verifying this localization, when these segments were introduced into the alphaXI-domain, the resulting chimeric receptor was converted into a high affinity NIF-binding protein... - The role of plasminogen in angiogenesis in vivoC W Oh
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, OH 44195, USA
J Thromb Haemost 1:1683-7. 2003..Plasminogen, by virtue of its role in the degradation of extracellular matrix proteins and by facilitation of cell migration, may contribute to angiogenesis... - Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogenT P Ugarova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 273:22519-27. 1998..The juxtapositioning of these two sequences may form an unique and complex binding site for alphaM beta2... - Ligand recognition by beta 3 integrinsK Suehiro
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, OH 44195, USA
Keio J Med 46:111-4. 1997..Since the beta 3 integrins have multiple functions in vivo and are targets for therapy, this classification system may be useful in the design and characterization of therapeutic agents... - A central role for plasminogen in the inflammatory response to biomaterialsS J Busuttil
Case Western Reserve University and Cleveland VAMC, Cleveland, Ohio, USA
J Thromb Haemost 2:1798-805. 2004..This role is distinct from that of fibrinogen, and the two inflammatory cell types use plasminogen in different ways. Plasminogen represents a therapeutic target for controlling the inflammatory response to implanted materials... - Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptorM J Zuscik
Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 276:13738-43. 2001..These results also suggest that this receptor subtype is not involved in the classic vasoconstrictory action of alpha(1)ARs that is important in systemic regulation of blood pressure... - Regulation of plasminogen binding to neutrophilsT Herren
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, OH, USA
Blood 97:1070-8. 2001.... - Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil functionElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Blood 106:3970-8. 2005..Thus, alpha(M)beta2 plays a central role in proinflammatory activities of TSP-4 (P387) and may contribute to the prothrombotic phenotype associated with this variant... - Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sitesOlga I Stenina
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 19:1893-5. 2005..Since these substitutions exert the opposite effects on Ca2+ binding, a decrease in TSP-1 and an increase in TSP-4, the two TSP variants are likely to influence cardiovascular functions in distinct but yet pathogenic ways... - Novel alpha1-adrenergic receptor signaling pathways: secreted factors and interactions with the extracellular matrixTing Shi
Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Mol Pharmacol 70:129-42. 2006..Our results indicate alpha1-ARs induce the secretion of factors that interact with the extracellular matrix to regulate cell adhesion, motility and proinflammatory responses through novel signaling pathways... - Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injuryKai Wang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 25:1584-9. 2005..This study was designed to determine whether P-selectin expression on platelet, endothelial, or both surfaces is critical to the inflammatory response and neointimal formation after arterial injury... - Kindlin-2 (Mig-2): a co-activator of beta3 integrinsYan Qing Ma
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
J Cell Biol 181:439-46. 2008..Our results thus identify kindlin-2 as a novel regulator of integrin activation; it functions as a coactivator... - Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophilsElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 279:18063-72. 2004..Thus, assembly of Plg and uPA on integrin alpha(M)beta(2) regulates Plm activity and, thereby, plays a crucial role in neutrophil-mediated thrombolysis... - The specificity and function of the metal-binding sites in the integrin beta3 A-domainMichelle M Pesho
Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Biol Chem 281:23034-41. 2006..These results indicate that the specificities of the three metal-binding sites for divalent cations are distinct and that each site can regulate the ligand binding potential of the beta3 A-domain... 
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signalingKumar B Reddy
Department of Molecular Cardiology and Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Cell Sci 121:1641-8. 2008..Our results suggest that Fyn and Src have distinct requirements for interaction with alphaIIbbeta3; and, consequently, the two SFK can mediate different functional responses...- Identification and characterization of two cation binding sites in the integrin beta 3 subunitAleksandra Cierniewska-Cieslak
Center for Microbiology and Virology, Polish Academy of Sciences, Lodz, Poland
J Biol Chem 277:11126-34. 2002..These results indicate that the ligand competent and Ca(2+)-specific inhibitory cation binding sites are distinct and reside in beta(3)-(95-373)... - The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motilityXiaohua Shi
Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Biol Chem 282:20455-66. 2007.... - Plasminogen is an important regulator in the pathogenesis of a murine model of asthmaCarmen M Swaisgood
Cleveland Clinic, Department of Molecular Cardiology, NB50, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 176:333-42. 2007..Asthma is a syndrome whose common pathogenic expression is inflammation of the airways. Plasminogen plays an important role in cell migration and is also implicated in tissue remodeling, but its role in asthma has not been defined... - P-selectin primes leukocyte integrin activation during inflammationHai bo Wang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Nat Immunol 8:882-92. 2007..Our data demonstrate the functional importance of this newly identified signaling pathway mediated by P-selectin glycoprotein ligand 1... - Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticlesElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
Blood 112:2327-35. 2008..Thus, cooperation of these 2 receptor/counterreceptor systems regulates the prothrombotic properties of PMN-derived MPs... - Phase II trial of GM-CSF + thalidomide in patients with androgen-independent metastatic prostate cancerRobert Dreicer
Department of Hematology Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA
Urol Oncol 23:82-6. 2005..We performed a Phase II trial of this combination to assess its toxicity and potential utility as an immunomodulatory approach to management of advanced prostate cancer... - Delineation of the key amino acids involved in neutrophil inhibitory factor binding to the I-domain supports a mosaic model for the capacity of integrin alphaMbeta 2 to recognize multiple ligandsValentin A Ustinov
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, and Department of Molecular Cardiology/NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 277:18769-76. 2002..Thus, the alpha(M)I-domain appears to present a mosaic of exposed amino acids within surface loops on its MIDAS face, and different ligands interact with different residues to attain high affinity binding... - Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endotheliumNatalya V Narizhneva
Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 19:1158-60. 2005..Taken together, this study identifies a novel mechanism regulating CAM expression and subsequent monocyte binding to endothelium, which might influence the development of anti-atherosclerosis therapeutic strategies... - Integrin alphaIIbbeta3 and its antagonismMartin J Quinn
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology NB50, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
Arterioscler Thromb Vasc Biol 23:945-52. 2003..An in-depth understanding of how antagonists engage and influence the function of alphaIIbbeta3 and platelets in the context of the new structural insights may explain its salutary and potential deleterious effects... - Identification of a novel binding site for platelet integrins alpha IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of fibrinogenNataly P Podolnikova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
J Biol Chem 278:32251-8. 2003..Thus, these data suggest that the P3 sequence in the gamma C-domain of fibrinogen defines a previously unknown recognition specificity of alpha IIb beta 3 and alpha 5 beta 1 and may function as a binding site for these integrins... - Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker ratOlga I Stenina
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 107:3209-15. 2003..This increase in TSP-1 production may be a direct response of vascular cells to glucose... - Thrombospondin-4 and its variants: expression and differential effects on endothelial cellsOlga I Stenina
Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Circulation 108:1514-9. 2003..TSP-4 had not previously been implicated in vascular pathology, and very little information is available on its expression and functions... - In vivo comparison of the inflammatory response induced by different vascular biomaterialsSteven J Busuttil
Department of Surgery, Case Western Reserve University and Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
Vascular 13:230-5. 2005..Stainless steel disks recruited both fewer neutrophils and fewer macrophages and support lower adherence of these cells than the other biomaterials. Copper incited an overwhelming and fatal response... - Histone H2B as a functionally important plasminogen receptor on macrophagesRiku Das
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH, USA
Blood 110:3763-72. 2007..Taken together, these data suggest that multiple Plg-Rs do contribute to Plg binding to macrophages, and among these, H2B plays a very prominent and functionally important role... - Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarctionNatalya V Narizhneva
Department of Molecular Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
J Biol Chem 279:21651-7. 2004..These data suggest a potential molecular and cellular basis for a genetic risk factor associated with early onset myocardial infarction... - Coronary artery disease and the thrombospondin single nucleotide polymorphismsOlga I Stenina
Joseph J. Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology/NB50, Cleveland Clinic Foundation/Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Int J Biochem Cell Biol 36:1013-30. 2004.... - Integrin bidirectional signaling: a molecular viewJun Qin
Lerner Research Institute, Cleveland Clinic Foundation, Ohio, USA
PLoS Biol 2:e169. 2004 - Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword?Martin J Quinn
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 106:379-85. 2002 - Structural basis for the autoinhibition of talin in regulating integrin activationEsen Goksoy
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Mol Cell 31:124-33. 2008..These data define a distinct autoinhibition mechanism for talin and suggest how it controls integrin activation and cell adhesion... - Identity of the amino acid residues involved in C3bi binding to the I-domain supports a mosaic model to explain the broad ligand repertoire of integrin alpha M beta 2Valentin A Ustinov
Joseph J. Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Biochemistry 44:4357-64. 2005..This divergence supports a mosaic model, in which different ligands engage different amino acids to bind to alpha(M)I-domain, accounting for the broad recognition capacity of integrin alpha(M)beta(2)... - Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2Elzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 181:3609-19. 2008..Hence, engagement of a single integrin by closely related ligands can induce distinct signaling pathways, which can elicit distinct cellular responses... - An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarctionGong Qing Shen
Department of Molecular Cardiology, Lerner Research Institute, Center for Cardiovascular Genetics, Cleveland, OH 44195, USA
Am J Hum Genet 81:780-91. 2007..This extensive study, involving multiple independent populations, provides the first evidence that genetic variants in LRP8 may contribute to the development of premature and familial CAD and MI... - Identification of pH-regulated antigen 1 released from Candida albicans as the major ligand for leukocyte integrin alphaMbeta2Dmitry A Soloviev
Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
J Immunol 178:2038-46. 2007..albicans. Together, these data indicate that Pra1p is a ligand of alpha(M)beta(2) on C. albicans and that the soluble form of Pra1p may assist the fungus in escaping host surveillance... - Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesisGanapati H Mahabeleshwar
Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Circ Res 101:570-80. 2007.... - Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian populationGong Qing Shen
Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
J Hum Genet 53:144-50. 2008..These results indicate that chromosome 9p21 confers risk for development of MI in an Italian population... - Thrombospondins, their polymorphisms, and cardiovascular diseaseOlga I Stenina
Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 27:1886-94. 2007..This review seeks to summarize current information that has emerged on each of these fronts... - Membrane-mediated structural transitions at the cytoplasmic face during integrin activationOlga Vinogradova
Structural Biology Program, Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Proc Natl Acad Sci U S A 101:4094-9. 2004..These data provide a structural basis of membrane-mediated changes at the cytoplasmic face in regulating integrin activation and signaling... - Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivoMatthew J Flick
Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 113:1596-606. 2004.... - P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophilsYan Qing Ma
University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
Blood 104:2549-56. 2004..We thus propose a model in which P-selectin induces an intermediate state of integrin activation and then cooperates with other extracellular stimuli to support maximal adhesion of human neutrophils... - Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2Dmitry A Solovjov
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 280:1336-45. 2005..These data indicate that each subunit of alphaMbeta2 contributes distinct properties to alphaMbeta2 and that, in most but not all cases, the response of the integrin is a composite of the functions of its individual subunits... - MET orchestrates cancer and blood coagulationOlga I Stenina
Nat Med 11:376-7. 2005 - In vivo regulation of plasminogen function by plasma carboxypeptidase BCarmen M Swaisgood
Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Clin Invest 110:1275-82. 2002..These studies demonstrate a definitive role of pCPB as a modulator of the pivotal functions of Plg in fibrinolysis and cell migration in vivo... - Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tailsYan Qing Ma
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Biochemistry 45:6656-62. 2006..Together, these data provide molecular insights into how distinct regions of the cytoplasmic tails differentially and cooperatively regulate integrin activation... - Identification of histone H2B as a regulated plasminogen receptorThomas Herren
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NB50, Cleveland, Ohio 44195, USA
Biochemistry 45:9463-74. 2006..Thus, histone H2B represents a regulated plasminogen receptor, which contributes significantly to the plasminogen binding capacity of cells... - Cell adhesion and migration assaysDmitry A Soloviev
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA
Methods Mol Med 129:267-78. 2006..In this chapter, several detailed protocols describing cell adhesion and migration assays are presented, and advantages and disadvantages of each method are discussed... - Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migrationElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, OH 44195, USA
Blood 101:1582-90. 2003..This complex may play an important role in the control of inflammatory cell migration and vascular homeostasis...
Research Grants
- THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIAEdward Plow; Fiscal Year: 2003..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
- LEUKOCYTE INTEGRIN ALPHA M BETA 2Edward Plow; Fiscal Year: 2004....
- Thrombospondins and AtherothrombosisEdward Plow; Fiscal Year: 2004..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
- 2004 Hemostasis Gordon Research ConferenceEdward Plow; Fiscal Year: 2004..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEdward Plow; Fiscal Year: 2005..Taken together, these studies seek to bring insights into the physiological and pathophysiological roles of the plasminogen system and its regulation. ..
- Training Program in Vascular Biology and PathologyEdward Plow; Fiscal Year: 2007....
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEdward Plow; Fiscal Year: 2007..Overall, these studies will provide new insights into the functions of plasminogen and will lead to a greater understanding of the molecular and cellular events that regulate its contribution to inflammatory responses. ..
- Activation of the beta-3 integrins: Role of the kindlinsEdward Plow; Fiscal Year: 2009..We seek to define how a new set of molecules influence platelets and endothelial cells to control aggregation and angiogenesis, thereby identifying new targets for treatment and prevention of cardiovascular disease. ..
- Activation of the beta-3 integrins: Role of the kindlinsEDWARD FRANKLIN PLOW; Fiscal Year: 2010..We seek to define how a new set of molecules influence platelets and endothelial cells to control aggregation and angiogenesis, thereby identifying new targets for treatment and prevention of cardiovascular disease. ..
- THE CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEdward Plow; Fiscal Year: 1993..On an overall basis, the proposed studies will continue to provide basic insights into the complex interface between cells and fibrinolysis, an interplay that is central to hemostasis, thrombosis and bleeding disorders...
- STRUCTURE AND FUNCTION OF PLATELET GPIIB IIIIAEdward Plow; Fiscal Year: 1999....
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEdward Plow; Fiscal Year: 2000..These studies also should serve as models to define the mechanisms which control proteinases and their activities at cell surfaces. ..
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEDWARD FRANKLIN PLOW; Fiscal Year: 2010..Overall, these studies will provide new insights into the functions of plasminogen and will lead to a greater understanding of the molecular and cellular events that regulate its contribution to inflammatory responses. ..