E P Pioro

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Diffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients
    Venkateswaran Rajagopalan
    Department of Biomedical Engineering, ND2, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Aging Res 2011:481745. 2011
  2. pmc Motor neuronopathy with dropped hands and downbeat nystagmus: a distinctive disorder? A case report
    Nimish J Thakore
    Department of Neurology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    BMC Neurol 6:3. 2006
  3. doi request reprint Current concepts in the pharmacotherapy of pseudobulbar affect
    Erik P Pioro
    Cleveland Clinic, OH 44195, USA
    Drugs 71:1193-207. 2011
  4. doi request reprint Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect
    Erik P Pioro
    Section of ALS and Related Disorders, Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Neurol 68:693-702. 2010
  5. ncbi request reprint Proton magnetic resonance spectroscopy (1H-MRS) in ALS
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:S7-16. 2000
  6. ncbi request reprint 1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla
    E P Pioro
    Department of Neurology and Neurosciences, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 53:71-9. 1999
  7. ncbi request reprint Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neuroreport 9:3041-6. 1998
  8. ncbi request reprint Role of brain-derived neurotrophic factor in wobbler mouse motor neuron disease
    K Tsuzaka
    Department of Neurology and Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Muscle Nerve 24:474-80. 2001
  9. ncbi request reprint Effects of cardiotrophin-1 (CT-1) in a mouse motor neuron disease
    H Mitsumoto
    Department of Neurology and Neurosciences, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Muscle Nerve 24:769-77. 2001
  10. ncbi request reprint MR spectroscopy in amyotrophic lateral sclerosis/motor neuron disease
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    J Neurol Sci 152:S49-53. 1997

Collaborators

Detail Information

Publications12

  1. pmc Diffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients
    Venkateswaran Rajagopalan
    Department of Biomedical Engineering, ND2, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Aging Res 2011:481745. 2011
    ..The IC abnormalities suggest a prominent axonopathy in UMN-predominant ALS and that tissue changes underlying CST hyperintensity have specific DTI changes, suggestive of unique axonal pathology...
  2. pmc Motor neuronopathy with dropped hands and downbeat nystagmus: a distinctive disorder? A case report
    Nimish J Thakore
    Department of Neurology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    BMC Neurol 6:3. 2006
    ..We report clinical and oculomotor findings in three patients with motor neuronopathy and downbeat nystagmus, a classic sign of vestibulocerebellar disease...
  3. doi request reprint Current concepts in the pharmacotherapy of pseudobulbar affect
    Erik P Pioro
    Cleveland Clinic, OH 44195, USA
    Drugs 71:1193-207. 2011
    ....
  4. doi request reprint Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect
    Erik P Pioro
    Section of ALS and Related Disorders, Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Neurol 68:693-702. 2010
    ..To evaluate dextromethorphan combined with ultra low-dose quinidine (DMq) for treating pseudobulbar affect (PBA) in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS)...
  5. ncbi request reprint Proton magnetic resonance spectroscopy (1H-MRS) in ALS
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:S7-16. 2000
    ..This review discusses the advantages and limitations of employing 1H-MRS as an investigative tool in the diagnosis of ALS...
  6. ncbi request reprint 1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla
    E P Pioro
    Department of Neurology and Neurosciences, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 53:71-9. 1999
    ....
  7. ncbi request reprint Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neuroreport 9:3041-6. 1998
    ..In vivo IH-MRS and correlative postmortem study of wobbler mouse brain will allow temporal monitoring of neuronal degeneration and responsiveness to neuroprotective pharmacotherapies...
  8. ncbi request reprint Role of brain-derived neurotrophic factor in wobbler mouse motor neuron disease
    K Tsuzaka
    Department of Neurology and Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Muscle Nerve 24:474-80. 2001
    ..Our study indicates that BDNF is important in halting nitric oxide (NO)-mediated motor neuron degeneration, which has potential implications for the treatment of neurodegenerative disorders...
  9. ncbi request reprint Effects of cardiotrophin-1 (CT-1) in a mouse motor neuron disease
    H Mitsumoto
    Department of Neurology and Neurosciences, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Muscle Nerve 24:769-77. 2001
    ..01). We conclude that CT-1 exerts myotrophic effects as well as neurotrophic effects in a mouse model of spontaneous MND, a finding that has potential therapeutic implications for human MND...
  10. ncbi request reprint MR spectroscopy in amyotrophic lateral sclerosis/motor neuron disease
    E P Pioro
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    J Neurol Sci 152:S49-53. 1997
    ....
  11. ncbi request reprint Development, analysis, refinement, and utility of an interdisciplinary amyotrophic lateral sclerosis database
    V Dal Bello-Haas
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:39-46. 2001
    ..Ongoing refinement will ensure that this HCP-driven ALS database continues to be informative, practical and effective for decision-making and enhancing delivery of care...
  12. ncbi request reprint Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment
    T Ishiyama
    Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    Exp Neurol 148:247-55. 1997
    ..Thus, the hybrid B6NZB-wr/wr mice have a more severe clinical phenotype and offer a unique opportunity to study the mechanisms of presymptomatic motor neuron degeneration and the effects of therapeutic agents for human MND...