Sanjay Pimplikar

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Neuroinflammation in Alzheimer's disease: from pathogenesis to a therapeutic target
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA
    J Clin Immunol 34:64-9. 2014
  2. pmc APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation
    Kaushik Ghosal
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11866. 2010
  3. pmc Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth
    Ping Song
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e34209. 2012
  4. pmc Amyloid precursor protein: more than just neurodegeneration
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, NC 30, Cleveland, OH 44195, USA
    Stem Cell Res Ther 2:39. 2011
  5. pmc Reassessing the amyloid cascade hypothesis of Alzheimer's disease
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States
    Int J Biochem Cell Biol 41:1261-8. 2009
  6. pmc Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
    Sanjay W Pimplikar
    Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Neurosci 30:14946-54. 2010
  7. pmc Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease
    Nicholas H Varvel
    Department of Neurosciences, NC30, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
    J Neurosci 28:10786-93. 2008
  8. ncbi request reprint AbetaPP, apoptosis and Alzheimer's disease
    Sanjay W Pimplikar
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 4:39-40. 2002
  9. doi request reprint Amyloid precursor protein is required for convergent-extension movements during Zebrafish development
    Powrnima Joshi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic NC 30, Cleveland, OH 44195, USA
    Dev Biol 335:1-11. 2009
  10. pmc Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain
    Kaushik Ghosal
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 106:18367-72. 2009

Research Grants

  1. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay Pimplikar; Fiscal Year: 2006
  2. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay Pimplikar; Fiscal Year: 2009
  3. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay W Pimplikar; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Neuroinflammation in Alzheimer's disease: from pathogenesis to a therapeutic target
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA
    J Clin Immunol 34:64-9. 2014
    ..Finally, after the remarkable success of the reductionist approach, a complimentary bottom-up systems approach is necessary to gain a better understanding of the highly complex, multifactorial nature of AD pathogenesis. ..
  2. pmc APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation
    Kaushik Ghosal
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11866. 2010
    ..Since impaired adult neurogenesis is shown to augment memory deficits in AD mouse models, here we examined the status of adult neurogenesis in AICD transgenic mice...
  3. pmc Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth
    Ping Song
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e34209. 2012
    ..Our results show that the zebrafish model provides a powerful system to delineate APP functions in vivo and to study the biological effects of APP mutations...
  4. pmc Amyloid precursor protein: more than just neurodegeneration
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, NC 30, Cleveland, OH 44195, USA
    Stem Cell Res Ther 2:39. 2011
    ..Thus, APP seems to play complex and disparate roles in neurodegeneration and neuroprotection...
  5. pmc Reassessing the amyloid cascade hypothesis of Alzheimer's disease
    Sanjay W Pimplikar
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States
    Int J Biochem Cell Biol 41:1261-8. 2009
    ..A view that Abeta is one of the factors, as opposed to the factor, that causes AD is more consistent with the present knowledge, and is more likely to promote comprehensive and effective therapeutic strategies...
  6. pmc Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
    Sanjay W Pimplikar
    Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Neurosci 30:14946-54. 2010
    ..A view of AD pathogenesis that encompasses both the amyloid-dependent and -independent mechanisms will help fill the gaps in our knowledge and reconcile the findings that cannot be explained solely by the amyloid hypothesis...
  7. pmc Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease
    Nicholas H Varvel
    Department of Neurosciences, NC30, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
    J Neurosci 28:10786-93. 2008
    ..Together, our data suggest that low molecular weight aggregates of Abeta induce neuronal cell cycle re-entry in mouse models of Alzheimer's disease...
  8. ncbi request reprint AbetaPP, apoptosis and Alzheimer's disease
    Sanjay W Pimplikar
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 4:39-40. 2002
  9. doi request reprint Amyloid precursor protein is required for convergent-extension movements during Zebrafish development
    Powrnima Joshi
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic NC 30, Cleveland, OH 44195, USA
    Dev Biol 335:1-11. 2009
    ..Collectively, this work demonstrates that the zebrafish model is a powerful system to define the role of APP during embryonic development and to evaluate the functional activity of fAD mutant APP...
  10. pmc Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain
    Kaushik Ghosal
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 106:18367-72. 2009
    ..The in vivo findings that AICD can contribute to AD pathology independently of Abeta have important therapeutic implications and may explain some observations that are discordant with the amyloid hypothesis...
  11. pmc Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
    Kathleen A Ryan
    Department of Pathology and Cell Biology Program, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cell Biol 171:327-35. 2005
    ..Our data suggest that AICD is biologically relevant, causes significant alterations in cell signaling, and may play a role in axonal elongation or pathfinding...
  12. ncbi request reprint Regulation of nuclear functions--nucleocytoplasmic transport in context
    Alan M Tartakoff
    Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Eur J Cell Biol 83:185-92. 2004

Research Grants4

  1. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay Pimplikar; Fiscal Year: 2006
    ..This proposal has relevance with respect to the development of new therapeutic strategies by identifying the signaling pathways that are perturbed in Alzheimer's disease. ..
  2. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay Pimplikar; Fiscal Year: 2009
    ..This proposal has relevance with respect to the development of new therapeutic strategies by identifying the signaling pathways that are perturbed in Alzheimer's disease. ..
  3. The In Vivo Role of AICD in Neuronal Dysfunction
    Sanjay W Pimplikar; Fiscal Year: 2010
    ..This proposal has relevance with respect to the development of new therapeutic strategies by identifying the signaling pathways that are perturbed in Alzheimer's disease. ..