Dianne Perez

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion
    Robert S Papay
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Pharmacol 83:939-48. 2013
  2. pmc G-protein-coupled receptors in adult neurogenesis
    Van A Doze
    Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Pharmacol Rev 64:645-75. 2012
  3. pmc Cardiac and neuroprotection regulated by α(1)-adrenergic receptor subtypes
    Dianne M Perez
    Department of Molecular Cardiology, NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Recept Signal Transduct Res 31:98-110. 2011
  4. pmc Structure-function of alpha1-adrenergic receptors
    Dianne M Perez
    Department of Molecular Cardiology, NB5, The Cleveland Clinic Foundation, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochem Pharmacol 73:1051-62. 2007
  5. ncbi request reprint Multiple signaling states of G-protein-coupled receptors
    Dianne M Perez
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Pharmacol Rev 57:147-61. 2005
  6. ncbi request reprint From plants to man: the GPCR "tree of life"
    Dianne M Perez
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Pharmacol 67:1383-4. 2005
  7. ncbi request reprint Polymorphic G-protein-coupled receptors and associated diseases
    Dianne M Perez
    Department of Molecular Cardiology NB50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Receptors Channels 8:57-64. 2002
  8. ncbi request reprint The evolutionarily triumphant G-protein-coupled receptor
    Dianne M Perez
    The Department of Molecular Cardiology, NB5, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Mol Pharmacol 63:1202-5. 2003
  9. pmc Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
    Sathyamangla V Naga Prasad
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:27487-99. 2009
  10. ncbi request reprint Novel alpha1-adrenergic receptor signaling pathways: secreted factors and interactions with the extracellular matrix
    Ting Shi
    Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Pharmacol 70:129-42. 2006

Collaborators

  • Zhong hui Duan
  • EDWARD FRANKLIN PLOW
  • Sadashiva Karnik
  • Carlo Croce
  • Qingyu Wu
  • Qing Wang
  • Subha Sen
  • M S Penn
  • Zhong Ying
  • George A Calin
  • Randall C Starling
  • Robert S Papay
  • June Yun
  • Ting Shi
  • Van A Doze
  • Dan F McCune
  • Sean A Ross
  • Sathyamangla V Naga Prasad
  • Robert J Gaivin
  • Pedro J Gonzalez-Cabrera
  • Michael T Piascik
  • Manveen K Gupta
  • Robert Papay
  • Daniel Jane-wit
  • Boyd R Rorabaugh
  • Michael J Zuscik
  • Pedro Gonzalez-Cabrera
  • Robert Gaivin
  • Brian W Nelson
  • Paul C Simpson
  • Bethany A Davis
  • Katie M Collette
  • James R Haselton
  • Elizabeth J Luger
  • Brianna L Goldenstein
  • Sarah G Wood
  • Mariaha J Lyons
  • Chang Gong Liu
  • Venkata Suresh K Surampudi
  • Ashwin Kotwal
  • Christine S Moravec
  • Stefano Volinia
  • Cengiz Z Altuntas
  • Zoran B Popovic
  • Sandro Yong
  • Pamela Clark
  • Vincent K Tuohy
  • Peter J Wickley
  • Justin M Johnson
  • Derek S Damron
  • Manveen Gupta
  • Carol A De La Motte
  • Elzbieta Pluskota
  • Imad Najm
  • Dan Chalothorn
  • D F McCune
  • Attaporn Boongird
  • Judy Drazba

Detail Information

Publications20

  1. pmc α₁A-adrenergic receptors regulate cardiac hypertrophy in vivo through interleukin-6 secretion
    Robert S Papay
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Pharmacol 83:939-48. 2013
    ..Because α₁A/B double knockout mice fail to develop hypertrophy in response to IL-6, our results suggest that IL-6 is a major mediator of α₁A-AR cardiac hypertrophy...
  2. pmc G-protein-coupled receptors in adult neurogenesis
    Van A Doze
    Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Pharmacol Rev 64:645-75. 2012
    ..Current evidence supporting adult neurogenesis as a model for self-repair in neuropathologic conditions, adult neural stem cell therapeutic strategies, and potential avenues for GPCR-based therapeutics are also discussed...
  3. pmc Cardiac and neuroprotection regulated by α(1)-adrenergic receptor subtypes
    Dianne M Perez
    Department of Molecular Cardiology, NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Recept Signal Transduct Res 31:98-110. 2011
    ....
  4. pmc Structure-function of alpha1-adrenergic receptors
    Dianne M Perez
    Department of Molecular Cardiology, NB5, The Cleveland Clinic Foundation, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochem Pharmacol 73:1051-62. 2007
    ..This review will explore past and current knowledge of the structure-function of the alpha(1)-adrenergic receptor subtypes...
  5. ncbi request reprint Multiple signaling states of G-protein-coupled receptors
    Dianne M Perez
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Pharmacol Rev 57:147-61. 2005
    ..Rhodopsin may serve as a primer for the study of multiple activation states. Therapeutic implications that utilize multiple signaling states hold vast promise in the rationale design of drugs...
  6. ncbi request reprint From plants to man: the GPCR "tree of life"
    Dianne M Perez
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Pharmacol 67:1383-4. 2005
    ..Their article describes the expansion and evolution of G protein-coupled receptors during the nematode-to-chordate split...
  7. ncbi request reprint Polymorphic G-protein-coupled receptors and associated diseases
    Dianne M Perez
    Department of Molecular Cardiology NB50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Receptors Channels 8:57-64. 2002
    ....
  8. ncbi request reprint The evolutionarily triumphant G-protein-coupled receptor
    Dianne M Perez
    The Department of Molecular Cardiology, NB5, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Mol Pharmacol 63:1202-5. 2003
  9. pmc Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
    Sathyamangla V Naga Prasad
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:27487-99. 2009
    ..Importantly, using network analysis we have identified a limited number of key functional targets that may regulate expression of the myriad proteins in heart failure and could be potential therapeutic targets...
  10. ncbi request reprint Novel alpha1-adrenergic receptor signaling pathways: secreted factors and interactions with the extracellular matrix
    Ting Shi
    Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Pharmacol 70:129-42. 2006
    ..Our results indicate alpha1-ARs induce the secretion of factors that interact with the extracellular matrix to regulate cell adhesion, motility and proinflammatory responses through novel signaling pathways...
  11. ncbi request reprint Gene expression profiling of alpha(1b)-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays
    June Yun
    The Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Res 57:443-55. 2003
    ..We wanted to explore potential gene expression differences that characterize this type of hypertrophy that may identify genes that prevent progression to heart failure...
  12. ncbi request reprint Dominance of the alpha1B-adrenergic receptor and its subcellular localization in human and TRAMP prostate cancer cell lines
    Ting Shi
    The Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation Cleveland, Ohio 44195, USA
    J Recept Signal Transduct Res 27:27-45. 2007
    ....
  13. pmc Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity
    Van A Doze
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA
    Mol Pharmacol 80:747-58. 2011
    ..This may afford a potential therapeutic target for counteracting the decline in cognitive function and mood associated with aging and neurological disorders...
  14. ncbi request reprint The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model
    Sean A Ross
    The Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Res 60:598-607. 2003
    ..In this study, we used a systemically expressing mouse model that overexpresses the alpha(1B)-AR to define the role of this subtype in cardiac function...
  15. pmc alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB
    Dianne M Perez
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Pharmacol 76:144-52. 2009
    ..Our results indicate that alpha(1)-ARs stimulated IL-6 expression and secretion through regulating both mRNA transcription and stability, involving p38 MAPK and NF-kappaB pathways...
  16. ncbi request reprint Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis
    Daniel Jane-wit
    Department of Immunology, NB30, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circulation 116:399-410. 2007
    ..The mechanism whereby these autoantibodies exert their pathogenic effect is unknown. Here, we define a causal mechanism whereby beta1AR-specific autoantibodies mediate noninflammatory cardiomyocyte cell death during murine DCM...
  17. ncbi request reprint Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130
    Pedro J Gonzalez-Cabrera
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Pharmacol 63:1104-16. 2003
    ..These results suggest that the alpha(1B)-AR has differential effects on the phosphorylation status of the STAT3 pathway and may not be as prohypertrophic as the other two subtypes...
  18. ncbi request reprint Gene expression profile of neurodegeneration induced by alpha1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis
    June Yun
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Brain 126:2667-81. 2003
    ..The alpha1BAR also co-localized with the glutamatergic distribution, suggesting a glutamate imbalance as a molecular rationale for the epileptic seizures...
  19. ncbi request reprint Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation
    Robert Papay
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neurochem 83:623-34. 2002
    ..We conclude that overexpression of the alpha(1B)-AR can cause a synucleinopathy similar to other parkinsonian syndromes...
  20. pmc The relationship between protein sequences and their gene ontology functions
    Zhong hui Duan
    Department of Computer Science, University of Akron, Akron, OH 44325, USA
    BMC Bioinformatics 7:S11. 2006
    ..The underlying assumption of these systems is that similar sequences imply similar biological functions. However, it has been noted that matching sequences do not always infer similar functions...

Research Grants9

  1. ALPHA1 ADRENOCEPTOR SUBTYPES AND ROLE IN PATHOPHYSIOLOGY
    Dianne Perez; Fiscal Year: 2002
    ..We will also explore possible pathologies from alpha1-subtype overactivity in vivo and to more clearly define the role of the alpha1a-subtype in cardiovascular function. ..
  2. Alpha1-Adrenoceptor Subtypes & Role in Pathophysiology
    Dianne Perez; Fiscal Year: 2006
    ....
  3. Protective signaling mechanisms of the alpha1A-adrenoceptor
    Dianne M Perez; Fiscal Year: 2010
    ....