W Frank Peacock

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi Primary role of B-type natriuretic peptide across the clinical spectrum: from emergency medicine to transitional care and beyond into the community
    W Frank Peacock
    Emergency Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 17:8-13. 2011
  2. pmc Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review
    W Frank Peacock
    The Cleveland Clinic, Cleveland, OH, USA
    Ther Clin Risk Manag 5:627-34. 2009
  3. doi A systematic review of nicardipine vs labetalol for the management of hypertensive crises
    W Frank Peacock
    Department of Emergency Medicine E19, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Emerg Med 30:981-93. 2012
  4. ncbi Emergency department perspectives on B-type natriuretic peptide utility
    W Frank Peacock
    The Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 14:17-20. 2008
  5. doi Short-term mortality risk in emergency department acute heart failure
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, OH, USA
    Acad Emerg Med 18:947-58. 2011
  6. pmc CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195 USA
    Crit Care 15:R157. 2011
  7. doi A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, OH, USA
    Acad Emerg Med 18:360-6. 2011
  8. ncbi Impact of early initiation of intravenous therapy for acute decompensated heart failure on outcomes in ADHERE
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cardiology 107:44-51. 2007
  9. ncbi Using the emergency department clinical decision unit for acute decompensated heart failure
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, OH 44195, USA
    Cardiol Clin 23:569-88, viii. 2005
  10. ncbi Impact of impedance cardiography on diagnosis and therapy of emergent dyspnea: the ED-IMPACT trial
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH, USA
    Acad Emerg Med 13:365-71. 2006

Detail Information

Publications94

  1. doi Primary role of B-type natriuretic peptide across the clinical spectrum: from emergency medicine to transitional care and beyond into the community
    W Frank Peacock
    Emergency Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 17:8-13. 2011
    ..This is particularly desirable in patients with diagnosed acute HF for accurate diagnosis and better treatment outcomes...
  2. pmc Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review
    W Frank Peacock
    The Cleveland Clinic, Cleveland, OH, USA
    Ther Clin Risk Manag 5:627-34. 2009
    ..7% vs 1.7%, P =0.0445) when compared to sodium nitroprusside. In the VELOCITY trial clevidipine demonstrated a reduction in blood pressure of 6% at the 3 minute mark, 15% within 9.5 minutes and 27% at the 18 hour mark...
  3. doi A systematic review of nicardipine vs labetalol for the management of hypertensive crises
    W Frank Peacock
    Department of Emergency Medicine E19, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Emerg Med 30:981-93. 2012
    ..The results of this systematic review show comparable efficacy and safety for nicardipine and labetalol, although nicardipine appears to provide more predictable and consistent BP control than labetalol...
  4. ncbi Emergency department perspectives on B-type natriuretic peptide utility
    W Frank Peacock
    The Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 14:17-20. 2008
    ..This allows early outcome-improving interventions to proceed with greater certainty. Finally, as a prognostic marker indicative of illness severity, knowledge of BNP levels can improve the accuracy of disposition decisions...
  5. doi Short-term mortality risk in emergency department acute heart failure
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, OH, USA
    Acad Emerg Med 18:947-58. 2011
    ..The purpose was to describe the accuracy of several biomarkers for predicting short-term death rates in patients diagnosed with AHF in the emergency department (ED)...
  6. pmc CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195 USA
    Crit Care 15:R157. 2011
    ..Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension...
  7. doi A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, OH, USA
    Acad Emerg Med 18:360-6. 2011
    ..The purpose of this study was to assess the safety and dynamics of the onset of antipyretic efficacy of intravenous (IV) acetaminophen versus oral (PO) acetaminophen in the treatment of endotoxin-induced fever...
  8. ncbi Impact of early initiation of intravenous therapy for acute decompensated heart failure on outcomes in ADHERE
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cardiology 107:44-51. 2007
    ....
  9. ncbi Using the emergency department clinical decision unit for acute decompensated heart failure
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, OH 44195, USA
    Cardiol Clin 23:569-88, viii. 2005
    ..New risk stratification data can aid in the identification of the appropriate candidate. The observation unit now represents a nonhospitalization disposition option for patients presenting to the emergency department with ADHF.viii CO..
  10. ncbi Impact of impedance cardiography on diagnosis and therapy of emergent dyspnea: the ED-IMPACT trial
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH, USA
    Acad Emerg Med 13:365-71. 2006
    ..Impedance cardiography (ICG) is a noninvasive method to measure hemodynamics that may assist in early ED decision making...
  11. doi Early vasoactive drugs improve heart failure outcomes
    William Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 15:256-64. 2009
    ..006), and the adjusted odds of death increased 6.8% for every 6 hours of treatment delay (95% confidence interval, 4.2-9.6; P<.0001). Early vasoactive initiation is associated with improved outcomes in patients hospitalized for ADHF...
  12. doi Morphine and outcomes in acute decompensated heart failure: an ADHERE analysis
    W F Peacock
    Emergency Department, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    Emerg Med J 25:205-9. 2008
    ..Morphine is a long-standing therapy in acute decompensated heart failure (ADHF), despite few supporting data. A study was undertaken to compare the outcomes of patients who did and did not receive morphine for ADHF...
  13. doi Risk stratification for suspected acute coronary syndromes and heart failure in the emergency department
    W Frank Peacock
    The Cleveland Clinic, Cleveland, OH, USA
    Acute Card Care 11:138-45. 2009
    ..In this manuscript, we discuss the value of biomarkers as an adjunct to the diagnosis and risk stratification process for patients presenting to the emergency department with suspected acute coronary syndromes and acute heart failure...
  14. doi Current technique of fluid status assessment
    W Frank Peacock
    Emergency Services Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Congest Heart Fail 16:S45-51. 2010
    ..In addition to discussing the accuracy of the history, physical examination, and radiography, acoustic cardiography and bedside ultrasonography are presented...
  15. doi Cardiac troponin and outcome in acute heart failure
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 358:2117-26. 2008
    ..The purpose of our study was to describe the association between elevated cardiac troponin levels and adverse events in hospitalized patients with acute decompensated heart failure...
  16. doi National Heart, Lung, and Blood Institute working group on emergency department management of acute heart failure: research challenges and opportunities
    W Frank Peacock
    The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 56:343-51. 2010
    ..We anticipate that this review will serve as a starting point for future investigations across the spectrum of funding sources...
  17. pmc Cardiologists' and emergency physicians' perspectives on and knowledge of reperfusion guidelines pertaining to ST-segment-elevation myocardial infarction
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic, Cleveland, Ohio 44195 0002, USA
    Tex Heart Inst J 35:152-61. 2008
    ....
  18. doi Current techniques of fluid status assessment
    W Frank Peacock
    Emergency Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Contrib Nephrol 164:128-42. 2010
    ..In addition to the history, physical exam, and standard radiographic techniques for volume assessment, the newer technologies of acoustic cardiography, bedside ultrasound, and bioimpedance are presented...
  19. doi Use of bioimpedance vector analysis in critically ill and cardiorenal patients
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Contrib Nephrol 165:226-35. 2010
    ..Knowledge of these parameters can provide insight as to the short-term prognosis, as well as the presenting volume status...
  20. doi Clevidipine for severe hypertension in acute heart failure: a VELOCITY trial analysis
    Frank W Peacock
    Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH 44195 0001, USA
    Congest Heart Fail 16:55-9. 2010
    ..Clevidipine safely decreases SBP in AHF and does not cause unexpected hypotension. The results of this post hoc subgroup analysis suggest that clevidipine is safe, well tolerated, and efficacious in AHF patients with hypertension...
  21. ncbi Reperfusion strategies in the emergency treatment of ST-segment elevation myocardial infarction
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Emerg Med 25:353-66. 2007
    ..Protocols should be regularly reviewed to accommodate changes in clinical practice arising from ongoing clinical trials...
  22. ncbi Emergency department management of patients with acute decompensated heart failure
    W Franklin Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Heart Fail Rev 9:187-93. 2004
    ..Use of the observation unit for the management of heart failure will also be discussed as a way of decreasing admissions from the ED...
  23. ncbi Prediction of short- and long-term outcomes by troponin T levels in low-risk patients evaluated for acute coronary syndromes
    I V Peacock WF
    Departments of Emergency Medicine, Cardiology, Clinical Pathology, and Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Emerg Med 35:213-20. 2000
    ..However, there are few studies validating this strategy. The purpose of this study was to determine the ability of cTnT levels to predict short- and long-term outcomes in low-risk patients with suspected acute coronary syndromes...
  24. ncbi Nesiritide added to standard care favorably reduces systolic blood pressure compared with standard care alone in patients with acute decompensated heart failure
    W Franklin Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Am J Emerg Med 23:327-31. 2005
    ..03]). Both treatment groups had similar incidences of symptomatic and asymptomatic hypotension. These data demonstrate that early administration of nesiritide in the emergency department is a safe and effective treatment of heart failure...
  25. ncbi Management of acute decompensated heart failure in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail . 2003
    ....
  26. pmc Clevidipine for severe hypertension in patients with renal dysfunction: a VELOCITY trial analysis
    W Frank Peacock
    The Cleveland Clinic, Cleveland, Ohio, USA
    Blood Press Suppl 1:20-5. 2011
    ..The purpose of this analysis was to assess the safety and efficacy of clevidipine in patients with RD...
  27. ncbi Retrospective review: the incidence of non-ST segment elevation MI in emergency department patients presenting with decompensated heart failure
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail 9:303-8. 2003
    ..The authors conclude that elevated cardiac markers are not rare in decompensated heart failure. These pilot data suggest these tests should be routinely obtained on heart failure patients...
  28. ncbi Observation unit management of heart failure
    W F Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Ohio State University, USA
    Emerg Med Clin North Am 19:209-32. 2001
    ..HF requires a comprehensive management program with extensive involvement from a multidisciplinary team committed to improving care for this population, however...
  29. ncbi The B-type natriuretic peptide assay: a rapid test for heart failure
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 69:243-51. 2002
    ..Other uses include screening for left ventricular dysfunction and predicting outcome in patients with an established diagnosis of heart failure or myocardial infarction...
  30. ncbi Clinical and economic impact of nesiritide
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Mail Code E 19, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Health Syst Pharm 60:S21-6. 2003
  31. ncbi Effective observation unit treatment of decompensated heart failure
    William Franklin Peacock
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Congest Heart Fail 8:68-73. 2002
    ..096) and 18% to 11% (p=0.099), respectively. An intensive outpatient ED OU HF management protocol safely decreases 90-day rates of emergency department visits and inpatient hospitalizations...
  32. ncbi Heart failure management in the emergency department observation unit
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, OH 44195, USA
    Prog Cardiovasc Dis 46:465-85. 2004
    ..This article reviews the newest diagnostics, therapeutics, and strategies for the management of heart failure and suggests appropriate implementation of these approaches in the emergency department observation unit...
  33. ncbi The elder patient with suspected acute coronary syndromes in the emergency department
    Jin H Han
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Acad Emerg Med 14:732-9. 2007
    ..To describe the evaluation and outcomes of elder patients with suspected acute coronary syndromes (ACS) presenting to the emergency department (ED)...
  34. doi Early treatment for non-ST-segment elevation acute coronary syndrome is associated with appropriate discharge care
    Gregory J Fermann
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0769, USA
    Clin Cardiol 32:519-25. 2009
    ..Acute treatment is associated with improved in-hospital outcomes for patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS)...
  35. pmc Low-risk acute heart failure patients: external validation of the Society of Chest Pain Center's recommendations
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267 0769, USA
    Crit Pathw Cardiol 8:99-103. 2009
    ..The goal of this analysis was to report on the outcomes experienced by ED patients with AHFS who do not have any of these high-risk criteria...
  36. doi Temporal trends and predictors in the use of aldosterone antagonists post-acute myocardial infarction
    Andrew N Rassi
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 61:35-40. 2013
    ..This study explored temporal trends in the use of aldosterone antagonist therapy among eligible patients with post-acute myocardial infarction (AMI) and reduced ejection fraction and characteristics associated with use in clinical practice...
  37. doi S3 detection as a diagnostic and prognostic aid in emergency department patients with acute dyspnea
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, OH 45267 0769, USA
    Ann Emerg Med 53:748-57. 2009
    ..This study evaluates the effect of an S3 captured by acoustic cardiography on emergency physician diagnostic accuracy and confidence in their diagnosis of acute decompensated heart failure, as well as the patient's prognosis...
  38. doi Association of hospital primary angioplasty volume in ST-segment elevation myocardial infarction with quality and outcomes
    Dharam J Kumbhani
    Cleveland Clinic, Cleveland, Ohio, USA
    JAMA 302:2207-13. 2009
    ..Earlier studies indicate an inverse relationship between hospital volume and mortality after primary angioplasty for patients presenting with ST-segment elevation myocardial infarction (STEMI). However, contemporary data are lacking...
  39. ncbi The Internet Tracking Registry of Acute Coronary Syndromes (i*trACS): a multicenter registry of patients with suspicion of acute coronary syndromes reported using the standardized reporting guidelines for emergency department chest pain studies
    Christopher J Lindsell
    Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
    Ann Emerg Med 48:666-77, 677.e1-9. 2006
    ..We describe the methods for data collection and the ED population enrolled in a multicenter registry of patients with chest pain...
  40. pmc International variations in the clinical, diagnostic, and treatment characteristics of emergency department patients with acute heart failure syndromes
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Eur J Heart Fail 12:1253-60. 2010
    ..We examine differences in the presentation and management of emergency department (ED) patients with dyspnoea from acute heart failure syndromes (AHFS) between the USA, Western Europe, and Eastern Europe...
  41. doi Patient characteristics associated with the choice of triple antithrombotic therapy in acute coronary syndromes
    Jeremiah P Depta
    Department of Internal Medicine Medicine Institute, Cleveland Clinic, Ohio, USA
    Am J Cardiol 104:1171-8. 2009
    ..In conclusion, for patients with ACS, atrial fibrillation and atrial flutter were most strongly associated with the use of triple therapy; however, this therapy was used less often than dual or single antiplatelet therapy...
  42. ncbi Predictors of emergency department observation unit outcomes
    John Burkhardt
    Department of Emergency Medicine, Case Western Reserve University, Cleveland, OH, USA
    Acad Emerg Med 12:869-74. 2005
    ..In some of these, the use of a short-stay emergency department observation unit (EDOU) decreases 90-day ED revisits and 90-day rehospitalizations and, if subsequent hospitalization is required, results in shorter stays...
  43. ncbi Nesiritide in congestive heart failure associated with acute coronary syndromes: a pilot study of safety and efficacy
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Card Fail 10:120-5. 2004
    ..031). In non-right heart-catheterized patients, there were no 30-day readmissions with nesiritide versus 17% with NTG (P>.2). CONCLUSIONS: Nesiritide is as safe as NTG in heart failure patients with acute coronary syndromes...
  44. ncbi Heart failure observation units: optimizing care
    W Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Emerg Med 47:22-33. 2006
    ..Aggressive follow-up is also arranged at discharge. Recent additions to the therapeutic armamentarium and future advances in diagnostics and monitoring will continue to improve patient care and prevent avoidable hospitalizations...
  45. ncbi The combined utility of an S3 heart sound and B-type natriuretic peptide levels in emergency department patients with dyspnea
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    J Card Fail 12:286-92. 2006
    ....
  46. doi Improving emergency department door-to-electrocardiogram time in ST segment elevation myocardial infarction
    Michael P Phelan
    Cleveland Clinic, Department of Emergency Medicine, Cleveland, OH 44195, USA
    Crit Pathw Cardiol 8:119-21. 2009
    ....
  47. doi Initial emergency department systolic blood pressure predicts left ventricular systolic function in acute decompensated heart failure
    Joseph F Styron
    Department of Epidemiology and Biostatistics, Division of Health Services Research, Case Western Reserve University, Cleveland, OH, USA
    Congest Heart Fail 15:9-13. 2009
    ..Having an ED systolic BP >120 mm Hg is associated with significantly higher rates of preserved left ventricular systolic function in patients with ADHF...
  48. doi Platelet aspirin resistance in ED patients with suspected acute coronary syndrome
    Jonathan Glauser
    Cleveland Clinic, Case Western Reserve University, Cleveland, OH 44195, USA
    Am J Emerg Med 28:440-4. 2010
    ..The prevalence of emergency department (ED) platelet aspirin resistance in suspected acute coronary syndrome (ACS) is not described. Our purpose was to determine the prevalence of platelet aspirin resistance...
  49. doi Outcomes associated with small changes in normal-range cardiac markers
    Nolan McMullin
    The Cleveland Clinic, Cleveland, OH, USA
    Am J Emerg Med 29:162-7. 2011
    ..We evaluate the association between troponin fluctuations below an institutional upper limit of normal and acute coronary syndrome (ACS)...
  50. doi Disparity of care in the acute care of patients with heart failure
    Deborah B Diercks
    Department of Emergency Medicine, University of California at Davis, Davis, CA, USA
    Acad Emerg Med 18:15-21. 2011
    ....
  51. doi Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension
    Charles V Pollack
    Department of Emergency Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA 19107, USA
    Ann Emerg Med 53:329-38. 2009
    ....
  52. doi Design and rationale of the URGENT Dyspnea study: an international, multicenter, prospective study
    Peter S Pang
    Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Ther 15:299-303. 2008
    ..URGENT Dyspnea (Ularitide Global Evaluation in Acute Decompensated Heart Failure) is a prospective multicenter study designed to address these issues...
  53. doi The association between self-reported exercise intensity and acute coronary syndrome in emergency department chest pain patients
    Adam J Singer
    Department of Emergency Medicine, Stony Brook University and Medical Center, Stony Brook, New York 11794 8350, USA
    J Emerg Med 44:17-22. 2013
    ..We studied the association between self-reported frequency of exercising and the likelihood of ACS in patients presenting to the Emergency Department (ED) with chest pain...
  54. doi Noninvasive ventilation outcomes in 2,430 acute decompensated heart failure patients: an ADHERE Registry Analysis
    Thomas A Tallman
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Acad Emerg Med 15:355-62. 2008
    ....
  55. ncbi Insurance status and the treatment of myocardial infarction at academic centers
    Brian C Hiestand
    Department of Emergency Medicine, The Ohio State University, 149 Means Hall, 1654 Upham Drive, Columbus, OH 43210 1270, USA
    Acad Emerg Med 11:343-8. 2004
    ..Numerous studies have documented treatment disparities in patients with acute coronary syndromes based on race and gender. Other causes for treatment disparities may exist...
  56. doi Central versus local adjudication of myocardial infarction in a cardiac biomarker trial
    Stephen W Smith
    Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, USA
    Am Heart J 165:273-279.e1. 2013
    ..We determined the impact of local (at the site of subject enrollment) versus central adjudication of AMI on final diagnosis...
  57. doi Myeloperoxidase in the diagnosis of acute coronary syndromes: the importance of spectrum
    W Frank Peacock
    Cleveland Clinic Foundation, OH, USA
    Am Heart J 162:893-9. 2011
    ..Myeloperoxidase (MPO) is proposed for risk stratification in patients with suspected acute coronary syndromes (ACSs). We determined if MPO has diagnostic value in patients being evaluated for ACS...
  58. ncbi The effect of treatment on the presence of abnormal heart sounds in emergency department patients with heart failure
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, OH 45267 0769, USA
    Am J Emerg Med 24:25-32. 2006
    ..We sought to assess the proportion of ED patients with an electronically detected S(3) or S(4), determine the relation of these heart sounds to heart failure (HF), and analyze how the proportion changes with ED treatment...
  59. doi Venous thromboembolism prophylaxis in hospitalized heart failure patients
    Preeti Jois-Bilowich
    Preeti Jois Bilowich, Department of Emergency Medicine, Desk E 19, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Card Fail 14:127-32. 2008
    ..Our purpose was to describe the rate of use and the characteristics of patients receiving VTE prophylaxis in the Acute Decompensated Heart Failure National Registry (ADHERE)...
  60. ncbi Time to treatment and acute coronary syndromes: bridging the gap in rapid decision making
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Rev Cardiovasc Med 11:S45-50. 2010
    ..It is useful to identify patients at high risk for adverse events through measurement of Tn and BNP levels so that timely treatment decisions can be made...
  61. doi A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach
    Peter S Pang
    Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Eur Heart J 29:816-24. 2008
    ..This proposed tool requires detailed validation but has face validity for the uniform assessment of dyspnoea...
  62. ncbi Prevalence of the third and fourth heart sound in asymptomatic adults
    Sean P Collins
    Department of Emergency Medicine, and the Institute of Health Policy and Health Sciences Research, University of Cincinnati, Cincinnati, OH 45267, USA
    Congest Heart Fail 11:242-7. 2005
    ..04; 95% CI, 1.03-1.05). We conclude that the prevalence of an S3 is increased earlier in life, that an S4 is less common than previous studies suggest, and that its detection, even in the elderly, should not be ignored...
  63. doi Acute detection of ST-elevation myocardial infarction missed on standard 12-Lead ECG with a novel 80-lead real-time digital body surface map: primary results from the multicenter OCCULT MI trial
    James W Hoekstra
    Department of Emergency Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27023, USA
    Ann Emerg Med 54:779-788.e1. 2009
    ..We sought to determine the prevalence, clinical care patterns, and clinical outcomes of patients with STEMI identified on 80-lead but not on 12-lead (80-lead-only STEMI)...
  64. ncbi Rapid optimization: strategies for optimal care of decompensated congestive heart-failure patients in the emergency department
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Rev Cardiovasc Med 3:S41-8. 2002
    ....
  65. ncbi Troponin T in elders with suspected acute coronary syndromes
    Thomas P Noeller
    Department of Emergency Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue E 19, Cleveland, OH 44195, USA
    Am J Emerg Med 21:293-7. 2003
    ..In both elders and younger patients with abnormal renal function, low TnT specificity warrants careful consideration of this marker as the sole criterion for aggressive medical management...
  66. ncbi Acute Emergency Department management of heart failure
    W Frank Peacock
    Director of ED Clinical Operations, Medical Director, Event Medicine, Associate Professor, The Ohio State University, The Cleveland Clinic, USA
    Heart Fail Rev 8:335-8. 2003
    ..It also discusses the value of the ED observation unit for short intensive management of HF, the potential financial benefits of this strategy, and the ability of nesiritide to decrease future revisits when used in this environment...
  67. ncbi Cardiac computed tomography in the rapid evaluation of acute cardiac emergencies
    Brian O'Neil
    Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Rev Cardiovasc Med 11:S35-44. 2010
    ..Coronary computed tomography angiography has great promise as a tool to expedite the triage of patients with acute chest pain to early discharge or further inpatient diagnosis and treatment...
  68. doi Hemodynamic changes as a diagnostic tool in acute heart failure--a pilot study
    Rakesh S Engineer
    Emergency Services Institute E 19, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Emerg Med 30:174-80. 2012
    ..To examine whether posturally induced changes in cardiac output differentiate patients presenting with dyspnea to the emergency department (ED) with acute heart failure (AHF) from other causes...
  69. doi The role of the Society for Academic Emergency Medicine in the development of guidelines and performance measures
    Jesse M Pines
    Department of Emergency Medicine, George Washington University School of Medicine, Washington, DC, USA
    Acad Emerg Med 17:e130-40. 2010
    ....
  70. ncbi Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative
    Deepak L Bhatt
    Cleveland Clinic Foundation, Department of Cardiovascular Medicine Desk F25, Cleveland, Ohio 44195, USA
    JAMA 292:2096-104. 2004
    ....
  71. ncbi Ability of troponins to predict adverse outcomes in patients with renal insufficiency and suspected acute coronary syndromes: a case-matched study
    F Van Lente
    Department of Clinical Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 33:471-8. 1999
    ....
  72. ncbi The combination of enoxaparin, glycoprotein IIb/IIIa inhibitors and an early invasive approach among acute coronary syndrome patients
    David S Lee
    Cleveland Clinic Foundation, Department of Cardiovascular Medicine, Desk F25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Invasive Cardiol 16:46-51. 2004
    ....
  73. ncbi Normal CK, elevated MB predicts complications in acute coronary syndromes
    W F Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Emerg Med 20:385-90. 2001
    ..These patients should be considered as having had an acute coronary syndrome...
  74. doi Initial risk stratification and presenting characteristics of patients with evolving myocardial infarctions
    C D Miller
    Department of Emergency Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1089, USA
    Emerg Med J 25:492-7. 2008
    ....
  75. ncbi Observation unit treatment of heart failure with nesiritide: results from the proaction trial
    W F Peacock
    Department of Emergency, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Emerg Med 29:243-52. 2005
    ..5 vs. 6.5 days, p = 0.032). The incidence of symptomatic hypotension was low and did not differ between the groups. This study showed that nesiritide is safe when used in the emergency department, observation units, or similar settings...
  76. ncbi Frequency and clinical implications of discordant creatine kinase-MB and troponin measurements in acute coronary syndromes
    L Kristin Newby
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715 7969, USA
    J Am Coll Cardiol 47:312-8. 2006
    ..We sought to evaluate the association between discordant cardiac marker results and in-hospital mortality and treatment patterns in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  77. ncbi Relationship between risk stratification by cardiac troponin level and adherence to guidelines for non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Arch Intern Med 165:1870-6. 2005
    ..The threshold of troponin elevation that stimulates changes in clinical decision making for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACSs) has not been previously evaluated...
  78. ncbi Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative
    Trip J Meine
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 149:1043-9. 2005
    ..The CRUSADE Initiative is a nonrandomized, retrospective, observational registry enrolling patients with NSTE ACS to evaluate acute medications and interventions, inhospital outcomes, and discharge treatments...
  79. ncbi A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 146:993-8. 2003
    ..The acute benefits of platelet glycoprotein IIb/IIIa inhibitors for non-ST-segment elevation acute coronary syndromes (NSTE ACS) remain unclear...
  80. ncbi The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure
    Javed Butler
    Cardiology Division, Center for Education and Research in Therapeutics, Vanderbilt University and Geriatric Research, Education and Clinical Center, Nashville VAMC, Nashville, TN, 37232 6300, USA
    Nephrol Dial Transplant 19:391-9. 2004
    ..In this study, we sought to explore the safety and efficacy of nesiritide in patients with acute congestive heart failure (CHF) and renal insufficiency (RI)...
  81. ncbi Influence of timing of troponin elevation on clinical outcomes and use of evidence-based therapies for patients with non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Ann Emerg Med 45:355-62. 2005
    ....
  82. ncbi Standardized reporting guidelines for studies evaluating risk stratification of emergency department patients with potential acute coronary syndromes
    Judd E Hollander
    University of Pennsylvania, Philadelphia, PA, USA
    Ann Emerg Med 44:589-98. 2004
  83. ncbi Frequency and consequences of recording an electrocardiogram >10 minutes after arrival in an emergency room in non-ST-segment elevation acute coronary syndromes (from the CRUSADE Initiative)
    Deborah B Diercks
    University of California Davis Medical Center, Sacramento, California, USA
    Am J Cardiol 97:437-42. 2006
    ..Women were significantly more likely than men to have delayed ECG acquisition. Emergency departments should focus on decreasing the time to initial ECG acquisition to improve treatment of acute coronary syndrome in this group...
  84. ncbi Impact of congestive heart failure in patients with non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 97:1707-12. 2006
    ..Further study is needed to determine the causes of these treatment differences and the optimal therapeutic approach for patients with NSTE ACS and concomitant CHF...
  85. ncbi The impact of emergency department structure and care processes in delivering care for non-ST-segment elevation acute coronary syndromes
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 152:648-60. 2006
    ..We sought to assess the influence of emergency department (ED) structure and care processes on adherence to practice guidelines for the treatment of patients with non-ST-segment elevation acute coronary syndromes...
  86. ncbi Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study
    James L Januzzi
    Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 50:607-13. 2007
    ..The aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea...
  87. doi Society of Chest Pain Centers Recommendations for the evaluation and management of the observation stay acute heart failure patient: a report from the Society of Chest Pain Centers Acute Heart Failure Committee
    W Frank Peacock
    Crit Pathw Cardiol 7:83-6. 2008
  88. ncbi Natriuretic peptides in acute coronary syndromes: prognostic value and clinical implications
    Dimitrios Farmakis
    Second Department of Cardiology, Athens University Medical School, Attikon University Hospital, Athens, Greece
    Congest Heart Fail 14:25-9. 2008
    ..In conclusion, natriuretic peptide values may improve risk stratification in ACS when used in addition to troponin levels and other prognostic markers, but more data are needed to define their role in ACS therapy...
  89. ncbi Usefulness of serial assessment of natriuretic peptides in the emergency department for patients with acute decompensated heart failure
    Salvatore Disomma
    Emergency Medicine Department, 2nd Medical School, University La Sapienza, Sant Andrea Hospital Rome, Italy
    Congest Heart Fail 14:21-4. 2008
    ..In ADHF, serial ED measurements of BNP are useful for monitoring the effects of treatment. A reduction in BNP from admission to discharge is indicative of clinical improvement...
  90. doi Chest pain center accreditation is associated with better performance of centers for Medicare and Medicaid services core measures for acute myocardial infarction
    Michael A Ross
    Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Cardiol 102:120-4. 2008
    ..04), for which unadjusted performance was the same. In conclusion, ACPCs were associated with better compliance with Centers for Medicare and Medicaid Services core measures and saw a greater proportion of patients with AMIs...
  91. ncbi Patterns and implications of B-type natriuretic peptide measurement in patients with non-ST-segment elevation acute coronary syndromes
    Brett D Atwater
    University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Cardiol 100:1727-33. 2007
    ..In conclusion, more widespread measurement of BNP levels for risk stratification of patients with NSTE ACS may be warranted...
  92. ncbi Acoustic cardiography augments prolonged QRS duration for detecting left ventricular dysfunction
    Michel Zuber
    Cardiology Outpatient Clinic, Othmarsingen and Frauenfeld, Switzerland
    Ann Noninvasive Electrocardiol 12:316-28. 2007
    ..The goal of this study was to compare the abilities of QRS duration and simultaneous digital ECG and heart sounds, that is acoustic cardiographic, parameters to identify patients with LV dysfunction...
  93. ncbi Initial results from the PROACTION study
    W Frank Peacock
    J Emerg Med 31:435-6. 2006
  94. ncbi Up-and-coming markers: myeloperoxidase, a novel biomarker test for heart failure and acute coronary syndrome application?
    Christoph Sinning
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Congest Heart Fail 14:46-8. 2008
    ..In terms of ACS, inclusion of MPO into a multiple marker strategy might add to enhance diagnosis and therapy decision making. Therefore, MPO is a biomarker worthwhile of further evaluation in the setting of cardiovascular disease...