Affiliation: Cleveland Clinic Foundation
- Treatment of alcoholic hepatitisRobert S O'Shea
Department of Gastroenterology and Hepatology A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Liver Dis 9:103-34. 2005....
- Chronic hepatitis B virus infection: issues in treatmentRobert O'Shea
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 74:557-60. 2007..if they have no evidence of active disease? Which is the best treatment strategy? What do we do with patients who develop resistance to our current drugs? Should we treat patients with HBV infection who have already developed cirrhosis?..
- Nonalcoholic fatty liver disease in patients with type 2 diabetesZobair M Younossi
The Cleveland Clinic Foundation, Cleveland, USA
Clin Gastroenterol Hepatol 2:262-5. 2004..The aim of this study was to assess the outcome of patients with NAFLD and DM...
- Nonalcoholic steatohepatitis in children: a multicenter clinicopathological studyChristine Carter-Kent
Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, USA
Hepatology 50:1113-20. 2009..01), perisinusoidal fibrosis (P < 0.001), and NAS > or =5 (P < 0.005). Serum aspartate aminotransferase levels were the only clinical or laboratory data that independently predicted severity of fibrosis (P = 0.003)...
- In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver diseaseAnna Wieckowska
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Hepatology 44:27-33. 2006..These data highlight the potential usefulness of this test as a noninvasive diagnostic means of determining histological disease severity in patients with NAFLD...
- Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis ratSrinivasan Dasarathy
Department of Gastroenterology, Cleveland Clinic, Lerner Research Institute and the Cleveland Clinic Lerner College of Medicine, NE40, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Physiol Gastrointest Liver Physiol 292:G1105-13. 2007....
- Differences in regulation of type I collagen synthesis in primary and passaged hepatic stellate cell cultures: the role of alpha5beta1-integrinMilan Dodig
Department of Gastroenterology and Hepatology, Cleveland Clinic and Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Physiol Gastrointest Liver Physiol 293:G154-64. 2007..Therefore alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary HSC cultures but appears to have no direct role once the HSC are fully activated...
- Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective studySrinivasan Dasarathy
Department of Gastroenterology, 9500 Euclid Avenue, NE4 208, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Hepatol 51:1061-7. 2009..Therefore, a double blinded prospective study was performed in consecutive patients undergoing liver biopsy to evaluate the accuracy of ultrasound to diagnose hepatic steatosis...
- Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometryTakhar Kasumov
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
Anal Biochem 401:154-61. 2010..This technique could be extended for quantification of other ceramides and sphingolipids with no significant modification...
- Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitisMansour A Parsi
Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Gastroenterology 135:803-7. 2008..The aim of this study was to assess the utility of ascitic fluid lactoferrin (AFLAC) for the diagnosis of SBP and to identify a cut-off level that can be used for future development of a rapid bedside test...
- Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation studyAriel E Feldstein
Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
Hepatology 50:1072-8. 2009..The area under the receiver operating characteristic curve for NASH diagnosis was estimated to be 0.83 (0.75, 0.91)...
- Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver diseaseChristine Carter-Kent
Department of Pathology, Cleveland Clinic, USA
J Pediatr Gastroenterol Nutr 52:190-7. 2011..The aims of the present study were to establish associations between steatosis amount, type, and distribution in a well-characterized group of children with biopsy-proven nonalcoholic fatty liver disease (NAFLD)...
- Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and futureAnna Wieckowska
Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Hepatology 46:582-9. 2007..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
- Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver diseaseMangesh Pagadala
Department of Gastroenterology and Hepatology, Digestive Disease Institute of the Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, A 31, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Liver Dis 13:591-606. 2009..More accurate predictors and scoring systems would allow identifying who would benefit most from liver biopsy and monitor disease progression and response to therapy...
- Pathophysiology of nonalcoholic steatohepatitisArthur J McCullough
Case Western Reserve University and Schwartz Center for Metabolism and Nutrition at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
J Clin Gastroenterol 40:S17-29. 2006..Which of the pathophysiologic factors (which are discussed in this review), either alone or in combination, will eventually provide the basis for the most effective therapy has yet to be determined...
- Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted ratSrinivasan Dasarathy
Schwartz Center for Metabolism and Nutrition, Division of Gastroenterology, Cleveland, Ohio, USA
Dig Dis Sci 47:1936-42. 2002....
- Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusionSrinivasan Dasarathy
Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland, USA
Am J Physiol Gastrointest Liver Physiol 297:G567-75. 2009..An increase in oxidative stress, induced by a higher rate of fatty acid oxidation in NASH, may have caused an increase in the contribution of serine to cystathionine to meet the higher demands for glutathione...
- Obesity, hepatic metabolism and diseaseJohn M Edmison
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
Nestle Nutr Workshop Ser Pediatr Program 63:163-72; discussion 172-6, 259-68. 2009..Bariatric surgery is indicated in selected patients. A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy...
- Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessmentClaudia O Zein
Division of Gastroenterology and Hepatology, University Hospitals of Cleveland, Cleveland, OH, USA
Hepatology 44:1564-71. 2006..In conclusion, smoking may accelerate the progression of PBC. This could be induced by exposure to chemicals in cigarette smoke...
- Inhibition of aromatase improves nutritional status following portacaval anastomosis in male ratsSrinivasan Dasarathy
Gastroenterology Division, Department of Medicine, Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA
J Hepatol 45:214-20. 2006..We hypothesized that failure to gain body weight in the PCA rat was the consequence of low testosterone levels and will be reversed by 4-hydroxyandrostenedione, a specific aromatase inhibitor...
- Pathologic features associated with fibrosis in nonalcoholic fatty liver diseaseTerry Gramlich
Cleveland Clinic Foundation, OH, USA
Hum Pathol 35:196-9. 2004..We conclude that the presence of hepatocyte injury in NAFLD is associated with fibrosis. These pathological features can be used to establish the pathological criteria for diagnosis of the progressive form of NAFLD or NASH...
- The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantationIbrahim A Hanouneh
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Liver Transpl 14:1287-93. 2008..9, P = 0.05) were independently associated with fibrosis progression. In conclusion, MS, a potentially modifiable disease, is common and is strongly associated with long-term fibrosis progression in the setting of recurrent HCV after OLT...
- Posttransplant metabolic syndrome: an epidemic waiting to happenMangesh Pagadala
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Liver Transpl 15:1662-70. 2009..Additional measures that may be potentially beneficial include the use of lipid-lowering agents, the optimal control of blood glucose, and the use of tacrolimus instead of cyclosporine...
- Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humansSatish C Kalhan
Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
Metabolism 57:305-12. 2008..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus...
- Update on nonalcoholic fatty liver diseaseArthur J McCullough
Division of Gastroenterology and the Robert Schwartz Center of Metabolism and Nutrition at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
J Clin Gastroenterol 34:255-62. 2002..Future therapies will depend on a greater understanding of the pathophysiology and should focus on diminishing fibrosis...
- Pathogenesis of non-alcoholic steatohepatitis: human dataJohn Edmison
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
Clin Liver Dis 11:75-104, ix. 2007..Although fatty liver may be caused by other factors, this review concentrates on fatty liver associated with insulin resistance, sometimes referred to as the primary form...
- Diabetes mellitus, obesity, and hepatic steatosisWael Youssef
Division of Gastroenterology, Case Western Reserve University, Cleveland, OH, USA
Semin Gastrointest Dis 13:17-30. 2002..These include anti-oxidants such as vitamin E and betaine, bile acid therapy with ursodeoxycholic acid, and improved insulin sensitivity with metformin. Another potential therapeutic strategy is the reduction of inflammatory cytokines...
- The clinical features, diagnosis and natural history of nonalcoholic fatty liver diseaseArthur J McCullough
Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
Clin Liver Dis 8:521-33, viii. 2004..The major risk factors for fibrosis include diabetes or obesity, an aspartate aminotransferase/alanine aminotransferase ratio of greater than 1, age older than 50, and hepatic histology...
- Steatohepatitis in obese individualsWael I Youssef
Division of Gastroenterology, The Robert Schwartz Center for Metabolism and Nutrition at Metro Health Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
Best Pract Res Clin Gastroenterol 16:733-47. 2002..Bariatric surgery is indicated in selected patients.A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy...
- Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis ratSrinivasan Dasarathy
Schwartz Center for Metabolism and Nutrition, Department of Medicine, Division of Gastroenterology, Case Western Reserve University, MetroHealth Medical Center, Cleveland OH 44109, USA
Am J Physiol Gastrointest Liver Physiol 287:G1124-30. 2004..05). These data suggest that skeletal muscle atrophy seen in the portacaval shunted rats is a consequence of impaired satellite cell proliferation and differentiation mediated, in part, by higher myostatin and lower IGF1 expression...
- Steroids or cocktails for alcoholic hepatitisRobert O'Shea
J Hepatol 44:633-6. 2006
- Gender differences in the regulation of amino acid metabolismLinda S Lamont
Exercise Science Program, University of Rhode Island, Kingston, RI 02881, USA
J Appl Physiol (1985) 95:1259-65. 2003..Gender-specific fuel preferences during exercise are regulated by beta-adrenergic-receptor activity. Substrate availability during exercise appears to modulate the amino acid oxidation differences between genders...
- Obesity and its nurturing effect on hepatitis CArthur J McCullough
Hepatology 38:557-9. 2003
- Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver diseaseNaga Chalasani
Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
J Hepatol 48:829-34. 2008..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
- Obesity and non-alcoholic fatty liver disease in chronic hepatitis CZobair M Younossi
Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, Virginia 22042, USA
J Clin Gastroenterol 38:705-9. 2004..Superimposed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) may affect HCV-related fibrosis. We performed a study to determine the relationship between NAFLD and chronic hepatitis C...
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseDavid E Kleiner
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Hepatology 41:1313-21. 2005..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..