Research Topics
| Udayakumar NavaneethanSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitisUdayakumar Navaneethan
Digestive Disease Institute, Department of Gastroenterology, The Cleveland Clinic, Cleveland, OH, USA
J Crohns Colitis 6:845-51. 2012..It is unclear whether characteristics of colon neoplasia have changed over time. The aim of the study was to examine the temporal trends in colon neoplasia in patients with PSC and UC...
Severity of primary sclerosing cholangitis and its impact on the clinical outcome of Crohn's diseaseUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH, USA
J Crohns Colitis 6:674-80. 2012..The aim of the study was to study the association between the severity of PSC and clinical outcome of CD, comparing the course of CD in patients with PSC not needing orthotopic liver transplantation (OLT) and those requiring OLT...
Severe disease on endoscopy and steroid use increase the risk for bowel perforation during colonoscopy in inflammatory bowel disease patientsUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Crohns Colitis 6:470-5. 2012..Colonoscopic perforation is a rare complication. We sought to determine its risk factors in patients with inflammatory bowel disease (IBD)...
Progressive primary sclerosing cholangitis requiring liver transplantation is associated with reduced need for colectomy in patients with ulcerative colitisUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Clin Gastroenterol Hepatol 10:540-6. 2012..We investigated the association between the severity of primary sclerosing cholangitis (PSC) and clinical outcomes of patients with ulcerative colitis (UC) on the basis of need for colectomy...
Duration and severity of primary sclerosing cholangitis is not associated with risk of neoplastic changes in the colon in patients with ulcerative colitisUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, Ohio, USA
Gastrointest Endosc 75:1045-1054.e1. 2012..Annual surveillance colonoscopy to detect colon cancer is recommended for patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). Limited data currently support these recommendations...
Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized inflammatory bowel disease patientsUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Crohns Colitis 5:189-95. 2011..Colonic perforation is a rare complication associated with colonoscopy. There are no population-based studies on the risk of colonic perforation in IBD inpatients...
Successful diagnosis and management of biliary cast syndrome in a liver transplant patient using single operator cholangioscopyUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
JOP 12:461-3. 2011..Endoscopic techniques are recently described in the successful removal of biliary casts. Peroral single operator cholangioscopy is useful for direct visualization of bile ducts, tissue sampling and therapeutic applications...
Herpes simplex virus hepatitis - it's high time we consider empiric treatmentUdayakumar Navaneethan
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, USA
J Gastrointestin Liver Dis 20:93-6. 2011..The above results demonstrate a significant impact to fulminant hepatic failure and should prompt clinicians to consider empiric acyclovir therapy for at risk patients...
Awareness about clostridium difficile infection among internal medicine residents in the United StatesU Navaneethan
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Minerva Gastroenterol Dietol 57:231-40. 2011..The principal objective of this study was to assess the knowledge and awareness of internal medicine (IM) residents regarding the epidemiology, clinical recognition, diagnosis and management of CDI...
Idiopathic hyperammonemia in a patient with total pancreatectomy and islet cell transplantationUdayakumar Navaneethan
Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44118, USA
JOP 11:620-4. 2010..Idiopathic hyperammonemia is characterized by elevated serum ammonia associated with neurological deterioration of no other obvious etiology associated with relatively normal liver function tests and normal amino-acid levels...
Clostridium difficile infection and inflammatory bowel disease: understanding the evolving relationshipUdayakumar Navaneethan
Victor W Fazio Center for Inflammatory Bowel Disease, Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, The Cleveland Clinic A31, 9500 Euclid Ave, Cleveland, OH 44195, United States
World J Gastroenterol 16:4892-904. 2010..For CDI in the setting of underlying IBD, vancomycin appears to be more efficacious than metronidazole. Randomized controlled trials are required to clearly define the appropriate management for CDI in patients with IBD...
Tissue infiltration of IgG4+ plasma cells in symptomatic patients with ileal pouch-anal anastomosisUdayakumar Navaneethan
Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Crohns Colitis 5:570-6. 2011..Inflammatory bowel disease (IBD) is reported to be associated with autoimmune pancreatitis. The aim of the study was to investigate serum IgG4 and tissue infiltration of IgG4+ plasma cells in symptomatic patients with ileal pouches...
Clostridium difficile infection is associated with worse long term outcome in patients with ulcerative colitisUdayakumar Navaneethan
Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
J Crohns Colitis 6:330-6. 2012..Clostridium difficile infection (CDI) is becoming prevalent in general population as well as in patients with inflammatory bowel disease (IBD)...
Impact of budesonide on liver function tests and gut inflammation in patients with primary sclerosing cholangitis and ileal pouch anal anastomosisUdayakumar Navaneethan
Departments of Gastroenterology and Colorectal Surgery, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Crohns Colitis 6:536-42. 2012..This study was designed to evaluate the efficacy of oral budesonide on liver function tests in patients with PSC and pouchitis associated with ileal pouch-anal anastomosis (IPAA)...
Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized end-stage renal disease patients on hemodialysisUdayakumar Navaneethan
Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Int J Colorectal Dis 27:811-6. 2012..We sought to determine nationwide, population-based prevalence in rates of colonic perforation during colonoscopy among ESRD inpatients on HD in the US, and to assess risk factors for colonic perforation in this patient population...
Presence of concomitant inflammatory bowel disease is associated with an increased risk of postcholecystectomy complicationsUdayakumar Navaneethan
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Inflamm Bowel Dis 18:1682-8. 2012..Surgery in patients with inflammatory bowel disease (IBD) is often associated with complications. The aim of our study was to evaluate whether concomitant IBD was associated with an increased risk of postcholecystectomy complications...
Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosisBo Shen
Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Inflamm Bowel Dis 17:1890-900. 2011..The aim of this study was to compare endoscopic and histologic inflammation in the afferent limb (prepouch ileum) and pouch between IPAA patients with and without PSC...
Influence of ileal pouch anal anastomosis on bone loss in ulcerative colitis patientsUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Crohns Colitis 5:415-22. 2011..It is unclear whether proctocolectomy with ileal pouch-anal anastomosis (IPAA) for UC alters the risk of bone loss. The aim of this study was to compare BMD in UC patients with and without IPAA...
Elevated serum IgG4 is associated with chronic antibiotic-refractory pouchitisUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Gastrointest Surg 15:1556-61. 2011..The aims of the study were to investigate the prevalence of elevated serum IgG4 in symptomatic patients with ileal pouches and to characterize clinical features of pouch disorders in these patients...
Impact of Clostridium difficile infection in patients with ulcerative colitisRevital Kariv
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
J Crohns Colitis 5:34-40. 2011..Clostridium difficile infection (CDI) is becoming prevalent in general population as well as in patients with inflammatory bowel disease (IBD)...
Prevalence and clinical implications of positive serum anti-microsomal antibodies in symptomatic patients with ileal pouchesUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Gastrointest Surg 15:1577-82. 2011..The aims of the study were to investigate the prevalence of positive anti-microsomal antibody in symptomatic patients with ileal pouches and to investigate its clinical implications...
Secondary pouchitis: those with identifiable etiopathogenetic or triggering factorsUdayakumar Navaneethan
The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
Am J Gastroenterol 105:51-64. 2010..Careful evaluation of these secondary causes of pouchitis that may contribute to resistance to antibiotics should be performed before the introduction of next-line medical therapy...
Current controversies in fluid resuscitation in acute pancreatitis: a systematic reviewGuru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
Pancreas 41:827-34. 2012..Crystalloids are the currently recommended fluids for management of these patients. Current studies are underway to determine the optimal end points of fluid resuscitation that determine outcome...
Hepatobiliary disorders and complications of inflammatory bowel diseasePreethi Gk Venkatesh
Department of Gastroenterology Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Dig Dis 12:245-56. 2011..Interdisciplinary approach, involving gastroenterologists, hepatologists and, in advanced cases, general, colorectal, and liver transplant surgeons, is advocated...
Utility of fecal and serum anti-Saccharomyces cerevisiae antibodies in the diagnosis of Crohn's disease-like condition of the pouchLinda Y Tang
Pouchitis Clinic, Digestive Disease Institute A31, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Int J Colorectal Dis 27:1455-63. 2012....
Laboratory tests for patients with ileal pouch-anal anastomosis: clinical utility in predicting, diagnosing, and monitoring pouch disordersUdayakumar Navaneethan
The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 104:2606-15. 2009....
IgG4-associated ampullitis and cholangiopathy in Crohn's diseaseUdayakumar Navaneethan
Department of Gastroenterology Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Crohns Colitis 5:451-6. 2011..His serum IgG4 was 164 mg/dL. The association of IgG4-expressing plasma cell accumulation in the gastrointestinal tract with IBD in patients with hepatobiliary manifestation may have pathogenetic, diagnostic and therapeutic implications...
Cytomegalovirus ileitis in a patient after liver transplantation-differentiating from de novo IBDUdayakumar Navaneethan
Department of Internal Medicine, University of Cincinnati College of Medicine, OH, USA
J Crohns Colitis 5:354-9. 2011..De novo IBD should be considered in the differential diagnosis in these patients who do not improve with anti-viral treatment...
Impact of inflammatory bowel disease on post-cholecystectomy complications and hospitalization costs: A Nationwide Inpatient Sample studyUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Crohns Colitis 7:e164-70. 2013..The aim of the current population-based study was to verify whether concomitant IBD was indeed associated with an increased risk of post-cholecystectomy complications...
Impact of ileal pouch-anal anastomosis on the surgical outcome of orthotopic liver transplantation for primary sclerosing cholangitisEmmanuel C Obusez
Lerner College of Medicine, Department of Gastroenterology and Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
J Crohns Colitis 7:230-8. 2013..While studies to date show that OLT may impact the outcome of IPAA, the effect of IPAA on the surgical outcome of OLT is not known...
Pros and cons of antibiotic therapy for pouchitisUdayakumar Navaneethan
The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Expert Rev Gastroenterol Hepatol 3:547-59. 2009..The risks and benefits should be carefully balanced in patients who require long-term antibiotic therapy, and safe, efficacious, non-antibiotic-based agents are needed...
Isospora belli superinfection in a patient with eosinophilic gastroenteritis--a diagnostic challengeUdayakumar Navaneethan
Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Crohns Colitis 6:236-9. 2012....
Intraductal papillary mucinous neoplasm and acute pancreatitisPreethi G K Venkatesh
Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH, USA
J Clin Gastroenterol 45:755-8. 2011..Future longitudinal and prospective studies to understand the natural history of AP in patients with IPMN are required to better manage patients with recurrent AP in the setting of IPMN...
Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel diseaseUdayakumar Navaneethan
Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Inflamm Bowel Dis 16:1598-619. 2010..An interdisciplinary approach, involving gastroenterologists, hepatologists, and, in advanced cases, general, colorectal, and transplant surgeons is advocated...
Diagnosis and management of pouchitis and ileoanal pouch dysfunctionUdayakumar Navaneethan
The Pouchitis Clinic, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Curr Gastroenterol Rep 12:485-94. 2010..Although management of antibiotic-dependent or antibiotic-refractory pouchitis has been challenging, secondary etiology for pouchitis should be evaluated and modified, if possible...
Increased serum levels of carbohydrate antigen 19-9 and outcomes in primary sclerosing cholangitis patients without cholangiocarcinomaPreethi G K Venkatesh
Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, OH, USA
Dig Dis Sci 58:850-7. 2013..Carbohydrate antigen 19-9 (CA 19-9) is the serum marker used to diagnose cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC)...
Elevated immunoglobulin G4 level is associated with reduced colectomy-free survival in patients with primary sclerosing cholangitis and ulcerative colitisUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
J Crohns Colitis 7:e35-41. 2013..The aim of the study was to investigate the clinical outcomes of PSC and UC in patients with elevated serum IgG4...
Diagnostic and therapeutic yield is not influenced by the timing of small-bowel enteroscopy: morning versus afternoonMadhusudhan R Sanaka
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Gastrointest Endosc 77:62-70. 2013..Small-bowel enteroscopies (BEs) are tedious and prolonged, and their efficacy may be affected by the timing of procedures...
Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel diseaseUdayakumar Navaneethan
The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 104:2467-75. 2009..The aim of this study was to evaluate the prevalence and to identify risk factors for abnormal LFTs in patients with IPAA and underlying IBD...
Diagnosis and therapeutic management of extra-intestinal manifestations of inflammatory bowel diseaseGuru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
Drugs 72:2333-49. 2012..Future research targeting the pathogenesis, early diagnosis and treatment of these EIMs is required...
Outcome of esophageal carcinoma in the veteran affairs population: a comparative analysis from the Veteran Affairs Central Cancer RegistryMuhammad Shaalan Beg
Department of Internal Medicine, Division of Hematology and Medical Oncology, University of Cincinnati and Cincinnati VA Medical Center, Cincinnati, OH 45267, USA
Am J Clin Oncol 32:286-90. 2009..However, data on esophageal carcinoma in the Veteran Affairs (VA) population is lacking. We set to describe site-specific and histology-specific characteristics of esophageal cancer in the VA population over the past decades...
An LC-ESI-MS method for the quantitative analysis of bile acids composition in fecal materialsXiaohan Cai
Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA
Biomed Chromatogr 26:101-8. 2012..05-5 µmol/L. This SA-IS method was successfully applied to the analysis of bile acids in the samples collected from patients diagnosed with inflammatory bowel disease...
Modern treatment of patients with chronic pancreatitisGuru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
Gastroenterol Clin North Am 41:63-76. 2012..Newer therapeutic targets that will transcend the management of CP beyond just pain control and enzyme supplementation are required in the future...
Infectious colitisUdayakumar Navaneethan
Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Curr Opin Gastroenterol 27:66-71. 2011....
Endoscopic management of difficult common bile duct stonesGuru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT 06269, United States
World J Gastroenterol 19:165-73. 2013..Biliary stenting may be an alternative treatment option for frail and elderly patients or those with serious co morbidities...
Antegrade is more effective than retrograde enteroscopy for evaluation and management of suspected small-bowel diseaseMadhusudhan R Sanaka
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Gastroenterol Hepatol 10:910-6. 2012..Antegrade and retrograde enteroscopy are useful for evaluating the proximal and distal small bowel, respectively. We compared the diagnostic yield, therapeutic yield, and complications of antegrade and retrograde enteroscopy...
Intra-abdominal fungal infections complicating acute pancreatitis: a reviewGuru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, Connecticut, USA
Am J Gastroenterol 106:1188-92. 2011..Although antifungal prophylaxis has been suggested for patients on broad-spectrum antibiotics, no randomized controlled trials have yet studied its efficacy in preventing PFI...
Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitisPreethi G K Venkatesh
Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
JOP 12:250-4. 2011..The risk of azathioprine use in patients with underlying disease of pancreas including autoimmune pancreatitis is unclear...
Pros and cons of medical management of ulcerative colitisUdayakumar Navaneethan
Center for Inflammatory Bowel Disease, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio
Clin Colon Rectal Surg 23:227-38. 2010..In addition, there is always a concern about patients' compliance to medical therapy, cost of medications, and risk for UC-associated dysplasia. The authors discuss the pros and cons of medications used in the treatment of UC...
Predicting the probable outcome of treatment in HCV patientsUdayakumar Navaneethan
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Therap Adv Gastroenterol 2:287-302. 2009..Future studies on the factors that predict treatment response and tailoring treatment based on this is required if we are to conquer this disease...
Hepatitis E and pregnancy: understanding the pathogenesisUdayakumar Navaneethan
Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA
Liver Int 28:1190-9. 2008..Further research in the immunology of HEV and pregnancy is required to conquer this disease in the near future...
