Cameron McIntyre

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron
    Thomas J Foutz
    Cleveland Clinic Foundation, Dept of Biomedical Engineering, Cleveland, OH 44195, USA
    J Neurophysiol 107:3235-45. 2012
  2. ncbi Computational analysis of deep brain stimulation
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Expert Rev Med Devices 4:615-22. 2007
  3. pmc Network perspectives on the mechanisms of deep brain stimulation
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH 44195, USA
    Neurobiol Dis 38:329-37. 2010
  4. pmc Customizing deep brain stimulation to the patient using computational models
    Cameron C McIntyre
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4228-9. 2009
  5. pmc Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA
    J Neurophysiol 100:2549-63. 2008
  6. pmc Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation
    Svjetlana Miocinovic
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Exp Neurol 216:166-76. 2009
  7. pmc Pallidal burst activity during therapeutic deep brain stimulation
    Philip J Hahn
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Neurol 211:243-51. 2008
  8. ncbi Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling
    Cameron C McIntyre
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Biomed Eng 30:249-81. 2002
  9. pmc Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2490-500. 2005
  10. ncbi Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric field models
    Ashutosh Chaturvedi
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1240-3. 2006

Research Grants

  1. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010
  2. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2009
  3. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
  4. Systems Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
  5. Patient-Specific Models of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2006
  6. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. pmc Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron
    Thomas J Foutz
    Cleveland Clinic Foundation, Dept of Biomedical Engineering, Cleveland, OH 44195, USA
    J Neurophysiol 107:3235-45. 2012
    ..The model system developed in this study represents a scientific instrument to characterize the effects of optogenetic neuromodulation, as well as an engineering design tool to help guide future development of optogenetic technology...
  2. ncbi Computational analysis of deep brain stimulation
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Expert Rev Med Devices 4:615-22. 2007
    ..We then provide a prospective view on the application of DBS-modeling tools to augment the clinical utility of DBS and to design the next generation of DBS technology...
  3. pmc Network perspectives on the mechanisms of deep brain stimulation
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH 44195, USA
    Neurobiol Dis 38:329-37. 2010
    ..Finally we attempt to summarize how DBS could be achieving its therapeutic effects by overriding pathological network activity...
  4. pmc Customizing deep brain stimulation to the patient using computational models
    Cameron C McIntyre
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4228-9. 2009
    ....
  5. pmc Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA
    J Neurophysiol 100:2549-63. 2008
    ..The models suggest that pallidal DBS may have broader network effects than previously realized and the modes of therapy may depend on the relative proportion of GPi and/or GPe efferents that are directly affected by the stimulation...
  6. pmc Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulation
    Svjetlana Miocinovic
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Exp Neurol 216:166-76. 2009
    ....
  7. pmc Pallidal burst activity during therapeutic deep brain stimulation
    Philip J Hahn
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Neurol 211:243-51. 2008
    ..Other physiological changes that contribute to its therapeutic effect must also occur...
  8. ncbi Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling
    Cameron C McIntyre
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Biomed Eng 30:249-81. 2002
    ....
  9. pmc Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2490-500. 2005
    ..In this study we evaluate the effects of the tissue and electrode capacitance on the volume of tissue activated (VTA) during deep brain stimulation (DBS)...
  10. ncbi Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric field models
    Ashutosh Chaturvedi
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1240-3. 2006
    ..In addition, the simplifications and assumptions typically utilized in neurostimulation models substantially overestimate neural activation...
  11. pmc Reversing cognitive-motor impairments in Parkinson's disease patients using a computational modelling approach to deep brain stimulation programming
    Anneke M M Frankemolle
    Department of Biomedical Engineering ND20, Center for Neurological Restoration, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Brain 133:746-61. 2010
    ....
  12. ncbi Optimization of microelectrode design for cortical recording based on thermal noise considerations
    Scott F Lempka
    Dept of Biomed Eng, Cleveland Clinic Found, OH 44195, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3361-4. 2006
    ..Our results suggest that intracortical microelectrodes with a contact size of ~380 microm2 will provide an increased SNR in vivo and improve the long-term recording capabilities of silicon-substrate microelectrode arrays...
  13. ncbi Optimizing deep brain stimulation parameter selection with detailed models of the electrode-tissue interface
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    Conf Proc IEEE Eng Med Biol Soc 1:893-5. 2006
    ..The goals of the StimExplorer system are to educate clinicians on the impact of stimulation parameter manipulation, and improve the customization of DBS to individual patients...
  14. pmc Role of electrode design on the volume of tissue activated during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Neural Eng 3:1-8. 2006
    ..Therefore, it may be possible to improve therapeutic benefit and minimize side effects from DBS with the design of target-specific electrodes...
  15. ncbi Prediction of myelinated nerve fiber stimulation thresholds: limitations of linear models
    Michael A Moffitt
    Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Biomed Eng 51:229-36. 2004
    ....
  16. ncbi Chronic subdural electrodes in the management of epilepsy
    Dileep R Nair
    Department of Neurology, Desk S51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Neurophysiol 119:11-28. 2008
    ..When they are employed to answer a specific question in an individual patient, subdural electrodes can optimize the clinical outcome of a candidate for epilepsy surgery...
  17. ncbi Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus
    Cameron C McIntyre
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Clin Neurophysiol 115:589-95. 2004
    ..The goal of this project was to develop a quantitative understanding of the volume of axonal tissue directly activated by deep brain stimulation (DBS) of the subthalamic nucleus (STN)...
  18. pmc Automated 3-dimensional brain atlas fitting to microelectrode recordings from deep brain stimulation surgeries
    J Luis Lujan
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Stereotact Funct Neurosurg 87:229-40. 2009
    ..We present an automated method for optimally fitting a 3-dimensional brain atlas to intraoperative MER and predicting a target DBS electrode location in stereotactic coordinates for the patient...
  19. pmc Pallidal stimulation that improves parkinsonian motor symptoms also modulates neuronal firing patterns in primary motor cortex in the MPTP-treated monkey
    Matthew D Johnson
    Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Exp Neurol 219:359-62. 2009
    ..These findings suggest that DBS improves parkinsonian motor symptoms by inducing global changes in firing pattern and rate along the pallido-thalamocortical sensorimotor circuit...
  20. pmc In vivo impedance spectroscopy of deep brain stimulation electrodes
    Scott F Lempka
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Neural Eng 6:046001. 2009
    ....
  21. ncbi Predicting the effects of deep brain stimulation with diffusion tensor based electric field models
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    Med Image Comput Comput Assist Interv 9:429-37. 2006
    ..In turn, the 3D tissue electrical properties of the brain play an important role in regulating the spread of neural activation generated by DBS...
  22. pmc Patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictions
    Ashutosh Chaturvedi
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Brain Stimul 3:65-7. 2010
    ..Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation...
  23. ncbi Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition
    Cameron C McIntyre
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    J Neurophysiol 91:1457-69. 2004
    ..In turn, the results of this study support the hypothesis of stimulation-induced modulation of pathological network activity as a therapeutic mechanism of DBS...
  24. ncbi How does deep brain stimulation work? Present understanding and future questions
    Cameron C McIntyre
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Clin Neurophysiol 21:40-50. 2004
    ....
  25. ncbi Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output
    Cameron C McIntyre
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 4912, USA
    J Neurophysiol 88:1592-604. 2002
    ..These outcomes provide a biophysical basis for understanding frequency-dependent outputs during CNS stimulation and provide useful tools for selective stimulation of the CNS...
  26. ncbi Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle
    Cameron C McIntyre
    Department of Biomedical Engineering, Case Western Reserve University, C B Bolton Building, Cleveland, Ohio 44106 4912, USA
    J Neurophysiol 87:995-1006. 2002
    ....
  27. ncbi Model-based analysis of cortical recording with silicon microelectrodes
    Michael A Moffitt
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, ND 20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2240-50. 2005
    ..The purpose of this study was to use computational modeling to better understand factors that impact neural recordings with silicon microelectrodes used in brain-machine interfaces...
  28. pmc Sources and effects of electrode impedance during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave ND 20, Cleveland, OH 44195, USA
    Clin Neurophysiol 117:447-54. 2006
    ....
  29. ncbi Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation
    Svjetlana Miocinovic
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Neurophysiol 96:1569-80. 2006
    ..Nonetheless, both neural targets may play important roles in the therapeutic mechanisms of STN DBS...
  30. pmc Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH 44195, USA
    Clin Neurophysiol 118:1889-94. 2007
    ..The goal of this study was to evaluate and compare the stimulation waveforms produced by each IPG model...
  31. pmc Current-controlled deep brain stimulation reduces in vivo voltage fluctuations observed during voltage-controlled stimulation
    Scott F Lempka
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    Clin Neurophysiol 121:2128-33. 2010
    ..The goal of this study was to experimentally evaluate the theoretical advantages of using current-controlled pulse generators for DBS applications...
  32. pmc Patient-specific analysis of the volume of tissue activated during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    Neuroimage 34:661-70. 2007
    ....
  33. pmc Mechanisms and targets of deep brain stimulation in movement disorders
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurotherapeutics 5:294-308. 2008
    ..Understanding these processes on a physiological level will be critically important if we are to reach the full potential of this powerful tool...
  34. pmc Anatomical connectivity between subcortical structures
    Kyle Taljan
    Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Brain Connect 1:111-8. 2011
    ..Our results suggest that care should be taken in using tractography to assess anatomical connectivity between subcortical structures...
  35. pmc Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates
    Svjetlana Miocinovic
    Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
    J Neurosci Methods 162:32-41. 2007
    ..Our experience suggests that Cicerone can improve anatomical targeting, enhance electrophysiological data visualization, and augment the design of stimulation experiments...
  36. pmc Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders
    J Luis Lujan
    Department of Biomedical Engineering, Cleveland Clinic Foundation Cleveland, Ohio 44195, USA
    Front Biosci 13:5892-904. 2008
    ..Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease...
  37. ncbi Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both
    Cameron C McIntyre
    Department of Neurology, Emory University School of Medicine, Woodruff Memorial Research Building, Suite 6000, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Clin Neurophysiol 115:1239-48. 2004
    ..Our analysis suggests stimulation-induced modulation of pathological network activity represents the most likely mechanism of DBS; however, several open questions remain to explicitly link the effects of DBS with therapeutic outcomes...
  38. doi Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model
    Yixin Guo
    Department of Mathematics, Drexel University, Philadelphia, PA, USA
    J Neurophysiol 99:1477-92. 2008
    ..Computationally generated inhibitory inputs yielded similar effects on TC relay. These results support the hypothesis that STN-DBS alters parkinsonian GPi activity in a way that may improve TC relay fidelity...

Research Grants11

  1. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010
    ..We will then use that knowledge to design more efficacious stimulation strategies for patients implanted with DBS systems. ..
  2. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2009
    ..We will then use that knowledge to design more efficacious stimulation strategies for patients implanted with DBS systems. ..
  3. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
    ....
  4. Systems Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2007
    ..abstract_text> ..
  5. Patient-Specific Models of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2006
    ....
  6. Model-Based Optimization of Clinical Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2010
    ....