Research Topics
| Cameron C McIntyreSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
| Collaborators
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Detail Information
Publications
Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycleCameron C McIntyre
Department of Biomedical Engineering, Case Western Reserve University, C.B. Bolton Building, Cleveland, Ohio 44106-4912, USA
J Neurophysiol 87:995-1006. 2002....- Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modelingCameron C McIntyre
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Crit Rev Biomed Eng 30:249-81. 2002.... - Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or bothCameron C McIntyre
Department of Neurology, Emory University School of Medicine, Woodruff Memorial Research Building, Suite 6000, 1639 Pierce Drive, Atlanta, GA 30322, USA
Clin Neurophysiol 115:1239-48. 2004..Our analysis suggests stimulation-induced modulation of pathological network activity represents the most likely mechanism of DBS; however, several open questions remain to explicitly link the effects of DBS with therapeutic outcomes... - Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleusCameron C McIntyre
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Clin Neurophysiol 115:589-95. 2004..The goal of this project was to develop a quantitative understanding of the volume of axonal tissue directly activated by deep brain stimulation (DBS) of the subthalamic nucleus (STN)... - Cellular effects of deep brain stimulation: model-based analysis of activation and inhibitionCameron C McIntyre
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
J Neurophysiol 91:1457-69. 2004..In turn, the results of this study support the hypothesis of stimulation-induced modulation of pathological network activity as a therapeutic mechanism of DBS... 
Experimental and theoretical characterization of the voltage distribution generated by deep brain stimulationSvjetlana Miocinovic
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Exp Neurol 216:166-76. 2009....- Automated 3-dimensional brain atlas fitting to microelectrode recordings from deep brain stimulation surgeriesJ Luis Lujan
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Stereotact Funct Neurosurg 87:229-40. 2009..We present an automated method for optimally fitting a 3-dimensional brain atlas to intraoperative MER and predicting a target DBS electrode location in stereotactic coordinates for the patient... - Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric field modelsAshutosh Chaturvedi
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
Conf Proc IEEE Eng Med Biol Soc 1:1240-3. 2006..In addition, the simplifications and assumptions typically utilized in neurostimulation models substantially overestimate neural activation... - Theoretical analysis of intracortical microelectrode recordingsScott F Lempka
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
J Neural Eng 8:045006. 2011..Such advances could help enable the long-term functionality required for chronic neural recording applications... - Pallidal burst activity during therapeutic deep brain stimulationPhilip J Hahn
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Neurol 211:243-51. 2008..Other physiological changes that contribute to its therapeutic effect must also occur... - In vivo impedance spectroscopy of deep brain stimulation electrodesScott F Lempka
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
J Neural Eng 6:046001. 2009.... - Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulationMatthew D Johnson
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA
J Neurophysiol 100:2549-63. 2008..The models suggest that pallidal DBS may have broader network effects than previously realized and the modes of therapy may depend on the relative proportion of GPi and/or GPe efferents that are directly affected by the stimulation... - Neural targets for relieving parkinsonian rigidity and bradykinesia with pallidal deep brain stimulationMatthew D Johnson
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
J Neurophysiol 108:567-77. 2012..Thus the beneficial effects of pallidal DBS for parkinsonian symptoms may occur from multiple targets within and near the target nucleus... - Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulationPhilip J Hahn
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
J Comput Neurosci 28:425-41. 2010.... - Pallidal stimulation that improves parkinsonian motor symptoms also modulates neuronal firing patterns in primary motor cortex in the MPTP-treated monkeyMatthew D Johnson
Lerner Research Institute, Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Exp Neurol 219:359-62. 2009..These findings suggest that DBS improves parkinsonian motor symptoms by inducing global changes in firing pattern and rate along the pallido-thalamocortical sensorimotor circuit... - Patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictionsAshutosh Chaturvedi
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Brain Stimul 3:65-7. 2010..Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation... - Optimizing deep brain stimulation parameter selection with detailed models of the electrode-tissue interfaceCameron C McIntyre
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
Conf Proc IEEE Eng Med Biol Soc 1:893-5. 2006..The goals of the StimExplorer system are to educate clinicians on the impact of stimulation parameter manipulation, and improve the customization of DBS to individual patients... - Probabilistic analysis of activation volumes generated during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Neuroimage 54:2096-104. 2011..The results suggest that selection of both electrode placement and clinical stimulation parameter settings could be tailored to the patient's primary symptoms using patient-specific models and PSAs... - Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
Clin Neurophysiol 116:2490-500. 2005..The results and methodology of this study provide the foundation for the quantitative analysis of the VTA during clinical neurostimulation... 
Axonal pathways linked to therapeutic and nontherapeutic outcomes during psychiatric deep brain stimulationJ Luis Lujan
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Hum Brain Mapp 33:958-68. 2012..As such, the goal of this study was to develop a method for identifying axonal pathways whose activation is most likely necessary for achieving therapeutic benefits during DBS...- Predicting the effects of deep brain stimulation with diffusion tensor based electric field modelsChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
Med Image Comput Comput Assist Interv 9:429-37. 2006..In turn, the 3D tissue electrical properties of the brain play an important role in regulating the spread of neural activation generated by DBS... - Current steering to control the volume of tissue activated during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Brain Stimul 1:7-15. 2008.... - Role of electrode design on the volume of tissue activated during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
J Neural Eng 3:1-8. 2006..Therefore, it may be possible to improve therapeutic benefit and minimize side effects from DBS with the design of target-specific electrodes... - Prediction of myelinated nerve fiber stimulation thresholds: limitations of linear modelsMichael A Moffitt
Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
IEEE Trans Biomed Eng 51:229-36. 2004.... - How does deep brain stimulation work? Present understanding and future questionsCameron C McIntyre
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Clin Neurophysiol 21:40-50. 2004.... - Patient-specific analysis of the volume of tissue activated during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
Neuroimage 34:661-70. 2007.... - Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulationSvjetlana Miocinovic
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Neurophysiol 96:1569-80. 2006..Nonetheless, both neural targets may play important roles in the therapeutic mechanisms of STN DBS... - Current-controlled deep brain stimulation reduces in vivo voltage fluctuations observed during voltage-controlled stimulationScott F Lempka
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
Clin Neurophysiol 121:2128-33. 2010..The goal of this study was to experimentally evaluate the theoretical advantages of using current-controlled pulse generators for DBS applications... - Evaluation of novel stimulus waveforms for deep brain stimulationThomas J Foutz
Cleveland Clinic Foundation, Department of Biomedical Engineering, 9500 Euclid Ave ND20, Cleveland, OH 44195, USA
J Neural Eng 7:066008. 2010..25 ms duration). In turn, there may be measureable energy savings when using appropriately designed non-rectangular pulses in clinical DBS applications, thereby warranting further experimental investigation... - Association of deep brain stimulation washout effects with Parkinson disease durationScott E Cooper
Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA Neurol 70:95-9. 2013..The duration of the gradual, slow washout varies across patients, and although the origin of this variability is unclear, it is hypothesized to be related to 1 or more clinical characteristics of patients... - Current steering to activate targeted neural pathways during deep brain stimulation of the subthalamic regionAshutosh Chaturvedi
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Brain Stimul 5:369-77. 2012.... - Mechanisms and targets of deep brain stimulation in movement disordersMatthew D Johnson
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Neurotherapeutics 5:294-308. 2008..Understanding these processes on a physiological level will be critically important if we are to reach the full potential of this powerful tool... - Computational analysis of deep brain stimulationCameron C McIntyre
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Expert Rev Med Devices 4:615-22. 2007..We then provide a prospective view on the application of DBS-modeling tools to augment the clinical utility of DBS and to design the next generation of DBS technology... - Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH 44195, USA
Clin Neurophysiol 118:1889-94. 2007..The goal of this study was to evaluate and compare the stimulation waveforms produced by each IPG model... - Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal outputCameron C McIntyre
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-4912, USA
J Neurophysiol 88:1592-604. 2002..These outcomes provide a biophysical basis for understanding frequency-dependent outputs during CNS stimulation and provide useful tools for selective stimulation of the CNS... - Network perspectives on the mechanisms of deep brain stimulationCameron C McIntyre
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH 44195, USA
Neurobiol Dis 38:329-37. 2010..Finally we attempt to summarize how DBS could be achieving its therapeutic effects by overriding pathological network activity... - Model-based analysis of cortical recording with silicon microelectrodesMichael A Moffitt
Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, ND-20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Neurophysiol 116:2240-50. 2005..The results of this study provide the foundation for refining and optimizing microelectrode design for human brain-machine interfaces... - Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primatesSvjetlana Miocinovic
Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
J Neurosci Methods 162:32-41. 2007..Our experience suggests that Cicerone can improve anatomical targeting, enhance electrophysiological data visualization, and augment the design of stimulation experiments... - Sources and effects of electrode impedance during deep brain stimulationChristopher R Butson
Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave. ND-20, Cleveland, OH 44195, USA
Clin Neurophysiol 117:447-54. 2006.... - Customizing deep brain stimulation to the patient using computational modelsCameron C McIntyre
Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4228-9. 2009.... - Chronic subdural electrodes in the management of epilepsyDileep R Nair
Department of Neurology, Desk S51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Neurophysiol 119:11-28. 2008..When they are employed to answer a specific question in an individual patient, subdural electrodes can optimize the clinical outcome of a candidate for epilepsy surgery... - Tracking the mechanisms of deep brain stimulation for neuropsychiatric disordersJ Luis Lujan
Department of Biomedical Engineering, Cleveland Clinic Foundation Cleveland, Ohio 44195, USA
Front Biosci 13:5892-904. 2008..Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease... - Optimization of microelectrode design for cortical recording based on thermal noise considerationsScott F Lempka
Dept of Biomed Eng, Cleveland Clinic Found, OH 44195, USA
Conf Proc IEEE Eng Med Biol Soc 1:3361-4. 2006..Our results suggest that intracortical microelectrodes with a contact size of ~380 microm2 will provide an increased SNR in vivo and improve the long-term recording capabilities of silicon-substrate microelectrode arrays... - Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational modelYixin Guo
Department of Mathematics, Drexel University, Philadelphia, PA, USA
J Neurophysiol 99:1477-92. 2008..Computationally generated inhibitory inputs yielded similar effects on TC relay. These results support the hypothesis that STN-DBS alters parkinsonian GPi activity in a way that may improve TC relay fidelity...