Arthur J McCullough

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Diagnosis and management of alcoholic liver disease
    Arthur J McCullough
    Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:257-62. 2011
  2. doi request reprint Epidemiology of the metabolic syndrome in the USA
    Arthur J McCullough
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:333-40. 2011
  3. pmc Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio
    J Appl Physiol (1985) 115:988-94. 2013
  4. doi request reprint Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease
    Christine Carter-Kent
    Department of Pathology, Cleveland Clinic, USA
    J Pediatr Gastroenterol Nutr 52:190-7. 2011
  5. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
  6. pmc Role of ceramides in nonalcoholic fatty liver disease
    Mangesh Pagadala
    Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Trends Endocrinol Metab 23:365-71. 2012
  7. pmc Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 56:1291-9. 2012
  8. pmc Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 54:1610-9. 2011
  9. pmc Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1072-8. 2009
  10. pmc Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling
    Ling Li
    Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 11:M111.014209. 2012

Collaborators

Detail Information

Publications58

  1. doi request reprint Diagnosis and management of alcoholic liver disease
    Arthur J McCullough
    Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:257-62. 2011
    ..Patients with endstage liver disease should be considered for liver transplantation. Six months of abstinence is considered to be a requirement prior to transplant, but this length of time may be adjusted in individual bases...
  2. doi request reprint Epidemiology of the metabolic syndrome in the USA
    Arthur J McCullough
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:333-40. 2011
    ....
  3. pmc Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio
    J Appl Physiol (1985) 115:988-94. 2013
    ..Together, our findings highlight a role for fetuin-A in skeletal muscle insulin resistance and suggest that part of the exercise-induced improvement in glucose tolerance in patients with NAFLD may be due to lowering fetuin-A. ..
  4. doi request reprint Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease
    Christine Carter-Kent
    Department of Pathology, Cleveland Clinic, USA
    J Pediatr Gastroenterol Nutr 52:190-7. 2011
    ..The aims of the present study were to establish associations between steatosis amount, type, and distribution in a well-characterized group of children with biopsy-proven nonalcoholic fatty liver disease (NAFLD)...
  5. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
    ..Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD)...
  6. pmc Role of ceramides in nonalcoholic fatty liver disease
    Mangesh Pagadala
    Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Trends Endocrinol Metab 23:365-71. 2012
    ..A better understanding of the role of ceramides in steatohepatitis has both diagnostic and therapeutic implications for the treatment of fatty liver disease...
  7. pmc Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 56:1291-9. 2012
    ..Additionally, this is the first report on the link between decreased oxidized lipid products and improved histological disease in the setting of a therapeutic trial in NASH...
  8. pmc Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 54:1610-9. 2011
    ..038). Although not statistically significant (P = 0.17), improvement in fibrosis was observed in a greater proportion (35%) of patients in the PTX group compared to placebo (15%). Adverse effects were similar in both groups...
  9. pmc Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1072-8. 2009
    ..The area under the receiver operating characteristic curve for NASH diagnosis was estimated to be 0.83 (0.75, 0.91)...
  10. pmc Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling
    Ling Li
    Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 11:M111.014209. 2012
    ..We conclude that this technique can effectively measure the synthesis of plasma proteins and can be used to study the regulation of protein homeostasis under physiological and pathological conditions...
  11. pmc Prevalence of hypothyroidism in nonalcoholic fatty liver disease
    Mangesh R Pagadala
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Dig Dis Sci 57:528-34. 2012
    ..A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association...
  12. pmc Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis
    Srinivasan Dasarathy
    Department of Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Gastroenterol Hepatol 23:382-8. 2011
    ..In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-activated receptor α activate fibroblast growth factor 21 (FGF21) and increase hepatic fatty acid oxidation...
  13. pmc Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion
    Srinivasan Dasarathy
    Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland, USA
    Am J Physiol Gastrointest Liver Physiol 297:G567-75. 2009
    ..An increase in oxidative stress, induced by a higher rate of fatty acid oxidation in NASH, may have caused an increase in the contribution of serine to cystathionine to meet the higher demands for glutathione...
  14. doi request reprint Obesity, hepatic metabolism and disease
    John M Edmison
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    Nestle Nutr Workshop Ser Pediatr Program 63:163-72; discussion 172-6, 259-68. 2009
    ..Bariatric surgery is indicated in selected patients. A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy...
  15. pmc Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio
    Helen M Heneghan
    Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Surg Obes Relat Dis 9:100-7. 2013
    ..We hypothesized that the beneficial effect of Roux-en-Y gastric bypass (RYGB) on CVD risk is related to ceramide-mediated improvement in lipoprotein profile...
  16. pmc Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease
    Ciarán E Fealy
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Appl Physiol (1985) 113:1-6. 2012
    ....
  17. pmc Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study
    Christine Carter-Kent
    Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1113-20. 2009
    ..01), perisinusoidal fibrosis (P < 0.001), and NAS > or =5 (P < 0.005). Serum aspartate aminotransferase levels were the only clinical or laboratory data that independently predicted severity of fibrosis (P = 0.003)...
  18. doi request reprint High prevalence of normal serum albumin in NASH patients with ascites: a retrospective analysis
    Achuthan Sourianarayanane
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Res Hepatol Gastroenterol 37:246-53. 2013
    ..This study investigated the relationship between the hepatic venous pressure gradient (HVPG) and serum albumin in ascitic patients with different etiologies of cirrhosis and mortality...
  19. pmc An improved measurement of isotopic ratios by high resolution mass spectrometry
    Serguei Ilchenko
    Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Am Soc Mass Spectrom 24:309-12. 2013
    ..Overall, this technique allows accurate measurements of the isotopic ratios of proteolytic peptides, a critical step for enabling routine studies of proteome dynamics...
  20. doi request reprint The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation
    Ibrahim A Hanouneh
    Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 14:1287-93. 2008
    ..9, P = 0.05) were independently associated with fibrosis progression. In conclusion, MS, a potentially modifiable disease, is common and is strongly associated with long-term fibrosis progression in the setting of recurrent HCV after OLT...
  21. pmc Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease
    Claudia O Zein
    Cleveland Clinic, Cleveland, OH, USA
    J Hepatol 54:753-9. 2011
    ..The aim of this paper was to study the potential association between cigarette smoking and advanced fibrosis in NAFLD...
  22. ncbi request reprint Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease
    Mangesh Pagadala
    Department of Gastroenterology and Hepatology, Digestive Disease Institute of the Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, A 31, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Liver Dis 13:591-606. 2009
    ..More accurate predictors and scoring systems would allow identifying who would benefit most from liver biopsy and monitor disease progression and response to therapy...
  23. ncbi request reprint Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
    ..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
  24. doi request reprint Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
    Achuthan Sourianarayanane
    Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, United States
    J Crohns Colitis 7:e279-85. 2013
    ..Metabolic risk factors are associated with non-alcoholic fatty liver disease (NAFLD), but they are less frequent in inflammatory bowel disease (IBD)...
  25. doi request reprint Increased serum levels of carbohydrate antigen 19-9 and outcomes in primary sclerosing cholangitis patients without cholangiocarcinoma
    Preethi G K Venkatesh
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Dig Dis Sci 58:850-7. 2013
    ..Carbohydrate antigen 19-9 (CA 19-9) is the serum marker used to diagnose cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC)...
  26. doi request reprint Impact of budesonide on liver function tests and gut inflammation in patients with primary sclerosing cholangitis and ileal pouch anal anastomosis
    Udayakumar Navaneethan
    Departments of Gastroenterology and Colorectal Surgery, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    J Crohns Colitis 6:536-42. 2012
    ..This study was designed to evaluate the efficacy of oral budesonide on liver function tests in patients with PSC and pouchitis associated with ileal pouch-anal anastomosis (IPAA)...
  27. doi request reprint The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis
    Mangesh R Pagadala
    Department of Gastroenterology and Hepatology, Cleveland Clinic, OH 44195, USA
    Clin Liver Dis 16:487-504. 2012
    ....
  28. pmc Plasma metabolomic profile in nonalcoholic fatty liver disease
    Satish C Kalhan
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 60:404-13. 2011
    ..Statistical analysis identified a panel of biomarkers that could effectively separate healthy controls from NAFLD and healthy controls from NASH. These biomarkers can potentially be used to follow response to therapeutic interventions...
  29. doi request reprint Posttransplant metabolic syndrome: an epidemic waiting to happen
    Mangesh Pagadala
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Liver Transpl 15:1662-70. 2009
    ..Additional measures that may be potentially beneficial include the use of lipid-lowering agents, the optimal control of blood glucose, and the use of tacrolimus instead of cyclosporine...
  30. ncbi request reprint Pathophysiology of nonalcoholic steatohepatitis
    Arthur J McCullough
    Case Western Reserve University and Schwartz Center for Metabolism and Nutrition at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    J Clin Gastroenterol 40:S17-29. 2006
    ..Which of the pathophysiologic factors (which are discussed in this review), either alone or in combination, will eventually provide the basis for the most effective therapy has yet to be determined...
  31. pmc Sarcopenia associated with portosystemic shunting is reversed by follistatin
    Srinivasan Dasarathy
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
    J Hepatol 54:915-21. 2011
    ..The present study was performed to examine the mechanisms of sarcopenia following PCA...
  32. pmc Post-liver transplantation sarcopenia in cirrhosis: a prospective evaluation
    Cynthia Tsien
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA
    J Gastroenterol Hepatol 29:1250-7. 2014
    ..Pre-transplant sarcopenia (reduced skeletal muscle mass) predicts poor outcome in cirrhosis. In contrast, whether muscle mass increases post-orthotopic liver transplantation (OLT) is not known and was studied prospectively...
  33. ncbi request reprint Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat
    Srinivasan Dasarathy
    Department of Gastroenterology, Cleveland Clinic, Lerner Research Institute and the Cleveland Clinic Lerner College of Medicine, NE40, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1105-13. 2007
    ....
  34. doi request reprint Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study
    Srinivasan Dasarathy
    Department of Gastroenterology, 9500 Euclid Avenue, NE4 208, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Hepatol 51:1061-7. 2009
    ..Therefore, a double blinded prospective study was performed in consecutive patients undergoing liver biopsy to evaluate the accuracy of ultrasound to diagnose hepatic steatosis...
  35. ncbi request reprint The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    Arthur J McCullough
    Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
    Clin Liver Dis 8:521-33, viii. 2004
    ..The major risk factors for fibrosis include diabetes or obesity, an aspartate aminotransferase/alanine aminotransferase ratio of greater than 1, age older than 50, and hepatic histology...
  36. ncbi request reprint Treatment of alcoholic hepatitis
    Robert S O'Shea
    Department of Gastroenterology and Hepatology A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Liver Dis 9:103-34. 2005
    ....
  37. ncbi request reprint Management and outcome in hepatorenal syndrome: need for renal replacement therapy in non-transplanted patients
    Achuthan Sourianarayanane
    Gastroenterology and Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Int Urol Nephrol 46:793-800. 2014
    ..To investigate this, we studied the outcome of different therapies (pharmacological, RRT, and LT) in patients with type 1 HRS...
  38. pmc Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease
    Jaividhya Dasarathy
    Department of Family Medicine, MetroHealth Medical Center, Cleveland, OH, USA
    Liver Int 34:e118-27. 2014
    ..Increased fat mass in patients with non-alcoholic fatty liver disease (NAFLD) may contribute to hypovitaminosis D. To determine the relation among plasma vitamin D concentration, severity of disease and body composition in NAFLD...
  39. doi request reprint Reversal of sarcopenia predicts survival after a transjugular intrahepatic portosystemic stent
    Cynthia Tsien
    Departments of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Gastroenterol Hepatol 25:85-93. 2013
    ..Changes in the skeletal muscle area and adipose tissue volume were quantified by computed tomography (CT) before and after TIPS...
  40. ncbi request reprint Nonalcoholic fatty liver disease in patients with type 2 diabetes
    Zobair M Younossi
    The Cleveland Clinic Foundation, Cleveland, USA
    Clin Gastroenterol Hepatol 2:262-5. 2004
    ..The aim of this study was to assess the outcome of patients with NAFLD and DM...
  41. pmc Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans
    Satish C Kalhan
    Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
    Metabolism 57:305-12. 2008
    ..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus...
  42. ncbi request reprint In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    Anna Wieckowska
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hepatology 44:27-33. 2006
    ..These data highlight the potential usefulness of this test as a noninvasive diagnostic means of determining histological disease severity in patients with NAFLD...
  43. doi request reprint Late evening snack: exploiting a period of anabolic opportunity in cirrhosis
    Cynthia D Tsien
    Departments of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, OH, USA
    J Gastroenterol Hepatol 27:430-41. 2012
    ..Published reports were evaluated to examine the effect of LES on regulation of substrate utilization (short-term studies) and nutritional outcomes (long-term studies)...
  44. doi request reprint Progressive primary sclerosing cholangitis requiring liver transplantation is associated with reduced need for colectomy in patients with ulcerative colitis
    Udayakumar Navaneethan
    Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 10:540-6. 2012
    ..We investigated the association between the severity of primary sclerosing cholangitis (PSC) and clinical outcomes of patients with ulcerative colitis (UC) on the basis of need for colectomy...
  45. doi request reprint Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitis
    Mansour A Parsi
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 135:803-7. 2008
    ..The aim of this study was to assess the utility of ascitic fluid lactoferrin (AFLAC) for the diagnosis of SBP and to identify a cut-off level that can be used for future development of a rapid bedside test...
  46. ncbi request reprint Pathogenesis of non-alcoholic steatohepatitis: human data
    John Edmison
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Clin Liver Dis 11:75-104, ix. 2007
    ..Although fatty liver may be caused by other factors, this review concentrates on fatty liver associated with insulin resistance, sometimes referred to as the primary form...
  47. doi request reprint Alcoholic liver disease
    Robert S O'Shea
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 105:14-32; quiz 33. 2010
    ....
  48. pmc Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    Takhar Kasumov
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Anal Biochem 401:154-61. 2010
    ..This technique could be extended for quantification of other ceramides and sphingolipids with no significant modification...
  49. ncbi request reprint Differences in regulation of type I collagen synthesis in primary and passaged hepatic stellate cell cultures: the role of alpha5beta1-integrin
    Milan Dodig
    Department of Gastroenterology and Hepatology, Cleveland Clinic and Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Physiol Gastrointest Liver Physiol 293:G154-64. 2007
    ..Therefore alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary HSC cultures but appears to have no direct role once the HSC are fully activated...
  50. ncbi request reprint Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessment
    Claudia O Zein
    Division of Gastroenterology and Hepatology, University Hospitals of Cleveland, Cleveland, OH, USA
    Hepatology 44:1564-71. 2006
    ..In conclusion, smoking may accelerate the progression of PBC. This could be induced by exposure to chemicals in cigarette smoke...
  51. pmc Measuring protein synthesis using metabolic ²H labeling, high-resolution mass spectrometry, and an algorithm
    Takhar Kasumov
    Department of Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Anal Biochem 412:47-55. 2011
    ..As a proof of principle, we demonstrate that this approach can detect the effect of nutritional status on albumin synthesis in rats given (2)H(2)O...
  52. ncbi request reprint Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted rat
    Srinivasan Dasarathy
    Schwartz Center for Metabolism and Nutrition, Division of Gastroenterology, Cleveland, Ohio, USA
    Dig Dis Sci 47:1936-42. 2002
    ....
  53. doi request reprint Editorial: non-alcoholic Fatty liver disease and obesity: not all about body mass index
    Mangesh R Pagadala
    Digestive Disease Institute and the Department of Gastroenterology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Gastroenterol 107:1859-61. 2012
    ..It is important for clinicians to be aware that these "metabolically obese" NAFLD patients should be monitored for the metabolic syndrome and its associated adverse outcomes irrespective of their BMI...
  54. ncbi request reprint Afternoon colonoscopies have higher failure rates than morning colonoscopies
    Madhusudhan R Sanaka
    Division of Gastroenterology, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Am J Gastroenterol 101:2726-30. 2006
    ..In addition, inadequate bowel preparation has been reported in procedures scheduled later in the day. Operator fatigue, which tends to be higher as the day passes on, may also impact colonoscopy completion rate...
  55. ncbi request reprint Steatohepatitis in obese individuals
    Wael I Youssef
    Division of Gastroenterology, The Robert Schwartz Center for Metabolism and Nutrition at Metro Health Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
    Best Pract Res Clin Gastroenterol 16:733-47. 2002
    ..Bariatric surgery is indicated in selected patients.A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy...
  56. ncbi request reprint Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats
    Srinivasan Dasarathy
    Gastroenterology Division, Department of Medicine, Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA
    J Hepatol 45:214-20. 2006
    ..We hypothesized that failure to gain body weight in the PCA rat was the consequence of low testosterone levels and will be reversed by 4-hydroxyandrostenedione, a specific aromatase inhibitor...
  57. ncbi request reprint Diabetes mellitus, obesity, and hepatic steatosis
    Wael Youssef
    Division of Gastroenterology, Case Western Reserve University, Cleveland, OH, USA
    Semin Gastrointest Dis 13:17-30. 2002
    ..These include anti-oxidants such as vitamin E and betaine, bile acid therapy with ursodeoxycholic acid, and improved insulin sensitivity with metformin. Another potential therapeutic strategy is the reduction of inflammatory cytokines...
  58. ncbi request reprint Update on nonalcoholic fatty liver disease
    Arthur J McCullough
    Division of Gastroenterology and the Robert Schwartz Center of Metabolism and Nutrition at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Clin Gastroenterol 34:255-62. 2002
    ..Future therapies will depend on a greater understanding of the pathophysiology and should focus on diminishing fibrosis...