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Species | Arthur J McCulloughSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Epidemiology of the metabolic syndrome in the USAArthur J McCullough
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio 44195, USA
J Dig Dis 12:333-40. 2011....- Diagnosis and management of alcoholic liver diseaseArthur J McCullough
Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
J Dig Dis 12:257-62. 2011..Patients with endstage liver disease should be considered for liver transplantation. Six months of abstinence is considered to be a requirement prior to transplant, but this length of time may be adjusted in individual bases... - Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver diseaseChristine Carter-Kent
Department of Pathology, Cleveland Clinic, USA
J Pediatr Gastroenterol Nutr 52:190-7. 2011..The aims of the present study were to establish associations between steatosis amount, type, and distribution in a well-characterized group of children with biopsy-proven nonalcoholic fatty liver disease (NAFLD)... 
Role of ceramides in nonalcoholic fatty liver diseaseMangesh Pagadala
Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
Trends Endocrinol Metab 23:365-71. 2012..A better understanding of the role of ceramides in steatohepatitis has both diagnostic and therapeutic implications for the treatment of fatty liver disease...- Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanismClaudia O Zein
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
Hepatology 56:1291-9. 2012..Additionally, this is the first report on the link between decreased oxidized lipid products and improved histological disease in the setting of a therapeutic trial in NASH... - Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trialClaudia O Zein
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
Hepatology 54:1610-9. 2011..Adverse effects were similar in both groups. CONCLUSION: PTX improved histological features of NASH compared to placebo. PTX was well tolerated in patients with NASH... - Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation studyAriel E Feldstein
Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
Hepatology 50:1072-8. 2009.... - Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labelingLing Li
Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
Mol Cell Proteomics 11:M111.014209. 2012..We conclude that this technique can effectively measure the synthesis of plasma proteins and can be used to study the regulation of protein homeostasis under physiological and pathological conditions... - Prevalence of hypothyroidism in nonalcoholic fatty liver diseaseMangesh R Pagadala
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA
Dig Dis Sci 57:528-34. 2012..A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association... - Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitisSrinivasan Dasarathy
Department of Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
Eur J Gastroenterol Hepatol 23:382-8. 2011..In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-activated receptor α activate fibroblast growth factor 21 (FGF21) and increase hepatic fatty acid oxidation... - Obesity, hepatic metabolism and diseaseJohn M Edmison
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
Nestle Nutr Workshop Ser Pediatr Program 63:163-72; discussion 172-6, 259-68. 2009..Bariatric surgery is indicated in selected patients. A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy... - Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusionSrinivasan Dasarathy
Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland, USA
Am J Physiol Gastrointest Liver Physiol 297:G567-75. 2009..An increase in oxidative stress, induced by a higher rate of fatty acid oxidation in NASH, may have caused an increase in the contribution of serine to cystathionine to meet the higher demands for glutathione... - Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver diseaseCiarán E Fealy
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
J Appl Physiol 113:1-6. 2012.... - Nonalcoholic steatohepatitis in children: a multicenter clinicopathological studyChristine Carter-Kent
Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, USA
Hepatology 50:1113-20. 2009..003). CONCLUSION: Our results highlight the limitations of published proposals to classify pediatric NAFLD, and identified histological lesions associated with progressive disease... - The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantationIbrahim A Hanouneh
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Liver Transpl 14:1287-93. 2008..9, P = 0.05) were independently associated with fibrosis progression. In conclusion, MS, a potentially modifiable disease, is common and is strongly associated with long-term fibrosis progression in the setting of recurrent HCV after OLT... 
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and futureAnna Wieckowska
Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Hepatology 46:582-9. 2007..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...- Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver diseaseClaudia O Zein
Cleveland Clinic, Cleveland, OH, USA
J Hepatol 54:753-9. 2011..The aim of this paper was to study the potential association between cigarette smoking and advanced fibrosis in NAFLD... - Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver diseaseMangesh Pagadala
Department of Gastroenterology and Hepatology, Digestive Disease Institute of the Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, A 31, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Liver Dis 13:591-606. 2009..More accurate predictors and scoring systems would allow identifying who would benefit most from liver biopsy and monitor disease progression and response to therapy... - The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitisMangesh R Pagadala
Department of Gastroenterology and Hepatology, Cleveland Clinic, OH 44195, USA
Clin Liver Dis 16:487-504. 2012.... - Impact of budesonide on liver function tests and gut inflammation in patients with primary sclerosing cholangitis and ileal pouch anal anastomosisUdayakumar Navaneethan
Departments of Gastroenterology and Colorectal Surgery, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
J Crohns Colitis 6:536-42. 2012..This study was designed to evaluate the efficacy of oral budesonide on liver function tests in patients with PSC and pouchitis associated with ileal pouch-anal anastomosis (IPAA)... - Plasma metabolomic profile in nonalcoholic fatty liver diseaseSatish C Kalhan
Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
Metabolism 60:404-13. 2011..Statistical analysis identified a panel of biomarkers that could effectively separate healthy controls from NAFLD and healthy controls from NASH. These biomarkers can potentially be used to follow response to therapeutic interventions... - Sarcopenia associated with portosystemic shunting is reversed by follistatinSrinivasan Dasarathy
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
J Hepatol 54:915-21. 2011..The present study was performed to examine the mechanisms of sarcopenia following PCA... - Pathophysiology of nonalcoholic steatohepatitisArthur J McCullough
Case Western Reserve University and Schwartz Center for Metabolism and Nutrition at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
J Clin Gastroenterol 40:S17-29. 2006..Which of the pathophysiologic factors (which are discussed in this review), either alone or in combination, will eventually provide the basis for the most effective therapy has yet to be determined... - Posttransplant metabolic syndrome: an epidemic waiting to happenMangesh Pagadala
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Liver Transpl 15:1662-70. 2009..Additional measures that may be potentially beneficial include the use of lipid-lowering agents, the optimal control of blood glucose, and the use of tacrolimus instead of cyclosporine... - Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis ratSrinivasan Dasarathy
Department of Gastroenterology, Cleveland Clinic, Lerner Research Institute and the Cleveland Clinic Lerner College of Medicine, NE40, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Physiol Gastrointest Liver Physiol 292:G1105-13. 2007.... - Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective studySrinivasan Dasarathy
Department of Gastroenterology, 9500 Euclid Avenue, NE4 208, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Hepatol 51:1061-7. 2009..Therefore, a double blinded prospective study was performed in consecutive patients undergoing liver biopsy to evaluate the accuracy of ultrasound to diagnose hepatic steatosis... - The clinical features, diagnosis and natural history of nonalcoholic fatty liver diseaseArthur J McCullough
Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
Clin Liver Dis 8:521-33, viii. 2004..The major risk factors for fibrosis include diabetes or obesity, an aspartate aminotransferase/alanine aminotransferase ratio of greater than 1, age older than 50, and hepatic histology... - Treatment of alcoholic hepatitisRobert S O'Shea
Department of Gastroenterology and Hepatology A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Liver Dis 9:103-34. 2005.... - Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratioHelen M Heneghan
Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Surg Obes Relat Dis 9:100-7. 2013..We hypothesized that the beneficial effect of Roux-en-Y gastric bypass (RYGB) on CVD risk is related to ceramide-mediated improvement in lipoprotein profile... - An improved measurement of isotopic ratios by high resolution mass spectrometrySerguei Ilchenko
Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA
J Am Soc Mass Spectrom 24:309-12. 2013..Overall, this technique allows accurate measurements of the isotopic ratios of proteolytic peptides, a critical step for enabling routine studies of proteome dynamics... - Nonalcoholic fatty liver disease in patients with type 2 diabetesZobair M Younossi
The Cleveland Clinic Foundation, Cleveland, USA
Clin Gastroenterol Hepatol 2:262-5. 2004..The aim of this study was to assess the outcome of patients with NAFLD and DM... - In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver diseaseAnna Wieckowska
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Hepatology 44:27-33. 2006..These data highlight the potential usefulness of this test as a noninvasive diagnostic means of determining histological disease severity in patients with NAFLD... - Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humansSatish C Kalhan
Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
Metabolism 57:305-12. 2008..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus... - Late evening snack: exploiting a period of anabolic opportunity in cirrhosisCynthia D Tsien
Departments of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, OH, USA
J Gastroenterol Hepatol 27:430-41. 2012..Published reports were evaluated to examine the effect of LES on regulation of substrate utilization (short-term studies) and nutritional outcomes (long-term studies)... - Progressive primary sclerosing cholangitis requiring liver transplantation is associated with reduced need for colectomy in patients with ulcerative colitisUdayakumar Navaneethan
Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Clin Gastroenterol Hepatol 10:540-6. 2012..We investigated the association between the severity of primary sclerosing cholangitis (PSC) and clinical outcomes of patients with ulcerative colitis (UC) on the basis of need for colectomy... - Pathogenesis of non-alcoholic steatohepatitis: human dataJohn Edmison
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
Clin Liver Dis 11:75-104, ix. 2007..Although fatty liver may be caused by other factors, this review concentrates on fatty liver associated with insulin resistance, sometimes referred to as the primary form... - Alcoholic liver diseaseRobert S O'Shea
Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Ohio 44195, USA
Am J Gastroenterol 105:14-32; quiz 33. 2010.... - Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitisMansour A Parsi
Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Gastroenterology 135:803-7. 2008..The aim of this study was to assess the utility of ascitic fluid lactoferrin (AFLAC) for the diagnosis of SBP and to identify a cut-off level that can be used for future development of a rapid bedside test... - Measuring protein synthesis using metabolic ²H labeling, high-resolution mass spectrometry, and an algorithmTakhar Kasumov
Department of Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
Anal Biochem 412:47-55. 2011..As a proof of principle, we demonstrate that this approach can detect the effect of nutritional status on albumin synthesis in rats given (2)H(2)O... - Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessmentClaudia O Zein
Division of Gastroenterology and Hepatology, University Hospitals of Cleveland, Cleveland, OH, USA
Hepatology 44:1564-71. 2006..In conclusion, smoking may accelerate the progression of PBC. This could be induced by exposure to chemicals in cigarette smoke... - Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometryTakhar Kasumov
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
Anal Biochem 401:154-61. 2010..This technique could be extended for quantification of other ceramides and sphingolipids with no significant modification... - Differences in regulation of type I collagen synthesis in primary and passaged hepatic stellate cell cultures: the role of alpha5beta1-integrinMilan Dodig
Department of Gastroenterology and Hepatology, Cleveland Clinic and Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Physiol Gastrointest Liver Physiol 293:G154-64. 2007..Therefore alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary HSC cultures but appears to have no direct role once the HSC are fully activated... - Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted ratSrinivasan Dasarathy
Schwartz Center for Metabolism and Nutrition, Division of Gastroenterology, Cleveland, Ohio, USA
Dig Dis Sci 47:1936-42. 2002.... - Editorial: non-alcoholic Fatty liver disease and obesity: not all about body mass indexMangesh R Pagadala
Digestive Disease Institute and the Department of Gastroenterology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Gastroenterol 107:1859-61. 2012..It is important for clinicians to be aware that these "metabolically obese" NAFLD patients should be monitored for the metabolic syndrome and its associated adverse outcomes irrespective of their BMI... - Reversal of sarcopenia predicts survival after a transjugular intrahepatic portosystemic stentCynthia Tsien
Departments of Gastroenterology, Hepatology and Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
Eur J Gastroenterol Hepatol 25:85-93. 2013..Changes in the skeletal muscle area and adipose tissue volume were quantified by computed tomography (CT) before and after TIPS... - Inhibition of aromatase improves nutritional status following portacaval anastomosis in male ratsSrinivasan Dasarathy
Gastroenterology Division, Department of Medicine, Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA
J Hepatol 45:214-20. 2006..We hypothesized that failure to gain body weight in the PCA rat was the consequence of low testosterone levels and will be reversed by 4-hydroxyandrostenedione, a specific aromatase inhibitor... - Afternoon colonoscopies have higher failure rates than morning colonoscopiesMadhusudhan R Sanaka
Division of Gastroenterology, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
Am J Gastroenterol 101:2726-30. 2006..4% of patients... - Steatohepatitis in obese individualsWael I Youssef
Division of Gastroenterology, The Robert Schwartz Center for Metabolism and Nutrition at Metro-Health Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
Best Pract Res Clin Gastroenterol 16:733-47. 2002..Bariatric surgery is indicated in selected patients.A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy... - Update on nonalcoholic fatty liver diseaseArthur J McCullough
Division of Gastroenterology and the Robert Schwartz Center of Metabolism and Nutrition at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
J Clin Gastroenterol 34:255-62. 2002..Future therapies will depend on a greater understanding of the pathophysiology and should focus on diminishing fibrosis... - Diabetes mellitus, obesity, and hepatic steatosisWael Youssef
Division of Gastroenterology, Case Western Reserve University, Cleveland, OH, USA
Semin Gastrointest Dis 13:17-30. 2002..These include anti-oxidants such as vitamin E and betaine, bile acid therapy with ursodeoxycholic acid, and improved insulin sensitivity with metformin. Another potential therapeutic strategy is the reduction of inflammatory cytokines...