Research Topics
| P M McCarthySummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
Permanent mechanical circulatory support with an implantable left ventricular assist deviceP M McCarthy
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195, USA
Ann Thorac Surg 63:1458-61. 1997..He was discharged from the hospital 13 days after the operation, and 5 months postoperatively he had returned to New York Heart Association functional class II...- Risk factors for death after heart transplantation: does a single-center experience correlate with multicenter registries?J F McCarthy
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 65:1574-8; discussion 1578-9. 1998..This study was performed to (1) evaluate pre-Tx factors affecting mortality in a single-center experience, and (2) compare these factors with risk factors obtained from multicenter registry reports... - A prospective randomized trial of Duraflo II heparin-coated circuits in cardiac reoperationsP M McCarthy
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 67:1268-73. 1999..We hypothesized that the beneficial effects of heparin-coated circuits might be seen in patients who had cardiac reoperations... - Implantable LVAD insertion in patients with previous heart surgeryP M McCarthy
Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 44195, USA
J Heart Lung Transplant 19:S95-100. 2000..In conclusion adjustment of standard LVAD implant technique can successfully manage most problems posed by patients with previous heart surgery... - Left ventricular reduction surgery with mitral valve repairP M McCarthy
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
J Heart Lung Transplant 19:S64-7. 2000..Many questions remain to be answered, but many patients have demonstrated early subjective and objective improvement... - Noninvasive assessment of mitral inertness [correction of inertance]: clinical results with numerical model validationM S Firstenberg
The Cleveland Clinic Foundation, Cleveland, USA
Comput Cardiol 28:613-6. 2001..98x - 0.045, r=0.90) and the results of numerical modeling (y=0.96x - 0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography... - Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitationM S Firstenberg
The Cleveland Clinic Foundation, Cleveland, USA
Comput Cardiol 28:177-80. 2001..1%), and was best predicted by (r=0.97, p<0.01) %delta(fSV)[correction of fVS]=34[MRa initial] - 46[MRa final] -0.5[elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs... - Initial clinical experience of real-time three-dimensional echocardiography in patients with ischemic and idiopathic dilated cardiomyopathyT Shiota
Department of Cardiology, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio, USA
Am J Cardiol 84:1068-73. 1999..The new real-time 3D echocardiography is feasible in patients with cardiomyopathy and may provide a faster and lower cost alternative to MRI for evaluating cardiac function in patients... - Is repair preferable to replacement for ischemic mitral regurgitation?A M Gillinov
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Cardiovasc Surg 122:1125-41. 2001..This study was undertaken to compare mitral valve repair and replacement as treatments for ischemic mitral regurgitation... - Partial left ventriculectomy for dilated cardiomyopathy: is this an alternative to transplantation?A Franco-Cereceda
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Thorac Cardiovasc Surg 121:879-93. 2001..To determine the late effectiveness of partial left ventriculectomy and risk factors for failure... - Is anterior leaflet repair always necessary in repair of bileaflet mitral valve prolapse?A M Gillinov
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 68:820-3; discussion 824. 1999..This study was undertaken to evaluate the effectiveness of a strategy of posterior leaflet resection and annuloplasty alone for patients with bileaflet prolapse and no anterior chordal rupture or severe anterior chordal elongation... - Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observationsR C Starling
George M and Linda H Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
J Am Coll Cardiol 36:2098-103. 2000..The study was done to prospectively measure the echocardiographic, hemodynamic and clinical outcomes after partial left ventriculectomy (PLV)... - Early and late rejection and HLA sensitization at the time of heart transplantation in patients bridged with left ventricular assist devicesG V Gonzalez-Stawinski
Department of Thoracic Surgery, Kaufman Center for Heart Failure and The Transplant Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Transplant Proc 37:1349-51. 2005.... - Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertionK Fukamachi
Department of Biomedical Engineering, The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 68:2181-4. 1999..Implantable left ventricular assist device (LVAD) insertion complicated by early right ventricular (RV) failure has a poor prognosis and is generally unpredictable... - Atrial L-type Ca2+ currents and human atrial fibrillationD R Van Wagoner
Department of Cardiology and Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circ Res 85:428-36. 1999..The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload... - Device-based change in left ventricular shape: a new concept for the treatment of dilated cardiomyopathyP M McCarthy
Department of Cardiology and Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Cardiovasc Surg 122:482-90. 2001..We tested a unique new device, the Myosplint device (Myocor, Inc, Maple Grove, Minn), which is designed to change left ventricular shape, reduce left ventricular wall stress, and improve left ventricular systolic function... - Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology?M H Yamani
Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Heart Lung Transplant 19:1077-80. 2000..A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate... - The atherosclerotic aorta at aortic valve replacement: surgical strategies and resultsA M Gillinov
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Thorac Cardiovasc Surg 120:957-63. 2000..2%) patients had a severely atherosclerotic ascending aorta and required hypothermic circulatory arrest to facilitate aortic valve replacement. They form the study group... - Mitral inertance in humans: critical factor in Doppler estimation of transvalvular pressure gradientsS Nakatani
Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195
Am J Physiol Heart Circ Physiol 280:H1340-5. 2001..65, P < 0.0001). Because mitral inertance causes the velocity to lag significantly behind the actual pressure gradient, it needs to be considered when assessing diastolic filling and the pressure difference across normal mitral valves... - Surgical treatments for heart failureG S Kumpati
Department of Thoracic and Cardiovascular Surgery, George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Cardiol Clin 19:669-81. 2001..These therapies are the basis of the discipline of CHF surgery within cardiovascular surgery... - Nosocomial bloodstream infections in patients with implantable left ventricular assist devicesS M Gordon
Department of Infectious Disease, The Cleveland Clinic Foundation, Ohio, USA
Ann Thorac Surg 72:725-30. 2001..Strategies for prevention of infection in LVAD recipients should focus on the drive line exit site until technical advances can achieve a totally implantable device... - Hypogammaglobulinemia following cardiac transplantation: a link between rejection and infectionM H Yamani
Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Heart Lung Transplant 20:425-30. 2001..IgG level may be a useful marker for identifying patients at high risk... - Partial left ventriculectomy: sunrise or sunset?R C Starling
Department of Cardiology, Kaufman Center for Heart Failure, Cleveland Clinic Foundation, OH 44195, USA
Eur J Heart Fail 1:313-7. 1999..PLV does not yield outcomes equivalent to cardiac transplantation based on current selection criteria and requires further investigation to determine its role in the treatment of advanced heart failure... - Relationship between early diastolic intraventricular pressure gradients, an index of elastic recoil, and improvements in systolic and diastolic functionM S Firstenberg
Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Circulation 104:I330-5. 2001..38[%DeltaIVPG]-8.39, r=0.85). CONCLUSIONS: Improvements in LV function also increase IVPGs. These changes in IVPGs, suggestive of increases in LV suction and elastic recoil, correlate directly with improvements in LV relaxation and ESV... - Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operationN Moazami
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 72:1933-7; discussion 1937-9. 2001..CONCLUSIONS: In select patients with acute ischemic stroke after recent cardiac operation, intraarterial thrombolysis appears to be reasonably safe and may lead to neurologic recovery... - Left ventricular assist device bridge to recovery: a review of the current statusG S Kumpati
George M and Linda H Kaufman Center for Heart Failure, Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 71:S103-8; discussion S114-5. 2001..Despite numerous markers of success, there is a disconnect from the limited clinical successes that are reviewed. The current status and future options to increase the chances of success are highlighted... - Clinical experience with 202 adults receiving extracorporeal membrane oxygenation for cardiac failure: survival at five yearsN G Smedira
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Cardiovasc Surg 122:92-102. 2001.... - Clinically available intracorporeal left ventricular assist devicesP M McCarthy
Kaufman Center for Heart Failure, Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, OH, USA
Prog Cardiovasc Dis 43:37-46. 2000..As the problem of infection is reduced, more widespread LVAD use can be anticipated... - Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heartM L Ogletree-Hughes
Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 104:881-6. 2001..This indicates that functional impairment of cardiac muscle in human heart failure is reversible... - High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasoundE M Tuzcu
Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circulation 103:2705-10. 2001..Detailed, in vivo data on atherosclerosis in young individuals are limited. Intravascular ultrasonography provides a unique opportunity for in vivo characterization of early atherosclerosis in a clinically relevant context... - A novel miniature ventricular assist device for hemodynamic supportM Takagaki
Department of Biomedical Engineering, Cleveland Clinic Foundation, Ohio 44195, USA
ASAIO J 47:412-6. 2001..Despite its small diameter, the enabler significantly improved the hemodynamics of failing hearts and may potentially serve as a means of peripheral left ventricular support. Further study is warranted... - Ineffectiveness and potential proarrhythmia of atrial pacing for atrial fibrillation prevention after coronary artery bypass graftingM K Chung
Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195 5245, USA
Ann Thorac Surg 69:1057-63. 2000..Atrial pacing is often used empirically to suppress atrial ectopy and prevent atrial fibrillation after coronary artery bypass grafting... - A simple method of left ventricular reconstruction without patch for ischemic cardiomyopathyC Caldeira
Department of Thoracic and Cardiovascular Surgery, The Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 72:2148-9. 2001.... - Left ventricular assist device as a bridge to recovery: present statusG S Kumpati
Department of Thoracic Surgery, George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Ohio 44195, USA
J Card Surg 16:294-301. 2001..Further studies of topics such as the timing of LVAD implantation and explantation, adjunct medical and surgical therapy, and optimum LVAD weaning protocols might help improve the success of this promising technology... - Curative surgery for atrial fibrillation. Current status and minimally invasive approachesJ L Navia
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Minerva Cardioangiol 52:155-68. 2004..New ablation technologies have been adapted to enable thoracoscopic and minimally invasive surgical AF ablation in patients with isolated AF, extending the possibility of cure to large numbers of patients... 
Preload-adjusted maximal power: a novel index of left ventricular contractility in atrial fibrillationM Takagaki
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Heart 88:170-6. 2002..Non-invasive application of this method, in combination with echocardiography and tonometry, may yield important information for optimising the treatment of patients with atrial fibrillation...- Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillationC A Carnes
College of Pharmacy, Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA
Circ Res 89:E32-8. 2001..The full text of this article is available at http://www.circresaha.org... - Impaired myofibrillar energetics and oxidative injury during human atrial fibrillationM J Mihm
Division of Pharmacology/College of Pharmacy, Ohio State University, Columbus, Ohio 43210, USA
Circulation 104:174-80. 2001.... - Novel device to change left ventricular shape for heart failure treatment: device design and implantation procedureM Takagaki
Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio, USA
ASAIO J 47:244-8. 2001..There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans...