Research Topics
Genomes and GenesSpecies | Peter MazzoneSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Preoperative evaluation of the lung resection candidatePeter Mazzone
Critical Care Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Cleve Clin J Med 79:eS17-22. 2012..Smoking cessation and pulmonary rehabilitation are perioperative measures that can improve patients' the short- and long-term outcomes...
Lung cancer screening: examining the issuesPeter Mazzone
Critical Care Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Cleve Clin J Med 79:eS1-6. 2012..In this past year, the National Lung Screening Trial reported a significant reduction in cancer-related mortality as a result of screening with chest CT imaging. This will shape the direction of future screening programs...
The rationale for, and design of, a lung cancer screening programPeter Mazzone
Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Cleve Clin J Med 79:337-45. 2012..Time and further technical advances will help to optimize the programs that are developed...
Current and emerging medical treatments for non-small cell lung cancer: a primer for pulmonologistsPeter Mazzone
Respiratory Institute, Cleveland Clinic, Mail Code A90, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Respir Med 106:473-92. 2012....
Lung cancer: Preoperative pulmonary evaluation of the lung resection candidatePeter J Mazzone
Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic Foundation, OH, USA
Am J Med 118:578-83. 2005..Published guidelines help to direct the order of testing, permitting us to offer resection to as many patients as possible...
Preoperative evaluation of the lung cancer resection candidatePeter J Mazzone
Respiratory Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Expert Rev Respir Med 4:97-113. 2010..Testing algorithms are provided from these guidelines. In addition, perioperative considerations and alternative surgical approaches are discussed...
Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor arrayPeter J Mazzone
Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic, 9500 Euclid Avenue, A90 Cleveland, OH 44195, USA
Thorax 62:565-8. 2007..The colours of these spots change based on the chemicals with which they come into contact. In this proof of principle study, the ability of this sensor system to detect a pattern of VOCs unique to lung cancer is assessed...
Lung cancer screening: is it time for a change in policy?Peter Mazzone
Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Cleve Clin J Med 74:441-8. 2007..These questions warrant further study prior to accepting CT screening as the standard of care. Hopefully, much of this knowledge will be gained when the results of ongoing controlled studies are available...
Lung cancer screeningPeter J Mazzone
Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Curr Oncol Rep 9:265-74. 2007..Current guidelines remain vague as randomized trials are being completed and technologic advances are occurring. The ultimate face of a successful lung cancer screening program is yet to be defined...
Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancerPeter J Mazzone
Respiratory Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Thorac Oncol 3:774-80. 2008....
Small vessel ischemic disease of the brain and brain metastases in lung cancer patientsPeter J Mazzone
Respiratory Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America
PLoS ONE 4:e7242. 2009..We aimed to determine if the presence of small vessel ischemic disease (SVID) of the brain is protective against the development of brain metastases in lung cancer patients...
Pathophysiological impact of cigarette smoke exposure on the cerebrovascular system with a focus on the blood-brain barrier: expanding the awareness of smoking toxicity in an underappreciated areaPeter Mazzone
Department of Pulmonary Medicine, Cleveland Clinic Lerner College of Medicine, E 100 St, Cleveland, OH 44106, USA
Int J Environ Res Public Health 7:4111-26. 2010..We also discuss the potential toxicity of recently marketed "potential-reduced exposure products"...
Endocrine paraneoplastic syndromes in lung cancerPeter J Mazzone
Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
Curr Opin Pulm Med 9:313-20. 2003..Knowledge about the clinical manifestations, pathophysiology, and treatment of these syndromes has evolved over time. This article provides an up-to-date overview of this knowledge...
Lung cancer screening: an update, discussion, and look aheadPeter J Mazzone
Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Curr Oncol Rep 12:226-34. 2010..I then discuss the evidence related to the areas that are currently debated, describe the ongoing trials that will help to clarify these issues, and speculate about the future...
Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancerPeter J Mazzone
Respiratory Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Thorac Oncol 7:137-42. 2012..Breath biosignature-based classification of homogeneous subgroups of lung cancer may be more accurate than a global breath signature. Combining breath biosignatures with clinical risk factors may improve the accuracy of the signature...
Cell-mediated immune response to influenza vaccination in lung transplant recipientsPeter J Mazzone
Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Heart Lung Transplant 23:1175-81. 2004..Cellular immune mechanisms serve an important role in influenza clearance. The cellular immune response to influenza vaccination has not been studied in transplant populations...
ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patientsNicola Marchi
Cerebrovascular Research, Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
Cancer 112:1313-24. 2008..However, a confounding factor was the presence of BBB changes due to cerebrovascular disease...
Comprehensive analysis of pulmonary function Test (PFT) changes after stereotactic body radiotherapy (SBRT) for stage I lung cancer in medically inoperable patientsKevin L Stephans
Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Oncol 4:838-44. 2009..To assess for variables predicting pulmonary function test (PFT) changes after stereotactic body radiotherapy (SBRT) for medically inoperable stage I lung cancer...
A comparison of four versions of a computer-aided detection system for pulmonary nodules on chest radiographsMoulay Meziane
Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Thorac Imaging 27:58-64. 2012..We evaluated the performance of a Food and Drug Administration-approved system and 3 of its subsequent versions to determine their potential to improve readers' accuracy...
Lung cancer: preoperative pulmonary evaluation of the lung resection candidateHataya Poonyagariyagorn
Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Semin Respir Crit Care Med 29:271-84. 2008..Knowledge of alternative treatment options will help to guide those deemed unfit for resection...
S100beta as a predictor of brain metastases: brain versus cerebrovascular damageMichael A Vogelbaum
Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cancer 104:817-24. 2005....
A comparison of two stereotactic body radiation fractionation schedules for medically inoperable stage I non-small cell lung cancer: the Cleveland Clinic experienceKevin L Stephans
Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Oncol 4:976-82. 2009..To assess the impact of fractionation upon tumor control and toxicity in medically inoperable early stage lung cancer patients treated with stereotactic body radiotherapy...
Bronchogenic carcinoma after lung transplantation: characteristics and outcomesOmar A Minai
Departments of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Thorac Oncol 3:1404-9. 2008..Lung cancer may occur in the lung transplant population because many patients are former smokers. Not much is known about risk factors and outcomes in these patients...
In vitro assessment of tobacco smoke toxicity at the BBB: do antioxidant supplements have a protective role?Mohammed Hossain
Cerebrovascular Research, Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195 USA
BMC Neurosci 12:92. 2011....
Bias, underestimation of risk, and loss of statistical power in patient-level analyses of lesion detectionNancy A Obuchowski
Department of Quantitative Health Sciences JJN3 and the Imaging Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Eur Radiol 20:584-94. 2010..For tests designed to find and diagnose lesions, e.g., lung nodules, the usual definitions of sensitivity and specificity may be misleading. In this paper we describe and compare five measures of accuracy of lesion detection...
What's the control in studies measuring the effect of computer-aided detection (CAD) on observer performance?Nancy A Obuchowski
Quantitative Health Sciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Acad Radiol 17:761-7. 2010..The crossover design is considered the most valid. The sequential design takes less time and is less expensive but may be biased. We conducted a study to investigate the differences between these two designs...
Interpreting pulmonary function tests: recognize the pattern, and the diagnosis will followFeyrouz Al-Ashkar
Department of General Internal Medicine, The Cleveland Clinic, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 70:866, 868, 871-3, passim. 2003..Once a pattern is recognized, the diagnosis will often follow...
Extrapleural pneumonectomy for scimitar syndromeDavid P Mason
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Cardiovasc Surg 132:704-5. 2006
Multiple pulmonary nodules in an elderly womanGustavo A Heresi
Deparment of Pulmonary, Allergy and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Thorac Oncol 1:580-1. 2006
Discordant utility of ideal body weight and body mass index as predictors of mortality in lung transplant recipientsDaniel A Culver
Department of Pulmonary and Critical Care Medicine, Cleveland, OH 44195, USA
J Heart Lung Transplant 24:137-44. 2005..A prior study used body mass index (BMI) to suggest greater mortality risk in obese allograft recipients, but the number of studied patients was small...
Electromagnetic navigation diagnostic bronchoscopy: a prospective studyThomas R Gildea
Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 174:982-9. 2006..Electromagnetic navigation bronchoscopy using superDimension/Bronchus System is a novel method to increase diagnostic yield of peripheral and mediastinal lung lesions...
Impact of induction concurrent chemoradiotherapy on pulmonary function and postoperative acute respiratory complications in esophageal cancerRony M Abou-Jawde
Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Taussig Cancer Center, R35, 9500 Euclid Ave, Cleveland, OH 44195, USA
Chest 128:250-5. 2005..To evaluate the effects of induction concurrent chemoradiotherapy (cCRT) on pulmonary function and postoperative acute respiratory complications (PARCs)...
A comparison of follow-up recommendations by chest radiologists, general radiologists, and pulmonologists using computer-aided detection to assess radiographs for actionable pulmonary nodulesMoulay Meziane
Imaging Institute, Cleveland Clinic Foundation, OH, USA
AJR Am J Roentgenol 196:W542-9. 2011..The primary objective of our study was to compare the effect of a chest radiography computer-aided detection (CAD) system on the follow-up recommendations of chest radiologists, general radiologists, and pulmonologists...
Bronchoscopy and needle biopsy techniques for diagnosis and staging of lung cancerPeter Mazzone
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Clin Chest Med 23:137-58, ix. 2002..This article provides a critical overview of indications, diagnostic yield, and limitations of bronchoscopy and TNB in the diagnosis of lung cancer...
A rational approach to the evaluation and treatment of the infected patient in the intensive care unitJaime F Avecillas
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Clin Chest Med 24:645-69. 2003..The information provided in this article, used in association with good clinical judgment, will help the critical care physician provide optimal initial management of the infected patient in the ICU...
The pulmonologist's perspective regarding the solitary pulmonary nodulePeter J Mazzone
Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Semin Thorac Cardiovasc Surg 14:250-60. 2002..Management decisions for these nodules are influenced by their low prevalence of malignancy and small size. Future advances will add to our ability to effectively meet our stated goal...
Detection of lung cancer by sensor array analyses of exhaled breathRoberto F Machado
Department of Pathobiology, Lerner Research Institute, Cleveland, OH, USA
Am J Respir Crit Care Med 171:1286-91. 2005..The results provide feasibility to the concept of using the electronic nose for managing and detecting lung cancer...
Hypotension in the intensive care unitAhmed Al-Hazzouri
Department of Internal Medicine, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 73:1091-7. 2006
Does noninvasive positive pressure ventilation have a role in managing hypercapnic respiratory failure due to an acute exacerbation of COPD?Ari J Gershman
Department of General Internal Medicine, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 75:458-61. 2008
A small pulmonary nodule, found incidentallyAqeel A Chowdhry
Department of Diagnostic Radiology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 74:531-3. 2007
Cause and effect in lung cancer: fueling the firePeter J Mazzone
Chest 128:6-8. 2005
Is lung cancer in the nonsmoker a different disease?Peter J Mazzone
Chest 126:326-9. 2004
Impact of positron emission tomography on clinical decision makingGustavo A Heresi
Chest 130:300-1. 2006
How many ways can we say that cigarette smoking is bad for you?Peter J Mazzone
Chest 126:1717-8. 2004
