E V Maytin
Affiliation: Cleveland Clinic Foundation
- Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanismsE V Maytin
Laboratory of Molecular Dermatology, Department of Biomedical Engineering, ND 20 Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Exp Cell Res 267:193-204. 2001..Thus, while the amino-terminal region of CHOP serves an important modulatory role (i.e., regulation by p38), the underlying apoptosis-inducing activity of CHOP resides within the bZIP region of the molecule...
- Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal modelGati Ajani
Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH 44195, USA
Exp Cell Res 313:3005-15. 2007..Given that no fibroblasts are present in the model, the ability to mount a hyperplastic response to barrier injury is an inherent property of keratinocytes...
- Proliferation and cornification during development of the mammalian epidermisJudith A Mack
Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
Birth Defects Res C Embryo Today 75:314-29. 2005..We end with a discussion about perturbations in epidermal proliferation and cornification as they pertain to human skin pathologies...
- Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic modelJudith A Mack
Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Ohio 44195, USA
J Biol Chem 280:29904-11. 2005..Our results suggest that Hoxb13 functions to promote epidermal differentiation, a critical process for skin regeneration and for the maintenance of normal barrier function...
- Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic miceJudith A Mack
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Invest Dermatol 130:856-65. 2010..Together, our results identify Hoxb13 as a potential important clinical target in wound healing and other pathologies characterized by abnormal or excessive inflammation, angiogenesis, or epidermal proliferation...
- Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healingJudith A Mack
Department of Research, Cleveland Clinic Florida, Weston, Florida, USA
FASEB J 17:1352-4. 2003..Because higher levels of hyaluronan and enhanced wound healing are characteristics of fetal skin, we conclude that loss of Hoxb13 produces a more "fetal-like" state in adult skin...
- Hyaluronan participates in the epidermal response to disruption of the permeability barrier in vivoEdward V Maytin
Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Pathol 165:1331-41. 2004..Overall, the data show that HA is a significant participant in the epidermal response to barrier injury...
- Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFRJames Monslow
Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Invest Dermatol 129:2046-58. 2009..In summary, rapid HA accumulation after epidermal wounding occurs through a mechanism requiring cleavage of HB-EGF and activation of EGFR signaling...
- Ultraviolet light (UVB and UVA) induces the damage-responsive transcription factor CHOP/gadd153 in murine and human epidermis: evidence for a mechanism specific to intact skinSanjay Anand
Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Invest Dermatol 125:323-33. 2005..Thus, induction of CHOP in keratinocytes requires factors present only in the native skin. Overall, the data suggest that CHOP participates in adaptive responses of the epidermis following UVB/UVA exposure in vivo...
- Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytesNobuyuki Sato
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Invest Dermatol 127:925-34. 2007..g., necrosis). In summary, Vit D may be useful as a biological enhancer of ALA-based PDT...
- Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivoSanjay Anand
Department of Dermatology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Clin Cancer Res 15:3333-43. 2009..To improve treatment efficacy and tumor cell selectivity of delta-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) via pretreatment of cells and tumors with methotrexate to enhance intracellular photosensitizer levels...
- Hyaluronan suppresses epidermal differentiation in organotypic cultures of rat keratinocytesAlberto Passi
Department of Biomedical Experimental and Clinical Sciences, University of Insubria, Varese, Italy
Exp Cell Res 296:123-34. 2004..Thus, it appears that the presence of intercellular HA in the epidermis acts as a brake upon intracellular events that occur during keratinocyte differentiation...
- All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytesSanna M Pasonen-Seppänen
Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
J Invest Dermatol 128:797-807. 2008..These results indicate that the effects of all-trans RA on keratinocyte proliferation and hyaluronan synthesis are partly mediated through EGFR signaling...
- Prospects for the use of differentiation-modulating agents as adjuvant of photodynamic therapy for proliferative dermatosesOleg E Akilov
Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA
J Dermatol 35:197-205. 2008....
- Topical protease therapy as a novel method of epidermal ablation: preliminary reportHoward Fein
Palos Verdes Dermatology Associates, Rolling Hills Estates, California, and Division of Dermatology, Harbor UCLA Medical Center, Torrance, California 90274, USA
Dermatol Surg 31:139-47; discussion 147-8. 2005..However, the topical, in vivo pharmacologic properties of these enzymes are virtually unknown. Previous therapeutic applications for topically applied proteases have been limited to wound debridement...