E V Maytin

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
    E V Maytin
    Laboratory of Molecular Dermatology, Department of Biomedical Engineering, ND 20 Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Exp Cell Res 267:193-204. 2001
  2. pmc Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal model
    Gati Ajani
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH 44195, USA
    Exp Cell Res 313:3005-15. 2007
  3. ncbi request reprint Proliferation and cornification during development of the mammalian epidermis
    Judith A Mack
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:314-29. 2005
  4. ncbi request reprint Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model
    Judith A Mack
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Ohio 44195, USA
    J Biol Chem 280:29904-11. 2005
  5. pmc Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice
    Judith A Mack
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 130:856-65. 2010
  6. ncbi request reprint Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing
    Judith A Mack
    Department of Research, Cleveland Clinic Florida, Weston, Florida, USA
    FASEB J 17:1352-4. 2003
  7. pmc Hyaluronan participates in the epidermal response to disruption of the permeability barrier in vivo
    Edward V Maytin
    Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 165:1331-41. 2004
  8. pmc Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR
    James Monslow
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 129:2046-58. 2009
  9. ncbi request reprint Ultraviolet light (UVB and UVA) induces the damage-responsive transcription factor CHOP/gadd153 in murine and human epidermis: evidence for a mechanism specific to intact skin
    Sanjay Anand
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Invest Dermatol 125:323-33. 2005
  10. ncbi request reprint Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes
    Nobuyuki Sato
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Invest Dermatol 127:925-34. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
    E V Maytin
    Laboratory of Molecular Dermatology, Department of Biomedical Engineering, ND 20 Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Exp Cell Res 267:193-204. 2001
    ..Thus, while the amino-terminal region of CHOP serves an important modulatory role (i.e., regulation by p38), the underlying apoptosis-inducing activity of CHOP resides within the bZIP region of the molecule...
  2. pmc Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal model
    Gati Ajani
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH 44195, USA
    Exp Cell Res 313:3005-15. 2007
    ..Given that no fibroblasts are present in the model, the ability to mount a hyperplastic response to barrier injury is an inherent property of keratinocytes...
  3. ncbi request reprint Proliferation and cornification during development of the mammalian epidermis
    Judith A Mack
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:314-29. 2005
    ..We end with a discussion about perturbations in epidermal proliferation and cornification as they pertain to human skin pathologies...
  4. ncbi request reprint Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model
    Judith A Mack
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, Ohio 44195, USA
    J Biol Chem 280:29904-11. 2005
    ..Our results suggest that Hoxb13 functions to promote epidermal differentiation, a critical process for skin regeneration and for the maintenance of normal barrier function...
  5. pmc Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice
    Judith A Mack
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 130:856-65. 2010
    ..Together, our results identify Hoxb13 as a potential important clinical target in wound healing and other pathologies characterized by abnormal or excessive inflammation, angiogenesis, or epidermal proliferation...
  6. ncbi request reprint Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing
    Judith A Mack
    Department of Research, Cleveland Clinic Florida, Weston, Florida, USA
    FASEB J 17:1352-4. 2003
    ..Because higher levels of hyaluronan and enhanced wound healing are characteristics of fetal skin, we conclude that loss of Hoxb13 produces a more "fetal-like" state in adult skin...
  7. pmc Hyaluronan participates in the epidermal response to disruption of the permeability barrier in vivo
    Edward V Maytin
    Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 165:1331-41. 2004
    ..Overall, the data show that HA is a significant participant in the epidermal response to barrier injury...
  8. pmc Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR
    James Monslow
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Invest Dermatol 129:2046-58. 2009
    ..In summary, rapid HA accumulation after epidermal wounding occurs through a mechanism requiring cleavage of HB-EGF and activation of EGFR signaling...
  9. ncbi request reprint Ultraviolet light (UVB and UVA) induces the damage-responsive transcription factor CHOP/gadd153 in murine and human epidermis: evidence for a mechanism specific to intact skin
    Sanjay Anand
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Invest Dermatol 125:323-33. 2005
    ..Thus, induction of CHOP in keratinocytes requires factors present only in the native skin. Overall, the data suggest that CHOP participates in adaptive responses of the epidermis following UVB/UVA exposure in vivo...
  10. ncbi request reprint Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes
    Nobuyuki Sato
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Invest Dermatol 127:925-34. 2007
    ..g., necrosis). In summary, Vit D may be useful as a biological enhancer of ALA-based PDT...
  11. pmc Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo
    Sanjay Anand
    Department of Dermatology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Cancer Res 15:3333-43. 2009
    ..To improve treatment efficacy and tumor cell selectivity of delta-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) via pretreatment of cells and tumors with methotrexate to enhance intracellular photosensitizer levels...
  12. ncbi request reprint Hyaluronan suppresses epidermal differentiation in organotypic cultures of rat keratinocytes
    Alberto Passi
    Department of Biomedical Experimental and Clinical Sciences, University of Insubria, Varese, Italy
    Exp Cell Res 296:123-34. 2004
    ..Thus, it appears that the presence of intercellular HA in the epidermis acts as a brake upon intracellular events that occur during keratinocyte differentiation...
  13. ncbi request reprint All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes
    Sanna M Pasonen-Seppänen
    Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
    J Invest Dermatol 128:797-807. 2008
    ..These results indicate that the effects of all-trans RA on keratinocyte proliferation and hyaluronan synthesis are partly mediated through EGFR signaling...
  14. doi request reprint Prospects for the use of differentiation-modulating agents as adjuvant of photodynamic therapy for proliferative dermatoses
    Oleg E Akilov
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA
    J Dermatol 35:197-205. 2008
    ....
  15. ncbi request reprint Topical protease therapy as a novel method of epidermal ablation: preliminary report
    Howard Fein
    Palos Verdes Dermatology Associates, Rolling Hills Estates, California, and Division of Dermatology, Harbor UCLA Medical Center, Torrance, California 90274, USA
    Dermatol Surg 31:139-47; discussion 147-8. 2005
    ..However, the topical, in vivo pharmacologic properties of these enzymes are virtually unknown. Previous therapeutic applications for topically applied proteases have been limited to wound debridement...