Nicholas F Marko

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Nanotechnology in proteomics
    Nicholas F Marko
    Cleveland Clinic Foundation, Department of Neurosurgery, 9500 Euclid Avenue, Cleveland, OH, USA
    Expert Rev Proteomics 4:617-26. 2007
  2. doi Mathematical modeling of molecular data in translational medicine: theoretical considerations
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Transl Med 2:56rv4. 2010
  3. doi Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases
    Nicholas F Marko
    Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    World Neurosurg 73:186-93; discussion e29. 2010
  4. doi The role of observational investigations in comparative effectiveness research
    Nicholas F Marko
    Department of Neurosurgery, The Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Value Health 13:989-97. 2010
  5. doi Radiotherapy: Neurocognitive considerations in the treatment of brain metastases
    Nicholas F Marko
    Department of Neurosurgery, The Brain Tumor and Neuro Oncology Center, Cleveland Clinic, ND 40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nat Rev Clin Oncol 7:185-6. 2010
  6. doi Immediate postoperative cortisol levels accurately predict postoperative hypothalamic-pituitary-adrenal axis function after transsphenoidal surgery for pituitary tumors
    Nicholas F Marko
    Department of Neurosurgery, S80, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Pituitary 13:249-55. 2010
  7. doi Integrated molecular analysis suggests a three-class model for low-grade gliomas: a proof-of-concept study
    Nicholas F Marko
    Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH, USA
    Genomics 95:16-24. 2010
  8. pmc Why is there a lack of consensus on molecular subgroups of glioblastoma? Understanding the nature of biological and statistical variability in glioblastoma expression data
    Nicholas F Marko
    Department of Neurosurgery and Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e20826. 2011
  9. doi A comparative effectiveness analysis of alternative strategies to assess hypothalamic-pituitary-adrenal axis function after microsurgical resection of pituitary tumors
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 68:1576-84; discussion 1585. 2011
  10. doi Relationship between HER2 status and prognosis in women with brain metastases from breast cancer
    Zhiyuan Xu
    Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH, USA
    Int J Radiat Oncol Biol Phys 82:e739-47. 2012

Collaborators

Detail Information

Publications24

  1. ncbi Nanotechnology in proteomics
    Nicholas F Marko
    Cleveland Clinic Foundation, Department of Neurosurgery, 9500 Euclid Avenue, Cleveland, OH, USA
    Expert Rev Proteomics 4:617-26. 2007
    ..In this review, we summarize several such techniques, highlight their implementation in current protein research and comment on their potential role in future proteomic investigations and biomedical applications...
  2. doi Mathematical modeling of molecular data in translational medicine: theoretical considerations
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Transl Med 2:56rv4. 2010
    ..Here, we propose five specific conceptual and theoretical changes in data modeling strategies that will facilitate improved translational analysis of large-volume molecular databases...
  3. doi Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases
    Nicholas F Marko
    Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    World Neurosurg 73:186-93; discussion e29. 2010
    ....
  4. doi The role of observational investigations in comparative effectiveness research
    Nicholas F Marko
    Department of Neurosurgery, The Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Value Health 13:989-97. 2010
    ..Accordingly, it is critical for clinicians to appreciate the strengths and limitations of observational research, particularly as they apply to CER...
  5. doi Radiotherapy: Neurocognitive considerations in the treatment of brain metastases
    Nicholas F Marko
    Department of Neurosurgery, The Brain Tumor and Neuro Oncology Center, Cleveland Clinic, ND 40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Nat Rev Clin Oncol 7:185-6. 2010
    ..the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases...
  6. doi Immediate postoperative cortisol levels accurately predict postoperative hypothalamic-pituitary-adrenal axis function after transsphenoidal surgery for pituitary tumors
    Nicholas F Marko
    Department of Neurosurgery, S80, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Pituitary 13:249-55. 2010
    ..Our data suggest that an immediate, postoperative, DOS cortisol level > or =15 microg/dL predicts distant, normal, post-operative HPA axis function following transsphenoidal surgery...
  7. doi Integrated molecular analysis suggests a three-class model for low-grade gliomas: a proof-of-concept study
    Nicholas F Marko
    Department of Neurosurgery, The Cleveland Clinic, Cleveland, OH, USA
    Genomics 95:16-24. 2010
    ....
  8. pmc Why is there a lack of consensus on molecular subgroups of glioblastoma? Understanding the nature of biological and statistical variability in glioblastoma expression data
    Nicholas F Marko
    Department of Neurosurgery and Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e20826. 2011
    ..We seek to clarify the nature and relative contributions of these factors, to focus additional investigations, and to improve the accuracy and consistency of translational glioblastoma analyses...
  9. doi A comparative effectiveness analysis of alternative strategies to assess hypothalamic-pituitary-adrenal axis function after microsurgical resection of pituitary tumors
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 68:1576-84; discussion 1585. 2011
    ..Observational methods can be used in conjunction with the comparative effectiveness research (CER) paradigm to inform decisions between alternative patient management strategies in real-world clinical settings...
  10. doi Relationship between HER2 status and prognosis in women with brain metastases from breast cancer
    Zhiyuan Xu
    Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH, USA
    Int J Radiat Oncol Biol Phys 82:e739-47. 2012
    ..To analyze factors affecting outcomes in breast cancer patients with brain metastases (BM) and characterize the role of HER2 status...
  11. doi Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA
    J Neurooncol 104:817-24. 2011
    ..Our findings suggest that SRS alone may be a viable therapeutic option for patients with incidentally-discovered NSCLC brain metastases...
  12. doi Stereotactic radiosurgical treatment of brain metastases to the choroid plexus
    Vitaly Siomin
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA
    Int J Radiat Oncol Biol Phys 80:1134-42. 2011
    ..Choroid plexus metastases (CPM) are uncommon lesions. Consequently, optimal management of CPM is uncertain. We summarize our experience with stereotactic radiosurgery (SRS) of CPM...
  13. doi Role of Gamma Knife surgery in patients with 5 or more brain metastases
    Alireza Mohammad Mohammadi
    The Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA
    J Neurosurg 117:5-12. 2012
    ..The authors evaluated overall survival and factors predicting outcome in patients with ≥ 5 brain metastases who were treated with Gamma Knife surgery (GKS)...
  14. doi Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, OH, USA
    J Neurosurg 117:522-38. 2012
    ..Treatment of acromegaly involves combinations of one or more discrete therapeutic modalities to achieve biochemical control. Unfortunately, data capable of informing decisions among alternate management strategies are presently lacking...
  15. doi Impact of preexisting tumor necrosis on the efficacy of stereotactic radiosurgery in the treatment of brain metastases in women with breast cancer
    Zhiyuan Xu
    Brain Tumor and Neuro Oncology Center, Department of Neurosurgery, Neurological Institute, Cleveland, Ohio, USA
    Cancer 118:1323-33. 2012
    ..Necrosis is a common feature of many brain tumors, including BM; however, the influence of tumor necrosis on treatment efficacy of SRS in women with breast cancer metastatic to the brain is unknown...
  16. doi Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations
    Gazanfar Rahmathulla
    The Burkhardt Brain Tumor and Neuro Oncology Center, Desk S 7, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Neurosci 20:485-502. 2013
    ..We discuss the pathobiology, clinical features, diagnosis, available treatment modalities, and outcomes in the management of patients with intracranial radiation necrosis that follows radiation used to treat brain tumors...
  17. doi Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation
    Nicholas F Marko
    Department of Neurosurgery, Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH, USA
    J Neurosurg 111:540-4. 2009
    ..The authors examine the role of the morning total serum cortisol level in the early postoperative period as a predictor of long-term HPA function...
  18. doi Genomic expression patterns distinguish long-term from short-term glioblastoma survivors: a preliminary feasibility study
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Genomics 91:395-406. 2008
    ..Future efforts will focus on building more robust classifiers and identifying additional subclasses of gliomas with phenotypic significance...
  19. ncbi Functional outcomes and survival in patients with high-grade gliomas in dominant and nondominant hemispheres
    Richard S Polin
    Department of Neurosurgery, School of Medicine, The George Washington University, Washington, DC 20037, USA
    J Neurosurg 102:276-83. 2005
    ....
  20. pmc The molecular biology of WHO grade I astrocytomas
    Nicholas F Marko
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 14:1424-31. 2012
    ....
  21. doi Relapsing, remitting hypercortisolism in Cushing's disease due to intratumoral hemorrhages in pituitary microadenoma
    Nicholas F Marko
    The Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Department of Neurosurgery, Neurological Institute, The Cleveland Clinic, Cleveland, OH, USA Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom Electronic address
    J Clin Neurosci 20:753-6. 2013
    ..To our knowledge this is the first report of patients in whom hemorrhage within a microadenoma caused cyclic CD. Both patients were treated successfully with transsphenoidal surgery...
  22. doi Predicting survival in women with breast cancer and brain metastasis: a nomogram outperforms current survival prediction models
    Nicholas F Marko
    Cancer Research UK Cambridge Research Institute and Department of Applied Mathematics and Theoretical Physics, Cambridge University, United Kingdom
    Cancer 118:3749-57. 2012
    ..A survival nomogram for breast cancer patients with BM was constructed, and its performance is compared to current predictive models of survival...
  23. doi Hyperosmolar therapy for intracranial hypertension
    Andrew Torre-Healy
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Neurocrit Care 17:117-30. 2012
    ....
  24. doi An introduction to comparative effectiveness research
    Nicholas F Marko
    Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 70:425-34; discussion 434. 2012
    ....