Nicola Marchi

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity
    Nicola Marchi
    Department of Cerebrovascular Research Cell Biology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106 Ohio, USA
    BMC Neurosci 11:34. 2010
  2. pmc The etiological role of blood-brain barrier dysfunction in seizure disorders
    Nicola Marchi
    Department of Molecular Medicine, Cleveland Clinic Foundation, NB 20 LRI 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Psychiatry Neurol 2011:482415. 2011
  3. pmc Cerebrovascular remodeling and epilepsy
    Nicola Marchi
    Departments of Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Neuroscientist 19:304-12. 2013
  4. doi request reprint Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches
    Nicola Marchi
    Departments of Molecular Medicine Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 53:1877-86. 2012
  5. pmc The role of shear stress in Blood-Brain Barrier endothelial physiology
    Luca Cucullo
    Cerebrovascular Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 USA
    BMC Neurosci 12:40. 2011
  6. pmc ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patients
    Nicola Marchi
    Cerebrovascular Research, Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Cancer 112:1313-24. 2008
  7. ncbi request reprint Seizure-promoting effect of blood-brain barrier disruption
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:732-42. 2007
  8. pmc Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow
    Chaitali Ghosh
    Department of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Epilepsia 51:1408-17. 2010
  9. pmc Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema
    Nicola Marchi
    Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 50:664-77. 2009
  10. pmc Cellular localization and functional significance of CYP3A4 in the human epileptic brain
    Chaitali Ghosh
    Cerebrovascular ResearchDepartments of Cell Biology Molecular Medicine Neurological Surgery Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 52:562-71. 2011

Collaborators

Detail Information

Publications35

  1. pmc Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity
    Nicola Marchi
    Department of Cerebrovascular Research Cell Biology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106 Ohio, USA
    BMC Neurosci 11:34. 2010
    ..Transcranial Doppler was used to monitor cerebral blood flow. EEG recordings were used to detect seizures. Immunocytochemical detection (Cresyl Violet, anti-human CD8 for TALL-104, Evans Blue for BBB damage, GFAP and NEUN) was performed...
  2. pmc The etiological role of blood-brain barrier dysfunction in seizure disorders
    Nicola Marchi
    Department of Molecular Medicine, Cleveland Clinic Foundation, NB 20 LRI 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Psychiatry Neurol 2011:482415. 2011
    ..The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more "holistic" approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy...
  3. pmc Cerebrovascular remodeling and epilepsy
    Nicola Marchi
    Departments of Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA
    Neuroscientist 19:304-12. 2013
    ..Finally, we speculate on whether the formation of leaky BBB vessels could have an impact on the cerebrovascular rheology and on the physiological mechanisms regulating brain homeostasis...
  4. doi request reprint Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches
    Nicola Marchi
    Departments of Molecular Medicine Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 53:1877-86. 2012
    ..We also present BBB neuroimaging as a tool to correlate BBB restoration to seizure mitigation. Add-on cerebrovascular drug could be of efficacy in reducing seizure burden when used in association with neuronal antiepileptic drugs...
  5. pmc The role of shear stress in Blood-Brain Barrier endothelial physiology
    Luca Cucullo
    Cerebrovascular Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 USA
    BMC Neurosci 12:40. 2011
    ..With the use of a well established humanized dynamic in vitro BBB model and cDNA microarrays, we have profiled the effect of SS in the induction/suppression of ECs genes and related functions...
  6. pmc ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patients
    Nicola Marchi
    Cerebrovascular Research, Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Cancer 112:1313-24. 2008
    ..However, a confounding factor was the presence of BBB changes due to cerebrovascular disease...
  7. ncbi request reprint Seizure-promoting effect of blood-brain barrier disruption
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:732-42. 2007
    ..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures...
  8. pmc Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow
    Chaitali Ghosh
    Department of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Epilepsia 51:1408-17. 2010
    ..We have evaluated the cerebrovascular CYP expression and function, hypothesizing possible implication in drug-resistant epilepsy...
  9. pmc Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema
    Nicola Marchi
    Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 50:664-77. 2009
    ..We tested the hypothesis that lipophilic and hydrophilic drug distribution is differentially affected by BBB damage...
  10. pmc Cellular localization and functional significance of CYP3A4 in the human epileptic brain
    Chaitali Ghosh
    Cerebrovascular ResearchDepartments of Cell Biology Molecular Medicine Neurological Surgery Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 52:562-71. 2011
    ..We have evaluated the pattern of expression of the specific enzyme CYP3A4 and studied its co-localization with MDR1. We also determined whether an association exists between CYP3A4 expression and cell survival...
  11. pmc Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Brain Res 1353:176-86. 2010
    ..Our data suggest that neither acute-induced nor chronic seizures correlate with WBC brain parenchymal migration while albumin and IgG brain leakage is a hallmark of acute and chronic seizures...
  12. ncbi request reprint Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    Luca Cucullo
    Center for Cerebrovascular Research, Cleveland, Ohio, USA
    Epilepsia 48:505-16. 2007
    ....
  13. pmc A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain
    Chaitali Ghosh
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurobiol Dis 46:692-700. 2012
    ..Our data suggest that a drug resistant BBB not only impedes drug access to the brain but may also allow the formation of neurotoxic metabolites...
  14. pmc Antagonism of peripheral inflammation reduces the severity of status epilepticus
    Nicola Marchi
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    Neurobiol Dis 33:171-81. 2009
    ..Animals pre-treated with IL-1ra exhibited significant reduction of SE onset and of BBB damage. Our data support the concept of targeting systemic inflammation and BBB for the prevention of status epilepticus...
  15. pmc Peripheral markers of brain damage and blood-brain barrier dysfunction
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Restor Neurol Neurosci 21:109-21. 2003
    ....
  16. pmc Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains
    Chaitali Ghosh
    Department of Cellular, Cleveland Clinic, Cleveland, Ohio, USA
    Epilepsia 54:1562-70. 2013
    ..The possibility that phase II metabolic enzymes could be expressed in the epileptic brain has been not evaluated. Phase II enzymes are involved in the metabolism of common antiepileptic drugs (AEDs)...
  17. pmc Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 52:1627-34. 2011
    ..We tested the hypothesis that immunosupression by splenectomy or lack of perforin, a downstream factor of natural killer (NK) and cytotoxic T cells, could reduce seizure onset...
  18. pmc Management of the patient with medically refractory epilepsy
    Tiziana Granata
    Department of Neurology, Cleveland, OH, USA and Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy
    Expert Rev Neurother 9:1791-802. 2009
    ..A promising approach is the use of corticosteroids that may have a dual beneficial effect. Resective brain surgery remains the ultimate and highly successful approach to multiple drug resistance in epileptic patients...
  19. ncbi request reprint S100beta as a predictor of brain metastases: brain versus cerebrovascular damage
    Michael A Vogelbaum
    Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 104:817-24. 2005
    ....
  20. pmc In vivo and in vitro effects of pilocarpine: relevance to ictogenesis
    Nicola Marchi
    Department of Cerebrovascular Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:1934-46. 2007
    ..The extent of such peripheral events and the contribution to SE are unknown and the possibility that pilocarpine also induces SE by peripheral actions is yet untested...
  21. pmc A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system
    Luca Cucullo
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 31:767-77. 2011
    ..We also observed abluminal extravasation of monocytes but only when the BBB was breached. In conclusion, the DIV-BBBr represents the most realistic in vitro system to study the immune cell trafficking across the BBB...
  22. ncbi request reprint Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases
    Chaitali Ghosh
    Molecular Medicine Cerebrovascular Research Cleveland Clinic Foundation NB 20 9500 Euclid Ave Cleveland, OH 44195, USA
    Curr Drug Metab 12:742-9. 2011
    ..Finally, a link between P450 and MDT expression in the diseased brain and cell survival is discussed...
  23. ncbi request reprint Peripheral markers of blood-brain barrier damage
    Nicola Marchi
    Department of Neurological Surgery, Cerebrovascular Research Center, NB20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Chim Acta 342:1-12. 2004
    ..We will present clinical and laboratory evidence supporting the use of these markers as modern neurodiagnostic tools...
  24. pmc Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
    PLoS ONE 6:e18200. 2011
    ..The mechanism encompasses improvement of BBB integrity. Our results also suggest that add on GCs could be of efficacy in controlling pediatric drug resistant seizures...
  25. pmc Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    Nicola Marchi
    Cerebrovascular Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Med 2:37. 2004
    ..Since various antiepileptic drugs (AEDs) can act as substrates for MDR1, the enhanced expression/function of this protein may increase their active extrusion from the brain, resulting in decreased responsiveness to AEDs...
  26. ncbi request reprint Blood-brain barrier damage induces release of alpha2-macroglobulin
    Luca Cucullo
    Department of Neurological Surgery, Cerebrovascular Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 2:234-41. 2003
    ..We conclude that, in addition to proinflammatory changes, BBB failure may also trigger protective release of alpha2M by perivascular astrocytes as well as peripheral source...
  27. ncbi request reprint Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy
    Matteo Marroni
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Drug Targets 4:297-304. 2003
    ..This second line of defense for xenobiotics may have profound implications for the pharmacokinetic properties of antiepileptic drugs and their capacity to reach neuronal targets...
  28. pmc Serum S100B: a potential biomarker for suicidality in adolescents?
    Tatiana Falcone
    Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11089. 2010
    ..Others reported a possible link between inflammation, a microgliosis and the blood-brain barrier (BBB) in suicidal patients. Serum S100B is a marker of BBB function commonly used to study cerebrovascular wall function...
  29. ncbi request reprint In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance
    Emily Oby
    Cerebrovascular Research Center, The Cleveland Clinic, OH 44195, USA
    Brain Res 1086:201-13. 2006
    ..Taken together, our results support the hypothesis that multiple drug resistance to AEDs involves cerebrovascular changes that impede the achievement of appropriate drug levels in the central nervous system...
  30. pmc A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches
    Damir Janigro
    Departments of Neurological Surgery, Cellular and Molecular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 54:30-2. 2013
    ..For instance, corticosteroids have been shown to be beneficial and the same agents may be able to further reduce seizure burden in conjunction with currently prescribed antiepileptic drugs. ..
  31. pmc Consequences of repeated blood-brain barrier disruption in football players
    Nicola Marchi
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    PLoS ONE 8:e56805. 2013
    ..The correlation of serum S100B, auto-antibodies and DTI changes support a link between repeated BBBD and future risk for cognitive changes...
  32. pmc Significance of ubiquitin carboxy-terminal hydrolase l1 elevations in athletes after sub-concussive head hits
    Vikram Puvenna
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 9:e96296. 2014
    ..UCH-L1 did not display any interpretable change in football players or in individuals with mild TBI. The significance of UCH-L1 changes in sub-concussions or mTBI needs to be further elucidated. ..
  33. pmc Is peripheral immunity regulated by blood-brain barrier permeability changes?
    Erin Bargerstock
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 9:e101477. 2014
    ..We propose a scenario where extravasated S100B may trigger a pathologic autoimmune reaction linking systemic and CNS immune responses. ..
  34. pmc Inflammatory pathways of seizure disorders
    Nicola Marchi
    Department of Molecular Medicine, Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA Department of Neurobiology, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France
    Trends Neurosci 37:55-65. 2014
    ..Here, we summarize recent advances in the understanding and treatment of epileptic seizures that derive from a non-neurocentric viewpoint and suggest key avenues for future research. ..
  35. ncbi request reprint Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption
    Nicola Marchi
    Division of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44196, USA
    J Neurosci 23:1949-55. 2003
    ..Because TTR is localized primarily in choroid plexus and, as a soluble monomer, in CSF, we concluded that although S-100beta is a marker of BBB integrity, TTR instead may be a peripheral tracer of blood-to-cerebrospinal barrier...