A M Lincoff


Affiliation: Cleveland Clinic Foundation
Country: USA


  1. request reprint
    Lincoff A, Bittl J, Harrington R, Feit F, Kleiman N, Jackman J, et al. Bivalirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA. 2003;289:853-63 pubmed
  2. Lincoff A, Mehran R, Povsic T, Zelenkofske S, Huang Z, Armstrong P, et al. Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial. Lancet. 2016;387:349-356 pubmed publisher
    ..Although statistical power was limited because of early termination, there was no evidence that REG1 reduced ischaemic events or bleeding compared with bivalirudin. Regado Biosciences Inc. ..
  3. request reprint
    Lincoff A, Bittl J, Kleiman N, Sarembock I, Jackman J, Mehta S, et al. Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events [REPLACE]-1 trial). Am J Cardiol. 2004;93:1092-6 pubmed
    ..52). This trial represents the largest prospective dataset of bivalirudin administered concomitantly with planned GP IIb/IIIa blockade and provides evidence of the safety and efficacy of this combined antithrombotic approach. ..
  4. request reprint
    Lincoff A, Kleiman N, Kereiakes D, Feit F, Bittl J, Jackman J, et al. Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial. JAMA. 2004;292:696-703 pubmed
    ..Long-term clinical outcome with bivalirudin and provisional Gp IIb/IIIa blockade is comparable with that of heparin plus planned Gp IIb/IIIa inhibition during contemporary PCI. ..
  5. Lincoff A, Steinhubl S, Manoukian S, Chew D, Pollack C, Feit F, et al. Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization . JACC Cardiovasc Interv. 2008;1:639-48 pubmed publisher
    ..If it is anticipated that clopidogrel will be given late or not at all after PCI, bivalirudin alone may be associated with worse ischemic outcomes. (Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes; NCT00093158). ..
  6. Menon V, Lincoff A. Cardiovascular safety evaluation in the development of new drugs for diabetes mellitus. Circulation. 2014;129:2705-13 pubmed publisher
  7. Wu W, Lincoff A. Pharmacotherapy During Saphenous Vein Graft Intervention. Interv Cardiol Clin. 2013;2:273-282 pubmed publisher
    ..No-reflow frequently complicates vein graft interventions but can be treated with vasoactive agents such as calcium channel blockers, adenosine, and nitroprusside. ..