Affiliation: Cleveland Clinic Foundation
Zhang L, Bell B, Yu M, Chan C, Peachey N, Fung J, et al
. Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. J Leukoc Biol. 2016;99:447-54 pubmed publisher
Xu J, Zhang L, Xie M, Li Y, Huang P, Saunders T, et al
. Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. J Immunol. 2018;200:4094-4101 pubmed publisher
..Our findings demonstrate a previously unknown but pivotal role of complement in CIPN and suggest that complement may be a new target for the development of novel therapeutics to manage this painful disease. ..
Zhang L, Fedorov Y, Adams D, Lin F. Identification of complement inhibitory activities of two chemotherapeutic agents using a high-throughput cell imaging-based screening assay. Mol Immunol. 2018;101:86-91 pubmed publisher
..In summary, this work has established a simple, large-scale, high-throughput assay for screening novel complement inhibitors and discovered previously unknown complement activation inhibitory activities for cisplatin and pyridostatin. ..
Han J, Enyindah Asonye G, Lin F, Smith J. CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice. BMC Res Notes. 2018;11:229 pubmed publisher
..Thus, loss of CD6 on lymphocytes did not lead to expected reductions in B1a cells and protective IgM levels, and in turn did not alter atherosclerosis in mice. ..
Zhang L, Sorensen M, Kristensen B, Reifenberger G, McIntyre T, Lin F. D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells. Clin Cancer Res. 2018;24:5381-5391 pubmed publisher
..b>Conclusions: D 2-HG suppresses the host immune system, potentially promoting immune escape of IDH-mutant tumors. Clin Cancer Res; 24(21); 5381-91. ©2018 AACR. ..
Li Y, Clow F, Fraser J, Lin F. Therapeutic potential of staphylococcal superantigen-like protein 7 for complement-mediated hemolysis. J Mol Med (Berl). 2018;96:965-974 pubmed publisher
..SSL7 functions in the presence of anti-SSL7 antibodies both in vitro and in vivo. • SSL7 has the potential to be developed as a new and economical complement inhibitor for treating complement-mediated hemolysis. ..
Li Y, Lu L, Qian S, Fung J, Lin F. Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1. J Immunol. 2016;196:1617-25 pubmed publisher
..This direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis. ..
Zhang L, Li Y, Qiu W, Bell B, Dvorina N, Baldwin W, et al
. Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun. 2018;90:84-93 pubmed publisher
..In addition, the newly developed mouse anti-mouse/human CD6 mAbs could be valuable tools for testing CD6-targeted therapies in other mouse models of human diseases. ..
Li Y, Kim B, Qian S, Letterio J, Fung J, Lu L, et al
. Hepatic Stellate Cells Inhibit T Cells through Active TGF-Î²1 from a Cell Surface-Bound Latent TGF-Î²1/GARP Complex. J Immunol. 2015;195:2648-56 pubmed publisher
..Our study reveals a new mechanism for HSC-mediated immune regulation and potentially for other conditions, such as liver fibrosis, that involve HSC-secreted TGF-Î²1. ..